Kirsten Kangelaris, MD, MAS
Professor
Medicine
School of Medicine

Dr. Kangelaris’ research program centers on sepsis, with an emphasis on early identification, clinical phenotyping, and the heterogeneity of disease presentation and outcomes. Her work spans the translational spectrum, integrating electronic health record–based studies, prospective clinical cohorts, and biomarker-driven investigations, including the integration of clinical data with molecular profiling approaches. She has expertise in the development and validation of EHR-derived datasets and prospective case adjudication. She has served as a site lead for clinical operations and data management for a large observational cohort and as a co-investigator on multiple multicenter clinical trials. In addition, she has experience using clinician-facing audit log (Signal) data to study care delivery and physician workload. She serves as a site principal investigator for a multi-center study of hospitalist workload and burnout and has led institutional efforts focused on physician experience, including co-leading a UCSF-wide burnout symposium and serving on the executive leadership team of the UCSF Physicians for Engagement, Representation, and Communication (PERC) initiative.

Clinically, Dr. Kangelaris cares for hospitalized adults on the teaching and direct care services at UCSF Moffitt-Long Hospital. Her clinical work is closely aligned with her research in sepsis, particularly in the areas of early recognition and the heterogeneity of disease presentation.

She received her medical degree and completed her residency in internal medicine at the University of Michigan, followed by fellowship training and a Master of Advanced Study in Clinical Research at the University of California, San Francisco.

• Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study.
  Critical care (London, England) 2025 Sanchez PA, Obeidalla S, Kerchberger VE, Moore AR, Maddali MV, Kangelaris KN, Hendrickson CM, Evrard B, Liu KD, Bastarache JA, Matthay MA, Rogers AJ, Calfee CS
• Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.
  The journal of allergy and clinical immunology. Global 2025 Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo …
• Neighborhood Health Measured by the Healthy Places Index (HPI), but Not by the Area Deprivation Index (ADI), Is Associated With Mortality for Critically Ill Sepsis Patients in the San Francisco Bay Area.
  American Journal of Respiratory and Critical Care Medicine 2025 K.M. Sullivan, A.M. Dedent, A. Willmore, K.N. Kangelaris, C.M. Hendrickson, C. Lin, C.S. Calfee, N. Thakur, M.A. Matthay
• Vasopressor Duration and Intensity Differs by Inflammatory Subphenotype in Sepsis.
  American Journal of Respiratory and Critical Care Medicine 2025 P.A. Sanchez, N. Alipanah-Lechner, C.M. Hendrickson, K.N. Kangelaris, C. Lin, L. Magee, O. Chao, S. Chak, K. Bardillon, M.A. Matthay, A. Rogers, C.S. Calfee
• A multi-institutional multi-methods analysis of jeopardy systems in academic hospital medicine.
  Journal of hospital medicine 2025 Kangelaris KN, Keniston A, Auerbach AD, Bowling G, Burden M, Kulkarni SA, Leykum LK, Linker AS, Sakumoto M, Schnipper J, Astik G
• Agreement between Sepsis-2 and Sepsis-3 Definitions among Patients Admitted to the Intensive Care Unit.
  Annals of the American Thoracic Society 2025 Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS
• Big brother or big opportunity? Utilization of EHR use metadata in the inpatient setting: A mixed methods study at 16 organizations.
  Journal of hospital medicine 2024 Burden M, Keniston A, McBeth L, Astik G, Kangelaris KN, Kochar A, Knees M, Segon A, Westergaard S, Yu A, Sakumoto M, Chadha R
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
  Nature communications 2024 Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET …
• Identifying and Measuring Administrative Harms Experienced by Hospitalists and Administrative Leaders.
  JAMA internal medicine 2024 Burden M, Astik G, Auerbach A, Bowling G, Kangelaris KN, Keniston A, Kochar A, Leykum LK, Linker AS, Sakumoto M, Rogers K, Schwatka N, Westergaard S
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Nature communications 2024 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Collaborative research: The power of multiorganizational affinity groups and adaptive research methods.
  Journal of hospital medicine 2024 Linker AS, Astik GJ, Bowling G, Kangelaris KN, Kara A, Keniston A, Kulkarni SA, Sakumoto M, Schwatka N, Westergaard S, Leykum LK, Auerbach A, Burden M
• Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
  CHEST critical care 2024 Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB
• Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
  Critical care (London, England) 2024 Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS
• Elevated Hemoglobin A1c and the Risk of Developing Acute Respiratory Distress Syndrome in Two Cohort Studies.
