Kevin Lou, PhD
Assistant Researcher
Bioengineering
School of Pharmacy

Publications (15)

Top publication keywords:
Drug RepositioningExonsFusion Proteins, bcr-ablProto-Oncogene Proteins p21(ras)Protein Interaction MapsProtein DomainsWerner Syndrome HelicaseDrug DiscoveryCyclin-Dependent Kinase 4Drug Resistance, NeoplasmPancreatic NeoplasmsSirolimusCyclin-Dependent Kinase Inhibitor p27Lung NeoplasmsMolecular Targeted Therapy

• Programmable translational inhibition by a molecular glue-oligonucleotide conjugate.
  bioRxiv : the preprint server for biology 2025 Wang S, Kovalski JR, Zapatero-Belinchón FJ, Bennett M, Kuzuoglu-Öztürk D, Li Q, Stevenson E, Liu J, Krogan NJ, Ott M, Swaney DL, Ruggero D, Lou K, Shokat KM
• Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations.
  bioRxiv : the preprint server for biology 2024 Yu JX, Suh JM, Popova KD, Garcia K, Joshi T, Culbertson B, Spinelli JB, Subramanyam V, Lou K, Shokat KM, Weissman J, Goodarzi H
• Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
  Leukemia 2024 Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP
• Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance.
  Neuro-oncology 2024 Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, …
• Correction: Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report.
  Cardio-oncology (London, England) 2023 Patel K, Hsu KY, Lou K, Soni K, Lee YJ, Mulvey CK, Baik AH

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• Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report.
  Cardio-oncology (London, England) 2023 Patel K, Hsu KY, Lou K, Soni K, Lee YJ, Mulvey CK, Baik AH
• IFITM proteins assist cellular uptake of diverse linked chemotypes.
  Science (New York, N.Y.) 2022 Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM
• Brain-restricted mTOR inhibition with binary pharmacology.
  Nature 2022 Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM
• Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas.
  Nature communications 2022 Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA…
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
  Science (New York, N.Y.) 2019 Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM
• A Bounty of New Challenging Targets in Oncology for Chemical Discovery.
  Biochemistry 2019 Lou K, Gilbert LA, Shokat KM
• KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.
  Science signaling 2019 Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA
• Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.
  Biology open 2018 Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio …