Kevan Shokat, PhD
Professor
Cellular Molecular Pharmacology
School of Medicine

Websites

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• Profile at pharmchem.ucsf.edu (pharmchem.ucsf.edu)
• My Lab Website (shokatlab.ucsf.edu)

Grants and Projects

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• Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis, NIH, 2020-2025
• Improving the efficacy of mTOR inhibition, NIH, 2018-2023
• Tissue-specific pharmacology to enhance healthspan, NIH, 2021-2022
• Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids, NIH, 2016-2021
• Drugging the Switch-II Pocket of K-Ras, NIH, 2014-2020
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse, NIH, 1996-2013
• A Chemical Map of T Cell Signaling, NIH, 1998-2008
• Engineering Orthogonal Protein Kinase and Nucleotides, NIH, 1996-2003

Publications (387)

Top publication keywords:
Enzyme InhibitorsPhosphotransferasesOncogene Protein pp60(v-src)TOR Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)Guanosine TriphosphateProtein KinasesProtein Kinase InhibitorsPhosphatidylinositol 3-KinasesAdenosine TriphosphateGuanosine DiphosphateSaccharomyces cerevisiae ProteinsSirolimusPhosphorylationSubstrate Specificity

• Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
  Nature chemical biology 2024 Zheng Q, Zhang Z, Guiley KZ, Shokat KM
• Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.
  Analytical chemistry 2023 Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H
• Selective activation of intracellular β1AR using a spatially restricted antagonist.
  bioRxiv : the preprint server for biology 2023 Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R
• Protocol for performing and optimizing differential scanning fluorimetry experiments.
  STAR protocols 2023 Wu T, Hornsby M, Zhu L, Yu JC, Shokat KM, Gestwicki JE
• Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.
  Nature communications 2023 Haas KM, McGregor MJ, Bouhaddou M, Polacco BJ, Kim EY, Nguyen TT, Newton BW, Urbanowski M, Kim H, Williams MAP, Rezelj VV, Hardy A, Fossati A, Stevenson EJ, Sukerman E, Kim T, Penugonda S, Moreno E, …

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• Direct Modulators of K-Ras-Membrane Interactions.
  ACS chemical biology 2023 Morstein J, Shrestha R, Van QN, López CA, Arora N, Tonelli M, Liang H, Zhou Y, Hancock JF, Stephen AG, Turbyville TJ, Shokat KM
• Evolutionarily divergent mTOR remodels translatome for tissue regeneration.
  Nature 2023 Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Öztürk D, Zhang Z, Ruggero D, Shokat KM, Barna M
• mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching.
  Cell reports 2023 Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO
• Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain.
  Molecular & cellular proteomics : MCP 2023 Dugan MP, Ferguson LB, Hertz NT, Chalkley RJ, Burlingame AL, Shokat KM, Parker PJ, Messing RO
• A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors.
  Nature cancer 2023 Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg…
• A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.
  Cancer discovery 2023 Guiley KZ, Shokat KM
• IFITM proteins assist cellular uptake of diverse linked chemotypes.
  Science (New York, N.Y.) 2022 Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM
• Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy.
  ACS chemical biology 2022 Peacock DM, Kelly MJS, Shokat KM
• State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.
  Cell 2022 Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM
• Brain-restricted mTOR inhibition with binary pharmacology.
  Nature 2022 Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM
• Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
  Science translational medicine 2022 Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS
• A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.
  Cancer cell 2022 Zhang Z, Rohweder PJ, Ongpipattanakul C, Basu K, Bohn MF, Dugan EJ, Steri V, Hann B, Shokat KM, Craik CS
• Tissue-restricted inhibition of mTOR using chemical genetics.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Wassarman DR, Bankapalli K, Pallanck LJ, Shokat KM
• Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.
  Journal of the American Chemical Society 2022 Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM
• Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).
  Nature chemical biology 2022 Zhang Z, Guiley KZ, Shokat KM
• CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization.
  Molecular cancer therapeutics 2022 Werr L, Plenker D, Dammert MA, Lorenz C, Brägelmann J, Tumbrink HL, Klein S, Schmitt A, Büttner R, Persigehl T, Shokat KM, Wunderlich FT, Schram AM, Peifer M, Sos ML, Reinhardt HC, Thomas RK
• Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2022 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• KRAS is vulnerable to reversible switch-II pocket engagement in cells.
  Nature chemical biology 2022 Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM
• Drugging the Next Undruggable KRAS Allele-Gly12Asp.
