Lawren Vandevrede, MD, PhD
Assistant Professor
Neurology
School of Medicine

VandeVrede's research focuses on improving scientific understanding of neurodegenerative disorders (conditions in which nerve cells progressively deteriorate or die) and developing treatments for them.

VandeVrede earned his medical degree and a doctorate in neuroscience from the University of Illinois at Chicago College of Medicine. He completed a residency in neurology at Brigham and Women's Hospital, followed by a fellowship in behavioral neurology at UCSF.

• An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson KR, Reed X, Johnson NL, Kollasch AW, Duffy MF, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Marks DS, Yokoyama JS, Kwan JY,…
• Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.
  JMIR aging 2024 Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, …
• Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.
  Annals of neurology 2024 Garcia-Cordero I, Anastassiadis C, Khoja A, Morales-Rivero A, Thapa S, Vasilevskaya A, Davenport C, Sumra V, Couto B, Multani N, Taghdiri F, Anor C, Misquitta K, Vandevrede L, Heuer H, Tang-Wai D, …
• Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Research square 2024 Saloner R, Staffaroni A, Dammer E, Johnson ECB, Paolillo E, Wise A, Heuer H, Forsberg L, Lago AL, Webb J, Vogel J, Santillo A, Hansson O, Kramer J, Miller B, Li J, Loureiro J, Sivasankaran R, …
• Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L
• Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.
  medRxiv : the preprint server for health sciences 2024 Scotton WJ, Shand C, Todd EG, Bocchetta M, Cash DM, VandeVrede L, Heuer HW, Young AL, Oxtoby N, Alexander DC, Rowe JB, Morris HR, PROSPECT Consortium, Boxer AL, 4RTNI Consortium, Rohrer JD, Wijeratne …
• Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
  Neurology 2024 Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto …
• Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia.
  bioRxiv : the preprint server for biology 2024 Hsiao-Nakamoto J, Chiu CL, VandeVrede L, Ravi R, Vandenberg B, De Groot J, Tsogtbaatar B, Fang M, Auger P, Gould NS, Marchioni F, Powers CA, Davis SS, Suh JH, Alkabsh J, Heuer HW, Lago AL, Scearce-…
• Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
  Acta neuropathologica 2024 Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat …
• Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Tsoy E, La Joie R, VandeVrede L, Rojas JC, Yballa C, Chan B, Lago AL, Rodriguez AM, Goode CA, Erlhoff SJ, Tee BL, Windon C, Lanata S, Kramer JH, Miller BL, Dilworth-Anderson P, Boxer AL, Rabinovici GD…
• Prevalence of cognitive impairment in liver transplant recipients.
  Clinical transplantation 2023 Berry K, Ruck JM, Barry F, Shui AM, Cortella A, Kent D, Seetharaman S, Wong R, VandeVrede L, Lai JC
• [18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2023 Blazhenets G, Soleimani-Meigooni DN, Thomas W, Mundada N, Brendel M, Vento S, VandeVrede L, Heuer HW, Ljubenkov P, Rojas JC, Chen MK, Amuiri AN, Miller Z, Gorno-Tempini ML, Miller BL, Rosen HJ, Litvan…
• An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.
  Research square 2023 Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson K, Reed X, Johnson NL, Kollasch AW, Duffy M, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Yokoyama JS, Marks DS, Kwan JY, …
• Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.
  Alzheimer's research & therapy 2023 Mundada NS, Rojas JC, Vandevrede L, Thijssen EH, Iaccarino L, Okoye OC, Shankar R, Soleimani-Meigooni DN, Lago AL, Miller BL, Teunissen CE, Heuer H, Rosen HJ, Dage JL, Jagust WJ, Rabinovici GD, Boxer …
• Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.
  Acta neuropathologica 2023 VandeVrede L, La Joie R, Horiki S, Mundada NS, Koestler M, Hwang JH, Ljubenkov PA, Rojas JC, Rabinovici GD, Boxer AL, Seeley WW
• Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH
• Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome.
  Alzheimer's research & therapy 2023 Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL…
• Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.
  The Journal of clinical investigation 2023 Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL
• Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome.
  JAMA neurology 2023 VandeVrede L, La Joie R, Thijssen EH, Asken BM, Vento SA, Tsuei T, Baker SL, Cobigo Y, Fonseca C, Heuer HW, Kramer JH, Ljubenkov PA, Rabinovici GD, Rojas JC, Rosen HJ, Staffaroni AM, Boeve BF, …
• Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.
