Lauren Higdon
Director, Biomarker Discover
Diabetes Center
School of Medicine

Education & Training

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• transplant immunology (postdoc) Stanford University 07/2022
• PhD Molecular and Cellular Biology University of Washington 06/2014

Interests

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• Immunology

Websites

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• Anderson lab (diabetes.ucsf.edu)

Publications (19)

Top publication keywords:
TransplantationGerminal CenterCell SeparationCytotoxicity, ImmunologicClonal Selection, Antigen-MediatedOrgan TransplantationCD8-Positive T-LymphocytesCytomegalovirus InfectionsSomatic Hypermutation, ImmunoglobulinViremiaSingle-Cell AnalysisPeroxidasesCytomegalovirusHeart TransplantationKidney Transplantation

• Infection, Rejection, and the Connection.
  Transplantation 2022 Higdon LE, Tan JC, Maltzman JS
• Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice.
  Kidney360 2022 Zheng X, Higdon L, Gaudet A, Shah M, Balistieri A, Li C, Nadai P, Palaniappan L, Yang X, Santo B, Ginley B, Wang XX, Myakala K, Nallagatla P, Levi M, Sarder P, Rosenberg A, Maltzman JS, de Freitas …
• CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia.
  Frontiers in immunology 2022 Higdon LE, Ahmad AA, Schaffert S, Margulies KB, Maltzman JS
• Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Higdon LE, Schaffert S, Huang H, Montez-Rath ME, Lucia M, Jha A, Saligrama N, Margulies KB, Martinez OM, Davis MM, Khatri P, Maltzman JS
• Functional Consequences of Memory Inflation after Solid Organ Transplantation.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Higdon LE, Schaffert S, Cohen RH, Montez-Rath ME, Lucia M, Saligrama N, Margulies KB, Martinez OM, Tan JC, Davis MM, Khatri P, Maltzman JS

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• Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.
  Frontiers in immunology 2021 Higdon LE, Gustafson CE, Ji X, Sahoo MK, Pinsky BA, Margulies KB, Maecker HT, Goronzy J, Maltzman JS
• Sestrins teach old T cells new tricks.
  Science immunology 2020 Maltzman JS, Higdon LE
• To debug or not to debug, a question worth asking.
  Science immunology 2019 Higdon LE, Maltzman JS
• Single cell immune profiling in transplantation research.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019 Higdon LE, Schaffert S, Khatri P, Maltzman JS
• Optimization of single-cell plate sorting for high throughput sequencing applications.
  Journal of immunological methods 2018 Higdon LE, Cain CJ, Colden MA, Maltzman JS
• Expanding the Toolkit for the Study of Allospecific B and T Cell Responses.
  Transplantation 2017 Higdon LE, Maltzman JS
• The outstanding questions in transplantation: It's about time….
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P…
• A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
  The Journal of clinical investigation 2017 Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, Nündel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP
• Cytomegalovirus-Responsive CD8+ T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Higdon LE, Trofe-Clark J, Liu S, Margulies KB, Sahoo MK, Blumberg E, Pinsky BA, Maltzman JS
• Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage.
  Transplantation direct 2016 Higdon LE, Lee K, Tang Q, Maltzman JS
• Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation.
  Immunity 2015 Higdon LE, Cancro MP
• ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
  The Journal of experimental medicine 2015 Moguche AO, Shafiani S, Clemons C, Larson RP, Dinh C, Higdon LE, Cambier CJ, Sissons JR, Gallegos AM, Fink PJ, Urdahl KB
• Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Higdon LE, Deets KA, Friesen TJ, Sze KY, Fink PJ
• Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Houston EG, Higdon LE, Fink PJ