  Journal of medicinal chemistry 2022 Zheng Q, Peacock DM, Shokat KM
• Drugging the undruggable: Ross Cagan interviews Kevan Shokat.
  Disease models & mechanisms 2022 Cagan R, Shokat K
• Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1.
  Oncogene 2022 Melnyk JE, Steri V, Nguyen HG, Hwang YC, Gordan JD, Hann B, Feng FY, Shokat KM
• Evolution of enhanced innate immune evasion by SARS-CoV-2.
  Nature 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, …
• Dissecting the biology of mTORC1 beyond rapamycin.
  Science signaling 2021 Yang G, Francis D, Krycer JR, Larance M, Zhang Z, Novotny CJ, Diaz-Vegas A, Shokat KM, James DE
• Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice.
  Nature communications 2021 Ehinger Y, Zhang Z, Phamluong K, Soneja D, Shokat KM, Ron D
• Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
  Science (New York, N.Y.) 2021 Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, …
• Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
  bioRxiv : the preprint server for biology 2021 Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, …
• Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.
  bioRxiv : the preprint server for biology 2021 Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR, Lyu J, Schadt H, White KM, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz…
• Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes.
  Stem cell reports 2021 Parker N, Laychur A, Sukwani M, Orwig KE, Oatley JM, Zhang C, Rutaganira FU, Shokat K, Wright WW
• Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
  bioRxiv : the preprint server for biology 2021 Reuschl AK, Thorne LG, Zuliani-Alvarez L, Bouhaddou M, Obernier K, Hiatt J, Soucheray M, Turner J, Fabius JM, Nguyen GT, Swaney DL, Rosales R, White KM, Avilés P, Kirby IT, Melnyk JE, Shi Y, Zhang Z, …
• Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
  Cancer research 2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, …
• Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
  Science (New York, N.Y.) 2021 White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, …
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
  ACS central science 2020 Zhang Z, Gao R, Hu Q, Peacock H, Peacock DM, Dai S, Shokat KM, Suga H
• The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells.
  Bioorganic & medicinal chemistry 2020 Melnyk JE, Steri V, Nguyen HG, Hann B, Feng FY, Shokat KM
• The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
  Cell 2020 Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray…
• Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
  Cancer cell 2020 Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, …
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• Betacellulin drives therapy resistance in glioblastoma.
  Neuro-oncology 2020 Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma.
  Science translational medicine 2020 Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, Duose DY, Solis LM, Mino B, Raso MG, Behrens…
• p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
  Science (New York, N.Y.) 2019 Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM
• Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.
  Cancer research 2019 Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW
• p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE
• Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins.
  Angewandte Chemie (International ed. in English) 2019 Zhang Z, Shokat KM
• A Bounty of New Challenging Targets in Oncology for Chemical Discovery.
  Biochemistry 2019 Lou K, Gilbert LA, Shokat KM
• KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.
  Science signaling 2019 Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA
• Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.
  Experimental & molecular medicine 2019 Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J
• A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
  Cell host & microbe 2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S
• Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.
  Science signaling 2019 Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R
• Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates.
  Protein science : a publication of the Protein Society 2019 Wong AW, Urisman A, Burlingame AL, Shokat KM
• Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.
  ACS chemical biology 2018 Ocasio CA, Warkentin AA, McIntyre PJ, Barkovich KJ, Vesely C, Spencer J, Shokat KM, Bayliss R
• Chemical genetic inhibition of DEAD-box proteins using covalent complementarity.
  Nucleic acids research 2018 Barkovich KJ, Moore MK, Hu Q, Shokat KM
• A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.
  Molecular cancer therapeutics 2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK
• A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9.
  Journal of visualized experiments : JoVE 2018 Chorba JS, Galvan AM, Shokat KM
• Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
  Nature chemical biology 2018 Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S
• Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
  PloS one 2018 Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP
• Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
  The Journal of biological chemistry 2018 Chorba JS, Galvan AM, Shokat KM
• Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP.
  Cell 2018 Hu Q, Shokat KM
• Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.
  Journal of chemical information and modeling 2018 Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N
• Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
  The Journal of biological chemistry 2017 Chorba JS, Galvan AM, Shokat KM
• Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
  Cell chemical biology 2017 Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM
• Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.
  Journal of medicinal chemistry 2017 Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LD
• A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice.
  Addiction biology 2017 Morisot N, Novotny CJ, Shokat KM, Ron D
• Drugging the 'undruggable' cancer targets.
