Konstantinos Chiotis, MD, PhD
Postdoctoral Scholar
Neurology
School of Medicine

Education & Training

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• Neurology Karolinska University Hospital 01/2024
• PhD Neuroscience Karolinska Institutet 01/2018
• MD Medicine University of Patras 07/2011

Publications (42)

Top publication keywords:
Cognitive DysfunctionQuinolinesWork EngagementAlzheimer DiseaseThiazolesAniline Compoundstau ProteinsAmyloid beta-PeptidesFluorodeoxyglucose F18RadiopharmaceuticalsAminopyridinesGliosisEthylene GlycolsAmyloidPositron-Emission Tomography

• Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory clinics.
  EBioMedicine 2024 Bluma M, Chiotis K, Bucci M, Savitcheva I, Matton A, Kivipelto M, Jeromin A, De Santis G, Di Molfetta G, Ashton NJ, Blennow K, Zetterberg H, Nordberg A
• Tau PET positivity predicts clinically relevant cognitive decline driven by Alzheimer's disease compared to comorbid cases; proof of concept in the ADNI study.
  Molecular psychiatry 2024 Ioannou K, Bucci M, Tzortzakakis A, Savitcheva I, Nordberg A, Chiotis K, Alzheimer’s Disease Neuroimaging Initiative
• Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach.
  Methods in molecular biology (Clifton, N.J.) 2024 Rodriguez-Vieitez E, Kumar A, Malarte ML, Ioannou K, Rocha FM, Chiotis K
• Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer's disease with multi-modal PET and plasma GFAP.
  Molecular neurodegeneration 2023 Chiotis K, Johansson C, Rodriguez-Vieitez E, Ashton NJ, Blennow K, Zetterberg H, Graff C, Nordberg A
• Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory clinic.
  Translational psychiatry 2023 Bucci M, Bluma M, Savitcheva I, Ashton NJ, Chiotis K, Matton A, Kivipelto M, Di Molfetta G, Blennow K, Zetterberg H, Nordberg A

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• Astrocyte Signature in Alzheimer's Disease Continuum through a Multi-PET Tracer Imaging Perspective.
  Cells 2023 Fontana IC, Scarpa M, Malarte ML, Rocha FM, Ausellé-Bosch S, Bluma M, Bucci M, Chiotis K, Kumar A, Nordberg A
• Blood β-synuclein is related to amyloid PET positivity in memory clinic patients.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Oeckl P, Bluma M, Bucci M, Halbgebauer S, Chiotis K, Sandebring-Matton A, Ashton NJ, Molfetta GD, Grötschel L, Kivipelto M, Blennow K, Zetterberg H, Savitcheva I, Nordberg A, Otto M
• Crossover of Work Engagement: The Moderating Role of Agreeableness.
  International journal of environmental research and public health 2022 Chiotis K, Michaelides G
• Correction to: The Strategic Biomarker Roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.
  European journal of nuclear medicine and molecular imaging 2021 Boccardi M, Dodich A, Albanese E, Gayet-Ageron A, Festari C, Ashton NJ, Bischof GN, Chiotis K, Leuzy A, Wolters EE, Walter M, Rabinovici GD, Carrillo M, Drzezga A, Hansson O, Nordberg A, Ossenkoppele …
• Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline.
  Molecular psychiatry 2021 Bucci M, Chiotis K, Nordberg A, Alzheimer’s Disease Neuroimaging Initiative
• Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.
  European journal of nuclear medicine and molecular imaging 2021 Chiotis K, Dodich A, Boccardi M, Festari C, Drzezga A, Hansson O, Ossenkoppele R, Frisoni G, Garibotto V, Nordberg A
• The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.
  European journal of nuclear medicine and molecular imaging 2021 Boccardi M, Dodich A, Albanese E, Gayet-Ageron A, Festari C, Ashton NJ, Bischof GN, Chiotis K, Leuzy A, Wolters EE, Walter MA, Rabinovici GD, Carrillo M, Drzezga A, Hansson O, Nordberg A, Ossenkoppele…
• Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD 2021 Colato E, Chiotis K, Ferreira D, Mazrina MS, Lemoine L, Mohanty R, Westman E, Nordberg A, Rodriguez-Vieitez E, Alzheimer’s Disease Neuroimaging Initiative
• Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism.
  Brain connectivity 2020 Smailovic U, Koenig T, Savitcheva I, Chiotis K, Nordberg A, Blennow K, Winblad B, Jelic V
• Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization.
  Brain communications 2020 Mohanty R, Mårtensson G, Poulakis K, Muehlboeck JS, Rodriguez-Vieitez E, Chiotis K, Grothe MJ, Nordberg A, Ferreira D, Westman E
• [18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer's disease.
  Molecular psychiatry 2020 Chiotis K, Savitcheva I, Poulakis K, Saint-Aubert L, Wall A, Antoni G, Nordberg A
• Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging.
  European journal of nuclear medicine and molecular imaging 2019 Murugan NA, Chiotis K, Rodriguez-Vieitez E, Lemoine L, Ågren H, Nordberg A
• Clinical impact of [18F]flutemetamol PET among memory clinic patients with an unclear diagnosis.
  European journal of nuclear medicine and molecular imaging 2019 Leuzy A, Savitcheva I, Chiotis K, Lilja J, Andersen P, Bogdanovic N, Jelic V, Nordberg A
• Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET.
  NeuroImage. Clinical 2019 Jonasson M, Wall A, Chiotis K, Leuzy A, Eriksson J, Antoni G, Nordberg A, Lubberink M
• Tau PET imaging in neurodegenerative tauopathies-still a challenge.
  Molecular psychiatry 2019 Leuzy A, Chiotis K, Lemoine L, Gillberg PG, Almkvist O, Rodriguez-Vieitez E, Nordberg A
• Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.
  European journal of nuclear medicine and molecular imaging 2019 Leuzy A, Cicognola C, Chiotis K, Saint-Aubert L, Lemoine L, Andreasen N, Zetterberg H, Ye K, Blennow K, Höglund K, Nordberg A
• Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer's disease.
  European journal of nuclear medicine and molecular imaging 2018 Carter SF, Chiotis K, Nordberg A, Rodriguez-Vieitez E
• Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.
  NeuroImage. Clinical 2018 Oliveira F, Leuzy A, Castelhano J, Chiotis K, Hasselbalch SG, Rinne J, Mendonça A, Otto M, Lleó A, Santana I, Johansson J, Anderl-Straub S, Arnim C, Beer A, Blesa R, Fortea J, Sanna-Kaisa H, Portelius…
• Spatial Normalization of 18F-Flutemetamol PET Images Using an Adaptive Principal-Component Template
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Lilja J, Leuzy A, Chiotis K, Savitcheva I, Sörensen J, Nordberg A
• Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain.
  European journal of nuclear medicine and molecular imaging 2018 Chiotis K, Stenkrona P, Almkvist O, Stepanov V, Ferreira D, Arakawa R, Takano A, Westman E, Varrone A, Okamura N, Shimada H, Higuchi M, Halldin C, Nordberg A
• Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2018 Lemoine L, Leuzy A, Chiotis K, Rodriguez-Vieitez E, Nordberg A
• Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2017 Leuzy A, Rodriguez-Vieitez E, Saint-Aubert L, Chiotis K, Almkvist O, Savitcheva I, Jonasson M, Lubberink M, Wall A, Antoni G, Nordberg A
• Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers.
  The Lancet. Neurology 2017 Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, Démonet JF, Garibotto V, Giannakopoulos P, Gietl A, Hansson O, Herholz K, Jack CR, Nobili F, Nordberg A, Snyder HM, Ten Kate M, …
• Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer's disease dementia.
  Molecular psychiatry 2017 Chiotis K, Saint-Aubert L, Rodriguez-Vieitez E, Leuzy A, Almkvist O, Savitcheva I, Jonasson M, Lubberink M, Wall A, Antoni G, Nordberg A
• Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.
  Neurobiology of aging 2017 Chiotis K, Saint-Aubert L, Boccardi M, Gietl A, Picco A, Varrone A, Garibotto V, Herholz K, Nobili F, Nordberg A, Geneva Task Force for the Roadmap of Alzheimer's Biomarkers
• Tau PET imaging: present and future directions.
  Molecular neurodegeneration 2017 Saint-Aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-Vieitez E, Nordberg A
• A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer's Disease in a Clinical Setting.
  Journal of Alzheimer's disease : JAD 2017 Iaccarino L, Chiotis K, Alongi P, Almkvist O, Wall A, Cerami C, Bettinardi V, Gianolli L, Nordberg A, Perani D
• Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer's disease.
  Alzheimer's research & therapy 2016 Saint-Aubert L, Almkvist O, Chiotis K, Almeida R, Wall A, Nordberg A
• Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer's disease.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Rodriguez-Vieitez E, Leuzy A, Chiotis K, Saint-Aubert L, Wall A, Nordberg A
• Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.
  Brain : a journal of neurology 2016 Leuzy A, Chiotis K, Hasselbalch SG, Rinne JO, de Mendonça A, Otto M, Lleó A, Castelo-Branco M, Santana I, Johansson J, Anderl-Straub S, von Arnim CA, Beer A, Blesa R, Fortea J, Herukka SK, Portelius E…
• Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm.
  European journal of nuclear medicine and molecular imaging 2016 Chiotis K, Saint-Aubert L, Savitcheva I, Jelic V, Andersen P, Jonasson M, Eriksson J, Lubberink M, Almkvist O, Wall A, Antoni G, Nordberg A
• Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 Rodriguez-Vieitez E, Carter SF, Chiotis K, Saint-Aubert L, Leuzy A, Schöll M, Almkvist O, Wall A, Långström B, Nordberg A
• Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease.
  Brain : a journal of neurology 2016 Rodriguez-Vieitez E, Saint-Aubert L, Carter SF, Almkvist O, Farid K, Schöll M, Chiotis K, Thordardottir S, Graff C, Wall A, Långström B, Nordberg A
• Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 Jonasson M, Wall A, Chiotis K, Saint-Aubert L, Wilking H, Sprycha M, Borg B, Thibblin A, Eriksson J, Sörensen J, Antoni G, Nordberg A, Lubberink M
• Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging.
  European journal of nuclear medicine and molecular imaging 2015 Chiotis K, Carter SF, Farid K, Savitcheva I, Nordberg A, Diagnostic Molecular Imaging (DiMI) network and the Alzheimer’s Disease Neuroimaging Initiative
• Concordance and Diagnostic Accuracy of [11C]PIB PET and Cerebrospinal Fluid Biomarkers in a Sample of Patients with Mild Cognitive Impairment and Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD 2015 Leuzy A, Carter SF, Chiotis K, Almkvist O, Wall A, Nordberg A
• Role of anthropometric characteristics in idiopathic carpal tunnel syndrome.
  Archives of physical medicine and rehabilitation 2012 Chiotis K, Dimisianos N, Rigopoulou A, Chrysanthopoulou A, Chroni E