Laura Koth, MD, MA
Professor
Medicine
School of Medicine

She is completed a Master's Degree in Epidemiology, Biostatistics and Data Science in 2021.

Her research activities focus on the immunologic mechanisms of lung inflammation and macrophage activation. Her clinical interest is Granulomatous Interstitial Lung Diseases and she launched the first research program focused on sarcoidosis in 2010.

She currently serves as Principle Investigator for a number of studies and research cohorts.

• Epidemiology of Sarcoidosis in U.S. Veterans from 2003 to 2019.
  Annals of the American Thoracic Society 2023 Seedahmed MI, Baugh AD, Albirair MT, Luo Y, Chen J, McCulloch CE, Whooley MA, Koth LL, Arjomandi M
• Risk Indicators of Sarcoidosis Evolution-Unified Protocol (RISE-UP): protocol for a multi-centre, longitudinal, observational study to identify clinical features that are predictive of sarcoidosis progression.
  BMJ open 2023 Drake WP, Hsia C, Samavati L, Yu M, Cardenas J, Gianella FG, Boscardin J, Koth LL
• Standardization of flow cytometry and cell sorting to enable a transcriptomic analysis in a multi-site sarcoidosis study.
  PloS one 2023 Magallon RE, Harmacek LD, Arger NK, Grewal P, Powers L, Werner BR, Barkes BQ, Li L, MacPhail K, Gillespie M, White EK, Collins SE, Brown T, Cardenas J, Chen ES, Maier LA, Leach SM, Hamzeh NY, Koth LL,…
• Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
  Scientific reports 2022 Elahi M, Talreja J, Steinbauer B, Koth LL, Samavati L
• Performance of a Computational Phenotyping Algorithm for Sarcoidosis Using Diagnostic Codes in Electronic Medical Records: Case Validation Study From 2 Veterans Affairs Medical Centers.
  JMIR formative research 2022 Seedahmed MI, Mogilnicka I, Zeng S, Luo G, Whooley MA, McCulloch CE, Koth L, Arjomandi M
• Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.
  The European respiratory journal 2021 Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, …
• Defining CD4 T helper and T regulatory cell endotypes of progressive and remitting pulmonary sarcoidosis (BRITE): protocol for a US-based, multicentre, longitudinal observational bronchoscopy study.
  BMJ open 2021 Koth LL, Harmacek LD, White EK, Arger NK, Powers L, Werner BR, Magallon RE, Grewal P, Barkes BQ, Li L, Gillespie M, Collins SE, Cardenas J, Chen ES, Maier LA, Leach SM, O'Connor BP, Hamzeh NY
• Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.
  Neurology(R) neuroimmunology & neuroinflammation 2021 Bradshaw MJ, Pawate S, Koth LL, Cho TA, Gelfand JM
• Molecular profiling in sarcoidosis.
  Current opinion in pulmonary medicine 2020 Arger NK, O'Connor B, Koth LL
• T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.
  Frontiers in immunology 2020 Arger NK, Machiraju S, Allen IE, Woodruff PG, Koth LL
• Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.
  American journal of respiratory and critical care medicine 2020 Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, Abston E, Bernstein RC, Blankstein R, Chen ES, Culver DA, Drake W, Drent M, Gerke AK, Ghobrial M, Govender P, Hamzeh N, James …
• CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis.
  Respiratory medicine 2019 Arger NK, Ho ME, Allen IE, Benn BS, Woodruff PG, Koth LL
• Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.
  Journal of the American Heart Association 2019 Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham…
• Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.
  Respiratory medicine 2019 Arger NK, Ho M, Woodruff PG, Koth LL
• Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.
  Journal of the American Heart Association 2019 Gu BH, Choi JC, Shen YH, Song LZ, Scheurer ME, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA
• Tissue Isn't the Issue.
  Journal of hospital medicine 2018 Santhosh L, Koth L, Baudendistel TE, Sharpe B, Monash B
• Migraine is common in patients with sarcoidosis.
  Cephalalgia : an international journal of headache 2018 Gelfand JM, Gelfand AA, Goadsby PJ, Benn BS, Koth LL
• Sleep disturbance and symptom burden in sarcoidosis.
  Respiratory medicine 2018 Benn BS, Lehman Z, Kidd SA, Miaskowski C, Sunwoo BY, Ho M, Sun S, Ramstein J, Gelfand JM, Koth LL
• Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.
  The European respiratory journal 2018 Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M
• Disease Burden and Variability in Sarcoidosis.
  Annals of the American Thoracic Society 2017 Gerke AK, Judson MA, Cozier YC, Culver DA, Koth LL
• Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series.
  Neurology 2017 Gelfand JM, Bradshaw MJ, Stern BJ, Clifford DB, Wang Y, Cho TA, Koth LL, Hauser SL, Dierkhising J, Vu N, Sriram S, Moses H, Bagnato F, Kaufmann JA, Ammah DJ, Yohannes TH, Hamblin MJ, Venna N, Green AJ…
• Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort.
  Lung 2017 Benn BS, Lehman Z, Kidd SA, Ho M, Sun S, Ramstein J, Arger NK, Nguyen CP, Su R, Gomez A, Gelfand JM, Koth LL
• Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis.
  Chest 2017 Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL
• IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.
  American journal of respiratory and critical care medicine 2016 Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL
• A diagnostic model for chronic hypersensitivity pneumonitis.
  Thorax 2016 Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR
• Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol.
  Annals of the American Thoracic Society 2015 Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, …
• Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria.
  Respiratory medicine 2015 Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS
• The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis.
  Respiratory medicine 2015 Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR
• Lung transplantation for hypersensitivity pneumonitis.
  Chest 2015 Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD
• Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.
  The European respiratory journal 2014 Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL
• The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.
  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2014 Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi…
• Predicting survival across chronic interstitial lung disease: the ILD-GAP model.
  Chest 2014 Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE, Collard HR
• Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis.
  American journal of respiratory and critical care medicine 2014 Mooney JJ, Koth LL
• Interferon-inducible chemokines reflect severity and progression in sarcoidosis.
  Respiratory research 2013 Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth LL
• Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.
  Chest 2013 Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen MLT, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL
• Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis.
  European journal of immunology 2013 Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL
• Prevalence and prognosis of unclassifiable interstitial lung disease.
  The European respiratory journal 2012 Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters PJ, Collard HR
• Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis.
  Thorax 2012 Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR
• Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.
  American journal of respiratory and critical care medicine 2011 Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG
• A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males.
  PloS one 2010 Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF
• DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG
• Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function.
  Lung 2010 Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE
• T-helper type 2-driven inflammation defines major subphenotypes of asthma.
  American journal of respiratory and critical care medicine 2009 Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV
• Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice.
  COPD 2009 Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL
• Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
  American journal of respiratory cell and molecular biology 2007 Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG
• Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?
  American journal of respiratory and critical care medicine 2007 Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE
• A distinctive alveolar macrophage activation state induced by cigarette smoking.
  American journal of respiratory and critical care medicine 2005 Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ
• Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water.
  Chest 2005 Marras TK, Wallace RJ, Koth LL, Stulbarg MS, Cowl CT, Daley CL
• Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
  Respiratory research 2004 Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ
• Spotted long oligonucleotide arrays for human gene expression analysis.
  Genome research 2003 Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ
• Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
  Nature medicine 2002 Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ
• Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression.
  Chest 2002 Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A
• Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
  American journal of respiratory cell and molecular biology 2001 Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D