  CHEST Critical Care 2024 Avery M. Bogart, Christine R. Lopez, Sarah N. Obeidalla, Chunxue Wang, Andrew Willmore, Alejandra Jauregui, Kirsten N. Kangelaris, Carolyn Hendrickson, Antonio Gomez, Kathleen D. Liu, Michael A. …
• Associations Between Volume of Early Intravenous Fluid and Hospital Outcomes in Septic Patients With and Without Heart Failure: A Retrospective Cohort Study.
  Critical care explorations 2024 Beagle AJ, Prasad PA, Hubbard CC, Walderich S, Oreper S, Abe-Jones Y, Fang MC, Kangelaris KN
• Rapidly improving ARDS differs clinically and biologically from persistent ARDS.
  Critical care (London, England) 2024 Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, …
• Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology.
  Science translational medicine 2024 Phan HV, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns CB, Eckalbar W, Guan L, …
• Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock.
  Journal of the American College of Emergency Physicians open 2024 Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN
• Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
  American journal of respiratory and critical care medicine 2024 Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee…
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Exploring the Impact of COVID-19 on Women Hospitalists: A Mixed-Gender Qualitative Analysis.
  Journal of general internal medicine 2023 Busch JI, Keniston A, Astik GJ, Auerbach A, Kangelaris KN, Kulkarni SA, Leykum LK, Linker AS, Nieto K, Pierce RG, Sakumoto M, Burden M
• Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
  The Lancet. Respiratory medicine 2023 Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, …
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
  Critical care (London, England) 2023 Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, …
• Building a thriving academic hospitalist workforce: A rapid qualitative analysis identifying key areas of focus in the field.
  Journal of hospital medicine 2023 Kulkarni SA, Keniston A, Linker AS, Astik GJ, Kangelaris KN, Leykum LK, Sakumoto M, Auerbach A, Burden M
• Severe recurrence of reactive infectious mucocutaneous eruption with extensive ocular involvement in an adult due to SARS-CoV-2.
  JAAD case reports 2023 Wu D, Lee EY, Lifton J, Zullo SW, Seiger K, Nadadur R, Fox LP, Escobar DJ, Dobry AS, Yung M, Kangelaris KN, Arakaki RY
• Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2023 Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS
• Practical Applications of Rapid Qualitative Analysis for Operations, Quality Improvement, and Research in Dynamically Changing Hospital Environments.
  Joint Commission journal on quality and patient safety 2022 Keniston A, McBeth L, Astik G, Auerbach A, Busch J, Kangelaris KN, Kulkarni SA, Linker AS, Sakumoto M, Leykum L, Burden M
• Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
  Nature microbiology 2022 Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, …
• Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
  Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, …
• Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ…
• Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
  American journal of respiratory and critical care medicine 2022 Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, …
• Adaptability on Shifting Ground: a Rapid Qualitative Assessment of Multi-institutional Inpatient Surge Planning and Workforce Deployment During the COVID-19 Pandemic.
  Journal of general internal medicine 2022 Keniston A, Sakumoto M, Astik GJ, Auerbach A, Eid SM, Kangelaris KN, Kulkarni SA, Lee T, Leykum LK, Linker AS, Worster DT, Burden M
• A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, …
• Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
  Shock (Augusta, Ga.) 2022 Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA
• Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
  The Lancet. Respiratory medicine 2022 Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz …
• Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial.
  The Lancet. Infectious diseases 2021 ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study Group
• Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
  Annals of internal medicine 2021 ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower …
• Increased rates of secondary bacterial infections, including Enterococcus bacteremia, in patients hospitalized with coronavirus disease 2019 (COVID-19).
  Infection control and hospital epidemiology 2021 DeVoe C, Segal MR, Wang L, Stanley K, Madera S, Fan J, Schouest J, Graham-Ojo R, Nichols A, Prasad PA, Ghale R, Love C, Abe-Jones Y, Kangelaris KN, Patterson SL, Yokoe DS, Langelier CR
• Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
  EClinicalMedicine 2021 Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J,…
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
  The New England journal of medicine 2021 REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, …
• Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
  The New England journal of medicine 2021 ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, …
• Identifying the Sickest During Triage: Using Point-of-Care Severity Scores to Predict Prognosis in Emergency Department Patients With Suspected Sepsis.