  Nature reviews. Cancer 2017 Dang CV, Reddy EP, Shokat KM, Soucek L
• Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
  ACS chemical biology 2017 Novotny CJ, Hamilton GL, McCormick F, Shokat KM
• Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.
  Biochemistry 2017 McGregor LM, Jenkins ML, Kerwin C, Burke JE, Shokat KM
• Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
  Science translational medicine 2017 Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J…
• Site-specific incorporation of phosphotyrosine using an expanded genetic code.
  Nature chemical biology 2017 Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat KM, Wang L
• Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.
  The Journal of clinical investigation 2017 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA
• Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks.
  Nature 2017 Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J
• Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
  Neurochemistry international 2017 Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K
• A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
  Cancer cell 2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA
• INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.
  Molecular cancer research : MCR 2017 Reed DE, Shokat KM
• An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases.
  Molecular & cellular proteomics : MCP 2016 Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL
• Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.
  Molecular pharmacology 2016 Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M
• Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response.
  Cellular signalling 2016 Lazarus MB, Levin RS, Shokat KM
• Overcoming resistance to HER2 inhibitors through state-specific kinase binding.
  Nature chemical biology 2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat KM
• From Powerful Review Articles to Research Breakthroughs.
  Cell chemical biology 2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H
• Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment.
  Antioxidants & redox signaling 2016 Jo A, Choi TG, Jo YH, Jyothi KR, Nguyen MN, Kim JH, Lim S, Shahid M, Akter S, Lee S, Lee KH, Kim W, Cho H, Lee J, Shokat KM, Yoon KS, Kang I, Ha J, Kim SS
• Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Levin RS, Hertz NT, Burlingame AL, Shokat KM, Mukherjee S
• Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.
  Nature reviews. Drug discovery 2016 Ostrem JM, Shokat KM
• Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.
  Molecular cancer therapeutics 2016 Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, …
• Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.
  Cancer discovery 2016 Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, …
• Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
  Nature 2016 Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM
• Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases.
  Analytical chemistry 2016 Tabaei SR, Guo F, Rutaganira FU, Vafaei S, Choong I, Shokat KM, Glenn JS, Cho NJ
• N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
  Cancer cell 2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON
• Our Advisors, Our Ambassadors, Our Editorial Board Members.
  Cell chemical biology 2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H
• Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ.
  Journal of medicinal chemistry 2016 Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE
• Voices of Chemical Biology: Charting the Next Decade.
  Cell chemical biology 2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H
• Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11.
  Protein science : a publication of the Protein Society 2016 Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE
• Cell Chemical Biology: Home of Exciting Chemical Biology.
  Cell chemical biology 2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H
• P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.
  Genes & development 2016 Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP
• Analog sensitive chemical inhibition of the DEAD-box protein DDX3.
  Protein science : a publication of the Protein Society 2015 Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA
• Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture.
  Antimicrobial agents and chemotherapy 2015 Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD
• Discovery and functional characterization of a neomorphic PTEN mutation.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD
• Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.
  Cell metabolism 2015 Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A
• Small molecule inhibition of Csk alters affinity recognition by T cells.
  eLife 2015 Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A
• Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
  Bioorganic & medicinal chemistry 2015 Lazarus MB, Shokat KM
• SR protein kinases promote splicing of nonconsensus introns.
  Nature structural & molecular biology 2015 Lipp JJ, Marvin MC, Shokat KM, Guthrie C
• WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
  Science signaling 2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I
• Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.
  eLife 2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P
• Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer.
  Frontiers in oncology 2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC
• Differential genetic interactions of yeast stress response MAPK pathways.
  Molecular systems biology 2015 Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ
• The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.
  The Biochemical journal 2015 Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA
• Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.
  ACS chemical biology 2015 Lazarus MB, Novotny CJ, Shokat KM
• Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy.
  eLife 2014 Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM
• Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma.
  Molecular cancer therapeutics 2014 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI
• Targeting osteosarcoma.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Reed DE, Shokat KM
• Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
  Cancer discovery 2014 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat …
• MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.
  Neuron 2014 Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN
• Reflecting on the past and looking forward to the future of bridging chemistry and biology.
  Chemistry & biology 2014 Crews C, Hertweck C, Shokat K, Suga H, Kostic M
• The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis.
  The Journal of biological chemistry 2014 Chorba JS, Shokat KM
• Drugging MYCN through an allosteric transition in Aurora kinase A.
  Cancer cell 2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA
• TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions.
  Journal of applied physiology (Bethesda, Md. : 1985) 2014 Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat KM, Sieck GC
• Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny.