  Journal of neurology, neurosurgery, and psychiatry 2023 Asken BM, Ljubenkov PA, Staffaroni AM, Casaletto KB, Vandevrede L, Cobigo Y, Rojas-Rodriguez JC, Rankin KP, Kornak J, Heuer H, Shigenaga J, Appleby BS, Bozoki AC, Domoto-Reilly K, Ghoshal N, Huey E, …
• Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning.
  Brain communications 2023 Scotton WJ, Shand C, Todd E, Bocchetta M, Cash DM, VandeVrede L, Heuer H, PROSPECT Consortium, 4RTNI Consortium , Young AL, Oxtoby N, Alexander DC, Rowe JB, Morris HR, Boxer AL, Rohrer JD, Wijeratne …
• Feasibility and Acceptability of a Multidisciplinary Academic Telemedicine System for Memory Care in Response to COVID-19.
  Neurology. Clinical practice 2022 Rini JF, Tsoy E, Peet B, Best J, Tanner JA, Asken BM, Sanchez A, Apple AC, VandeVrede L, Stephens ML, Erkkinen M, Kramer JH, Miller BL
• CSF tau microtubule-binding region identifies pathological changes in primary tauopathies.
  Nature medicine 2022 Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller …
• Temporal order of clinical and biomarker changes in familial frontotemporal dementia.
  Nature medicine 2022 Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, …
• Oxford Textbook of Neuropsychiatry.
  Journal of Neuropsychiatry 2022 Lawren VandeVrede
• Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Berry K, Asken BM, Grab JD, Chan B, Lario Lago A, Wong R, Seetharaman S, LaHue SC, Possin KL, Rojas JC, Kramer JH, Boxer AL, Lai JC, VandeVrede L
• Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series.
  Journal of neurotrauma 2022 Asken BM, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, …
• Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.
  Neurology 2022 Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici …
• A data-driven model of brain volume changes in progressive supranuclear palsy.
  Brain communications 2022 Scotton WJ, Bocchetta M, Todd E, Cash DM, Oxtoby N, VandeVrede L, Heuer H, PROSPECT Consortium, 4RTNI Consortium, Alexander DC, Rowe JB, Morris HR, Boxer A, Rohrer JD, Wijeratne PA
• Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.
  JAMA network open 2022 Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, …
• A phase 1b, randomized, double-blind, placebo-controlled, parallel cohort safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy study of intravenously infused BIIB092 in patients with four different primary tauopathy syndromes.
  Alzheimer's & Dementia 2021 Peter A. Ljubenkov, Lawren Vandevrede, Julio C. Rojas, Richard Tsai, Mary Koestler, Danielle Graham, Tien Dam, Adam L. Boxer
• Distinct patters of associations between cognitive performance and Alzheimer’s disease biomarkers in a multinational cohort of clinically normal older adults.
  Alzheimer's & Dementia 2021 Elena Tsoy, Anna Brugulat-Serrat, Lawren Vandevrede, Sabrina J Erlhoff, Kaitlin B Casaletto, Katherine P Rankin, Joel H Kramer, Kate L Possin, EPAD Consortium
• Clinical value of CSF tau, p-tau181, neurogranin and neurofilaments in familial frontotemporal lobar degeneration.
  Alzheimer's & Dementia 2021 Julio C. Rojas, Hilary W. Heuer, Weiping Chen, Julie Czerkowicz, Danielle Graham, Leah K. Forsberg, Danielle Brushaber, Brian Appleby, Eliana Marisa Ramos, Giovanni Coppolla, Yvette M. Bordelon, Hugo …
• Demographic and psychosocial factors associated with the decision to learn mutation status in familial frontotemporal dementia and the impact of disclosure on mood.
  Alzheimer's & Dementia 2021 Lynn P. Bajorek, Rachel Kiekhofer, Matthew Hall, Joanne Taylor, Diane E Lucente, Danielle Brushaber, Brian Appleby, Giovanni Coppolla, Yvette M Bordelon, Hugo Botha, Brad C Dickerson, Dennis W Dickson…
• Diagnostic value of plasma P-tau217 in frontotemporal dementia spectrum disorders.
  Alzheimer's & Dementia 2021 Julio C. Rojas, Lawren Vandevrede, Hilary W. Heuer, Gianina Toller, Elisabeth H. Thijssen, Nicholas Proctor, Leah K. Forsberg, Danielle Brushaber, Eliana Marisa Ramos, Giovanni Coppola, Brian Appleby,…
• Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
  The Lancet. Neurology 2021 Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin…
• Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care.
