Laurence Tecott, MD, PhD
Professor Emeritus
Psychiatry
School of Medicine

Education & Training

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• M.D. School of Medicine University of California, San Francisco 1983
• Residency School of Medicine University of California, San Francisco

Websites

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• Profile at UCSF Department of Psychiatry (psych.ucsf.edu)

Videos

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• Food and Addiction: Reflections on the Research (youtube.com)

Grants and Projects

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• Striatal Circuits In The Serotonergic Modulation Of Hedonic States, NIH, 2015-2018
• Impact of Energy Status on the Serotonergic Regulation of Energy Balance, NIH, 2010-2014
• Management and Analysis of Mouse Behavioral Datasets, NIH, 2007-2009
• A Quantitative Approach for Detecting Anxiolytic Drug Effects in the Mouse, NIH, 2007-2009
• Serotonergic genetic influences on the impact of maternal environment, NIH, 2007-2009
• Genetic Approaches to Serotonin and Feeding Behavior, NIH, 2000-2006
• Ingestive Behavior in Serotonin Receptor Mutant Mice, NIH, 2000-2006
• Serotonin 5Ht2C Receptors and the Actions of Cocaine, NIH, 1998-2002
• Models to Analyze Serotonin Receptor Functions, NIH, 1995-2000
• Opiates and Neuronal Substrates of Associative Learning, NIH, 1984-1900

Publications (58)

Top publication keywords:
SerotoninReceptors, SerotoninReceptor, Serotonin, 5-HT2CIntegrasesReflex, StartleVocalization, AnimalStereotyped BehaviorSatiety ResponseHypothalamo-Hypophyseal SystemNeural PathwaysFeeding BehaviorConditioning, OperantBehavior, AnimalEnergy MetabolismHypothalamus

• Gene Targeting Models of Epilepsy: Technical and Analytical Considerations.
  Neuropharmacology Methods in Epilepsy Research 2019 Laurence H. Tecott
• Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits.
  Aging 2016 Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA
• Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.
  PloS one 2015 Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH
• Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2015 Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL
• Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS

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• Axonal control of the adult neural stem cell niche.
  Cell stem cell 2014 Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A
• Serotonin and the regulation of mammalian energy balance.
  Frontiers in neuroscience 2013 Donovan MH, Tecott LH
• Impact of serotonin (5-HT)2C receptors on executive control processes.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012 Pennanen L, van der Hart M, Yu L, Tecott LH
• Convergence of the insulin and serotonin programs in the pancreatic β-cell.
  Diabetes 2011 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS
• A flexible estimating equations approach for mapping function-valued traits.
  Genetics 2011 Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S
• Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.
  Pain 2011 Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI
• The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression.
  5-HT2C Receptors in the Pathophysiology of CNS Disease 2011 Eliyahu Dremencov, Joost H. A. Folgering, Sandra Hogg, Laurence Tecott, Thomas I. F. H. Cremers
• Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
  Journal of biomedical science 2010 Honig G, Liou A, Berger M, German MS, Tecott LH
• CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.
  Genes & development 2010 Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G
• Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice.
  PloS one 2010 Hsu JL, Yu L, Sullivan E, Bowman M, Mistlberger RE, Tecott LH
• Serotonin regulates pancreatic beta cell mass during pregnancy.
  Nature medicine 2010 Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German …
• Serotonin activates murine alveolar macrophages through 5-HT2C receptors.
  American journal of physiology. Lung cellular and molecular physiology 2010 Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer W
• A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.
  Cell 2009 Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G
• Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.
  PloS one 2009 Honig G, Jongsma ME, van der Hart MC, Tecott LH
• Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.
  Journal of neurodevelopmental disorders 2009 Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M
• Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH
• Rodent Behavior: Approaches.
  Encyclopedia of Neuroscience 2009 L.H. Tecott, E.J. Nestler
• A robust automated system elucidates mouse home cage behavioral structure.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Goulding EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH
• Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.
  Neuron 2008 Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY
• It is time to take a stand for medical research and against terrorism targeting medical scientists.
  Biological psychiatry 2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff…
• Relevance of animal models to human eating disorders and obesity.
  Psychopharmacology 2008 Casper RC, Sullivan EL, Tecott L
• Expression level of 5-HT1A receptor alters firing rate and concentration-dependency in YFP-labeled 5-HT dorsal raphe neurons.
  The FASEB Journal 2008 Kayla L Metzger, Lyngine H Calizo, Alisson Stephen, Miles Berger, Laurence H Tecott, Sheryl G Beck
• 5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement.
  The open neuropsychopharmacology journal 2008 Scott-McKean JJ, Wenger GR, Tecott LH, Costa AC
• A novel method for automatic quantification of psychostimulant-evoked route-tracing stereotypy: application to Mus musculus.
  Psychopharmacology 2007 Bonasera SJ, Schenk AK, Luxenberg EJ, Tecott LH
• Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors.
  Endocrinology 2007 Wade JM, Juneja P, MacKay AW, Graham J, Havel PJ, Tecott LH, Goulding EH
• Serotonin and the orchestration of energy balance.
  Cell metabolism 2007 Tecott LH
• Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH
• Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.
  Nature neuroscience 2006 Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ
• Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.
  The Journal of clinical investigation 2006 O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC
• A null mutation of the serotonin 6 receptor alters acute responses to ethanol.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006 Bonasera SJ, Chu HM, Brennan TJ, Tecott LH
• Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.
  Molecular pharmacology 2006 Kushwaha N, Harwood SC, Wilson AM, Berger M, Tecott LH, Roth BL, Albert PR
• Serotonin System Gene Knockouts.
  The Serotonin Receptors 2006 Miles Berger, Laurence H. Tecott
• Social circuits: peptidergic regulation of mammalian social behavior.
  Neuron 2005 Storm EE, Tecott LH
• Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice.
  Neuron 2004 Cannon CM, Abdallah L, Tecott LH, During MJ, Palmiter RD
• Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004 Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Arnt J, Mørk A, Honig G, Bøgesø KP, Westerink BH, den Boer H, Wikstrom HV, Tecott LH
• Neurobehavioral assessment in the information age.
  Nature neuroscience 2004 Tecott LH, Nestler EJ
• Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems.
  European journal of pharmacology 2004 Giorgetti M, Tecott LH
• Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice.
  CNS spectrums 2003 Tecott LH, Abdallah L
• Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.
  Nature neuroscience 2003 Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF
• Central serotonin and melanocortin pathways regulating energy homeostasis.
  Annals of the New York Academy of Sciences 2003 Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK
• The genes and brains of mice and men.
  The American journal of psychiatry 2003 Tecott LH
• Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice.
  Diabetes 2003 Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH
• Activation of central melanocortin pathways by fenfluramine.
  Science (New York, N.Y.) 2002 Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK
• Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice.
  Biochemical and biophysical research communications 2002 Nonogaki K, Memon RA, Grunfeld C, Feingold KR, Tecott LH
• Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors.
  Journal of neuroscience research 2002 López-Giménez JF, Tecott LH, Palacios JM, Mengod G, Vilaró MT
• FOOD INTAKE IN THE GENETICALLY ALTERED MOUSE.
  Behavioural Pharmacology 1999 Laurence Tecott
• Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT(2C) receptor gene mutation.
  The international journal of neuropsychopharmacology 1999 Heisler LK, Tecott LH
• NEUROBEHAVIORAL ANALYSIS OF SEROTONIN RECEPTOR MUTANT MICE.
  Behavioural Pharmacology 1998 L. H. Tecott, L. K. Heisler, K. Nonogaki, H. M. Chu
• NEUROBEHAVIORAL ANALYSIS OF SEROTONIN RECEPTOR MUTANT MICE.
  Behavioural Pharmacology 1998 L. H. Tecott, L. K. Heisler, K. Nonogaki, H. M. Chu
• NEUROBEHAVIORAL ANALYSIS OF SEROTONIN RECEPTOR MUTANT MICE.
  Behavioural Pharmacology 1998 L. H. Tecott, L. K. Heisler, K. Nonogaki, H. M. Chu
• Gene Targeting Models of Epilepsy.
  Neuropharmacology Methods in Epilepsy Research 1998 Laurence Tecott
• Gene targeting approaches to analyse neurotransmitter receptor function.
  Seminars in Neuroscience 1996 Laurence H. Tecott, Thomas J. Brennan, Lucia Guh
• Methodological Considerations in the Utilization of In Situ Hybridization.
  In Situ Hybridization in Neurobiology 1994 Laurence H Tecott, James H Eberwine, Jack D Barchas, Karen L Valentino