  Biology of reproduction 2014 Parker N, Falk H, Singh D, Fidaleo A, Smith B, Lopez MS, Shokat KM, Wright WW
• Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
  eLife 2014 Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF
• A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A
• Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.
  Cell reports 2014 Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM
• OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
• Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
  Nature immunology 2014 Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A
• Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.
  Science (New York, N.Y.) 2014 Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL
• A crosslinker based on a tethered electrophile for mapping kinase-substrate networks.
  Chemistry & biology 2014 Riel-Mehan MM, Shokat KM
• Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface.
  Methods in enzymology 2014 Shokat KM
• The logic and design of analog-sensitive kinases and their small molecule inhibitors.
  Methods in enzymology 2014 Lopez MS, Kliegman JI, Shokat KM
• Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.
  Cell reports 2013 Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM
• Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
  Nature immunology 2013 Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A
• PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras.
  Science signaling 2013 Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K
• Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma.
  Journal of neurosurgery 2013 Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ
• K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
  Nature 2013 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM
• Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.
  Journal of the American Chemical Society 2013 Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM
• EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
  Cancer cell 2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA
• A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.
  Cell 2013 Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM
• Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
  ACS chemical biology 2013 Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM
• Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D
• PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.
  Cancer medicine 2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS
• A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.
  Molecular cell 2013 Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP
• Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
  Oncogene 2013 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS
• Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
  Journal of medicinal chemistry 2013 Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD
• Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.
  Cell metabolism 2013 Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH
• News from the Chemistry & Biology editorial team.
  Chemistry & biology 2012 Crews C, Shokat K, Suga H, Kostic M
• A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.
  Nature neuroscience 2012 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME
• Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
  Nature structural & molecular biology 2012 Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP
• Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
  PLoS genetics 2012 Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP
• A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.
  PLoS genetics 2012 Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC
• Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW
• Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
  The Journal of clinical investigation 2012 Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D
• The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae.
  The Journal of biological chemistry 2012 Young ET, Zhang C, Shokat KM, Parua PK, Braun KA
• In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish.
  PloS one 2012 Cibrián Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat KM, Selbach M, Abdelilah-Seyfried S
• Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide.
  Cancer research 2012 Jang M, Kim Y, Won H, Lim S, K R J, Dashdorj A, Min YH, Kim SY, Shokat KM, Ha J, Kim SS
• Hierarchical modularity and the evolution of genetic interactomes across species.
  Molecular cell 2012 Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat …
• Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
  Nature 2012 Dar AC, Das TK, Shokat KM, Cagan RL
• Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.
  Molecular biology of the cell 2012 Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG
• Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
  Molecular and cellular biology 2012 St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP
• Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A
• The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult.
  Stem cells (Dayton, Ohio) 2012 Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW
• Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers.
  Cancer discovery 2012 Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA
• Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
  Neuron 2012 Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN
• The translational landscape of mTOR signalling steers cancer initiation and metastasis.
  Nature 2012 Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D
• Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
  Investigational new drugs 2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM
• Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.
  Molecular & cellular proteomics : MCP 2012 Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM
• A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins.
  Methods in enzymology 2012 Simon MD, Shokat KM
• Covalent cross-linking of kinases with their corresponding peptide substrates.
  Methods in molecular biology (Clifton, N.J.) 2012 Statsuk AV, Shokat KM
• Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.
  Molecular cell 2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A
• Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe.
  Cell cycle (Georgetown, Tex.) 2011 Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat KM, Gregan J
• Genetic deletion of trkB.T1 increases neuromuscular function.
  American journal of physiology. Cell physiology 2011 Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, Talmadge R, Harvey BK, Wyatt RM, Vernon…
• The Cryptosporidium parvum kinome.
  BMC genomics 2011 Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J,…
• Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
  Science signaling 2011 Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A
• The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM
• Chemical genetic strategy for targeting protein kinases based on covalent complementarity.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM
• TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Yoshii A, Murata Y, Kim J, Zhang C, Shokat KM, Constantine-Paton M
• Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
  BMC biology 2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Structural and functional basis for RNA cleavage by Ire1.
  BMC biology 2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma.
  Journal of molecular medicine (Berlin, Germany) 2011 Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM
• Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
  Molecular cell 2011 Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP
• A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Nature 2011 Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
• Chemistry & Biology editors announce changes to the editorial team.
  Chemistry & biology 2011 Crews C, Shokat K, Wohlleben W, Kostic M
• Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
  Cancer research 2011 Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K
• Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules.
