Laurence Huang, MD
Professor
Medicine
School of Medicine

Currently, I am PI/Co-PI on these main studies:

I AM OLD and I AM OLD-DA (renewal): The Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study and The Inflammation, Aging, Microbes, Obstructive Lung Disease, and Diffusion Abnormalities (I AM OLD-DA) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine potential mechanisms for development of obstructive lung disease and progression of airflow obstruction and diffusion abnormalities in a multi-national cohort of HIV-infected subjects with opportunistic pneumonia.

I AM GOLD: The Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine airway microbial communities (the lung microbiome) and inflammatory gene expression markers at the time of acute infection and during chronic stable disease that are associated with HIV-associated COPD and lung function decline in HIV and to perform integrative analyses of the airway microbiome, microbial and human transcriptome, metabolome and lung radiographic changes in HIV-associated COPD.

Recent, former studies: IHOP: The International HIV-associated Opportunistic Pneumonias (IHOP) Study is a multi-national cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to improve our understanding of the epidemiology, etiology, and outcome of pneumonias in persons with HIV infection. IHOP was part of the Lung HIV Study, a collaborative multi-R01 consortium established by the National Heart, Lung, and Blood Institute (NHLBI) to examine a diverse range of infectious and non-infectious pulmonary diseases in HIV-infected persons.

Lung MicroCHIP: The Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroChip) Study is a multi-cohort study with clinical sites in San Francisco and Kampala, Uganda, whose goal is to examine the composition and function of the lung microbiome in persons with HIV. Lung MicroChip was part of the Lung HIV Microbiome Project, a collaborative multi-U01 consortium established by the NHLBI to study the lung microbiome in HIV infection.

I am also involved in training the next generation of clinical and translational researchers at both fellowship and junior faculty levels, including through the following NIH-funded training programs:

Multidisciplinary Training Program in Lung Disease (NIH T32 HL007185): This is a continuation of the UCSF Multidisciplinary Training Program in Lung Disease, which provides training in basic and clinical sciences important to the respiratory system. The program draws on the basic and clinical research skills of the broad group of faculty at UCSF addressing questions directly relevant to lung biology and disease. The grant is to accommodate a total of 13 postdoctoral trainees, including both MDs and PhDs. The main program is an actual research experience under the close supervision of a Preceptor and a review committee selected on the basis of the experimental approaches of the trainee. These approaches include disciplines applicable at the molecular, cellular, tissue, organ, whole animal, clinical, or population levels.

CHIC (NIH K12 HL143961): The UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC) is a K12 training grant whose goals are: (1) To recruit MD, MD/PhD and PhD scholars dedicated to independent research careers conducting clinical and translational research in HIV-related heart, lung, and blood research; (2) To design, implement, and monitor individualized and tailored research training and career development of these scholars using an interdisciplinary, team-science, and team-mentoring approach that combines didactic training in research methods with supervised research under the mentorship of an experienced faculty mentor and mentoring team; (3) To produce the ‘next generation’ of researchers in HIV-associated heart, lung and blood diseases.

• Magnetic-activated cell sorting identifies a unique lung microbiome community.
  Microbiome 2023 Dunlap DG, Yang L, Qin S, Li K, Fitch A, Huang L, McVerry BJ, Hand TW, Methé BA, Morris A
• Diagnostic accuracy of Xpert MTB/RIF Ultra and culture assays to detect Mycobacterium Tuberculosis using OMNIgene-sputum processed stool among adult TB presumptive patients in Uganda.
  PloS one 2023 Sessolo A, Musisi E, Kaswabuli S, Zawedde J, Byanyima P, Sabiiti W, Walimbwa S, Ola J, Sanyu I, Lalitha R, Kamya M, Davis L, Worodria W, Huang L
• Lung Function in Women With and Without Human Immunodeficiency Virus.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Wang RJ, Nouraie M, Kunisaki KM, Huang L, Tien PC, Anastos K, Bhandari N, Bhatt SP, Bolivar H, Cribbs SK, Foronjy R, Gange SJ, Lazarous D, Morris A, Drummond MB
• Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.
  Journal of acquired immune deficiency syndromes (1999) 2022 Drummond MB, Edmonds A, Ramirez C, Stosor V, Barjaktarevic IZ, Morris A, McCormack MC, Bhatt SP, Alcaide ML, Cribbs SK, D'Souza G, Bhandari N, Kunisaki KM, Huang L, Kassaye SG, Foronjy R, Sharma A, …
• Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort.
  Annals of the American Thoracic Society 2022 Konstantinidis I, Qin S, Fitzpatrick M, Kessinger C, Gentry H, McMahon D, Weinman RD, Tien P, Huang L, McCormack M, Barjaktarevic I, Reddy D, Foronjy R, Lazarous D, Cohen MH, McKay H, Adimora AA, …
• Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda.
  Microbiology spectrum 2022 Byanyima P, Kaswabuli S, Musisi E, Nabakiibi C, Zawedde J, Sanyu I, Sessolo A, Andama A, Worodria W, Huang L, Davis JL
• Accuracy of GenoQuick MTB test in detection of Mycobacterium tuberculosis in sputum from TB presumptive patients in Uganda.
  SAGE open medicine 2022 Kaswabuli S, Musisi E, Byanyima P, Sessolo A, Sanyu I, Zawedde J, Worodria W, Huang L, Okeng A, Bwanga F
• Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy.
  Medicine 2022 Cyktor J, Qin S, Staines B, Nouraie M, Fitzpatrick M, Kessinger C, DeSensi R, Huang L, Rinaldo CR, Kingsley L, Tien PC, Mellors JW, Morris A
• Optimal Lung Cancer Screening Criteria Among Persons Living With HIV.
  Journal of acquired immune deficiency syndromes (1999) 2022 Sellers SA, Edmonds A, Ramirez C, Cribbs SK, Ofotokun I, Huang L, Morris A, Mccormack MC, Kunisaki KM, D'souza G, Rivera MP, Drummond MB, Adimora AA
• Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study.
  The Lancet. Microbe 2022 Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi …
• Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection.
  Frontiers in immunology 2022 Li W, Syed F, Yu R, Yang J, Xia Y, Relich RF, Russell PM, Zhang S, Khalili M, Huang L, Kacena MA, Zheng X, Yu Q
• High Mycobacterium tuberculosis Bacillary Loads Detected by Tuberculosis Molecular Bacterial Load Assay in Patient Stool: a Potential Alternative for Nonsputum Diagnosis and Treatment Response Monitoring of Tuberculosis.
