Lawrence Litt, MD, PhD
Professor Emeritus
Anesthesia
School of Medicine
Now an emeritus professor, I am retired from all research, teaching, and clinical activities. Laboratory research was supported by 28 years of NIH funding via R01 GM034767, during which time I was a member of NIH's Neurology A Study Section for 7 years, and then a member of the Surgery, Anesthesiology and Trauma Study Section for 5 years.
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Publications listed below are from a list of 88 peer-reviewed publications in professional journals, with 21 being as an experimental elementary particle physicist with post-doc and junior faculty appointments at Harvard, Rockefeller University, and Michigan State University, and visiting scientist appointments at the Centre Européenne pour la Recherche Nucléaire (CERN), Brookhaven, and Fermilab. Approximately 40% of my time during my 33 years at the Parnassus Campus was in clinical anesthesia teaching and care in the Moffitt-Long Hospital Operating rooms, with an emphasis on anesthesia for neurological surgery.
Education & Training
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- Anesthesia Residency UCSF 06/1982
- M.D. medicine Univ of Miami School of Medicine 06/1979
- PhD physics Harvard Graduate School of Arts and Sciences 06/1971
- A.B. physics Columbia College 06/1963
Grants and Projects
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Publications (16)
Top publication keywords:
Hypoxia, BrainFructosediphosphatesAdenosine TriphosphateCerebral CortexBrain ChemistryMetabolomeForamen Ovale, PatentHypothermia, InducedOxidative StressAnimals, NewbornPyruvatesPoly(ADP-ribose) PolymerasesCholecystitis, AcuteHypoxia-Ischemia, BrainNeuroprotective Agents
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13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation.
Anesthesiology 2013 Liu J, Segal MR, Kelly MJ, Pelton JG, Kim M, James TL, Litt L -
1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries.
Pediatric research 2013 Liu J, Sheldon RA, Segal MR, Kelly MJ, Pelton JG, Ferriero DM, James TL, Litt L -
Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.
International journal of molecular sciences 2011 Liu J, Litt L, Segal MR, Kelly MJ, Pelton JG, Kim M -
Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open?
Journal of clinical anesthesia 2010 Thoma MS, Maa J, Schiller NB, Litt L -
Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Liu J, Litt L, Segal MR, Kelly MJ, Yoshihara HA, James TL -
Anesthetic concerns in patients with known cerebrovascular insufficiency.
Anesthesiology clinics 2010 Logvinova AV, Litt L, Young WL, Lee CZ -
Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices.
Brain research 2008 Liu J, Hirai K, Litt L -
Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.
Anesthesiology 2007 Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L -
Awareness without recall during anesthesia for electroconvulsive therapy.
Anesthesiology 2007 Litt L, Li D -
Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006 Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L -
Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices.
Journal of bioenergetics and biomembranes 2004 Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L -
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.
Brain research. Molecular brain research 2004 Hirai K, Hayashi T, Chan PH, Zeng J, Yang GY, Basus VJ, James TL, Litt L -
Physiologic monitoring and anesthesia considerations in acute ischemic stroke.
Journal of vascular and interventional radiology : JVIR 2004 Lee CZ, Litt L, Hashimoto T, Young WL -
Temperature control of respiring rat brain slices during high field NMR spectroscopy.
Brain research. Brain research protocols 2003 Litt L, Hirai K, Basus VJ, James TL -
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002 Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U -
Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators.
Anesthesia and analgesia 2004 Fourcade O, Simon MF, Litt L, Samii K, Chap H