Kenneth Ng, DDS
Professor
Preventive & Restor Dent Sci
School of Dentistry

Education & Training

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• D.D.S. Dentistry University of California, San Francisco 1995

Publications (44)

Top publication keywords:
Phosphoprotein PhosphatasesStructure-Activity RelationshipEnterotoxinsBerberine AlkaloidsBenzylisoquinolinesNorwalk virusModels, MolecularPapaverCrystallography, X-RayNorovirusPlant ProteinsNAD (+) and NADP (+) Dependent Alcohol OxidoreductasesStreptavidinMethyltransferasesBacterial Toxins

• Deep Mutational Scanning in Disease-related Genes with Saturation Mutagenesis-Reinforced Functional Assays (SMuRF).
  bioRxiv : the preprint server for biology 2023 Ma K, Ng KK, Huang S, Lake NJ, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Ho V, O'Connor CL, Joseph S, Brindley MA, Campbell KP, Lek M
• Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.
  bioRxiv : the preprint server for biology 2023 Tanaka M, Lum L, Hu K, Ledezma-Soto C, Samad B, Superville D, Ng K, Adams Z, Kersten K, Fong L, Combes AJ, Krummel M, Reeves M
• Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation.
  Nature communications 2022 Ozber N, Carr SC, Morris JS, Liang S, Watkins JL, Caldo KM, Hagel JM, Ng KKS, Facchini PJ
• Preparation and identification of carboxymethyl cellulose-degrading enzyme candidates for oilfield applications.
  Journal of biotechnology 2022 Scheffer G, Rachel NM, Ng KKS, Sen A, Gieg LM
• Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis.
  The Journal of biological chemistry 2021 Carr SC, Torres MA, Morris JS, Facchini PJ, Ng KKS

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• The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes.
  Scientific reports 2021 Kerk D, Mattice JF, Valdés-Tresanco ME, Noskov SY, Ng KK, Moorhead GB
• Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features.
  BBA advances 2021 Kerk D, Valdés-Tresanco ME, Toth R, Noskov SY, Ng KK, Moorhead GB
• Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity.
  Scientific reports 2020 Marangoni JM, Wu SC, Fogen D, Wong SL, Ng KKS
• Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition.
  The Journal of biological chemistry 2019 Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS
• Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
  The Plant journal : for cell and molecular biology 2018 Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
• Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy.
  The Plant journal : for cell and molecular biology 2018 Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ
• Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates.
  Science signaling 2018 Labandera AM, Uhrig RG, Colville K, Moorhead GB, Ng KKS
• A conserved DGGK motif is essential for the function of the PglB oligosaccharyltransferase from Campylobacter jejuni.
  Glycobiology 2017 Barre Y, Nothaft H, Thomas C, Liu X, Li J, Ng KKS, Szymanski CM
• Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
  Proteins 2017 Shaik MM, Bhattacharjee N, Feliks M, Ng KK, Field MJ
• Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.
  The Journal of biological chemistry 2016 Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK
• Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa.
  Archives of biochemistry and biophysics 2015 Wheatley RW, Ng KKS, Kapoor M
• Engineering Streptavidin and a Streptavidin-Binding Peptide with Infinite Binding Affinity and Reversible Binding Capability: Purification of a Tagged Recombinant Protein to High Purity via Affinity-Driven Thiol Coupling.
  PloS one 2015 Fogen D, Wu SC, Ng KK, Wong SL
• Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins.
  Organic & biomolecular chemistry 2015 Sanhueza CA, Cartmell J, El-Hawiet A, Szpacenko A, Kitova EN, Daneshfar R, Klassen JS, Lang DE, Eugenio L, Ng KK, Kitov PI, Bundle DR
• Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase.
  Acta crystallographica. Section D, Biological crystallography 2014 Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK
• The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order.
  Journal of virology 2014 May J, Viswanathan P, Ng KK, Medvedev A, Korba B
• Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile.
  The Journal of biological chemistry 2013 Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK
• The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits.
  Acta crystallographica. Section D, Biological crystallography 2013 Barrette-Ng IH, Wu SC, Tjia WM, Wong SL, Ng KK
• Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan.
  The Journal of biological chemistry 2012 Wheatley RW, Zheng RB, Richards MR, Lowary TL, Ng KK
• Development of a tetrameric streptavidin mutein with reversible biotin binding capability: engineering a mobile loop as an exit door for biotin.
  PloS one 2012 O'Sullivan VJ, Barrette-Ng I, Hommema E, Hermanson GT, Schofield M, Wu SC, Honetschlaeger C, Ng KK, Wong SL
• Unexpected structure of a C. difficile toxin A ligand necessitates an annotation correction in a popular screening library.
  Chemical communications (Cambridge, England) 2011 Zhang P, Razi N, Eugenio L, Fentabil M, Kitova EN, Klassen JS, Bundle DR, Ng KK, Ling CC
• Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction.
  Proteins 2009 Wu SC, Ng KK, Wong SL
• PII in higher plants: a modern role for an ancient protein.
  Trends in plant science 2009 Uhrig RG, Ng KK, Moorhead GB
• Structural insights into antibody recognition of mycobacterial polysaccharides.
  Journal of molecular biology 2009 Murase T, Zheng RB, Joe M, Bai Y, Marcus SL, Lowary TL, Ng KK
• A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta).
  Acta crystallographica. Section D, Biological crystallography 2009 Toyota E, Iyaguchi D, Sekizaki H, Tateyama M, Ng KK
• Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.
  Journal of molecular biology 2009 Zamyatkin DF, Parra F, Machín A, Grochulski P, Ng KK
• Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile.
  Glycobiology 2008 Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin S, Klassen JS, Palcic MM, Ng KK, Armstrong GD
• Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase.
  The Journal of biological chemistry 2008 Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK
• Structure-function relationships among RNA-dependent RNA polymerases.
  Current topics in microbiology and immunology 2008 Ng KK, Arnold JJ, Cameron CE
• Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana.
  The Journal of biological chemistry 2007 Mizuno Y, Moorhead GB, Ng KK
• Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants.
  Biochemistry 2007 Mizuno Y, Berenger B, Moorhead GB, Ng KK
• Carbohydrate recognition by Clostridium difficile toxin A.
  Nature structural & molecular biology 2006 Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK
• The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase.
  The Journal of biological chemistry 2005 Chen YM, Ferrar TS, Lohmeier-Vogel EM, Lohmeir-Vogel E, Morrice N, Mizuno Y, Berenger B, Ng KK, Muench DG, Moorhead GB
• Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Ho JG, Greco A, Rupnik M, Ng KK
• Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands.
  The Journal of biological chemistry 2005 Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK
• Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft.
  The Journal of biological chemistry 2004 Ng KK, Pendás-Franco N, Rojo J, Boga JA, Machín A, Alonso JM, Parra F
• Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots.
  The Journal of biological chemistry 2003 Lian Q, Szarka SJ, Ng KK, Wong SL
• Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg.
  The Journal of biological chemistry 2003 Barrette-Ng IH, Ng KK, Cherney MM, Pearce G, Ryan CA, James MN
• Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
  The Journal of biological chemistry 2002 Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN
• Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.
  The Journal of biological chemistry 2002 Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN