Kurt Giles, PhD
Associate Director
HDF Comprehensive Cancer Ctr
School of Medicine

Grants and Projects

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• Degenerative and Dementing Diseases of Aging, NIH, 1981-2025

Publications (65)

Top publication keywords:
PrPC ProteinsMice, TransgenicBiological AssayPrion DiseasesAmidesCreutzfeldt-Jakob SyndromeThiazolesalpha-SynucleinInfectious Disease Incubation PeriodGerstmann-Straussler-Scheinker DiseaseParkinsonian DisordersPrPSc ProteinsEncephalopathy, Bovine SpongiformPrionsMultiple System Atrophy

• CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model.
  Nature communications 2023 Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, Condello C
• Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.
  Acta neuropathologica communications 2019 Krejciova Z, Carlson GA, Giles K, Prusiner SB
• α-Synuclein: Multiple System Atrophy Prions.
  Cold Spring Harbor perspectives in medicine 2018 Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB
• Modeling Multiple System Atrophy Prion Propagation in Astrocytes From Transgenic Mice.
  The FASEB Journal 2018 Zuzana Krejciova, George Carlson, Kurt Giles, Stanley B. Prusiner
• Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB

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• Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB
• A novel vector for transgenesis in the rat CNS.
  Acta neuropathologica communications 2017 Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB
• Bioassays and Inactivation of Prions.
  Cold Spring Harbor perspectives in biology 2017 Giles K, Woerman AL, Berry DB, Prusiner SB
• Developing Therapeutics for PrP Prion Diseases.
  Cold Spring Harbor perspectives in medicine 2017 Giles K, Olson SH, Prusiner SB
• Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.
  Journal of virology 2016 Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB
• Towards authentic transgenic mouse models of heritable PrP prion diseases.
  Acta neuropathologica 2016 Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB
• Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
  The Journal of pharmacology and experimental therapeutics 2016 Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB
• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K
• Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation.
  Annals of neurology 2015 Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB
• Propagation of prions causing synucleinopathies in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K…
• Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
  The Journal of pharmacology and experimental therapeutics 2015 Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB
• Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.
  The Journal of infectious diseases 2015 Berry D, Giles K, Oehler A, Bhardwaj S, DeArmond SJ, Prusiner SB
• Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB
• Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB
• Evidence that bank vole PrP is a universal acceptor for prions.
  PLoS pathogens 2014 Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB
• Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.
  Bioorganic & medicinal chemistry 2014 Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB
• Transmission of multiple system atrophy prions to transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB
• Drug resistance confounding prion therapeutics.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K
• Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
  The Journal of pharmacology and experimental therapeutics 2013 Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB
• Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
  Pharmaceutical research 2013 Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB
• Chimeric elk/mouse prion proteins in transgenic mice.
  The Journal of general virology 2012 Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB
• Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.
  PloS one 2012 Ahn M, Ghaemmaghami S, Huang Y, Phuan PW, May BC, Giles K, DeArmond SJ, Prusiner SB
• Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K
• Identification of I137M and other mutations that modulate incubation periods for two human prion strains.
  Journal of virology 2012 Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB
• Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB
• Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.
  Molecular therapy. Nucleic acids 2012 Nazor Friberg K, Hung G, Wancewicz E, Giles K, Black C, Freier S, Bennett F, Dearmond SJ, Freyman Y, Lessard P, Ghaemmaghami S, Prusiner SB
• Salivary prions in sheep and deer.
  Prion 2012 Tamgüney G, Richt JA, Hamir AN, Greenlee JJ, Miller MW, Wolfe LL, Sirochman TM, Young AJ, Glidden DV, Johnson NL, Giles K, DeArmond SJ, Prusiner SB
• Spontaneous generation of anchorless prions in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K
• Protease-resistant prions selectively decrease Shadoo protein.
  PLoS pathogens 2011 Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB
• Conserved properties of human and bovine prion strains on transmission to guinea pigs.
