Kevin Leung, PhD
Full Researcher
Pharmaceutical Chemistry
School of Pharmacy

Publications (35)

Top publication keywords:
Gene Expression Regulation, LeukemicCasein Kinase IIDNA, NeoplasmNAD(P)H Dehydrogenase (Quinone)ProteomeChloroquineNeoplasm ProteinsQuinone ReductasesAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, CoronavirusIntercalating AgentsFlavin-Adenine DinucleotideAzacitidineProteomics

• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  Scientific reports 2024 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang …
• Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
  Nature chemical biology 2024 Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
• Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells.
  ACS central science 2023 Bartholow TG, Burroughs PWW, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA
• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  bioRxiv : the preprint server for biology 2023 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang …
• Site-specific proximity labeling at single residue resolution for identification of protein partners in vitro and on cells.
  bioRxiv : the preprint server for biology 2023 Bartholow TG, Burroughs P, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA

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• Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.
  Journal of the American Chemical Society 2023 Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR
• Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Chopra S, Trepka K, Sakhamuri S, Carretero-González A, Zhu J, Egusa E, Zhou J, Leung K, Zhao N, Hooshdaran N, Feng FY, Wells JA, Chou J, Evans MJ
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  Structure (London, England : 1993) 2023 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG …
• Using Split Luminescent Biosensors for SARS-CoV-2 Antibody Detection in Serum, Plasma, and Blood Samples.
  Current protocols 2022 Elledge SK, Eigl I, Phelps M, McClinton K, Zhou XX, Leung KK, Tato CM, Wells JA
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  bioRxiv : the preprint server for biology 2022 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural …
• CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, …
• The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.
  Nature communications 2022 Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL…
• Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation.
  Molecular & cellular proteomics : MCP 2022 Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA
• The Unusual Cosubstrate Specificity of NQO2: Conservation Throughout the Amniotes and Implications for Cellular Function.
  Frontiers in pharmacology 2022 Islam F, Leung KK, Walker MD, Al Massri S, Shilton BH
• Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
  The Journal of clinical investigation 2022 Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA
• CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma.
  Scientific reports 2022 Safaee MM, Wang EJ, Jain S, Chen JS, Gill S, Zheng AC, Garcia JH, Beniwal AS, Tran Y, Nguyen AT, Trieu M, Leung K, Wells J, Maclean JM, Wycoff K, Aghi MK
• Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy.
  Nature communications 2021 Zhao P, Xia X, Xu X, Leung KKC, Rai A, Deng Y, Yang B, Lai H, Peng X, Shi P, Zhang H, Chiu PWY, Bian L
• Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.
  Frontiers in immunology 2021 Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q
• Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
  Nature biotechnology 2021 Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA
• Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA
• Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2.
  mAbs 2021 Lim SA, Gramespacher JA, Pance K, Rettko NJ, Solomon P, Jin J, Lui I, Elledge SK, Liu J, Bracken CJ, Simmons G, Zhou XX, Leung KK, Wells JA
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
  Nature chemical biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.
  Journal of the American Chemical Society 2020 Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA
• Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA
• Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.
  mSphere 2020 Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA
• Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ
• Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA
• Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.
  Molecular & cellular proteomics : MCP 2019 Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ
• Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA
• Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
  Journal of the American Chemical Society 2018 Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA
• Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2.
  Biochemistry 2015 Leung KK, Shilton BH
• Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT.
  Biochemistry 2014 Leung KK, Shilton BH
• Chloroquine binding reveals flavin redox switch function of quinone reductase 2.
  The Journal of biological chemistry 2013 Leung KK, Shilton BH
• Flavin adenine dinucleotide content of quinone reductase 2: analysis and optimization for structure-function studies.
  Analytical biochemistry 2011 Leung KK, Litchfield DW, Shilton BH