Khaled Moussawi, MD, PhD
Associate Professor
Neurology
School of Medicine

The goal of the lab is to identify neural biomarkers of craving and drug-seeking behaviors and leverage those findings to develop individualized clinical treatments with neuromodulation.

• Associations of Mild Behavioral Impairment Domains with Brain Volumes: Cross-sectional Analysis of Atherosclerosis Risk in Community (ARIC) Study.
  Journal of the Academy of Consultation-Liaison Psychiatry 2024 Young L, Richey LN, Law CA, Esagoff AI, Ismail Z, Senjem ML, Jack CR, Shrestha S, Gottesman RF, Moussawi K, Peters ME, Schneider ALC
• Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.
  Brain sciences 2024 Keihani A, Sanguineti C, Chaichian O, Huston CA, Moore C, Cheng C, Janssen SA, Donati FL, Mayeli A, Moussawi K, Phillips ML, Ferrarelli F
• Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.
  medRxiv : the preprint server for health sciences 2024 Abiola OA, Lehmann C, Moussawi K, Jalal H
• Generalized cue reactivity in dopamine neurons after opioids.
  bioRxiv : the preprint server for biology 2024 Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K
• Opioid modulation of prefrontal cortex cells and circuits.
  Neuropharmacology 2024 Cole RH, Moussawi K, Joffe ME
• Stable, neuron-specific gene expression in the mouse brain.
  Journal of biological engineering 2024 Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM
• Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.
  The American journal of psychiatry 2023 Soleimani G, Joutsa J, Moussawi K, Siddiqi SH, Kuplicki R, Bikson M, Paulus MP, Fox MD, Hanlon CA, Ekhtiari H
• Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2022 Lehmann CM, Moussawi K
• Brain lesions disrupting addiction map to a common human brain circuit.
  Nature medicine 2022 Joutsa J, Moussawi K, Siddiqi SH, Abdolahi A, Drew W, Cohen AL, Ross TJ, Deshpande HU, Wang HZ, Bruss J, Stein EA, Volkow ND, Grafman JH, van Wijngaarden E, Boes AD, Fox MD
• Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease.
  Brain stimulation 2021 Moussawi K, Kim MJ, Baybayan S, Wood M, Mills KA
• Operant Vapor Self-administration in Mice.
  Bio-protocol 2021 Marchette RCN, Tunstall BJ, Vendruscolo LF, Moussawi K
• Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential.
  eLife 2021 Gantz SC, Ortiz MM, Belilos AJ, Moussawi K
• A 33-Year-Old Man with Progressive Diffuse and Focal Neuropsychiatric Signs without Localizing Correlates on Brain Imaging: A Systematic Approach to Diagnosis.
  Journal of psychiatry and psychiatric disorders 2020 Moussawi K, Gholipour T, Rao V
• Fentanyl vapor self-administration model in mice to study opioid addiction.
  Science advances 2020 Moussawi K, Ortiz MM, Gantz SC, Tunstall BJ, Marchette RCN, Bonci A, Koob GF, Vendruscolo LF
• Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons.
  eLife 2020 Gantz SC, Moussawi K, Hake HS
• Paraneoplastic PRES from lymphoma induced hypercalcemia: Case report and review of the literature.
  eNeurologicalSci 2018 Moussawi K, Meltzer EI, Levin SN, Prasad S
• Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.
  Current opinion in neurobiology 2018 Francis TC, Gantz SC, Moussawi K, Bonci A
• Report of transient events in a cocaine-dependent volunteer who received iTBS.
  Brain stimulation 2018 Steele VR, Maxwell AM, Ross TJ, Moussawi K, Abulseoud OO, Stein EA, Salmeron BJ
• Teaching Clinical Reasoning with an Example Mnemonic for the Neuropsychiatric Syndromes of Traumatic Brain Injury.
  Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry 2017 Peters ME, Moussawi K, Rao V
• Intracranial Tuberculoma in a Patient With Untreated Human Immunodeficiency Virus.
  JAMA neurology 2017 Meltzer E, Moussawi K
• Clinical Reasoning: A 20-year-old man with headache and double vision.
  Neurology 2016 Moussawi K, Gupta A, Reda H
• Abstinence From Drug Dependence After Bilateral Globus Pallidus Hypoxic-Ischemic Injury.
  Biological psychiatry 2016 Moussawi K, Kalivas PW, Lee JW
• Brainstem and limbic encephalitis with paraneoplastic neuromyelitis optica.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2015 Moussawi K, Lin DJ, Matiello M, Chew S, Morganstern D, Vaitkevicius H
• Optogenetic inhibition of cocaine seeking in rats.
  Addiction biology 2012 Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, Deisseroth K, Kalivas PW, LaLumiere RT
• Role of mGluR5 neurotransmission in reinstated cocaine-seeking.
  Addiction biology 2012 Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW
• The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
  Biological psychiatry 2011 Kupchik YM, Moussawi K, Tang XC, Wang X, Kalivas BC, Kolokithas R, Ogburn KB, Kalivas PW
• Extracellular glutamate: functional compartments operate in different concentration ranges.
  Frontiers in systems neuroscience 2011 Moussawi K, Riegel A, Nair S, Kalivas PW
• Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW
• Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
  The Journal of pharmacology and experimental therapeutics 2011 Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE
• Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB, Kalivas PW
• Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Knackstedt LA, Moussawi K, Lalumiere R, Schwendt M, Klugmann M, Kalivas PW
• Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction.
  European journal of pharmacology 2010 Moussawi K, Kalivas PW
• Altered dendritic spine plasticity in cocaine-withdrawn rats.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Shen HW, Toda S, Moussawi K, Bouknight A, Zahm DS, Kalivas PW
• N-Acetylcysteine reverses cocaine-induced metaplasticity.
  Nature neuroscience 2009 Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW