Kristin Shimano, MD
Professor
Pediatrics
School of Medicine

Education & Training

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• Fellowship Pediatric Hematology/Oncology University of California, San Francisco 2010
• Residency School of Medicine - Pediatrics University of California, San Francisco 2006
• M.D. School of Medicine Harvard University 2003
• Fellowship Pediatric Hematology/Oncology Boston Children's Hospital/Dana Farber Cancer Institute

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Publications (65)

Top publication keywords:
Thrombotic MicroangiopathiesSpinal Cord DiseasesPyridonesPyrimidinonesAnemia, AplasticThrombosisProto-Oncogene Proteins p21(ras)Purpura, Thrombocytopenic, IdiopathicPolycythemia VeraSirolimusPlatelet CountHematopoietic Stem Cell TransplantationVascular MalformationsMyeloproliferative DisordersArteriovenous Malformations

• International Consensus in Aiming to Define "Refractory ITP".
  Blood advances 2025 O'Farrell C, Grimes AB, Nakano TA, Klaassen RJ, Lambert MP, Neunert CE, Rothman JA, Shimano KA, Grace RF
• Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia.
  Blood advances 2024 Kim TO, Geris JM, Flanagan JM, Grace RF, Lambert MP, O'Farrell C, Rose MJ, Shimano KA, Niss O, Neunert C, Nakano TA, MacMath D, Dinu B, Kirk SE, Neufeld EJ, Despotovic JM, Scheurer ME, Grimes AB
• Effective Use of ALK Inhibitors in EML4::ALK-Positive Lymphatic Malformations.
  Pediatric blood & cancer 2024 Apsel Winger B, Dowd CF, Shimano KA, Devine WP, Mathes E, Frieden I, Schaefer C, Kothari A
• Efficacy Findings in a Phase 3, Randomized Trial of Eltrombopag Vs. Standard First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia in Children.
  Blood 2024 Kristin A. Shimano, Amanda B. Grimes, Melissa J Rose, Shipra Kaicker, Sanjay J. Shah, Michael Briones, Elizabeth Gunn, Taizo A. Nakano, Jeffrey D Lebensburger, Michele P. Lambert, Stephanie A. Fritch …
• Pediatric Autoimmune Hemolytic Anemia Is Associated with a High Incidence of an Underlying Immune Disorder and High Mortality Rate.
  Blood 2024 Rachael F Grace, MacGregor Steele, Tatiana Kalashnikova, Ellis Bloom, Aila Khan, Sherif M. Badawy, Hannah Elkus, Vicky R. Breakey, Sureka Pavalagantharajah, Stephanie A. Fritch Lilla, John Leister, …

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• What is in a name: defining pediatric refractory ITP.
  Blood advances 2024 Nakano TA, Grimes AB, Klaassen RJ, Lambert MP, Neunert C, Rothman JA, Shimano KA, Amend C, Askew M, Badawy SM, Baker JM, Breakey V, Crary S, Davini M, Fritch Lilla S, Gilbert M, Hays T, Hege K, …
• Cyclophosphamide and Thiotepa Increases Risk of Transplant-Associated Thrombotic Microangiopathy.
  Transplantation and cellular therapy 2024 Higham CS, Shimano KA, Kharbanda S, Chu J, Cisneros GS, Winestone LE, Dara J, Huang JN, Hermiston ML, Long-Boyle JR, Dvorak CC
• Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations.
  Pediatric blood & cancer 2024 Shimano KA, Sasa G, Broglie L, Gloude NJ, Myers K, Nakano TA, Sharathkumar A, Rothman JA, Pereda MA, Overholt K, Narla A, McGuinn C, Lau BW, Geddis AE, Dror Y, de Jong JLO, Castillo P, Allen SW, …
• MRD at the end of induction and EFS in T-cell lymphoblastic lymphoma: Children's Oncology Group trial AALL1231.
  Blood 2024 Hayashi RJ, Hermiston ML, Wood BL, Teachey DT, Devidas M, Chen Z, Annett RD, Asselin BL, August K, Cho S, Dunsmore KP, Freedman JL, Galardy PJ, Harker-Murray P, Horton TM, Jaju A, Lam A, Messinger YH,…
• Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations.
  Pediatric blood & cancer 2024 Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, …
• 13 Long-Term Medical Management of Patients with Chronic Granulomatous Disease, Wiskott-Aldrich Syndrome, and Primary Immune Regulatory Disorders: A Primary Immune Deficiency Treatment Consortium Survey.
  Clinical Immunology 2024 Christin Deal, Stephanie Si Lim, Kyle Ishikawa, Athanasios Tsalatsanis, Elisa Ochfeld, Aleks Petrovic, Kanwaldeep Mallhi, Avni Joshi, Kristin Shimano, Christopher Dvorak, Elie Haddad, Donald B. Kohn, …
• 169 Long Term Management of Transplanted Patients with Chronic Granulomatous Disease, Wiskott-Aldrich Syndrome, and Primary Immune Regulatory Disorders: A PIDTC Survey.
  Clinical Immunology 2024 Stephanie Si Lim, Christin Deal, Kyle Ishikawa, Athanasios Tsalatsanis, Elisa Ochfeld, Aleks Petrovic, Kanwaldeep Mallhi, Avni Joshi, Kristin Shimano, Christopher Dvorak, Elie Haddad, Donald B. Kohn, …
• Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols.
  Transplantation and cellular therapy 2024 Salinas Cisneros G, Dvorak CC, Long-Boyle J, Kharbanda S, Shimano KA, Melton A, Chu J, Winestone LE, Dara J, Huang JN, Hermiston ML, Zinter M, Higham CS
• A Napaac Survey to Understand Practices in Diagnosis and Treatment of Children with Moderate Aplastic Anemia.
  Blood 2023 Paul Castillo, Linah Omer, Steven W. Allen, Arnav Barpujari, Nicholas Joseph Gloude, Catherine McGuinn, Taizo A. Nakano, Elizabeth Ogando-Rivas, Kathleen Overholt, Kristin A. Shimano, Adrianna Vlachos…
• A Novel Online Decision Support Tool to Determine Practice Patterns and Concordance with Experts in the Treatment of Patients with Immune Thrombocytopenia.
  Blood 2023 Jacqueline L. Olin, Catherine M. Broome, Sandhya R Panch, Kristen Rosenthal, Timothy A. Quill, Kristin A. Shimano, Hanny Al-Samkari
• A Phase 3 Study of Eltrombopag Vs. Standard First-Line Management for Newly Diagnosed Immune Thrombocytopenia in Children: Trial in Progress Update.
  Blood 2023 Amanda B. Grimes, Rachael F. Grace, Melissa J. Rose, Sanjay J. Shah, Shipra Kaicker, Carolyn Bennett, Michael Briones, Taizo A. Nakano, Stephanie A. Fritch Lilla, Jeffrey D. Lebensburger, Alexis A. …
• Genetic Variants in Canonical Wnt Signaling Pathway Associated with Pediatric ITP.
  Blood 2023 Taylor Olmsted Kim, Jennifer M. Geris, Amanda B. Grimes, Rachael F. Grace, Michele P. Lambert, Melissa J. Rose, Kristin A. Shimano, Omar Niss, Cindy Neunert, Taizo A. Nakano, Derek Macmath, Bogdan …
• EML4::ALK fusions in complex lymphatic malformations.
  Pediatric blood & cancer 2023 Apsel Winger B, Devine WP, Hsiao EC, Zapala M, Van Ziffle J, Gupta N, Frieden IJ, Shimano KA
• 172 Diagnosing and Grading of SOS: Which Criteria Are Best?.
  Transplantation and Cellular Therapy 2023 Gabriel Salinas Cisneros, Christopher C. Dvorak, Sandhya Kharbanda, Kristin A. Shimano, Alexis Melton, Julia Chu, Lena E. Winestone, Jasmeen Dara, James N. Huang, Michelle Hermiston, Christine S. …
• 345 Prophylactic Tocilizumab Decreases Incidence of Acute Graft-Versus-Host Disease Following Alpha/Beta T-Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation in Children and Young Adults.
  Transplantation and Cellular Therapy 2023 Soohee Cho, Christopher C. Dvorak, Christine S. Higham, Gabriel Salinas Cisneros, Julia Chu, Alexis Melton, Lena E. Winestone, Kristin A. Shimano, Jasmeen Dara, Michelle Hermiston, James N. Huang, …
• 62 Immunohematologic Disorders.