  Frontiers in neurology 2021 Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R, Duquette A, Fernandez HH, Fleisher JE, Grossman M, Howell M, Kerwin DR, Leegwater-Kim J, …
• Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
  Journal of the International Neuropsychological Society : JINS 2021 Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB
• Lipid metabolism dysfunction in progranulin mutation carriers: Unbiased metabolomics reveals strong relationship to clinical status in FTLD.
  Alzheimer's & Dementia 2020 Lawren Vandevrede, Julio C. Rojas, Ping Wang, Hilary W. Heuer, Anna M. Karydas, Peter A. Ljubenkov, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer, ARTFL and LEFFTDS Consortia Investigators
• Plasma biomarkers of inflammation reflect disease state in autosomal dominant forms of familial frontotemporal dementia.
  Alzheimer's & Dementia 2020 Peter A. Ljubenkov, Adam M. Staffaroni, Kaitlin B. Casaletto, Julio C. Rojas, Lawren Vandevrede, Hilary W. Heuer, Fanny M. Elahi, Danielle Brushaber, Tatiana M. Foroud, Leah K. Forsberg, Anna M. …
• Symptomatic amyloid-related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2020 VandeVrede L, Gibbs DM, Koestler M, La Joie R, Ljubenkov PA, Provost K, Soleimani-Meigooni D, Strom A, Tsoy E, Rabinovici GD, Boxer AL
• Four-Repeat Tauopathies: Current Management and Future Treatments.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 VandeVrede L, Ljubenkov PA, Rojas JC, Welch AE, Boxer AL
• Targeting tau: Clinical trials and novel therapeutic approaches.
  Neuroscience letters 2020 VandeVrede L, Boxer AL, Polydoro M
• Open-Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy.
  Movement disorders clinical practice 2020 VandeVrede L, Dale ML, Fields S, Frank M, Hare E, Heuer HW, Keith K, Koestler M, Ljubenkov PA, McDermott D, Ohanesian N, Richards J, Rojas JC, Thijssen EH, Walsh C, Wang P, Wolf A, Quinn JF, Tsai R, …
• Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy.
  JAMA neurology 2020 Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici …
• Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.
  Nature medicine 2020 Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H,…
• Dizziness caused by meningocele-associated intracranial hypotension in neurofibromatosis type 1.
  Neurology 2016 VandeVrede L, Colorado RA, Lee JW
• Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.
  Molecular neurodegeneration 2016 Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR
• A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.
  Molecular neurodegeneration 2016 Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR
• Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.
  BMC neuroscience 2015 Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Ben Aissa M, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR
• Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
  British journal of pharmacology 2014 Vandevrede L, Tavassoli E, Luo J, Qin Z, Yue L, Pepperberg DR, Thatcher GR
• An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk.
  PloS one 2013 VandeVrede L, Abdelhamid R, Qin Z, Choi J, Piyankarage S, Luo J, Larson J, Bennett BM, Thatcher GR
• Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway.
  BMC Pharmacology and Toxicology 2013 Marton I Siklos, Ronak P Gandhi, Rui Xiong, Isaac T Schiefer, Vladislav Litosh, Lawren VandeVrede, Gregory RJ Thatcher
• NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-ß neuropathology in transgenic models of Alzheimer’s disease.
  BMC Pharmacology and Toxicology 2013 Gregory RJ Thatcher, Jia Luo, Lawren VandeVrede, Zhihui Qin, Sue Lee, Ramy Abdelhamid, Brian M Bennett, Mary Jo LaDu, Leon Tai, John Larson
• Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.
  Journal of medicinal chemistry 2012 Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR
• Mechanistic investigation of nitrate chimeras for Alzheimer's disease.
  Alzheimer's & Dementia 2012 Jia Luo, Lawren VandeVrede, Zhihui Qin, Ehsan Tavasolli, Gregory Thatcher
• Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.
  Journal of medicinal chemistry 2012 Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR
• Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism.
  ACS chemical neuroscience 2011 Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR
• Chapter 1: Seven New Species and a New Subgenus of Forest Mice (Rodentia: Muridae: Apomys) from Luzon Island.
  Fieldiana Life and Earth Sciences 2011 Lawrence R. Heaney, Danilo S. Balete, Eric A. Rickart, Phillip A. Alviola, Mariano Roy M. Duya, Melizar V. Duya, M. Josefa Veluz, Lawren VandeVrede, Scott J. Steppan