Kevin Leu, MD, PhD
Resident
Radiology
School of Medicine

Publications (26)

Top publication keywords:
Image Interpretation, Computer-AssistedExtravasation of Diagnostic and Therapeutic MaterialsDiffusion Magnetic Resonance ImagingBlood VolumeMagnetic Resonance ImagingNucleic AcidsMagnetic Resonance AngiographyGliomaAlgorithmsBrain NeoplasmsCerebrovascular CirculationCerebral Blood VolumeGlioblastomaBlood Volume DeterminationTumor Burden

• Spinal Cord Perfusion MR Imaging Implicates Both Ischemia and Hypoxia in the Pathogenesis of Cervical Spondylosis.
  World neurosurgery 2019 Ellingson BM, Woodworth DC, Leu K, Salamon N, Holly LT
• Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry.
  Scientific reports 2019 Chakhoyan A, Yao J, Leu K, Pope WB, Salamon N, Yong W, Lai A, Nghiemphu PL, Everson RG, Prins RM, Liau LM, Nathanson DA, Cloughesy TF, Ellingson BM
• Post-chemoradiation volumetric response predicts survival in newly diagnosed glioblastoma treated with radiation, temozolomide, and bevacizumab or placebo.
  Neuro-oncology 2018 Ellingson BM, Abrey LE, Garcia J, Chinot O, Wick W, Saran F, Nishikawa R, Henriksson R, Mason WP, Harris RJ, Leu K, Woodworth DC, Mehta A, Raymond C, Chakhoyan A, Pope WB, Cloughesy TF
• Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma.
  Neuro-oncology 2018 Ellingson BM, Aftab DT, Schwab GM, Hessel C, Harris RJ, Woodworth DC, Leu K, Chakhoyan A, Raymond C, Drappatz J, de Groot J, Prados MD, Reardon DA, Schiff D, Chamberlain M, Mikkelsen T, Desjardins A, …
• Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI).
  Magnetic resonance in medicine 2018 Harris RJ, Yao J, Chakhoyan A, Raymond C, Leu K, Liau LM, Nghiemphu PL, Lai A, Salamon N, Pope WB, Cloughesy TF, Ellingson BM