  Clinical Immunology 2023 Kristin Ammon Shimano, Pierre Noel
• Current practices in pediatric hospital-acquired thromboembolism: Survey of the Children's Hospital Acquired Thrombosis (CHAT) Consortium.
  Research and practice in thrombosis and haemostasis 2022 Abrams CM, Jaffray J, Stillings A, Branchford BR, Young G, Goldenberg NA, Abajas YL, CHAT Consortium Investigators, VTE Risk Factors and Thromboprophylaxis Working Group of the Pediatric and Neonatal …
• Correlation of Minimal Residual Disease (MRD) at the End of Induction (EOI) and Event Free Survival (EFS) in T-Cell Lymphoblastic Lymphoma (T-LL), a Report from the Children's Oncology Group (COG) Trial AALL1231.
  Blood 2022 Robert J. Hayashi, Michelle L. Hermiston, David T. Teachey, Meenakshi Devidas, Brent L. Wood, Zhiguo Chen, Robert D Annett, Barbara L Asselin, Keith J August, Steve Y Cho, Kimberly P. Dunsmore, Jason …
• Clinical features associated with thrombotic events in children with myeloproliferative neoplasms.
  American journal of hematology 2022 Shimano KA, Vanderpoel V, Stone H, Resar L, Kucine N
• Eczema and Petechiae in an Infant.
  Pediatrics in review 2022 Lloyd-McLennan AM, Shimano KA, Dorsey M, Cordoro KM
• A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high-risk pediatric patients.
  Pediatric blood & cancer 2022 Higham CS, Shimano KA, Melton A, Kharbanda S, Chu J, Dara J, Winestone LE, Hermiston ML, Huang JN, Dvorak CC
• How we approach the use of sirolimus and new agents: Medical therapy to treat vascular anomalies.
  Pediatric blood & cancer 2022 Shimano KA, Eng W, Adams DM
• Hematopoietic Cell Transplantation-Comorbidity Index Score Is Correlated with Treatment-Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplantation in Children.
  Transplantation and cellular therapy 2021 Forlanini F, Zinter MS, Dvorak CC, Bailey-Olson M, Winestone LE, Shimano KA, Higham CS, Melton A, Chu J, Kharbanda S
• An Unusual Presentation of Kaposiform Hemangioendothelioma in the Mandibular Bone.
  Blood 2021 Aarati V Rao, Katharine L Ostedgaard, Youran Zou, Kristin A. Shimano
• Angiographic Evidence of Response to Trametinib Therapy for a Spinal Cord Arteriovenous Malformation.
  2021 Daniel L. Cooke, Ilona J. Frieden, Kristin A. Shimano
• Phase 3 randomised trial of eltrombopag versus standard first-line pharmacological management for newly diagnosed immune thrombocytopaenia (ITP) in children: study protocol.
  BMJ open 2021 Shimano KA, Grace RF, Despotovic JM, Neufeld EJ, Klaassen RJ, Bennett CM, Ma C, London WB, Neunert C
• Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium.
  American journal of hematology 2021 Shimano KA, Narla A, Rose MJ, Gloude NJ, Allen SW, Bergstrom K, Broglie L, Carella BA, Castillo P, de Jong JLO, Dror Y, Geddis AE, Huang JN, Lau BW, McGuinn C, Nakano TA, Overholt K, Rothman JA, …
• Use of Complete Blood Cell Count Components to Screen for Hereditary Spherocytosis in Neonates.
  Pediatrics 2021 Weiss NM, Kuzniewicz MW, Shimano KA, Walsh EM, Newman TB
• Transplant-associated thrombotic microangiopathy in pediatric patients: pre-HSCT risk stratification and prophylaxis.
  Blood advances 2021 Higham CS, Collins G, Shimano KA, Melton A, Kharbanda S, Winestone LE, Huang JN, Dara J, Long-Boyle JR, Dvorak CC
• Quality of life is an important indication for second-line treatment in children with immune thrombocytopenia.
  Pediatric blood & cancer 2021 Shimano KA, Neunert C, Bussel JB, Klaassen RJ, Bhat R, Pastore YD, Lambert MP, Bennett CM, Despotovic JM, Forbes P, Grace RF
• A Pilot Trial of Pre-Transplant Risk Stratification and Prophylactic Defibrotide to Prevent Serious Thrombotic Microangiopathy in High-Risk Pediatric Hematopoietic Stem Cell Transplant Patients.