  Microbiology spectrum 2022 Musisi E, Sessolo A, Kaswabuli S, Zawedde J, Byanyima P, Kasinga S, Sanyu I, Uwimaana E, Walimbwa S, Olore J, Ssengooba W, Sekaggya C, Joloba ML, Worodria W, Huang L, Gillespie SH, Sloan DJ, Sabiiti W
• CD4+ cell count and outcomes among HIV-infected compared with uninfected medical ICU survivors in a national cohort.
  AIDS (London, England) 2021 Akgün KM, Krishnan S, Butt AA, Gibert CL, Graber CJ, Huang L, Pisani MA, Rodriguez-Barradas MC, Hoo GWS, Justice AC, Crothers K, Tate JP
• A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV: Opportunities for improvement.
  Medicine 2021 Zifodya JS, Triplette M, Shahrir S, Attia EF, Akgun KM, Soo Hoo GW, Rodriguez-Barradas MC, Wongtrakool C, Huang L, Crothers K
• Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden.
  Microbiology spectrum 2021 Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, Kaswabuli S, Byanyima P, Sanyu I, Zawedde J, Worodria W, Voskuil MI, Savic RM, Nahid P, Davis JL, Huang L, Moore CM, Walter ND
• Brief Report: Association Between Pain, Pulmonary Function, and Respiratory Symptoms in People With HIV.
  Journal of acquired immune deficiency syndromes (1999) 2021 Singhvi DG, Nouraie M, Kessinger C, McMahon DK, Weinman R, Crothers K, Huang L, Bon J, Morris A, Merlin J
• Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV.
  AIDS (London, England) 2021 Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L
• Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens.
  Nature communications 2021 Walter ND, Born SEM, Robertson GT, Reichlen M, Dide-Agossou C, Ektnitphong VA, Rossmassler K, Ramey ME, Bauman AA, Ozols V, Bearrows SC, Schoolnik G, Dolganov G, Garcia B, Musisi E, Worodria W, Huang …
• Association of Monocyte Migration Marker CD11b With Pulmonary Function in People Living With HIV.
  Journal of acquired immune deficiency syndromes (1999) 2021 Kuniholm MH, Bramah-Lawani M, Fitzpatrick M, Nouraie M, Qin S, Huang L, Vallejo AN, Landay AL, Morris A
• C-Reactive Protein Testing for Active Tuberculosis among Inpatients without HIV in Uganda: a Diagnostic Accuracy Study.
  Journal of clinical microbiology 2020 Meyer AJ, Ochom E, Turimumahoro P, Byanyima P, Sanyu I, Lalitha R, Kaswabuli S, Andama A, Walter ND, Katamba A, Cattamanchi A, Worodria W, Huang L, Yoon C, Davis JL
• Chronic obstructive pulmonary disease in HIV.
  Expert review of respiratory medicine 2020 Byanova K, Kunisaki KM, Vasquez J, Huang L
• Community-Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV.
  Journal of the American Heart Association 2020 Zifodya JS, Duncan MS, So-Armah KA, Attia EF, Akgün KM, Rodriguez-Barradas MC, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Soo Hoo GW, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice …
• Associations of marijuana with markers of chronic lung disease in people living with HIV.
  HIV medicine 2020 Wenger DS, Triplette M, Shahrir S, Akgun KM, Wongtrakool C, Brown ST, Kim JW, Soo Hoo GW, Rodriguez-Barradas MC, Huang L, Feemster LC, Zifodya J, Crothers K
• Distinct lung microbiota associate with HIV-associated chronic lung disease in children.
  Scientific reports 2020 Bhadriraju S, Fadrosh DW, Shenoy MK, Lin DL, Lynch KV, McCauley K, Ferrand RA, Majonga ED, McHugh G, Huang L, Lynch SV, Metcalfe JZ
• Sonographic B-Lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis.
  American journal of respiratory and critical care medicine 2020 Wang RJ, Katha G, Phiri M, Delbridge P, Gordon SB, Calfee CS, Huang L, Rylance J
• Validation for using electronic health records to identify community acquired pneumonia hospitalization among people with and without HIV.
  Pneumonia (Nathan Qld.) 2020 Rodriguez-Barradas MC, McGinnis KA, Akgün K, Tate JP, Brown ST, Butt AA, Fine M, Goetz MB, Graber CJ, Huang L, Rimland D, Justice A, Crothers K
• HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
  Scientific reports 2020 Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, …
• Association Between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living With HIV and HIV-Uninfected Individuals.
  Journal of acquired immune deficiency syndromes (1999) 2020 Qin S, Vodovotz L, Zamora R, Fitzpatrick M, Kessinger C, Kingsley L, McMahon D, DeSensi R, Leader JK, Crothers K, Huang L, Morris A, Nouraie M
• Pneumoproteins are associated with pulmonary function in HIV-infected persons.
  PloS one 2019 Jeon D, Chang EG, McGing M, Hartman-Filson M, Sommers M, Lewis E, Balmes JR, Moisi D, Lederman MM, Madsen KA, Woodruff PG, Hunt PW, Huang L, Inflammation, Aging, Microbes and Obstructive Lung Disease…
• Global Health-related Training Opportunities. A National Survey of Pulmonary and Critical Care Medicine Fellowship Programs.
  Annals of the American Thoracic Society 2019 North CM, Attia EF, Rudd KE, Siddharthan T, Papali A, Çoruh B, Carter EJ, Christiani DC, Richards JB, Huang L, Engelberg R, Checkley W, West TE
• Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.
  Journal of human genetics 2019 Wang S, Chang E, Byanyima P, Huang P, Sanyu I, Musisi E, Sessolo A, Davis JL, Worodria W, Huang L, Lin J, Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study
• HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia.
  PloS one 2019 Wang RJ, Moore J, Moisi D, Chang EG, Byanyima P, Kaswabuli S, Musisi E, Sanyu I, Sessolo A, Lalitha R, Worodria W, Davis JL, Crothers K, Lin J, Lederman MM, Hunt PW, Huang L
• HIV infection is an independent risk factor for decreased 6-minute walk test distance.
  PloS one 2019 Robertson TE, Nouraie M, Qin S, Crothers KA, Kessinger CJ, McMahon D, Chandra D, Kingsley LA, Greenblatt RM, Huang L, Fitzpatrick ME, Morris A
• Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction.
  Microbiome 2019 Shenoy MK, Fadrosh DW, Lin DL, Worodria W, Byanyima P, Musisi E, Kaswabuli S, Zawedde J, Sanyu I, Chang E, Fong S, McCauley K, Davis JL, Huang L, Lynch SV
• Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States: A National, Retrospective Cohort Study, 1997-2014.
  Journal of acquired immune deficiency syndromes (1999) 2019 Rentsch CT, Tate JP, Steel T, Butt AA, Gibert CL, Huang L, Pisani M, Soo Hoo GW, Crystal S, Rodriguez-Barradas MC, Brown ST, Freiberg MS, Graber CJ, Kim JW, Rimland D, Justice AC, Fiellin DA, Crothers…
• Predictors of Mortality Among Hospitalized Patients With Lower Respiratory Tract Infections in a High HIV Burden Setting.
  Journal of acquired immune deficiency syndromes (1999) 2018 Worodria W, Chang E, Andama A, Sanyu I, Byanyima P, Musisi E, Kaswabuli S, Zawedde J, Ayakaka I, Sessolo A, Lalitha R, Davis JL, Huang L
• Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals.
  Journal of acquired immune deficiency syndromes (1999) 2018 Li Y, Nouraie SM, Kessinger C, Weinman R, Huang L, Greenblatt RM, Kleerup E, Kingsley L, McMahon D, Fitzpatrick M, Morris A
• The Relationship between Pneumocystis Infection in Animal and Human Hosts, and Climatological and Environmental Air Pollution Factors: A Systematic Review.
  OBM genetics 2018 Miller RF, Huang L, Walzer PD
• Diagnostic performance of blood inflammatory markers for tuberculosis screening in people living with HIV.
  PloS one 2018 Farr K, Ravindran R, Strnad L, Chang E, Chaisson LH, Yoon C, Worodria W, Andama A, Ayakaka I, Bbosa Nalwanga P, Byanyima P, Kalema N, Kaswabuli S, Katagira W, Aman KD, Musisi E, Tumwine NW, Sanyu I, …
• Tropheryma whipplei colonization in HIV-infected individuals is not associated with lung function or inflammation.
  PloS one 2018 Qin S, Clausen E, Nouraie SM, Kingsley L, McMahon D, Kleerup E, Huang L, Ghedin E, Greenblatt RM, Morris A
• Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB.
  African health sciences 2018 Musisi E, Matovu DK, Bukenya A, Kaswabuli S, Zawedde J, Andama A, Byanyima P, Sanyu I, Sessolo A, Seremba E, Davis JL, Worodria W, Huang L, Walter ND, Mayanja-Kizza H
• Does discovery of differentially culturable M tuberculosis really demand a new treatment paradigm? Longitudinal analysis of DNA clearance from sputum.
  BMC infectious diseases 2018 Walter ND, Moore CM, Kayigire XA, Dide-Agossou C, Worodria W, Huang L, Everett CK, Schoolnik GS, Nahid P, Davis JL
• Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model.
  BioData mining 2018 Tipton L, Cuenco KT, Huang L, Greenblatt RM, Kleerup E, Sciurba F, Duncan SR, Donahoe MP, Morris A, Ghedin E
• Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals.
  Annals of the American Thoracic Society 2018 Gingo MR, Nouraie M, Kessinger CJ, Greenblatt RM, Huang L, Kleerup EC, Kingsley L, McMahon DK, Morris A
• Fungi stabilize connectivity in the lung and skin microbial ecosystems.
  Microbiome 2018 Tipton L, Müller CL, Kurtz ZD, Huang L, Kleerup E, Morris A, Bonneau R, Ghedin E
• Unusual Radiographic Presentation of Pneumocystis Pneumonia in a Patient with AIDS.
  Case reports in infectious diseases 2017 Block BL, Mehta T, Ortiz GM, Ferris SP, Vu TH, Huang L, Cattamanchi A
• Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study.
  The Lancet. Infectious diseases 2017 Yoon C, Semitala FC, Atuhumuza E, Katende J, Mwebe S, Asege L, Armstrong DT, Andama AO, Dowdy DW, Davis JL, Huang L, Kamya M, Cattamanchi A
• Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda.
  PloS one 2017 Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A
• Effects of clinical and environmental factors on bronchoalveolar antibody responses to Pneumocystis jirovecii: A prospective cohort study of HIV+ patients.
  PloS one 2017 Blount RJ, Daly KR, Fong S, Chang E, Grieco K, Greene M, Stone S, Balmes J, Miller RF, Walzer PD, Huang L
• Sputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda.
  PloS one 2017 Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL
• Approach to Fungal Infections in Human Immunodeficiency Virus-Infected Individuals: Pneumocystis and Beyond.
  Clinics in chest medicine 2017 Wang RJ, Miller RF, Huang L
• Investigation of OMNIgene·SPUTUM performance in delayed tuberculosis testing by smear, culture, and Xpert MTB/RIF assays in Uganda.
  Journal of epidemiology and global health 2017 Kelly-Cirino CD, Musisi E, Byanyima P, Kaswabuli S, Andama A, Sessolo A, Sanyu I, Zawedde J, Curry PS, Huang L
• Use of rosuvastatin in HIV-associated chronic obstructive pulmonary disease.
  AIDS (London, England) 2017 Morris A, Fitzpatrick M, Bertolet M, Qin S, Kingsley L, Leo N, Kessinger C, Michael H, Mcmahon D, Weinman R, Stone S, Leader JK, Kleerup E, Huang L, Wisniewski SR
• A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV.
  PloS one 2017 Triplette M, Attia EF, Akgün KM, Soo Hoo GW, Freiberg MS, Butt AA, Wongtrakool C, Goetz MB, Brown ST, Graber CJ, Huang L, Crothers K
• High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy.
  Antimicrobial agents and chemotherapy 2017 Ponce CA, Chabé M, George C, Cárdenas A, Durán L, Guerrero J, Bustamante R, Matos O, Huang L, Miller RF, Vargas SL
• Immune Response and Mortality Risk Relate to Distinct Lung Microbiomes in Patients with HIV and Pneumonia.
  American journal of respiratory and critical care medicine 2017 Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV
• Predictors and short-term outcomes of recurrent pulmonary tuberculosis, Uganda: a cohort study.
  South African respiratory journal 2017 Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A
• HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis.
  PloS one 2016 Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L
• Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients.
  The Journal of infectious diseases 2016 Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, …
• Empiric TB Treatment of Severely Ill Patients With HIV and Presumed Pulmonary TB Improves Survival.
  Journal of acquired immune deficiency syndromes (1999) 2016 Katagira W, Walter ND, Den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL
• Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.
  Nature microbiology 2016 Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD
• Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort.