  Methods in molecular biology (Clifton, N.J.) 2011 Salomon D, Zhang C, Shokat KM, Sessa G
• The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.
  Annual review of biochemistry 2011 Dar AC, Shokat KM
• Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
  Science signaling 2010 Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, Colman-Lerner A, Nolan GP, …
• Rewiring of genetic networks in response to DNA damage.
  Science (New York, N.Y.) 2010 Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, …
• Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.
  Genes & development 2010 Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I
• Akt and autophagy cooperate to promote survival of drug-resistant glioma.
  Science signaling 2010 Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA
• A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
  Nature immunology 2010 Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A
• A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
  Nature cell biology 2010 Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE
• GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO
• Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications.
  Analytical chemistry 2010 Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR
• Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells.
  Journal of hepatology 2010 Tak E, Lee S, Lee J, Rashid MA, Kim YW, Park JH, Park WS, Shokat KM, Ha J, Kim SS
• Chemical-genomic dissection of the CTD code.
  Nature structural & molecular biology 2010 Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ
• Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
  The Journal of cell biology 2010 Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV
• Synthesis and evaluation of indazole based analog sensitive Akt inhibitors.
  Molecular bioSystems 2010 Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM
• Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.
  Nature 2010 Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD
• A drug-drug interaction crystallizes a new entry point into the UPR.
  Molecular cell 2010 Shokat KM
• Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.
  PloS one 2010 Sliedrecht T, Zhang C, Shokat KM, Kops GJ
• Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.
  Science (New York, N.Y.) 2010 Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL
• mTOR complex-2 activates ENaC by phosphorylating SGK1.
  Journal of the American Society of Nephrology : JASN 2010 Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D
• RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
  Nature 2010 Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N
• Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
  Cancer cell 2010 Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D
• Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.
  Current protocols in chemical biology 2010 Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM
• Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K
• The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
  Nature chemical biology 2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL
• Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.
  Chemistry & biology 2010 Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM
• Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.
  The Journal of biological chemistry 2010 An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ
• Targeting the cancer kinome through polypharmacology.
  Nature reviews. Cancer 2010 Knight ZA, Lin H, Shokat KM
• The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
  Nature chemical biology 2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL
• Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.
  Science translational medicine 2010 Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM
• New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).
  Current topics in microbiology and immunology 2010 Feldman ME, Shokat KM
• Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
  The Journal of biological chemistry 2009 Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF
• Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.
  Molecular cell 2009 Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM
• Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.
  Science (New York, N.Y.) 2009 Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY
• Use of a semisynthetic epitope to probe histidine kinase activity and regulation.
  Analytical biochemistry 2009 Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA
• Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, …
• TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.
  Molecular and cellular biology 2009 Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL
• Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
  Molecular and cellular biology 2009 Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S
• PIKfyve regulation of endosome-linked pathways.
  Traffic (Copenhagen, Denmark) 2009 de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ
• Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
  PLoS biology 2009 Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ
• Inhibitor hijacking of Akt activation.
  Nature chemical biology 2009 Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM
• Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
  PLoS biology 2009 Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV
• Tuning the activation threshold of a kinase network by nested feedback loops.
  Science (New York, N.Y.) 2009 Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM
• Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands.
  The Journal of biological chemistry 2009 Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G
• TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.
  Molecular cell 2009 Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP
• Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.
  Blood 2009 Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA
• Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, Hann B, Blair J, Shokat K, Welm AL, Moasser MM
• Functional organization of the S. cerevisiae phosphorylation network.
  Cell 2009 Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ
• Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
  PLoS biology 2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM
• A complex-based reconstruction of the Saccharomyces cerevisiae interactome.
  Molecular & cellular proteomics : MCP 2009 Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D
• EGFR signals to mTOR through PKC and independently of Akt in glioma.
  Science signaling 2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA
• Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
  Cancer research 2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ,…
• Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Miller AL, Zhang C, Shokat KM, Lowell CA
• SHIP prevents lipopolysaccharide from triggering an antiviral response in mice.
  Blood 2009 Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G
• Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
  Cell 2009 Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH
• Tuning a three-component reaction for trapping kinase substrate complexes.
  Journal of the American Chemical Society 2008 Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM
• The unfolded protein response signals through high-order assembly of Ire1.
  Nature 2008 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P
• Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS
• Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
  Molecular cell 2008 Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP
• Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.
  Journal of cell science 2008 Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B
• Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO
• Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
  Molecular cell 2008 Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H
• A chemical genomics study identifies Snf1 as a repressor of GCN4 translation.
