Kristen Mengwasser, MD, PhD
Assistant Professor
Medicine
School of Medicine

Awards

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• Early Career Investigator Award, SPARTAN Network, 2025-2027
• ZSFG Human Biospecimen Pipeline Development Award - shared with Dr. Diana Alba, Office of Collaborative Research, 2025-2026
• SAA/Bruckel Early Career Investigator Award, SAA, 2025-2026
• Catalyst Award, UCSF Catalyst Program, 2025
• Distinguished Fellow Award, American College of Rheumatology, 2025
• Postdoctoral Research Fellowship and Leadership Award, A.P. Giannini Foundation, 2024-2027
• Mentored Fellowship Award, SPARTAN Network, 2024-2025
• Diversity in Bench Sciences Award, UCSF Department of Medicine, 2022-2026

Education & Training

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• Internal Medicine Residency Medicine Brigham and Women's Hospital
• MD Medicine Harvard Medical School/MIT
• BA Biochemical Sciences Harvard University
• PhD Genetics Harvard University
• Rheumatology Fellowship Rheumatology UCSF
• MPhil Biochemistry University of Cambridge

Publications (8)

Top publication keywords:
CRISPR-Cas SystemsPichiaFlap EndonucleasesSynthetic Lethal MutationsLipopolysaccharidesOncogenesLymphocyte Antigen 96RNA InterferenceBRCA2 ProteinGenes, LethalAllosteric RegulationDNA-(Apurinic or Apyrimidinic Site) LyaseAntigens, SurfaceHirudinsCulture Media

• Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJ
• Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.
  Cell reports 2019 Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C
• Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
  Molecular cell 2019 Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ
• Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.
  Genes & development 2016 Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ
• Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.
  Cell 2013 Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ
• LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding.
  Protein expression and purification 2010 Mengwasser KE, Bryant CE, Gay NJ, Gangloff M
• The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ
• Hirudin binding reveals key determinants of thrombin allostery.
  The Journal of biological chemistry 2005 Mengwasser KE, Bush LA, Shih P, Cantwell AM, Di Cera E