  Journal of acquired immune deficiency syndromes (1999) 2016 Leader JK, Crothers K, Huang L, King MA, Morris A, Thompson BW, Flores SC, Drummond MB, Rom WN, Diaz PT
• Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia.
  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2016 Esteves F, de Sousa B, Calderón EJ, Huang L, Badura R, Maltez F, Bassat Q, de Armas Y, Antunes F, Matos O
• Evaluation and Diagnosis of HIV-Associated Lung Disease.
  Seminars in respiratory and critical care medicine 2016 Maximous S, Huang L, Morris A
• Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs.
  Seminars in respiratory and critical care medicine 2016 Drummond MB, Kunisaki KM, Huang L
• Pulmonary Complications of HIV Infection.
  Seminars in respiratory and critical care medicine 2016 Huang L, Morris A, Crothers K
• Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection.
  Microbiome 2016 Cribbs SK, Uppal K, Li S, Jones DP, Huang L, Tipton L, Fitch A, Greenblatt RM, Kingsley L, Guidot DM, Ghedin E, Morris A
• Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals.
  American journal of respiratory and critical care medicine 2015 Beck JM, Schloss PD, Venkataraman A, Twigg H, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, …
• Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans.
  Journal of acquired immune deficiency syndromes (1999) 2015 Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Soo Hoo GW, Rimland D, Gibert CL, Huang L, Freiberg MS, …
• Factors associated with abnormal spirometry among HIV-infected individuals.
  AIDS (London, England) 2015 Drummond MB, Huang L, Diaz PT, Kirk GD, Kleerup EC, Morris A, Rom W, Weiden MD, Zhao E, Thompson B, Crothers K
• Use of Oropharyngeal Washes to Diagnose and Genotype Pneumocystis jirovecii.
  Open forum infectious diseases 2015 Juliano JJ, Barnett E, Parobek CM, Taylor SM, Meshnick SR, Stone S, Chang E, Fong S, Huang L
• A Clinical Predictor Score for 30-Day Mortality among HIV-Infected Adults Hospitalized with Pneumonia in Uganda.
  PloS one 2015 Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L, International HIV-associated Opportunistic Pneumonias (IHOP) Study
• Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study.
  Public health action 2015 Semitala FC, Chaisson LH, den Boon S, Walter N, Cattamanchi A, Awor M, Katende J, Huang L, Joloba M, Albert H, Kamya MR, Davis JL
• Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease.
  American journal of respiratory and critical care medicine 2015 Cui L, Lucht L, Tipton L, Rogers MB, Fitch A, Kessinger C, Camp D, Kingsley L, Leo N, Greenblatt RM, Fong S, Stone S, Dermand JC, Kleerup EC, Huang L, Morris A, Ghedin E
• Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis.
  The Journal of infectious diseases 2015 Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, …
• Pulmonary Function in HIV-Infected Recreational Drug Users in the Era of Anti-Retroviral Therapy.
  Journal of AIDS & clinical research 2014 Simonetti JA, Gingo MR, Kingsley L, Kessinger C, Lucht L, Balasubramani G, Leader JK, Huang L, Greenblatt RM, Dermand J, Kleerup EC, Morris A
• The microbiome and the lung.
  Annals of the American Thoracic Society 2014 Cui L, Morris A, Huang L, Beck JM, Twigg HL, von Mutius E, Ghedin E
• Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts.
  BMC pulmonary medicine 2014 Gingo MR, Balasubramani GK, Rice TB, Kingsley L, Kleerup EC, Detels R, Seaberg EC, Greenblatt RM, Holman S, Huang L, Sutton SH, Bertolet M, Morris A
• The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients.
  PloS one 2014 Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV
• Association of chronic cough and pulmonary function with 6-minute walk test performance in HIV infection.
  Journal of acquired immune deficiency syndromes (1999) 2014 Campo M, Oursler KK, Huang L, Goetz MB, Rimland D, Hoo GS, Brown ST, Rodriguez-Barradas MC, Au D, Akgün KM, Shahrir S, Crothers K
• Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV.
  Journal of acquired immune deficiency syndromes (1999) 2014 Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A
• Multilocus microsatellite genotyping array for investigation of genetic epidemiology of Pneumocystis jirovecii.
  Journal of clinical microbiology 2014 Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ
• Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections.
  Respirology (Carlton, Vic.) 2014 Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L, International HIV-Associated Opportunistic Pneumonias (IHOP) Study Group
• Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia.
  PloS one 2013 Blount RJ, Djawe K, Daly KR, Jarlsberg LG, Fong S, Balmes J, Miller RF, Walzer PD, Huang L, International HIV-associated Opportunistic Pneumonias Study
• HIV infection is associated with diffusing capacity impairment in women.
  Journal of acquired immune deficiency syndromes (1999) 2013 Fitzpatrick ME, Gingo MR, Kessinger C, Lucht L, Kleerup E, Greenblatt RM, Claman D, Ponath C, Fong S, Huang L, Morris A
• HIV infection is associated with reduced pulmonary diffusing capacity.
  Journal of acquired immune deficiency syndromes (1999) 2013 Crothers K, McGinnis K, Kleerup E, Wongtrakool C, Hoo GS, Kim J, Sharafkhaneh A, Huang L, Luo Z, Thompson B, Diaz P, Kirk GD, Rom W, Detels R, Kingsley L, Morris A
• Antibody responses against Pneumocystis jirovecii in health care workers over time.
  Emerging infectious diseases 2013 Fong S, Daly KR, Tipirneni R, Jarlsberg LG, Djawe K, Koch JV, Swartzman A, Roth B, Walzer PD, Huang L
• Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise.
  The Lancet. Respiratory medicine 2013 Twigg HL, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G, Lung HIV Microbiome Project
• The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report.
  American journal of respiratory and critical care medicine 2013 Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM
• Medical ICU admission diagnoses and outcomes in human immunodeficiency virus-infected and virus-uninfected veterans in the combination antiretroviral era.
  Critical care medicine 2013 Akgün KM, Tate JP, Pisani M, Fried T, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K
• Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda.
  Journal of acquired immune deficiency syndromes (1999) 2013 Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L, International HIV-Associated Opportunistic Pneumonias (IHOP) Study
• Recent global estimates indicate that approximately 34 million people are living with HIV infection. Introduction.
  Clinics in chest medicine 2013 Crothers K, Huang L, Morris A
• Comparison of the respiratory microbiome in healthy nonsmokers and smokers.
  American journal of respiratory and critical care medicine 2013 Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman …
• Widespread colonization of the lung by Tropheryma whipplei in HIV infection.
  American journal of respiratory and critical care medicine 2013 Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, …
• Characteristics of Drug-Susceptible and Drug-Resistant Staphylococcus aureus Pneumonia in Patients with HIV.
  Epidemiology (Sunnyvale, Calif.) 2013 Everett CK, Subramanian A, Jarisberg LG, Fei M, Huang L
• Evaluation of respiratory disease.
  Clinics in chest medicine 2013 Tokman S, Huang L
• Pneumocystis pneumonia associated with human immunodeficiency virus.
  Clinics in chest medicine 2013 Miller RF, Huang L, Walzer PD
• Mobile digital fluorescence microscopy for diagnosis of tuberculosis.
  Journal of clinical microbiology 2013 Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A
• The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts.
  PloS one 2013 Gingo MR, Balasubramani GK, Kingsley L, Rinaldo CR, Alden CB, Detels R, Greenblatt RM, Hessol NA, Holman S, Huang L, Kleerup EC, Phair J, Sutton SH, Seaberg EC, Margolick JB, Wisniewski SR, Morris A
• Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort.
  Medical mycology 2013 Yoon C, Subramanian A, Chi A, Crothers K, Meshnick SR, Taylor SM, Beard CB, Jarlsberg LG, Lawrence GG, Avery M, Swartzman A, Fong S, Roth B, Huang L, International HIV-Associated Opportunistic …
• A double-edged sword.
  Journal of hospital medicine 2013 Baxi S, Platts-Mills J, Dhruva S, Huang L, Hanks D, Dhaliwal G
• Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected Veterans.
  Journal of acquired immune deficiency syndromes (1999) 2013 Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K
• Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms.
  PloS one 2012 Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L, International HIV-Associated Opportunistic Pneumonias (IHOP) Study
• Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda.
  PloS one 2012 Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L, International HIV-associated Opportunistic Pneumonias Study
• Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda.
  PloS one 2012 Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L
• Environmental risk factors for Pneumocystis pneumonia hospitalizations in HIV patients.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Djawe K, Levin L, Swartzman A, Fong S, Roth B, Subramanian A, Grieco K, Jarlsberg L, Miller RF, Huang L, Walzer PD
• Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda.
  BMC research notes 2012 Nakiyingi L, Kateete DP, Ocama P, Worodria W, Sempa JB, Asiimwe BB, Katabazi FA, Katamba A, Huang L, Joloba ML, Mayanja-Kizza H
• Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study.
  PloS one 2012 Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L
• Oral and airway microbiota in HIV-infected pneumonia patients.
  Journal of clinical microbiology 2012 Iwai S, Fei M, Huang D, Fong S, Subramanian A, Grieco K, Lynch SV, Huang L
• Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients.
  PloS one 2012 Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L
• A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills.
  Clinical and translational science 2012 Feldman MD, Steinauer JE, Khalili M, Huang L, Kahn JS, Lee KA, Creasman J, Brown JS
• Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.
  Diagnostic microbiology and infectious disease 2011 Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L, International HIV-associated Opportunistic Pneumonias (IHOP) Study
• Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis.
  The Journal of infectious diseases 2011 Metcalfe JZ, Everett CK, Steingart KR, Cattamanchi A, Huang L, Hopewell PC, Pai M
• The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country.
  PloS one 2011 Worodria W, Anderson J, Cattamanchi A, Davis JL, den Boon S, Andama A, Yoo SD, Joloba M, Huang L, Kato-Maeda M
• Risk and incidence of pulmonary diseases among HIV-infected patients in the era of combination antiretroviral therapy.
  American journal of respiratory and critical care medicine 2011 Hung CC, Chang SY, Lee KY, Sun HY, Lu CL
• Chest radiographic findings of pulmonary tuberculosis in severely immunocompromised patients with the human immunodeficiency virus.
  The British journal of radiology 2011 Kisembo HN, Boon SD, Davis JL, Okello R, Worodria W, Cattamanchi A, Huang L, Kawooya MG
• Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda.
  Respirology (Carlton, Vic.) 2011 Yoo SD, Cattamanchi A, Den Boon S, Worodria W, Kisembo H, Huang L, Davis JL
• Critical illness in HIV-infected patients in the era of combination antiretroviral therapy.
  Proceedings of the American Thoracic Society 2011 Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K
• HIV and chronic obstructive pulmonary disease: is it worse and why?
  Proceedings of the American Thoracic Society 2011 Morris A, George MP, Crothers K, Huang L, Lucht L, Kessinger C, Kleerup EC, Lung HIV Study
• HIV-associated Pneumocystis pneumonia.
  Proceedings of the American Thoracic Society 2011 Huang L, Cattamanchi A, Davis JL, den Boon S, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H, International HIV-associated Opportunistic Pneumonias (IHOP) Study, Lung HIV Study
• HIV-associated lung infections and complications in the era of combination antiretroviral therapy.
  Proceedings of the American Thoracic Society 2011 Crothers K, Thompson BW, Burkhardt K, Morris A, Flores SC, Diaz PT, Chaisson RE, Kirk GD, Rom WN, Huang L, Lung HIV Study
• Pandemic (H1N1) 2009 and HIV Infection.
  Emerging infectious diseases 2011 Dhanireddy S, Harrington RD, Crane HM, Gingo MR, Morris A, Huang L, Crothers K
• Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef.
  Proceedings of the American Thoracic Society 2011 Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC, Lung HIV Study
• Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study.
  Lancet (London, England) 2011 Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, …
• Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services.
  American journal of respiratory and critical care medicine 2011 Davis J, Katamba A, Vasquez J, Crawford E, Sserwanga A, Kakeeto S, Kizito F, Dorsey G, den Boon S, Vittinghoff E, Huang L, Adatu F, Kamya MR, Hopewell PC, Cattamanchi A
• An official ATS workshop report: Emerging issues and current controversies in HIV-associated pulmonary diseases.
  Proceedings of the American Thoracic Society 2011 Morris A, Crothers K, Beck JM, Huang L, American Thoracic Society Committee on HIV Pulmonary Disease
• Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis.
  Journal of acquired immune deficiency syndromes (1999) 2011 Cattamanchi A, Smith R, Steingart KR, Metcalfe JZ, Date A, Coleman C, Marston BJ, Huang L, Hopewell PC, Pai M
• Clinical and translational research in pneumocystis and pneumocystis pneumonia.
  Parasite (Paris, France) 2011 Huang L
• Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study.