  Blood 2020 Christine S Higham, Alexis Melton, Sandhya Kharbanda, Jasmeen Dara, Lena E. Winestone, James N Huang, Kristin A. Shimano
• Cranial Radiation Can be Eliminated in Most Children with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-Cell Lymphoblastic Lymphoma (T-LL): Results of Children's Oncology Group (COG) Trial AALL1231.
  Blood 2020 David T. Teachey, Meenakshi Devidas, Brent L Wood, Zhiguo Chen, Robert James Hayashi, Robert D Annett, Barbara L Asselin, Keith J August, Steve Y Cho, Kimberly P. Dunsmore, Brian T. Fisher, Jason L. …
• Monitoring Arteriovenous Malformation Response to Genotype-Targeted Therapy.
  Pediatrics 2020 Edwards EA, Phelps AS, Cooke D, Frieden IJ, Zapala MA, Fullerton HJ, Shimano KA
• Reduced Toxicity Conditioning for Nonmalignant Hematopoietic Cell Transplants.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2020 Contreras CF, Long-Boyle JR, Shimano KA, Melton A, Kharbanda S, Dara J, Higham C, Huang JN, Cowan MJ, Dvorak CC
• Fatigue in children and adolescents with immune thrombocytopenia.
  British journal of haematology 2020 Grace RF, Klaassen RJ, Shimano KA, Lambert MP, Grimes A, Bussel JB, Breakey VR, Pastore YD, Black V, Overholt K, Bhat R, Forbes PW, Neunert C
• The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.
  Pediatric blood & cancer 2019 Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC
• A Phase 3 Study of Eltrombopag Vs. Standard First-Line Management for Newly Diagnosed Immune Thrombocytopenia in Children.
  Blood 2019 Kristin A. Shimano, Rachael F. Grace, Carolyn M. Bennett, Robert J Klaassen, Cindy Neunert, Ellis J. Neufeld, Clement Ma, Wendy B. London, Jenny M. Despotovic
• Reduced Toxicity Conditioning for Non-Malignant Hematopoietic Cell Transplants.
  Blood 2019 Cristina F Contreras, Janel R Long-Boyle, Kristin A. Shimano, Jasmeen Dara, James N Huang, Sandhya Kharbanda, Alexis Melton, Christine Higham, Morton J Cowan, Christopher C. Dvorak
• Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis.
  Blood 2019 Aleksandra S. Dain, Michelle L. Hermiston, Kristin A. Shimano, Sandhya Kharbanda, Alexis Melton, Jasmeen Dara, James N Huang, Christopher C. Dvorak
• Autoimmune Cytopenias in Pediatric Hematopoietic Cell Transplant Patients.
  Frontiers in pediatrics 2019 Neely JA, Dvorak CC, Pantell MS, Melton A, Huang JN, Shimano KA
• Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes.
  American journal of hematology 2019 Grace RF, Shimano KA, Bhat R, Neunert C, Bussel JB, Klaassen RJ, Lambert MP, Rothman JA, Breakey VR, Hege K, Bennett CM, Rose MJ, Haley KM, Buchanan GR, Geddis A, Lorenzana A, Jeng M, Pastore YD, …
• Transplant-Associated Thrombotic Microangiopathy in Pediatric Hematopoietic Cell Transplant Recipients: A Practical Approach to Diagnosis and Management.
  Frontiers in pediatrics 2019 Dvorak CC, Higham C, Shimano KA
• Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ
• The Impact of Total Body Irradiation-Based Regimens on Outcomes in Children and Young Adults with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
  Biology of Blood and Marrow Transplantation 2019 Brian D. Friend, Mara Bailey-Olson, Christine Higham, Jasmeen Dara, Alexis Melton, Kristin A. Shimano, James Huang, Sandhya Kharbanda, Christopher C. Dvorak
• Anemia and Neutropenia.
  2019 Kristin Shimano
• Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation.
  Blood advances 2018 Schuetz C, Hoenig M, Moshous D, Weinstock C, Castelle M, Bendavid M, Shimano K, Tolbert V, Schulz AS, Dvorak CC
• Physician decision making in selection of second-line treatments in immune thrombocytopenia in children.