  The Journal of biological chemistry 2008 Shirra MK, McCartney RR, Zhang C, Shokat KM, Schmidt MC, Arndt KM
• Small molecule recognition of c-Src via the Imatinib-binding conformation.
  Chemistry & biology 2008 Dar AC, Lopez MS, Shokat KM
• Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
  Cancer research 2008 Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S
• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
  Nature chemical biology 2008 Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA
• The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.
  Molecular biology of the cell 2008 Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffery JM, Luca FC
• A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
  The Biochemical journal 2008 Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D
• Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
  The Journal of allergy and clinical immunology 2008 Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ
• PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
  Cancer research 2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F
• Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.
  The Journal of biological chemistry 2008 Bateman RL, Rauh D, Tavshanjian B, Shokat KM
• A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation.
  Neural development 2008 Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M
• The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
  Nature structural & molecular biology 2008 Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat KM, Luger K
• Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.
  The Journal of clinical investigation 2008 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA
• Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.
  Cancer cell 2008 Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM
• The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value.
  The European journal of neuroscience 2008 Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD
• Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.
  American journal of physiology. Renal physiology 2008 Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D
• An integrated platform of genomic assays reveals small-molecule bioactivities.
  Nature chemical biology 2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C
• Nuclear HuR accumulation through phosphorylation by Cdk1.
  Genes & development 2008 Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M
• Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
  Journal of molecular biology 2008 Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y
• PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.
  Leukemia 2008 Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D
• T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M
• Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
  Experimental cell research 2008 Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D
• Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma.
  Molecular cancer therapeutics 2008 Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D
• Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
  The Journal of biological chemistry 2008 Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A
• Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast.
  Genes & development 2008 Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM
• Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Blethrow JD, Glavy JS, Morgan DO, Shokat KM
• Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling.
  Biochemistry 2008 Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T
• Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.
  Molecular biology of the cell 2007 Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T
• Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
  Nature chemical biology 2007 Weiss WA, Taylor SS, Shokat KM
• IRE1 signaling affects cell fate during the unfolded protein response.
  Science (New York, N.Y.) 2007 Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P
• Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase.
  The Journal of biological chemistry 2007 Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC
• A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
  Chemistry & biology 2007 Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM
• A surface on the androgen receptor that allosterically regulates coactivator binding.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ
• Suppression of p53-dependent senescence by the JNK signal transduction pathway.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ
• Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
  The Journal of biological chemistry 2007 Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO
• A remodelled protease that cleaves phosphotyrosine substrates.
  Journal of the American Chemical Society 2007 Knight ZA, Garrison JL, Chan K, King DS, Shokat KM
• A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
  Cancer research 2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA
• Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.
  Organic & biomolecular chemistry 2007 Bateman R, Rauh D, Shokat KM
• A semisynthetic epitope for kinase substrates.
  Nature methods 2007 Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM
• HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.
  Cell host & microbe 2007 Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G
• Chemically targeting the PI3K family.
  Biochemical Society transactions 2007 Knight ZA, Shokat KM
• Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Kanin EI, Kipp RT, Kung C, Slattery M, Viale A, Hahn S, Shokat KM, Ansari AZ
• Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
  Molecular cell 2007 Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP
• The site-specific installation of methyl-lysine analogs into recombinant histones.
  Cell 2007 Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM
• Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV
• Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
  Nature chemical biology 2007 Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM
• Chemical genetics: where genetics and pharmacology meet.
  Cell 2007 Knight ZA, Shokat KM
• Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.
  Nature 2007 Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM
• A membrane capture assay for lipid kinase activity.
  Nature protocols 2007 Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM
• Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe.
  Nature protocols 2007 Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat KM
• Structure and properties of a re-engineered homeodomain protein-DNA interface.
  ACS chemical biology 2006 Simon MD, Feldman ME, Rauh D, Maris AE, Wemmer DE, Shokat KM
• Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination.
  Genetics 2006 Wan L, Zhang C, Shokat KM, Hollingsworth NM
• Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.
  The Journal of biological chemistry 2006 Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T
• JNK2 is a positive regulator of the cJun transcription factor.
  Molecular cell 2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ
• To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.
  The Journal of cell biology 2006 Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR
• Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.
  The Plant journal : for cell and molecular biology 2006 Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman MA, Shokat KM, Rietz S, Parker J, Mundy J
• Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia.
  Molecular pain 2006 Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M
• A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
  Cancer cell 2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA
• A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
  Cell 2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM
• Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators.
  ACS chemical biology 2006 Allen JJ, Shokat KM
• Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage.
  Molecular cancer therapeutics 2006 Sturgeon CM, Knight ZA, Shokat KM, Roberge M
• Selective kinase inhibition by exploiting differential pathway sensitivity.