  PloS one 2011 Davis JL, Huang L, Worodria W, Masur H, Cattamanchi A, Huber C, Miller C, Conville PS, Murray P, Kovacs JA
• Serum antibody levels to the Pneumocystis jirovecii major surface glycoprotein in the diagnosis of P. jirovecii pneumonia in HIV+ patients.
  PloS one 2010 Djawe K, Huang L, Daly KR, Levin L, Koch J, Schwartzman A, Fong S, Roth B, Subramanian A, Grieco K, Jarlsberg L, Walzer PD
• Causes of early mortality in HIV-infected TB suspects in an East African referral hospital.
  Journal of acquired immune deficiency syndromes (1999) 2010 Kyeyune R, den Boon S, Cattamanchi A, Davis JL, Worodria W, Yoo SD, Huang L
• HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era.
  American journal of respiratory and critical care medicine 2010 Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC
• Integrated strategies to optimize sputum smear microscopy: a prospective observational study.
  American journal of respiratory and critical care medicine 2010 Cattamanchi A, Huang L, Worodria W, den Boon S, Kalema N, Katagira W, Byanyima P, Yoo S, Matovu J, Hopewell PC, Davis JL
• Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients.
  The European respiratory journal 2010 Worodria W, Davis JL, Cattamanchi A, Andama A, den Boon S, Yoo SD, Hopewell PC, Huang L
• The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda.
  Journal of acquired immune deficiency syndromes (1999) 2010 Deok-jong Yoo S, Worodria W, Davis JL, Cattamanchi A, den Boon S, Kyeyune R, Kisembo H, Huang L
• Respiratory emergencies in HIV-infected persons.
  Emergency medicine clinics of North America 2010 Everett CK, Fei MW, Huang L
• Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis?
  Journal of clinical microbiology 2010 Cattamanchi A, Davis JL, Pai M, Huang L, Hopewell PC, Steingart KR
• Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional study.
  PloS one 2010 Davis JL, Worodria W, Kisembo H, Metcalfe JZ, Cattamanchi A, Kawooya M, Kyeyune R, den Boon S, Powell K, Okello R, Yoo S, Huang L
• Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection.
  BMC infectious diseases 2010 Cattamanchi A, Ssewenyana I, Davis JL, Huang L, Worodria W, den Boon S, Yoo S, Andama A, Hopewell PC, Cao H
• Misleading conclusion.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2010 Klatser P, Anthony R, den Hertog A, Leeflang M, Boer K
• Pneumocystis infection: unraveling the colonization-to-disease shift.
  Expert review of anti-infective therapy 2010 Calderon EJ, Dei-Cas E
• Clinical approach to HIV-associated pulmonary disease
  Clin Pulm Med. 2010 Blount RJ, Huang L
• Restriction fragment length polymorphism typing demonstrates substantial diversity among Pneumocystis jirovecii isolates.
  The Journal of infectious diseases 2009 Ripamonti C, Orenstein A, Kutty G, Huang L, Schuhegger R, Sing A, Fantoni G, Atzori C, Vinton C, Huber C, Conville PS, Kovacs JA
• Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study.
  Thorax 2009 Fei MW, Kim EJ, Sant CA, Jarlsberg LG, Davis JL, Swartzman A, Huang L
• Healthcare worker occupation and immune response to Pneumocystis jirovecii.
  Emerging infectious diseases 2009 Tipirneni R, Daly KR, Jarlsberg LG, Koch JV, Swartzman A, Roth BM, Walzer PD, Huang L
• Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2009 Cattamanchi A, Davis JL, Worodria W, den Boon S, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Byanyima P, Andama A, Joloba M, Osmond DH, Hopewell PC, Huang L
• Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series.
  AIDS (London, England) 2009 Jagannathan P, Davis E, Jacobson M, Huang L
• The ART of caring for patients with HIV infection in the ICU.
  Intensive care medicine 2009 Powell K, Huang L
• Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era.
  PloS one 2009 George MP, Kannass M, Huang L, Sciurba FC, Morris A
• Modified Giemsa method for confirmation of Pneumocystis pneumonia in low-income countries.
  BMJ case reports 2009 Andama AO, Cattamanchi A, Davis JL, den Boon S, Worodria W, Huang L
• Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program.
  Clinical and translational science 2009 Feldman MD, Huang L, Guglielmo BJ, Jordan R, Kahn J, Creasman JM, Wiener-Kronish JP, Lee KA, Tehrani A, Yaffe K, Brown JS
• Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis.
  BMC infectious diseases 2009 Cattamanchi A, Dowdy DW, Davis JL, Worodria W, Yoo S, Joloba M, Matovu J, Hopewell PC, Huang L
• HIV-associated opportunistic pneumonias.
  Respirology (Carlton, Vic.) 2009 Huang L, Crothers K
• Pulmonary complications of immune reconstitution inflammatory syndromes in HIV-infected patients.
  Respirology (Carlton, Vic.) 2009 Crothers K, Huang L
• Non-infectious pulmonary diseases in HIV
  Chest Pulmonary Critical Care Updates 2009. 2009 Crothers, K, Huang, L, and Morris, A.
• Nonadherence to primary prophylaxis against Pneumocystis jirovecii pneumonia.
  PloS one 2009 Heffelfinger JD, Voetsch AC, Nakamura GV, Sullivan PS, McNaghten AD, Huang L
• High sensitivity and specificity of acid-fast microscopy for diagnosis of pulmonary tuberculosis in an African population with a high prevalence of human immunodeficiency virus.
  Journal of clinical microbiology 2009 Shea YR, Davis JL, Huang L, Kovacs JA, Masur H, Mulindwa F, Opus S, Chow Y, Murray PR
• Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009 Davis JL, Huang L, Kovacs JA, Masur H, Murray P, Havlir DV, Worodria WO, Charlebois ED, Srikantiah P, Cattamanchi A, Huber C, Shea YR, Chow Y, Fischer SH
• Performance of modified universal sample processing method in a field study in Uganda.
  Journal of clinical microbiology 2009 Chakravorty S, Tyagi JS, Cattamanchi A, Davis JL, Worodria W, Yoo S, Huang L
• Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: an observational cohort study.
  Scandinavian journal of infectious diseases 2009 Fei MW, Sant CA, Kim EJ, Swartzman A, Davis JL, Jarlsberg LG, Huang L
• Survival for patients With HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy.
  Chest 2008 Powell K, Davis JL, Morris AM, Chi A, Bensley MR, Huang L
• Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in Uganda.