  American journal of hematology 2018 Grace RF, Despotovic JM, Bennett CM, Bussel JB, Neier M, Neunert C, Crary SE, Pastore YD, Klaassen RJ, Rothman JA, Hege K, Breakey VR, Rose MJ, Shimano KA, Buchanan GR, Geddis A, Haley KM, Lorenzana A…
• Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.
  bioRxiv 2018 Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Kensho Iwanaga, Ngoc P Ly, Meghan E McGarry, Gwynne D Church, Lauren E Faricy, Courtney M Rowan, Janet R Hume, Marie E Steiner, Emily D Crawford…
• Health Related Quality of Life and Fatigue Improve on Second Line Treatments in Pediatric Immune Thrombocytopenia (ITP).
  Blood 2017 Rachael F. Grace, Robert J Klaassen, Rukhmi Bhat, Michelle Neier, Melissa J. Rose, Jenny M. Despotovic, Carolyn M. Bennett, James B. Bussel, Jennifer A. Rothman, Vicky R. Breakey, Kerry Hege, Kristin …
• Sirolimus for management of complex vascular anomalies - A proposed dosing regimen for very young infants.
  International journal of pediatric otorhinolaryngology 2017 Czechowicz JA, Long-Boyle JR, Rosbe KW, Mathes EF, Frieden IJ, Shimano KA
• JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
  Leukemia 2017 Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML
• Clinical Characteristics and Quality of Life of Children with ITP Starting Second Line Treatments: Data from the ITP Consortium of North America ICON1 Study.
  Blood 2016 Rachael F Grace, Robert J. Klaassen, Jennifer A Rothman, Kerry Hege, Ellis J Neufeld, Carolyn M. Bennett, Michele Lambert, Vicky R. Breakey, James B. Bussel, George R. Buchanan, Melissa J. Rose, Amy …
• Comparison of Bleeding Tools in a Cohort of Pediatric Patients with ITP: Data from the Pediatric ITP Consortium of North America ICON1 Study.
  Blood 2016 Breakey R. Vicky, Rachael F Grace, Carolyn M. Bennett, Jenny M. Despotovic, Jennifer A Rothman, Yves D. Pastore, Ellis J Neufeld, Robert J. Klaassen, Michele Lambert, James B. Bussel, George R. …
• Daratumumab Is Effective in the Treatment of Refractory Post-Transplant Autoimmune Hemolytic Anemia: A Pediatric Case Report.
  Blood 2016 Vanessa P. Tolbert, Robert Goldsby, James Huang, Kristin Shimano, Alexis Melton, Jennifer Willert, Biljana N. Horn, Christopher C. Dvorak, Justin T. Wahlstrom
• JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia.
  Blood 2016 Cristina Delgado-Martin, Kristin Shimano, Matthew S Zinter, Justin T. Wahlstrom, Geoffrey A. Smith, Jack Taunton, Stuart S. Winter, Justine E. Roderick, Michelle Kelliher, Terzah M. Horton, Brent L. …
• Physician Factors Determining Treatment Decisions in Selecting Second Line Agents for Pediatric ITP.
  Blood 2016 Michele P. Lambert, Rachael F Grace, Cindy Neunert, Jenny M. Despotovic, Rukhmi Bhat, Yves D. Pastore, George R. Buchanan, Robert J. Klaassen, Carolyn M. Bennett, Jennifer A Rothman, Vicky R. Breakey,…
• Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study.
  Pediatric blood & cancer 2016 Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, Pastore Y, Brown T, Forbes PW, Grace RF, Pediatric ITP Consortium of North America (ICON…
• Autoimmune Cytopenias in Pediatric Hematopoietic Cell Transplant (HCT) Patients.
  Biology of Blood and Marrow Transplantation 2016 Jessica Neely, Christopher C. Dvorak, Matthew Pantell Pantell, Kristin A. Shimano
• The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
  Nature 2012 Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, …
• Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project.
  Blood 2011 Jinghui Zhang, Li Ding, Linda Holmfeldt, Gang Wu, Susan L. Heatley, Debbie Payne-Turner, John Easton, Xiang Chen, Jianmin Wang, Michael Rusch, Charles Lu, Shann-Ching Chen, Racquel Collins-Underwood, …