Laurence Cheng, MD, PhD
Assistant Clinical Professor
Pediatrics
School of Medicine

The long-term goal of my laboratory's research is to enhance understanding of human allergic disease through a combination of basic investigation in animal models coupled with translational approaches in patients with allergic diseases, including food allergy, atopic dermatitis, and asthma. Approaches in model systems include the use of genetically modified reporter/deleter mice coupled with cellular and imaging approaches, including intravital imaging.

Education & Training

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• Clinical Fellowship Allergy and Immunology University of California, San Francisco and Stanford University 2009
• Residency Pediatrics University of California, San Francisco 2006
• M.D. School of Medicine University of Washington 2004
• Ph.D. Immunology University of Washington 2002

Interests

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• Microscopy
• Allergy
• Cellular and molecular mechanisms underlying allergic inflammation
• Immunology
• Mast Cells
• Hypersensitivity Reactions
• Basophils
• Immunoglobulin E (IgE)
• Cellular immunology

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Grants and Projects

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• Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity, NIH, 2011-2016

Publications (25)

Top publication keywords:
SoapsInducible T-Cell Co-Stimulator LigandReceptors, IgEMast CellsPneumocystis cariniiBasophilsCodon, NonsenseImmunity, HumoralHypersensitivityHand HygieneImmunoglobulin ETransendothelial and Transepithelial MigrationArthritisEosinophilsParasitic Diseases

• Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study.
  Allergy 2023 Bissonnette R, DuBois J, Facheris P, Del Duca E, Kim M, Correa Da Rosa J, Trujillo DL, Bose S, Pagan AD, Wustrow D, Brockstedt DG, Wong B, Kassner PD, Jankicevic J, Ho W, Cheng LE, Guttman-Yassky E
• Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study.
  ACR open rheumatology 2022 Abuqayyas L, Cheng LE, Teixeira Dos Santos M, Sullivan BA, Ruiz-Santiago N, Wang H, Zhou Y, Chindalore V, Cohen S, Kivitz AJ, Posch MG, Parnes JR
• Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target.
  Frontiers in immunology 2021 Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF, Teixeira Dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S, Mytych DT
• FRI0084 SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, IMMUNOGENICITY, AND PRELIMINARY EFFICACY OF ROZIBAFUSP ALFA IN SUBJECTS WITH RHEUMATOID ARTHRITIS: INTERIM ANALYSIS OF A PHASE 1B RANDOMIZED, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE CLINICAL TRIAL.
  Annals of the Rheumatic Diseases 2020 L. Abuqayyas, L. Cheng, D. Mitragotri, S. Smith, M. Teixeira Dos Santos, Y. Zhou, V. Chindalore, S. Cohen, A. Kivitz, M. Posch, B. Sullivan, J. Parnes
• Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis.
  Arthritis & rheumatology (Hoboken, N.J.) 2018 Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB

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• Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity.
  Journal of clinical immunology 2015 Ahmed A, Reith W, Puck JM, Cheng LE
• IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
  The Journal of Cell Biology 2015 Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley
• Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.
  PloS one 2015 Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF
• IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
  The Journal of experimental medicine 2015 Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM
• Dishing it out to allergies.
  Pediatrics 2015 Cheng LE, Cabana MD
• Allergic inflammation--innately homeostatic.
  Cold Spring Harbor perspectives in biology 2014 Cheng LE, Locksley RM
• Type 2 innate lymphoid cells control eosinophil homeostasis.
  Nature 2013 Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM
• Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
  The Journal of experimental medicine 2013 Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM
• TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome.
  Journal of Allergy and Clinical Immunology 2013 Alice Chan, Morton Cowan, Jennifer M. Puck, Laurence E. Cheng
• Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
  Immunity 2013 Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM
• Genetic analysis of basophil function in vivo.
  Nature immunology 2011 Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM
• Murine B cells regulate serum IgE levels in a CD23-dependent manner.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Cheng LE, Wang ZE, Locksley RM
• Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome.
  Clinical immunology (Orlando, Fla.) 2009 Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW
• Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Cheng LE, Greenberg PD
• CD8(+) T cell responses: it's all downhill after their prime.
  Nature immunology 2002 Blattman JN, Cheng LE, Greenberg PD
• CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function.
  The Journal of experimental medicine 2002 Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD
• Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Cheng LE, Ohlén C, Nelson BH, Greenberg PD
• Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.
  The EMBO journal 1997 Cheng LE, Chan FK, Cado D, Winoto A
• Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis.
  Molecular and cellular biology 1995 Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A
• Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
  Molecular and cellular biology 1995 Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A