Kirsten Obernier, PhD
Director-Science and Strategy
Quantitative_Bioscience_Ins
School of Pharmacy

Education & Training

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• Ph.D. Neurobiology University of Heidelberg 2010
• Postdoctoral Studies Neurosurgery University of California, San Francisco

Websites

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• Profile at UCSF Department of Neurological Surgery (neurosurgery.ucsf.edu)

Publications (42)

Top publication keywords:
Protein Interaction MapsNeural Stem CellsStem Cell NicheDepsipeptidesProsencephalonLateral VentriclesNeurogenesisCell LineageCell DifferentiationInterneuronsCell Self RenewalOlfactory BulbEpendymaAdult Stem CellsReceptors, Cytoplasmic and Nuclear

• Central control of dynamic gene circuits governs T cell rest and activation.
  Nature 2024 Arce MM, Umhoefer JM, Arang N, Kasinathan S, Freimer JW, Steinhart Z, Shen H, Pham MTN, Ota M, Wadhera A, Dajani R, Dorovskyi D, Chen YY, Liu Q, Zhou Y, Swaney DL, Obernier K, Shy BR, Carnevale J, …
• A Perturbation Cell Atlas of Human Induced Pluripotent Stem Cells.
  bioRxiv : the preprint server for biology 2024 Nourreddine S, Doctor Y, Dailamy A, Forget A, Lee YH, Chinn B, Khaliq H, Polacco B, Muralidharan M, Pan E, Zhang Y, Sigaeva A, Hansen JN, Gao J, Parker JA, Obernier K, Clark T, Chen JY, Metallo C, …
• Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone.
  bioRxiv : the preprint server for biology 2024 Cebrian-Silla A, Assis Nascimento M, Mancia W, Gonzalez-Granero S, Romero-Rodriguez R, Obernier K, Steffen DM, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A
• Predicted mechanistic impacts of human protein missense variants.
  bioRxiv : the preprint server for biology 2024 Jänes J, Müller M, Selvaraj S, Manoel D, Stephenson J, Gonçalves C, Lafita A, Polacco B, Obernier K, Alasoo K, Lemos MC, Krogan N, Martin M, Saraiva LR, Burke D, Beltrao P
• Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines.
  bioRxiv : the preprint server for biology 2024 Clark T, Mohan J, Schaffer L, Obernier K, Al Manir S, Churas CP, Dailamy A, Doctor Y, Forget A, Hansen JN, Hu M, Lenkiewicz J, Levinson MA, Marquez C, Nourreddine S, Niestroy J, Pratt D, Qian G, …