  Journal of clinical microbiology 2008 Cattamanchi A, Davis JL, Worodria W, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Andama A, Joloba M, Osmond D, Hopewell P, Huang L
• A hydrophilic-interaction chromatography tandem mass spectrometry method for quantitation of serum s-adenosylmethionine in patients infected with human immunodeficiency virus.
  Clinica chimica acta; international journal of clinical chemistry 2008 Wang P, Huang L, Davis JL, Swartzman A, Roth B, Stone J, Wu AH
• Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury.
  Thorax 2008 Davis JL, Morris A, Kallet RH, Powell K, Chi AS, Bensley M, Luce JM, Huang L
• Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension.
  AIDS (London, England) 2008 Hsue PY, Deeks SG, Farah HH, Palav S, Ahmed SY, Schnell A, Ellman AB, Huang L, Dollard SC, Martin JN
• Respiratory infection complicating HIV infection.
  Current opinion in infectious diseases 2008 Davis JL, Fei M, Huang L
• Epidemiology and clinical significance of pneumocystis colonization.
  The Journal of infectious diseases 2008 Morris A, Wei K, Afshar K, Huang L
• HIV-associated pneumonias
  BETA 2008 Fei, M Huang, L
• Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia.
  Thorax 2007 Davis JL, Welsh DA, Beard CB, Jones JL, Lawrence GG, Fox MR, Crothers K, Morris A, Charbonnet D, Swartzman A, Huang L
• A 36-year-old man with AIDS and relapsing, nonproductive cough.
  Chest 2007 Davis JL, Shum AK, Huang L
• An Official ATS Workshop Summary: Recent advances and future directions in pneumocystis pneumonia (PCP).
  Proceedings of the American Thoracic Society 2006 Huang L, Morris A, Limper AH, Beck JM, ATS Pneumocystis Workshop Participants
• Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patients.
  Diagnostic microbiology and infectious disease 2006 de Oliveira A, Unnasch TR, Crothers K, Eiser S, Zucchi P, Moir J, Beard CB, Lawrence GG, Huang L
• Intensive care of patients with HIV infection.
  The New England journal of medicine 2006 Saccente M
• Antibody response to Pneumocystis jirovecii major surface glycoprotein.
  Emerging infectious diseases 2006 Daly KR, Huang L, Morris A, Koch J, Crothers K, Levin L, Eiser S, Satwah S, Zucchi P, Walzer PD
• Intensive care of patients with HIV infection.
  The New England journal of medicine 2006 Huang L, Quartin A, Jones D, Havlir DV
• A need for standardized definitions for clinical studies of Pneumocystis.
  The Journal of eukaryotic microbiology 2006 Miller RF, Huang L
• Current issues in critical care of the human immunodeficiency virus-infected patient.
  Critical care medicine 2006 Morris A, Masur H, Huang L
• Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia.
  The Journal of eukaryotic microbiology 2006 Huang L, Welsh DA, Miller RF, Beard CB, Lawrence GG, Fox M, Swartzman A, Bensley MR, Carbonnet D, Davis JL, Chi A, Yoo BJ, Jones JL
• A rose is a rose: but what about Pneumocystis pneumonia?
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2005 Huang L, Murray JF
• Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: Epidemiological Implications.
  The Journal of infectious diseases 2005 Beard CB, Fox MR, Lawrence GG, Guarner J, Hanzlick RL, Huang L, del Rio C, Rimland D, Duchin JS, Colley DG
• Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations.
  AIDS (London, England) 2005 Crothers K, Beard CB, Turner J, Groner G, Fox M, Morris A, Eiser S, Huang L
• Current epidemiology of Pneumocystis pneumonia.
  Emerging infectious diseases 2004 Morris A, Lundgren JD, Masur H, Walzer PD, Hanson DL, Frederick T, Huang L, Beard CB, Kaplan JE
• Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance.
  Emerging infectious diseases 2004 Huang L, Crothers K, Atzori C, Benfield T, Miller R, Rabodonirina M, Helweg-Larsen J
• Resolution of lymphocytic interstitial pneumonitis in an HIV infected adult after treatment with HAART.
  Sexually transmitted infections 2004 Innes AL, Huang L, Nishimura SL
• Pneumocystis jirovecii infection.
  Thorax 2004 Miller R, Huang L
• Intensive care of patients with HIV infection: HAART warming improvement but beware of future HAART (and heart) attacks.
  Chest 2004 Morris A, Huang L
• Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization.
  American journal of respiratory and critical care medicine 2004 Morris A, Sciurba FC, Lebedeva IP, Githaiga A, Elliott WM, Hogg JC, Huang L, Norris KA
• A prospective, blinded study of quantitative touch-down polymerase chain reaction using oral-wash samples for diagnosis of Pneumocystis pneumonia in HIV-infected patients.
  The Journal of infectious diseases 2004 Larsen HH, Huang L, Kovacs JA, Crothers K, Silcott VA, Morris A, Turner JR, Beard CB, Masur H, Fischer SH
• Recurrence of Pneumocystis carinii pneumonia in an HIV-infected patient: apparent selective immune reconstitution after initiation of antiretroviral therapy.
  HIV medicine 2003 Crothers K, Huang L
• Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence.
  Chest 2003 Morris DG, Jasmer RM, Huang L, Gotway MB, Nishimura S, King TE
• Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir.
  Journal of virology 2003 Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TS, Peterlin BM
• Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia.
  AIDS (London, England) 2003 Morris A, Wachter RM, Luce J, Turner J, Huang L
• Application of an mRNA-based molecular viability assay to oropharyngeal washes for the diagnosis of Pneumocystis pneumonia in HIV-infected patients. A pilot study.
  The Journal of eukaryotic microbiology 2003 Huang L, Crothers K, DeOliveira A, Eiser S, Zucchi P, Beard CB, Unnasch TR
• Pneumocystis colonization in HIV-infected patients.
  The Journal of eukaryotic microbiology 2003 Huang L, Crothers K, Morris A, Groner G, Fox M, Turner JR, Merrifield C, Eiser S, Zucchi P, Beard CB
• Pneumocystis dihydropteroate synthase mutations in patients with Pneumocystis pneumonia who are newly diagnosed with HIV infection.
  The Journal of eukaryotic microbiology 2003 Crothers K, Huang L, Morris A, Fox M, Groner G, Turner JR, Merrifield C, Eiser S, Friedly J, Gravari E, Zucchi P, Beard CB
• Analysis of variation in tandem repeats in the intron of the major surface glycoprotein expression site of the human form of Pneumocystis carinii.
  The Journal of infectious diseases 2002 Ma L, Kutty G, Jia Q, Imamichi H, Huang L, Atzori C, Beckers P, Groner G, Beard CB, Kovacs JA
• Clinical and radiographic predictors of the etiology of computed tomography-diagnosed intrathoracic lymphadenopathy in HIV-infected patients.
  Journal of acquired immune deficiency syndromes (1999) 2002 Jasmer RM, Gotway MB, Creasman JM, Webb WR, Edinburgh KJ, Huang L
• Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy.
  American journal of respiratory and critical care medicine 2002 Morris A, Creasman J, Turner J, Luce JM, Wachter RM, Huang L
• Genetic diversity of Pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rRNA genes.
  Journal of clinical microbiology 2002 Nimri LF, Moura IN, Huang L, del Rio C, Rimland D, Duchin JS, Dotson EM, Beard CB
• Update on the epidemiology and transmission of Pneumocystis carinii.
  Microbes and infection 2002 Morris A, Beard CB, Huang L
• Pulmonary complications of HIV infection. Report of the Fourth NHLBI Workshop.
  American journal of respiratory and critical care medicine 2001 Beck JM, Rosen MJ, Peavy HH
• Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study.
  Lancet (London, England) 2001 Navin TR, Beard CB, Huang L, del Rio C, Lee S, Pieniazek NJ, Carter JL, Le T, Hightower A, Rimland D
• Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients.
  Blood 2001 Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, Huang L, Levy JA, Liu YJ
• Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS.
  The Journal of infectious diseases 2001 Kazanjian P, Armstrong W, Hossler PA, Lee CH, Huang L, Beard CB, Carter J, Crane L, Duchin J, Burman W, Richardson J, Meshnick SR
• Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis.
  The Journal of eukaryotic microbiology 2001 Meshnick SR, Hossler PA, Enger KS, Kazanjian P, Rest JS, Mindell D, Li B, Lee CH, Nimri LF, Carter JL, Beard CB, Huang L
• Pneumocystis carinii dihydropteroate synthase genotypes in HIV-infected persons residing in San Francisco: possible implications for disease transmission.
  The Journal of eukaryotic microbiology 2001 Huang L, Friedly J, Morris AM, Carter JL, Turner JR, Merrifield C, Navin TR, Beard CB
• Pneumocystis carinii dihydropteroate synthase mutations and treatment with sulfa or sulfone regimens: a proposal for standardized definitions for clinical evaluation.
  The Journal of eukaryotic microbiology 2001 Huang L, Morris AM, Beard CB
• Why does Pneumocystis carinii pneumonia still occur?
  AIDS (London, England) 2000 Huang L, Hecht FM
• Geographic distribution of human immunodeficiency virus-associated Pneumocystis carinii pneumonia in San Francisco.
  American journal of respiratory and critical care medicine 2000 Morris AM, Swanson M, Ha H, Huang L
• Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene.
  The Journal of infectious diseases 2000 Huang L, Beard CB, Creasman J, Levy D, Duchin JS, Lee S, Pieniazek N, Carter JL, del Rio C, Rimland D, Navin TR
• Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group.
  American journal of respiratory and critical care medicine 2000 Morris AM, Huang L, Bacchetti P, Turner J, Hopewell PC, Wallace JM, Kvale PA, Rosen MJ, Glassroth J, Reichman LB, Stansell JD
• Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy.
  Thorax 2000 Morris AM, Nishimura S, Huang L
• Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.
  Emerging infectious diseases 2000 Beard CB, Carter JL, Keely SP, Huang L, Pieniazek NJ, Moura IN, Roberts JM, Hightower AW, Bens MS, Freeman AR, Lee S, Stringer JR, Duchin JS, del Rio C, Rimland D, Baughman RP, Levy DA, Dietz VJ, …
• Clinical and radiographic predictors of the etiology of pulmonary nodules in HIV-infected patients.
  Chest 2000 Jasmer RM, Edinburgh KJ, Thompson A, Gotway MB, Creasman JM, Webb WR, Huang L
• Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes.
  Radiology 2000 Edinburgh KJ, Jasmer RM, Huang L, Reddy GP, Chung MH, Thompson A, Halvorsen RA, Webb RA
• Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study Group.
  Chest 1999 Huang L, Stansell J, Osmond D, Turner J, Shafer KP, Fulkerson W, Kvale P, Wallace J, Rosen M, Glassroth J, Reichman L, Hopewell P
• Pseudallescheria boydii infection in AIDS.
  Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1999 Horton CK, Huang L, Goozé L
• Definitive diagnosis or empiric therapy of Pneumocystis carinii pneumonia
  Pulmonary Infections Forum 1999 Huang, L.
• Decline in the rate of specific opportunistic infections at San Francisco General Hospital, 1994-1997.
  AIDS (London, England) 1998 Holtzer CD, Jacobson MA, Hadley WK, Huang L, Stanley HD, Montanti R, Wong MK, Stansell JD
• Bronchoscopy versus sputum induction as the initial procedure for the diagnosis of Pneumocystis carinii pneumonia in patients infected with HIV
  Journal of Bronchology. 1998 Huang L, Hopewell PC
• High-resolution CT in the evaluation of clinically suspected Pneumocystis carinii pneumonia in AIDS patients with normal, equivocal, or nonspecific radiographic findings.
  AJR. American journal of roentgenology 1997 Gruden JF, Huang L, Turner J, Webb WR, Merrifield C, Stansell JD, Gamsu G, Hopewell PC
• TB or not TB
  AIDS Care 1997 Jasmer, R Huang, L
• The challenge of multidrug-resistant tuberculosis: the clinical features, diagnosis, and treatment of TB in patients with HIV infection
  HIV Newsline 1997 Jasmer, R Huang, L
• AIDS and the lung.
  The Medical clinics of North America 1996 Huang L, Stansell JD
• Presentation of AIDS-related pulmonary Kaposi's sarcoma diagnosed by bronchoscopy.
  American journal of respiratory and critical care medicine 1996 Huang L, Schnapp LM, Gruden JF, Hopewell PC, Stansell JD
• Pneumocystis carinii pneumonia: who to prophylax, who to evaluate, who to treat empirically
  HIV Newsline 1996 Huang, L
• Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful?
  American journal of respiratory and critical care medicine 1995 Huang L, Hecht FM, Stansell JD, Montanti R, Hadley WK, Hopewell PC
• AIDS-related Kaposi sarcoma of the lung: radiographic findings and staging system with bronchoscopic correlation.
  Radiology 1995 Gruden JF, Huang L, Webb WR, Gamsu G, Hopewell PC, Sides DM