  Chemistry & biology 2006 Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM
• Chemical genetic analysis of the time course of signal transduction by JNK.
  Molecular cell 2006 Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ
• The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.
  Cell cycle (Georgetown, Tex.) 2006 Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat KM, Fisher RP
• Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.
  FEBS letters 2005 Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO
• Combining chemical genetics and proteomics to identify protein kinase substrates.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Dephoure N, Howson RW, Blethrow JD, Shokat KM, O'Shea EK
• Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
  Nature structural & molecular biology 2005 Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP
• The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
  Nature cell biology 2005 Pinsky BA, Kung C, Shokat KM, Biggins S
• Chemical genetic engineering of G protein-coupled receptor kinase 2.
  The Journal of biological chemistry 2005 Kenski DM, Zhang C, von Zastrow M, Shokat KM
• The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects.
  Molecular cell 2005 D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat KM, Amon A
• A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.
  Nature methods 2005 Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM
• Features of selective kinase inhibitors.
  Chemistry & biology 2005 Knight ZA, Shokat KM
• Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
  Science (New York, N.Y.) 2005 Cohen MS, Zhang C, Shokat KM, Taunton J
• Chemicals call bacteria, and a new membrane protein machine answers.
  Cell 2005 Shokat KM
• Bio-orthogonal affinity purification of direct kinase substrates.
  Journal of the American Chemical Society 2005 Allen JJ, Lazerwith SE, Shokat KM
• Targeting the gatekeeper residue in phosphoinositide 3-kinases.
  Bioorganic & medicinal chemistry 2005 Alaimo PJ, Knight ZA, Shokat KM
• A chemical-genetic approach to studying neurotrophin signaling.
  Neuron 2005 Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD
• An unbiased cell morphology-based screen for new, biologically active small molecules.
  PLoS biology 2005 Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KM, Adams CL
• The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
  Cell 2005 Muratani M, Kung C, Shokat KM, Tansey WP
• Small-molecule kinase-inhibitor target assessment.
  Chembiochem : a European journal of chemical biology 2005 Kung C, Shokat KM
• Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM
• Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.
  Current biology : CB 2005 Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M
• Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON
• Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.
  Bioorganic & medicinal chemistry 2004 Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM
• A mechanism-based cross-linker for the identification of kinase-substrate pairs.
  Journal of the American Chemical Society 2004 Maly DJ, Allen JA, Shokat KM
• Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models.
  Assay and drug development technologies 2004 Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL
• A phage display selection of engrailed homeodomain mutants and the importance of residue Q50.
  Nucleic acids research 2004 Simon MD, Sato K, Weiss GA, Shokat KM
• Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide.
  Journal of the American Chemical Society 2004 Simon MD, Shokat KM
• Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning.
  Chemistry & biology 2004 Sato K, Simon MD, Levin AM, Shokat KM, Weiss GA
• Design and use of analog-sensitive protein kinases.
  Current protocols in molecular biology 2004 Blethrow J, Zhang C, Shokat KM, Weiss EL
• Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA
• Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
  Molecular and cellular biology 2004 Liu Y, Kung C, Fishburn J, Ansari AZ, Shokat KM, Hahn S
• Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position.
  FEBS letters 2004 Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC
• Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
  Cancer research 2003 Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA
• Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.
  Molecular biology of the cell 2003 Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM
• Targets of the cyclin-dependent kinase Cdk1.
  Nature 2003 Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO
• Bypassing a kinase activity with an ATP-competitive drug.
  Science (New York, N.Y.) 2003 Papa FR, Zhang C, Shokat K, Walter P
• Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis.
  The Journal of cell biology 2003 Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat KM, Wendland B, McDonald KL, McCaffery JM, Drubin DG
• Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events.
  Molecular and cellular biology 2003 Sreenivasan A, Bishop AC, Shokat KM, Kellogg DR
• Phosphospecific proteolysis for mapping sites of protein phosphorylation.
  Nature biotechnology 2003 Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM
• Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A
• Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues.
  Biochemistry 2003 Ulrich SM, Kenski DM, Shokat KM
• Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.
  Genes & development 2003 Benjamin KR, Zhang C, Shokat KM, Herskowitz I
• Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ
• Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.
  The Journal of biological chemistry 2003 Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ
• Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy.
  Molecular biology of the cell 2003 Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ
• A chemical genetic approach for the identification of direct substrates of protein kinases.
  Methods in molecular biology (Clifton, N.J.) 2003 Shah K, Shokat KM
• A kinase sequence database: sequence alignments and family assignment.