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• A foundational atlas of autism protein interactions reveals molecular convergence.
  bioRxiv : the preprint server for biology 2024 Wang B, Vartak R, Zaltsman Y, Naing ZZC, Hennick KM, Polacco BJ, Bashir A, Eckhardt M, Bouhaddou M, Xu J, Sun N, Lasser MC, Zhou Y, McKetney J, Guiley KZ, Chan U, Kaye JA, Chadha N, Cakir M, Gordon M,…
• SARS-CoV-2 variants evolve convergent strategies to remodel the host response.
  Cell 2023 Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, …
• Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2022 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
  Science (New York, N.Y.) 2022 Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano …
• Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
  Life science alliance 2022 Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, Fernandez de Orueta L, Torralba M, Fortun J, Vates R, Barberan J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, …
• Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
  Science (New York, N.Y.) 2021 Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez…
• Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches.
  mSystems 2021 Cakir M, Obernier K, Forget A, Krogan NJ
• Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.
  eLife 2021 Cebrian-Silla A, Nascimento MA, Redmond SA, Mansky B, Wu D, Obernier K, Romero Rodriguez R, Gonzalez-Granero S, García-Verdugo JM, Lim DA, Álvarez-Buylla A
• Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
  bioRxiv : the preprint server for biology 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, …
• Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
  medRxiv : the preprint server for health sciences 2021 Varona JF, Landete P, Lopez-Martin JA, Estrada V, Paredes R, Guisado-Vasco P, de Orueta LF, Torralba M, Fortún J, Vates R, Barberán J, Clotet B, Ancochea J, Carnevali D, Cabello N, Porras L, Gijón P, …
• Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
  bioRxiv : the preprint server for biology 2021 Reuschl AK, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J, Fabius JM, Nguyen GT, Swaney DL, Rosales R, White KM, Avilés P, Kirby IT, Melnyk JE, Shi Y, Zhang Z, …
• Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
  Science (New York, N.Y.) 2021 White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, …
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
  Cell 2020 Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray…
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.
  Cell reports 2019 Redmond SA, Figueres-Oñate M, Obernier K, Nascimento MA, Parraguez JI, López-Mascaraque L, Fuentealba LC, Alvarez-Buylla A
• Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain.
  Development (Cambridge, England) 2019 Obernier K, Alvarez-Buylla A
• A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
  Nature cell biology 2018 Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, …
• A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
  Cancer cell 2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-…
• Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation.
  Cell stem cell 2018 Obernier K, Cebrian-Silla A, Thomson M, Parraguez JI, Anderson R, Guinto C, Rodas Rodriguez J, Garcia-Verdugo JM, Alvarez-Buylla A
• Embryonic Origin of Postnatal Neural Stem Cells.
  Cell 2015 Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A
• Primary cilia are required in a unique subpopulation of neural progenitors.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Tong CK, Han YG, Shah JK, Obernier K, Guinto CD, Alvarez-Buylla A
• Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair.
  Frontiers in neuroscience 2014 Obernier K, Tong CK, Alvarez-Buylla A
• Axonal control of the adult neural stem cell niche.
  Cell stem cell 2014 Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A
• Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.
  Scientific reports 2014 Khatri P, Obernier K, Simeonova IK, Hellwig A, Hölzl-Wenig G, Mandl C, Scholl C, Wölfl S, Winkler J, Gaspar JA, Sachinidis A, Ciccolini F
• Molecular diversity subdivides the adult forebrain neural stem cell population.
  Stem cells (Dayton, Ohio) 2014 Giachino C, Basak O, Lugert S, Knuckles P, Obernier K, Fiorelli R, Frank S, Raineteau O, Alvarez-Buylla A, Taylor V
• Lineage progression from stem cells to new neurons in the adult brain ventricular-subventricular zone.
  Cell cycle (Georgetown, Tex.) 2013 Ponti G, Obernier K, Alvarez-Buylla A
• Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Ponti G, Obernier K, Guinto C, Jose L, Bonfanti L, Alvarez-Buylla A
• Adult neural stem cells bridge their niche.
  Cell stem cell 2012 Fuentealba LC, Obernier K, Alvarez-Buylla A
• Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone.
  Stem cells (Dayton, Ohio) 2011 Obernier K, Simeonova I, Fila T, Mandl C, Hölzl-Wenig G, Monaghan-Nichols P, Ciccolini F
• GABAA receptor signaling induces osmotic swelling and cell cycle activation of neonatal prominin+ precursors.
  Stem cells (Dayton, Ohio) 2011 Cesetti T, Fila T, Obernier K, Bengtson CP, Li Y, Mandl C, Hölzl-Wenig G, Ciccolini F
• Multipotent precursors in the anterior and hippocampal subventricular zone display similar transcription factor signatures but their proliferation and maintenance are differentially regulated.
  Molecular and cellular neurosciences 2010 Carrillo-García C, Suh Y, Obernier K, Hölzl-Wenig G, Mandl C, Ciccolini F
• Interaction between DLX2 and EGFR regulates proliferation and neurogenesis of SVZ precursors.
  Molecular and cellular neurosciences 2009 Suh Y, Obernier K, Hölzl-Wenig G, Mandl C, Herrmann A, Wörner K, Eckstein V, Ciccolini F
• Analysis of stem cell lineage progression in the neonatal subventricular zone identifies EGFR+/NG2- cells as transit-amplifying precursors.
  Stem cells (Dayton, Ohio) 2009 Cesetti T, Obernier K, Bengtson CP, Fila T, Mandl C, Hölzl-Wenig G, Wörner K, Eckstein V, Ciccolini F
• Functional characterization and transcriptome analysis of embryonic stem cell-derived contractile smooth muscle cells.
  Hypertension (Dallas, Tex. : 1979) 2008 Potta SP, Liang H, Pfannkuche K, Winkler J, Chen S, Doss MX, Obernier K, Kamisetti N, Schulz H, Hübner N, Hescheler J, Sachinidis A