Kwun Wah Wen, MD, PhD
Associate Professor
Pathology
School of Medicine

Publications (62)

Top publication keywords:
Sarcoma, KaposiBile Duct NeoplasmsFlow CytometryGlutamate-Ammonia LigaseCholangiocarcinomaAppendiceal NeoplasmsLymphoma, Large B-Cell, DiffuseLymphoma, T-Cell, PeripheralAneuploidyLymphoma, B-Cell, Marginal ZoneDNAEpstein-Barr Virus InfectionsCarcinoid TumorHerpesvirus 8, HumanPrecancerous Conditions

• Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
  Nature cell biology 2025 Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
• Identification of Genomic Biomarkers of Disease Progression and Survival in Primary CNS Lymphoma.
  Blood advances 2024 Geng H, Mo SS, Chen L, Ballapuram A, Tsang M, Lu M, Rauschecker AM, Wen KW, Devine WP, Solomon DA, Rubenstein JL
• Clinicopathologic features and outcomes of hepatic inflammatory pseudotumour (IPT) and hepatic IPT-like lesions.
  Histopathology 2024 Nguyen ED, Wen KW, Kakar S, Balitzer DJ
• Should We Rest on a Rest? A Well-Differentiated Neuroendocrine Tumor Arising From Pancreatic Heterotopia.
  The American journal of gastroenterology 2024 Leet DE, Wen KW, Kouanda A
• Functional screen for mediators of onco-mRNA translation specificity.
  bioRxiv : the preprint server for biology 2024 Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D

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• Glutamine synthetase staining patterns in cirrhosis.
  Human pathology 2024 Nguyen ED, Ding CC, Umetsu SE, Ferrell LD, Wen KW
• Molecular Analysis of Persistent and Recurrent Barrett's Esophagus in the Setting of Endoscopic Therapy.
  Clinical and translational gastroenterology 2024 Kumar A, Rara M, Yu M, Wen KW, Grady WM, Chak A, Iyer PG, Rustgi AK, Wang TC, Rubenstein JH, Liu Y, Kresty L, Westerhoff M, Kwon RS, Wamsteker E, Wang T, Berry L, Canto MI, Shaheen NJ, Wang KK, Abrams…
• Utility of PD-1, PD-L1, and IDO-1 Stains in Ocular Extranodal Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL).
  Applied immunohistochemistry & molecular morphology : AIMM 2024 Craig A, Güney E, Pekmezci M, Bloomer M, Laszik Z, Ohgami RS, Toland A, Vogel H, Forns T, Wang E, Rubenstein J, Wen KW
• Clinicopathologic Features of Gastrointestinal Tract Langerhans Cell Histiocytosis.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2024 Hu S, Graham RP, Choi WT, Wen KW, Putra J, Chen W, Lin J, Gonzalez IA, Panarelli N, Liu Q, Zhao L, Gong S, Mejia-Bautista M, Escobar DJ, Ma C, Shalaby A, Du X, Kang LI, Zhang W, Chen X, Ding X, Chen …
• Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
  Gastroenterology clinics of North America 2023 Wen KW, Kakar S
• Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer.
  Cancer cell 2023 Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM…
• Copy Number Loss at Chromosome 14q11.2 Correlates With the Proportion of T Cells in Biopsies and Helps Identify T-Cell Neoplasms.
  Archives of pathology & laboratory medicine 2023 Saglam A, Singh K, Kumar J, Gollapudi S, Mukherjee S, Singh A, Butzmann A, Kaplan L, Andreadis C, Ai WZ, Fakhri B, Rajkovic A, Wen KW, Onodera C, Van Ziffle J, Devine PW, Ohgami RS
• Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS.
  Blood advances 2023 Guney E, Lucas CG, Singh K, Pekmezci M, Fernandez-Pol S, Mirchia K, Toland A, Vogel H, Bannykh S, Schafernak KT, Alexandrescu S, Mobley BC, Powell S, Davidson CJ, Neltner J, Boué DR, Hattab E, Ferris …
• Use of orcein as an adjunct stain in the evaluation of advanced liver fibrosis.
  Histopathology 2023 Nguyen ED, Ding CC, Umetsu SE, Choi WT, Ferrell LD, Wen KW
• ALK+ ALCL in the setting of adalimumab-related hidradenitis suppurativa.
  Clinical case reports 2023 Craig A, Wen KW
• Incidental Langerhans cell histiocytosis associated with metastatic neuroendocrine tumor in the adult liver.
  Clinical case reports 2023 Joseph NM, Wen KW
• Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
• Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto-Heme Interinstitutional Collaborative study.
  Cancer cytopathology 2022 Fitzpatrick MJ, Sundaram V, Ly A, Abramson JS, Balassanian R, Cheung MC, Cook SL, Falchi L, Frank AK, Gupta S, Hasserjian RP, Lin O, Long SR, Menke JR, Mou E, Reed DR, Ruiz-Cordero R, Volaric AK, Wang…
• Diagnostic Discrepancies in Small-volume Biopsy for the Initial Diagnosis, Recurrence, and Transformation of Follicular Lymphoma: A Multi-Institutional Collaborative Study.
  The American journal of surgical pathology 2022 Volaric AK, Lin O, Balassanian R, Cook S, Falchi L, Fitzpatrick MJ, Frank AK, Gupta S, Hasserjian RP, Long S, Ly A, Menke JR, Mou E, Natkunam Y, Reed DR, Ruiz-Cordero R, Wang L, Wen KW, Xie Y, Zadeh …
• EBV-positive high-grade B-cell lymphoma with MYC and BCL6 rearrangements.
  Blood 2022 Craig A, Wen KW
• Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.
  Cytogenetic and genome research 2022 Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J
• A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.
  Blood advances 2022 Güney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak K, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen …
• Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models.
  Blood advances 2022 Wu CH, Wang L, Yang CY, Wen KW, Hinds B, Gill R, McCormick F, Moasser M, Pincus L, Ai WZ
• Distinct pathologic feature of myeloid neoplasm with t(v;11p15); NUP98 rearrangement.
  Human pathology 2022 Lauw MIS, Qi Z, Eversmeyer L, Prakash S, Wen KW, Yu J, Monaghan SA, Aggarwal N, Wang L
• Global Cytopathology-Hematopathology Practice Trends.
  American journal of clinical pathology 2022 Zadeh SL, Balassanian R, Cheung MC, Falchi L, Hasserjian R, Lin O, Long SR, Ly A, Menke JR, Mou E, Natkunam Y, Ruiz-Cordero R, Volaric AK, Wang L, Wen KW, Gratzinger D
• Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts, thrombocytosis, and mutated JAK2/SF3B1 without anemia.
  Blood 2022 Neumann NM, Wen KW
• Corrigendum to: Global Cytopathology-Hematopathology Practice Trends.
  American journal of clinical pathology 2022 Zadeh SL, Balassanian R, Cheung MC, Falchi L, Hasserjian R, Lin O, Long SR, Ly A, Menke JR, Mou E, Natkunam Y, Ruiz-Cordero R, Volaric AK, Wang L, Wen KW, Gratzinger D
• TNF-α inhibition in the setting of undiagnosed HIV infection: a call for enhanced screening guidelines.
  AIDS (London, England) 2021 Claytor JD, Viramontes O, Conner S, Wen KW, Beck K, Chin-Hong PV, Henrich TJ, Peluso MJ
• Adenomatoid tumours of the gastrointestinal tract - a case-series and review of the literature.
  Histopathology 2021 Hissong E, Graham RP, Wen KW, Alpert L, Shi J, Lamps LW
• Cancers associated with human gammaherpesviruses.
  The FEBS journal 2021 Wen KW, Wang L, Menke JR, Damania B
• Inhibin-positive hepatic carcinoma: proposal for a solid-tubulocystic variant of intrahepatic cholangiocarcinoma.
  Human pathology 2021 Wen KW, Joseph NM, Srivastava A, Saunders TA, Jain D, Rank J, Feely M, Zarrinpar A, Al Diffalha S, Shyn PB, Graham RP, Drage MG, Kakar S
• Impact of initial biopsy type on the time to final diagnostic biopsy in patients with follicular lymphoma and suspected histologic transformation.
  Leukemia & lymphoma 2021 Mou E, Falchi L, Sundaram V, Abramson JS, Balassanian R, Beygi S, Fitzpatrick MJ, Frank AK, Gupta S, Lin O, Reed JR, Long SR, Ly A, Menke JR, Reed DR, Ruiz-Cordero R, Volaric AK, Xie Y, Wang L, Wen KW…
• A solid variant of splenic mesothelial cyst, a rare case report with next generation sequencing
  Human Pathology: Case Reports 2021 Guney E, Wen KW, Ruiz-Cordero R, Ferrell L , Gill R, O’Malley D, Jones K, Ohgami R
• Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
  Nature cell biology 2021 Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM
• A Case of EBV-Negative Aggressive NK-cell Leukemia: Use of Next-Generation Sequencing in Demystifying a Diagnostic Dilemma and Guiding Clinical Care.