  Bioinformatics (Oxford, England) 2002 Buzko O, Shokat KM
• The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor.
  The Journal of cell biology 2002 Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC
• Novel chemical genetic approaches to the discovery of signal transduction inhibitors.
  Drug discovery today 2002 Shokat K, Velleca M
• Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.
  The Journal of biological chemistry 2002 Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS
• The emerging power of chemical genetics.
  Current opinion in cell biology 2002 Specht KM, Shokat KM
• A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.
  Cell 2002 Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG
• Chemical Genetic Analysis of Protein Kinase Cascades.
  TheScientificWorldJournal 2002 Alaimo PJ, Shogren-Knaak MA, Shokat KM
• Green fluorescent protein-based protein kinase biosensor substrates.
  Methods in molecular biology (Clifton, N.J.) 2002 Ulrich S, Shokat K
• Chemical genetic approaches for the elucidation of signaling pathways.
  Current opinion in chemical biology 2001 Alaimo PJ, Shogren-Knaak MA, Shokat KM
• Magic bullets for protein kinases.
  Trends in cell biology 2001 Bishop AC, Buzko O, Shokat KM
• Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.
  The Journal of biological chemistry 2001 Habelhah H, Shah K, Huang L, Burlingame AL, Shokat KM, Ronai Z
• ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
  Nature cell biology 2001 Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z
• Phage-display evolution of tyrosine kinases with altered nucleotide specificity.
  Biopolymers 2001 Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG
• Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities.
  Biochemistry 2000 Liu Y, Witucki LA, Shah K, Bishop AC, Shokat KM
• Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p.
  Nature cell biology 2000 Weiss EL, Bishop AC, Shokat KM, Drubin DG
• A chemical switch for inhibitor-sensitive alleles of any protein kinase.
  Nature 2000 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM
• Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.
  The Journal of experimental medicine 2000 Weintraub BC, Jun JE, Bishop AC, Shokat KM, Thomas ML, Goodnow CC
• Unnatural ligands for engineered proteins: new tools for chemical genetics.
  Annual review of biophysics and biomolecular structure 2000 Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM
• Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs.
  The Journal of biological chemistry 1999 Gillespie PG, Gillespie SK, Mercer JA, Shah K, Shokat KM
• Blocking HIV entry.
  Nature structural biology 1999 Buzko OV, Shokat KM
• Structural basis for selective inhibition of Src family kinases by PP1.
  Chemistry & biology 1999 Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM
• Acquisition of inhibitor-sensitive protein kinases through protein design.
  Pharmacology & therapeutics 1999 Bishop AC, Shokat KM
• Highly efficient green fluorescent protein-based kinase substrates.
  Analytical biochemistry 1999 Yang F, Liu Y, Bixby SD, Friedman JD, Shokat KM
• A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src.
  Bioorganic & medicinal chemistry 1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM
• Chromophore-assisted light inactivation and self-organization of microtubules and motors.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S
• Design of allele-specific inhibitors to probe protein kinase signaling.
  Current biology : CB 1998 Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM
• Engineering Src family protein kinases with unnatural nucleotide specificity.
  Chemistry & biology 1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM
• Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Shah K, Liu Y, Deirmengian C, Shokat KM
• Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Liblau RS, Tisch R, Shokat K, Yang X, Dumont N, Goodnow CC, McDevitt HO
• Tyrosine kinases: modular signaling enzymes with tunable specificities.
  Chemistry & biology 1995 Shokat KM
• Antigen-induced B-cell death and elimination during germinal-centre immune responses.
  Nature 1995 Shokat KM, Goodnow CC
• High-dose soluble antigen: peripheral T-cell proliferation or apoptosis.
  Immunological reviews 1994 Liblau RS, Pearson CI, Shokat K, Tisch R, Yang XD, McDevitt HO
• Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
  The Journal of experimental medicine 1994 Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC
• Catalytic antibodies.
  Methods in enzymology 1991 Shokat KM, Schultz PG
• The generation of antibody combining sites containing catalytic residues.
  Ciba Foundation symposium 1991 Shokat KM, Schultz PG
• Catalytic antibodies.
  Annual review of immunology 1990 Shokat KM, Schultz PG
• A new strategy for the generation of catalytic antibodies.
  Nature 1989 Shokat KM, Leumann CJ, Sugasawara R, Schultz PG
• Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model.
  Biochemistry 1987 McClard RW, Shokat KM