  Laboratory investigation; a journal of technical methods and pathology 2011 Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB
• Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB
• Multiple effects of the cellular prion protein on tooth development.
  The International journal of developmental biology 2011 Zhang Y, Kim SO, Opsahl-Vital S, Ho SP, Souron JB, Kim C, Giles K, Den Besten PK
• Human prion strain selection in transgenic mice.
  Annals of neurology 2010 Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB
• A tangible 3D model of the human Adipocyte Plasma Membrane-Associated Protein (APMAP).
  The FASEB Journal 2010 Galileo SMART team, Shannon Colton, Tim Herman, Kurt Giles, Ben Koo, Sabine Jeske, Michael Hicks, Stan DeBella
• Design of a Three Dimensional Physical Model of P-glycoprotein.
  The FASEB Journal 2010 Lincoln SMART Team, Shannon Colton, Tim Herman, Kurt Giles, Ben Koo, Sabine Jeske, Anita Grover, Richard Gin
• Exploring Caspase Specificity with a Physical Three-Dimensional Model.
  The FASEB Journal 2010 Galileo SMART team, Shannon Colton, Tim Herman, Kurt Giles, Ben Koo, Sabine Jeske, Emily Crawford, Stan DeBella
• How HIV-1 Rev Gets its Groove On.
  The FASEB Journal 2010 Galileo SMART team, Shannon Colton, Tim Herman, Kurt Giles, Ben Koo, Sabine Jeske, Jason Fernandes, Stan DeBella
• Structural analysis of HIV-1 protease inhibition using physical models.
  The FASEB Journal 2010 Lincoln SMART Team, Shannon Colton, Tim Herman, Kurt Giles, Ben Koo, Sabine Jeske, Noah Ollikainen, Julie Reis
• Continuous quinacrine treatment results in the formation of drug-resistant prions.
  PLoS pathogens 2009 Ghaemmaghami S, Ahn M, Lessard P, Giles K, Legname G, DeArmond SJ, Prusiner SB
• Design and construction of diverse mammalian prion strains.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB
• Measuring prions by bioluminescence imaging.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Tamgüney G, Francis KP, Giles K, Lemus A, DeArmond SJ, Prusiner SB
• The molecular basis for transmission of human prion strains.
  The FASEB Journal 2009 Kurt Giles, Smita Patel, Gian De Nicola, Carston Korth, Azucena Lemus, Stephen DeArmond, Stanley B Prusiner
• Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein.
  The Journal of general virology 2009 Tamgüney G, Miller MW, Giles K, Lemus A, Glidden DV, DeArmond SJ, Prusiner SB
• Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation.
  PLoS pathogens 2008 Giles K, Glidden DV, Beckwith R, Seoanes R, Peretz D, DeArmond SJ, Prusiner SB
• A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ
• Genes contributing to prion pathogenesis.
  The Journal of general virology 2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz…
• Telling a molecular story: Tangible models of Cdc42 interacting with Intersectin.
  The FASEB Journal 2008 Lincoln SMART Team, Sabine Jeske, Angela H. Chau, Kurt Giles, Shannondoah A. Colton, Julie Reis
• Disinfection of Prions.
  New Biocides Development 2007 Kurt Giles, Surachai Supattapone, David Peretz, David V. Glidden, Henry Baron, Stanley B. Prusiner
• Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.
  The Journal of general virology 2007 Phuan PW, Zorn JA, Safar J, Giles K, Prusiner SB, Cohen FE, May BCH
• Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.
  Molecular medicine (Cambridge, Mass.) 2007 Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB
• Transgenic mouse brains for the evaluation and quality control of BSE tests.
  Biological chemistry 2007 Philipp WJ, Groth D, Giles K, Vodrazka P, Schimmel H, Feyssaguet M, Toomik R, Schacher P, Osman AA, Lachmann I, Wear A, Arsac JN, Prusiner SB
• Transmission of elk and deer prions to transgenic mice.
  Journal of virology 2006 Tamgüney G, Giles K, Bouzamondo-Bernstein E, Bosque PJ, Miller MW, Safar J, DeArmond SJ, Prusiner SB
• Inactivation of prions by acidic sodium dodecyl sulfate.
  Journal of virology 2006 Peretz D, Supattapone S, Giles K, Vergara J, Freyman Y, Lessard P, Safar JG, Glidden DV, McCulloch C, Nguyen HO, Scott M, Dearmond SJ, Prusiner SB
• Diagnosis of human prion disease.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Safar JG, Geschwind MD, Deering C, Didorenko S, Sattavat M, Sanchez H, Serban A, Vey M, Baron H, Giles K, Miller BL, Dearmond SJ, Prusiner SB
• Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
  Acta crystallographica. Section D, Biological crystallography 2000 Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL
• Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization.
  Journal of neurochemistry 2000 Navaratnam DS, Fernando FS, Priddle JD, Giles K, Clegg SM, Pappin DJ, Craig I, Smith AD
• aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server.
  Nucleic acids research 1998 Cousin X, Hotelier T, Giles K, Toutant JP, Chatonnet A
• Interactions underlying subunit association in cholinesterases.
  Protein engineering 1997 Giles K
• The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER.
  Nucleic acids research 1997 Cousin X, Hotelier T, Giles K, Lievin P, Toutant JP, Chatonnet A
• Involvement of the NMDA receptor in a non-cholinergic action of acetylcholinesterase in guinea-pig substantia nigra pars compacta neurons.
  The European journal of neuroscience 1996 Webb CP, Nedergaard S, Giles K, Greenfield SA