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• Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging.
  AJNR. American journal of neuroradiology 2017 Chakhoyan A, Leu K, Pope WB, Cloughesy TF, Ellingson BM
• Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Ellingson BM, Gerstner ER, Smits M, Huang RY, Colen R, Abrey LE, Aftab DT, Schwab GM, Hessel C, Harris RJ, Chakhoyan A, Gahrmann R, Pope WB, Leu K, Raymond C, Woodworth DC, de Groot J, Wen PY, …
• Perfusion and diffusion MRI signatures in histologic and genetic subtypes of WHO grade II-III diffuse gliomas.
  Journal of neuro-oncology 2017 Leu K, Ott GA, Lai A, Nghiemphu PL, Pope WB, Yong WH, Liau LM, Cloughesy TF, Ellingson BM
• Evaluation of Encephaloduroarteriosynangiosis Efficacy Using Probabilistic Independent Component Analysis Applied to Dynamic Susceptibility Contrast Perfusion MRI.
  AJNR. American journal of neuroradiology 2017 Laiwalla AN, Kurth F, Leu K, Liou R, Pamplona J, Ooi YC, Salamon N, Ellingson BM, Gonzalez NR
• Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas.
  AJNR. American journal of neuroradiology 2016 Leu K, Boxerman JL, Ellingson BM
• Baseline pretreatment contrast enhancing tumor volume including central necrosis is a prognostic factor in recurrent glioblastoma: evidence from single and multicenter trials.
  Neuro-oncology 2016 Ellingson BM, Harris RJ, Woodworth DC, Leu K, Zaw O, Mason WP, Sahebjam S, Abrey LE, Aftab DT, Schwab GM, Hessel C, Lai A, Nghiemphu PL, Pope WB, Wen PY, Cloughesy TF
• Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange.
  AJNR. American journal of neuroradiology 2016 Leu K, Boxerman JL, Cloughesy TF, Lai A, Nghiemphu PL, Liau LM, Pope WB, Ellingson BM
• Bidirectional Contrast agent leakage correction of dynamic susceptibility contrast (DSC)-MRI improves cerebral blood volume estimation and survival prediction in recurrent glioblastoma treated with bevacizumab.
  Journal of magnetic resonance imaging : JMRI 2016 Leu K, Boxerman JL, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM
• Association between lesion location and language function in adult glioma using voxel-based lesion-symptom mapping.
  NeuroImage. Clinical 2015 Banerjee P, Leu K, Harris RJ, Cloughesy TF, Lai A, Nghiemphu PL, Pope WB, Bookheimer SY, Ellingson BM
• Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex.
  Journal of child neurology 2015 Ellingson BM, Hirata Y, Yogi A, Karavaeva E, Leu K, Woodworth DC, Harris RJ, Enzmann DR, Wu JY, Mathern GW, Salamon N
• Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Study.
  PloS one 2015 Woodworth D, Mayer E, Leu K, Ashe-McNalley C, Naliboff BD, Labus JS, Tillisch K, Kutch JJ, Farmer MA, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Landis JR, Deutsch G, Harris RE, Clauw DJ, Mullins C,…
• Diffusion MR Characteristics Following Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma.
  Tomography (Ann Arbor, Mich.) 2015 Chang W, Pope WB, Harris RJ, Hardy AJ, Leu K, Mody RR, Nghiemphu PL, Lai A, Cloughesy TF, Ellingson BM
• Relationship Between [18F]FDOPA PET Uptake, Apparent Diffusion Coefficient (ADC), and Proliferation Rate in Recurrent Malignant Gliomas.
  Molecular imaging and biology 2015 Karavaeva E, Harris RJ, Leu K, Shabihkhani M, Yong WH, Pope WB, Lai A, Nghiemphu PL, Liau LM, Chen W, Czernin J, Cloughesy TF, Ellingson BM
• Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3.
  Neuroradiology 2015 Kamrava M, Sepahdari AR, Leu K, Wang PC, Roberts K, Demanes DJ, McCannel T, Ellingson BM
• Hypervascular tumor volume estimated by comparison to a large-scale cerebral blood volume radiographic atlas predicts survival in recurrent glioblastoma treated with bevacizumab.
  Cancer imaging : the official publication of the International Cancer Imaging Society 2014 Leu K, Enzmann DR, Woodworth DC, Harris RJ, Tran AN, Lai A, Nghiemphu PL, Pope WB, Cloughesy TF, Ellingson BM
• Using Fractal Geometry and Universal Growth Curves as Diagnostics for Comparing Tumor Vasculature and Metabolic Rate With Healthy Tissue and for Predicting Responses to Drug Therapies.
  Discrete and continuous dynamical systems. Series B 2013 Savage VM, Herman AB, West GB, Leu K
• Imaging biomarkers for antiangiogenic therapy in malignant gliomas.
  CNS oncology 2013 Leu K, Pope WB, Cloughesy TF, Lai A, Nghiemphu PL, Chen W, Liau LM, Ellingson BM
• Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences.
  Journal of the American Chemical Society 2012 Leu K, Kervio E, Obermayer B, Turk-MacLeod RM, Yuan C, Luevano JM, Chen E, Gerland U, Richert C, Chen IA
• Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences.
  Nucleic acids research 2012 Derr J, Manapat ML, Rajamani S, Leu K, Xulvi-Brunet R, Joseph I, Nowak MA, Chen IA
• The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA.
  Nucleic acids research 2011 Leu K, Obermayer B, Rajamani S, Gerland U, Chen IA
• Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication.
  Journal of the American Chemical Society 2010 Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA