Kliment Verba, PhD
Assistant Professor
Cellular Molecular Pharmacology
School of Medicine
Publications (28)
Top publication keywords:
Protein MultimerizationCryoelectron MicroscopyCell Cycle ProteinsProtein Interaction MapsCytoskeletal ProteinsReceptor, ErbB-2HSP90 Heat-Shock ProteinsDetergentsReceptor, ErbB-314-3-3 ProteinsMicellesMultiprotein ComplexesCyclin-Dependent Kinase 4ChaperoninsProtein Unfolding
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Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
eLife 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N -
High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
bioRxiv : the preprint server for biology 2024 Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Gulati S, Lander GC, Verba KA -
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
Nature chemical biology 2024 Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA -
Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
bioRxiv : the preprint server for biology 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N -
SARS-CoV-2 variants evolve convergent strategies to remodel the host response.
Cell 2023 Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, …
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Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nature communications 2023 Torosyan H, Paul MD, Forget A, Lo M, Diwanji D, Pawlowski K, Krogan NJ, Jura N, Verba KA -
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
Structure (London, England : 1993) 2023 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG … -
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
Nature communications 2022 Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Hüttenhain R, Carette JE, Krogan NJ -
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
bioRxiv : the preprint server for biology 2022 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural … -
An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.
Methods in enzymology 2022 Trenker R, Diwanji D, Verba KA, Jura N -
Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.
Methods in enzymology 2022 Diwanji D, Trenker R, Jura N, Verba KA -
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
Nature 2022 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, … -
Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
Nature 2022 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N -
Evolution of enhanced innate immune evasion by SARS-CoV-2.
Nature 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, … -
Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
Nature 2021 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N -
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
bioRxiv : the preprint server for biology 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, … -
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, … -
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, … -
Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM.
Journal of structural biology 2021 Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA -
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Cancer research 2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, … -
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor… -
Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor.
Acta crystallographica. Section D, Structural biology 2020 Agarwal S, Smith M, De La Rosa I, Verba KA, Swartz P, Segura-Totten M, Mattos C -
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, … -
Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae.
Bio-protocol 2017 Verba KA, Agard DA -
How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.
Trends in biochemical sciences 2017 Verba KA, Agard DA -
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy.
Nature methods 2017 Zheng SQ, Palovcak E, Armache JP, Verba KA, Cheng Y, Agard DA -
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
Science (New York, N.Y.) 2016 Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA -
Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity.
Journal of molecular biology 2011 Street TO, Lavery LA, Verba KA, Lee CT, Mayer MP, Agard DA