  Journal of hospital medicine 2021 Prasad PA, Fang MC, Martinez SP, Liu KD, Kangelaris KN
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
  Critical care explorations 2021 Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA
• Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
  Thorax 2021 Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB…
• Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic.
  Critical care medicine 2021 Mathews KS, Seitz KP, Vranas KC, Duggal A, Valley TS, Zhao B, Gundel S, Harhay MO, Chang SY, Hough CL, National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (…
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• Evaluation of a novel metric for personalized opioid prescribing after hospitalization.
  PloS one 2020 Iverson NR, Lau CY, Abe-Jones Y, Fang MC, Kangelaris KN, Prasad P, Shah SJ, Najafi N
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.
  The New England journal of medicine 2020 ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG,…
• Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
  JAMA 2020 Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, …
• Alternative Tobacco Product Use in Critically Ill Patients.
  International journal of environmental research and public health 2020 Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS
• Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses.
  Nature communications 2020 Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, …
• Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
  American journal of physiology. Renal physiology 2020 Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD
• Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.
  EClinicalMedicine 2020 Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G, CZB CLIAhub Consortium, Dadasovich RM, …
• Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
  Critical care medicine 2020 Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS
• Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
  Intensive care medicine 2020 Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS
• The Association between Limited English Proficiency and Sepsis Mortality.
  Journal of hospital medicine 2020 Jacobs ZG, Prasad PA, Fang MC, Abe-Jones Y, Kangelaris KN
• Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
  Critical care medicine 2020 Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN
• Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
  The European respiratory journal 2020 Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ
• Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
  Critical care (London, England) 2019 Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, …
• The Association between Limited English Proficiency and Sepsis Mortality.
  Journal of Hospital Medicine 2019 Zachary G Jacobs, Priya A Prasad, Margaret C Fang, Yumiko Abe-Jones, Kirsten N Kangelaris
• ASSOCIATION OF ANGIOPOIETIN-2 AND ATRIAL FIBRILLATION BURDEN IN CRITICALLY ILL PATIENTS.
  Journal of the American College of Cardiology 2019 Lily Stern, Kathleen Liu, Hanjing Zhuo, Kirsten Kangelaris, Antonio Gomez, Alejandra Jauregui, Kathryn Vessel, Thomas Deiss, Jason Abbott, Ashish Agrawal, Michael Matthay, Carolyn S. Calfee, Liviu …
• External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.
  Intensive care medicine 2017 Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB
• Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.
  American journal of respiratory and critical care medicine 2017 Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS, ARDS Network
• Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
  Survey of Anesthesiology 2016 Kirsten Neudoerffer Kangelaris, Lorraine B. Ware, Chen Yu Wang, David R. Janz, Hanjing Zhuo, Michael A. Matthay, Carolyn S. Calfee
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• Implementation and evaluation of a "works-in-progress" session to promote scholarship in an academic hospitalist group.
  Journal of hospital medicine 2016 Patel H, Fang MC, Harrison JD, Auerbach A, Kangelaris KN
• Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS
• Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
  Critical care medicine 2015 Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB
• Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.
  Chest 2015 Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network
• Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network
• From storm to suppression in sepsis: are bands the link?*.
  Critical care medicine 2014 Kangelaris KN, Seeley EJ
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
  Journal of intensive care 2014 Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS
• Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
  Journal of critical care 2014 Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS
• Is there still a role for the lung injury score in the era of the Berlin definition ARDS?
  Annals of intensive care 2014 Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB
• One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.
  Intensive care medicine 2014 Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN
• Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
  American journal of respiratory and critical care medicine 2013 Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS
• 681.
  Critical Care Medicine 2012 Erika Moseson, Hanjing Zhuo, John Stein, Jeff Chu, Michael Matthay, Kirsten Kangelaris, Kathleen Liu, Carolyn Calfee
• The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
  Chest 2011 Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.
  Annals of intensive care 2011 Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD
• Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study.
  Journal of general internal medicine 2010 Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA
• Genetic Testing Before Anticoagulation? A Systematic Review of Pharmacogenetic Dosing of Warfarin.
  Journal of General Internal Medicine 2009 Kirsten Neudoerffer Kangelaris, Stephen Bent, Robert L. Nussbaum, David A. Garcia, Jeffrey A. Tice
• Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin.
  Journal of general internal medicine 2009 Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA
• Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer.
  JAMA 2007 Kangelaris KN, Gruber SB