  Clinical lymphoma, myeloma & leukemia 2021 Kennedy VE, Ruiz-Cordero R, Jangam D, Wen KW, Dunavin N, Ohgami RS, Bhargava P, Ai W, Fakhri B
• Primary Central Nervous System Lymphomas: A Diagnostic Overview of Key Histomorphologic, Immunophenotypic, and Genetic Features.
  Diagnostics (Basel, Switzerland) 2020 Lauw MIS, Lucas CG, Ohgami RS, Wen KW
• Post-operative assessment in patients after liver transplantation: imaging parameters associated with 1-year graft failure.
  European radiology 2020 Chang WC, M Yeh B, Chu L, Kim SY, Wen KW, Chiu SH, Ding CC, Wu EH, Roberts JP, Huang GS, Hsu HH
• A rare presentation of hepatolithiasis in an adolescent patient: A case report.
  International journal of surgery case reports 2020 Freise J, Mena J, Wen KW, Stoller M, Ho S, Corvera C
• Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin lymphomas and overlapping peripheral T-cell lymphomas simplified: An evidence-based guide.
  Annals of diagnostic pathology 2020 Wen KW, Fakhri B, Menke J, Ruiz-Cordero R, Gill RM, Ohgami RS
• Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
  Nature 2020 Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC
• Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions.
  Virchows Archiv : an international journal of pathology 2020 Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT
• DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease.
  Histopathology 2019 Wen KW, Umetsu SE, Goldblum JR, Gill RM, Kim GE, Joseph NM, Rabinovitch PS, Kakar S, Lauwers GY, Choi WT
• Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT.
  Clinical nuclear medicine 2019 Raghavan K, Wen KW, Small EJ, Ha P, Flavell RR
• Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT
• Synchronous Breast Implant-associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and Management Implications.
  Plastic and reconstructive surgery. Global open 2019 Mukhtar RA, Holland M, Sieber DA, Wen KW, Rugo HS, Kadin ME, Bean GR
• Immature Terminal Deoxynucleotidyl Transferase Positive B Cells are Detected in a Subset of Adult and Pediatric Liver Biopsies.
  Applied immunohistochemistry & molecular morphology : AIMM 2019 Wen KW, Gill RM
• Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease.
  Journal of Crohn's & colitis 2019 Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT
• How Dye May Prevent Dying from Cancer: Perceiving Imperceptible Dysplasia in Inflammatory Bowel Disease.
  Digestive diseases and sciences 2019 Lewin SM, Wen KW, Velayos FS, Mahadevan U, Beck KR
• Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001.
  Oncotarget 2018 Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A
• DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas.
  Histopathology 2018 Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM
• Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT
• Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma.
  Human pathology 2018 Wen KW, Grenert JP, Joseph NM, Shafizadeh N, Huang A, Hosseini M, Kakar S
• Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells.
  Blood cancer journal 2017 Bhavanasi D, Wen KW, Liu X, Vergez F, Danet-Desnoyers G, Carroll M, Huang J, Klein PS
• Adipocyte size variability in benign and malignant lipomatous tumors and morphologic mimics: a quantitative definition using digital pathology.
  Human pathology 2017 Bean GR, Wen KW, Horvai AE
• Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology.
  Human pathology 2017 Wen KW, Hale G, Shafizadeh N, Hosseini M, Huang A, Kakar S
• Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
  PLoS pathogens 2012 Chen W, Sin SH, Wen KW, Damania B, Dittmer DP
• The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
  Immunity 2012 Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP
• Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1.
  Oncogene 2010 Wen KW, Damania B
• Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
  Cancer letters 2009 Wen KW, Damania B
• Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus.
  Journal of virology 2009 Wen KW, Dittmer DP, Damania B
• A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.
  Chembiochem : a European journal of chemical biology 2005 Mahmud T, Wenzel SC, Wan E, Wen KW, Bode HB, Gaitatzis N, Müller R
• A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus.
  The Journal of experimental medicine 2004 Baguet A, Epler J, Wen KW, Bix M