Kevin Bender, PhD
Associate Professor
Neurology
School of Medicine

Websites

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• @@neurobender on Twitter (twitter.com)
• Bender Lab Web Site (benderlab.ucsf.edu)

Grants and Projects

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• Convergent mechanisms for neurodevelopmental disorder genes, NIH, 2021-2026
• The function of SCN2A in neocortex, NIH, 2021-2026
• Adolescent alcohol drinking and GABA signaling, NIH, 2019-2024
• Molecular and circuit mechanisms of antipsychotics, NIH, 2017-2022
• Development and physiology of axo-axonic synapses, NIH, 2016-2019
• Cellular mechanisms for dopaminergic control of learning in prefrontal cortex, NIH, 2013-2019
• Function and regulation of action potential bursts in the auditory system., NIH, 2011-2015
• Function and regulation of action potential bursts in the auditory system., NIH, 2010-2012

Publications (53)

Top publication keywords:
Autism Spectrum DisorderAction PotentialsNeurodevelopmental DisordersSynaptic TransmissionCalcium Channels, T-TypeCalcium ChannelsHaploinsufficiencyNAV1.2 Voltage-Gated Sodium ChannelAxon Initial SegmentPyramidal CellsPrefrontal CortexAxonsLong-Term Synaptic DepressionSynapsesInterneurons

• Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.
  Neuron 2024 Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ
• Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
  Neuron 2024 Nelson AD, Catalfio AM, Gupta JP, Min L, Caballero-Florán RN, Dean KP, Elvira CC, Derderian KD, Kyoung H, Sahagun A, Sanders SJ, Bender KJ, Jenkins PM
• Dynamic Foraging Behavior Performance Is Not Affected by Scn2a Haploinsufficiency.
  eNeuro 2023 Schamiloglu S, Wu H, Zhou M, Kwan AC, Bender KJ
• Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Lipkin AM, Bender KJ
• Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.
  bioRxiv : the preprint server for biology 2023 Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ

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• Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance.
  Biological psychiatry 2023 Schamiloglu S, Lewis E, Keeshen CM, Hergarden AC, Bender KJ, Whistler JL
• Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice.
  Frontiers in cellular neuroscience 2022 Ehrlich AT, Couvineau P, Schamiloglu S, Wojcik S, Da Fonte D, Mezni A, von Zastrow M, Bender KJ, Bouvier M, Kieffer BL
• Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.
  Human molecular genetics 2022 Echevarria-Cooper DM, Hawkins NA, Misra SN, Huffman AM, Thaxton T, Thompson CH, Ben-Shalom R, Nelson AD, Lipkin AM, George AL, Bender KJ, Kearney JA
• Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice.
  eLife 2022 Schor JS, Gonzalez Montalvo I, Spratt PWE, Brakaj RJ, Stansil JA, Twedell EL, Bender KJ, Nelson AB
• LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
  Journal of neurodevelopmental disorders 2022 Fazel Darbandi S, Nelson AD, Pai EL, Bender KJ, Rubenstein JLR
• NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.
  Journal of neuroscience methods 2021 Ben-Shalom R, Ladd A, Artherya NS, Cross C, Kim KG, Sanghevi H, Korngreen A, Bouchard KE, Bender KJ
• Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain.
  Genome medicine 2021 Liang L, Fazel Darbandi S, Pochareddy S, Gulden FO, Gilson MC, Sheppard BK, Sahagun A, An JY, Werling DM, Rubenstein JLR, Sestan N, Bender KJ, Sanders SJ
• Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells.
  Cell reports 2021 Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Kyoung H, Keeshen CM, Sanders SJ, Bender KJ
• Dendritic Integration Dysfunction in Neurodevelopmental Disorders.
  Developmental neuroscience 2021 Nelson AD, Bender KJ
• Functional Microstructure of CaV-Mediated Calcium Signaling in the Axon Initial Segment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Lipkin AM, Cunniff MM, Spratt PWE, Lemke SM, Bender KJ
• Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.
  Neuron 2020 Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL
• Flipping the Switch: Homeostatic Tuning of Chandelier Synapses Follows Developmental Changes in GABA Polarity.
  Neuron 2020 Lipkin AM, Bender KJ
• Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants.
  The Journal of general physiology 2020 Thompson CH, Ben-Shalom R, Bender KJ, George AL
• The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex.
  Neuron 2019 Spratt PWE, Ben-Shalom R, Keeshen CM, Burke KJ, Clarkson RL, Sanders SJ, Bender KJ
• Modulation of Ion Channels in the Axon: Mechanisms and Function.
  Frontiers in cellular neuroscience 2019 Burke KJ, Bender KJ
• Author Correction: The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
  Nature communications 2018 Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA
• Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.
  Neuron 2018 Burke KJ, Keeshen CM, Bender KJ
• The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
  Cell 2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, …
• The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
  Nature communications 2018 Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA
• Progress in Understanding and Treating SCN2A-Mediated Disorders.
  Trends in neurosciences 2018 Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, …
• Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
  eLife 2017 Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ
• Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
  Neuron 2017 Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC, Becker HC, Bender KJ, Alvarez VA, Ron D
• Social Control of Hypothalamus-Mediated Male Aggression.
  Neuron 2017 Yang T, Yang CF, Chizari MD, Maheswaranathan N, Burke KJ, Borius M, Inoue S, Chiang MC, Bender KJ, Ganguli S, Shah NM
• Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Ellwood IT, Patel T, Wadia V, Lee AT, Liptak AT, Bender KJ, Sohal VS
• Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.
  Cell reports 2017 Rinetti-Vargas G, Phamluong K, Ron D, Bender KJ
• D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ
• A Visible-Light-Sensitive Caged Serotonin.
  ACS chemical neuroscience 2017 Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R
• Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.
  Biological psychiatry 2017 Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ
• β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.
  Cell reports 2016 Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ
• Medial amygdalar aromatase neurons regulate aggression in both sexes.
  Cell reports 2015 Unger EK, Burke KJ, Yang CF, Bender KJ, Fuller PM, Shah NM
• Interlamellar CA1 network in the hippocampus.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Yang S, Yang S, Moreira T, Hoffman G, Carlson GC, Bender KJ, Alger BE, Tang CM
• Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor.
  PloS one 2012 Fink AE, Bender KJ, Trussell LO, Otis TS, DiGregorio DA
• The physiology of the axon initial segment.
  Annual review of neuroscience 2012 Bender KJ, Trussell LO
• Short- and long-term plasticity at the axon initial segment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ
• Control of firing patterns through modulation of axon initial segment T-type calcium channels.
  The Journal of physiology 2011 Bender KJ, Uebele VN, Renger JJ, Trussell LO
• Synaptic plasticity in inhibitory neurons of the auditory brainstem.
  Neuropharmacology 2010 Bender KJ, Trussell LO
• Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation.
  Neuron 2010 Bender KJ, Ford CP, Trussell LO
• Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex.
  Neuron 2009 Li L, Bender KJ, Drew PJ, Jadhav SP, Sylwestrak E, Feldman DE
• Dendritic calcium channels and their activation by synaptic signals in auditory coincidence detector neurons.
  Journal of neurophysiology 2009 Blackmer T, Kuo SP, Bender KJ, Apostolides PF, Trussell LO
• Axon initial segment Ca2+ channels influence action potential generation and timing.
  Neuron 2009 Bender KJ, Trussell LO
• CB1 receptor signaling is required for whisker map development and plasticity in rat somatosensory cortex.
  International Journal of Developmental Neuroscience 2008 L. Li, K.J. Bender, P.J. Drew, E. Sylwestrak, D.E. Feldman
• Fidelity of complex spike-mediated synaptic transmission between inhibitory interneurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Roberts MT, Bender KJ, Trussell LO
• Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex.
  Neuroscience 2007 Deshmukh S, Onozuka K, Bender KJ, Bender VA, Lutz B, Mackie K, Feldman DE
• Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Bender KJ, Allen CB, Bender VA, Feldman DE
• Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Bender VA, Bender KJ, Brasier DJ, Feldman DE
• LTD as a Mechanism for Map Plasticity in Rat Barrel Cortex.
  Development and Plasticity in Sensory Thalamus and Cortex 2006 Kevin J. Bender, Suvarna Deshmukh, Daniel E. Feldman
• Development of columnar topography in the excitatory layer 4 to layer 2/3 projection in rat barrel cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Bender KJ, Rangel J, Feldman DE
• Inheritance of cis-AB in three generations (family Lam.).
  Vox sanguinis 1977 Hummel K, Badet J, Bauermeister W, Bender K, Duffner G, Lopez M, Mauff G, Pulverer G, Salmon C, Schmidts W