Kenneth Feingold, MD
Professor Emeritus
Medicine
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Websites

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• Profile at endocrine.medicine.ucsf.edu (endocrine.medicine.ucsf.edu)

Grants and Projects

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• Relationship of Keratinocyte Function to Differentiation, NIH, 1988-2010
• Stratum Corneum Acidification in the Neonate, NIH, 1994-2010
• Effects of Psychological Stress on the Stratum Corneum, NIH, 2004-2009
• PPARs and LXR Regulate Epidermal Differentiation, NIH, 2004-2008
• Regulation of Epidermal Lipid Metabolism, NIH, 1991-2001
• Cholesterol Synthesis in Diabetic Animals, NIH, 1983-1986

Publications (160)

Top publication keywords:
EpidermisAcute-Phase ReactionCeramidesProprotein Convertase 9Receptors, Cytoplasmic and NuclearLipid MetabolismSkinCholesterolPeroxisome Proliferator-Activated ReceptorsHomeostasisKeratinocytesLipoproteinsLipoproteins, HDLLipopolysaccharidesPermeability

• The role of ceramides in the disruption of the cutaneous permeability barrier, a common manifestation of skin disorders.
  Journal of lipid research 2024 Feingold KR, Elias PM
• Recent advances in lipidology.
  Best practice & research. Clinical endocrinology & metabolism 2023 Feingold KR, Chait A
• The bidirectional interaction of COVID-19 infections and lipoproteins.
  Best practice & research. Clinical endocrinology & metabolism 2023 Feingold KR
• Lipid and Lipoprotein Metabolism.
  Endocrinology and metabolism clinics of North America 2022 Feingold KR
• Approach to patients with elevated low-density lipoprotein cholesterol levels.
  Best practice & research. Clinical endocrinology & metabolism 2022 Feingold KR, Chait A

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• Approach to patients with hypertriglyceridemia.
  Best practice & research. Clinical endocrinology & metabolism 2022 Chait A, Feingold KR
• The bidirectional link between HDL and COVID-19 infections.
  Journal of lipid research 2021 Feingold KR
• Stress test of the skin: The cutaneous permeability barrier treadmill.
  Experimental dermatology 2019 Schmuth M, Feingold KR, Elias PM
• Maximizing the benefits of cholesterol-lowering drugs.
  Current opinion in lipidology 2019 Feingold KR
• Going from A to Z.
  The New England journal of medicine 2018 Atri D, Furfaro D, Dhaliwal G, Feingold KR, Manesh R
• Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines.
  The Journal of investigative dermatology 2017 Hu L, Mauro TM, Dang E, Man G, Zhang J, Lee D, Wang G, Feingold KR, Elias PM, Man MQ
• Stressing Signal Versus Noise: An Exercise in Clinical Reasoning.
  Journal of general internal medicine 2016 Gupta N, Feingold K, Dhaliwal G
• Effect of inflammation on HDL structure and function.
  Current opinion in lipidology 2016 Feingold KR, Grunfeld C
• Symptomatic Graves' Disease After Autoimmune Hypothyroidism.
  The American journal of medicine 2016 Brondfield S, Feingold KR
• High-Density Lipoprotein Subclasses and Noncardiovascular, Noncancer Chronic Inflammatory-Related Events Versus Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis.
  Journal of the American Heart Association 2015 Duprez DA, Otvos J, Tracy RP, Feingold KR, Greenland P, Gross MD, Lima JA, Mackey RH, Neaton JD, Sanchez OA, Jacobs DR
• TLR3: a receptor that recognizes cell injury is essential for permeability barrier homeostasis following UV irradiation.
  The Journal of investigative dermatology 2015 Feingold KR
• Statin myopathy: a problem looking for a solution.
  Atherosclerosis 2015 Feingold KR
• Lowered humidity produces human epidermal equivalents with enhanced barrier properties.
  Tissue engineering. Part C, Methods 2015 Sun R, Celli A, Crumrine D, Hupe M, Adame LC, Pennypacker SD, Park K, Uchida Y, Feingold KR, Elias PM, Ilic D, Mauro TM
• Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.
  Journal of lipid research 2014 Feingold KR, Moser A, Shigenaga JK, Grunfeld C
• Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.
  The Journal of investigative dermatology 2014 Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM
• Basis for enhanced barrier function of pigmented skin.
  The Journal of investigative dermatology 2014 Man MQ, Lin TK, Santiago JL, Celli A, Zhong L, Huang ZM, Roelandt T, Hupe M, Sundberg JP, Silva KA, Crumrine D, Martin-Ezquerra G, Trullas C, Sun R, Wakefield JS, Wei ML, Feingold KR, Mauro TM, Elias …
• The adverse effect of IFN gamma on stratum corneum structure and function in psoriasis and atopic dermatitis.
  The Journal of investigative dermatology 2014 Feingold KR
• The important role of lipids in the epidermis and their role in the formation and maintenance of the cutaneous barrier.
  Biochimica et biophysica acta 2014 Feingold K, Elias P
• Capsule commentary on Radin, pitfalls in hemoglobin A1c measurement: when results may be misleading.
  Journal of general internal medicine 2014 Feingold KR
• Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.
  Biochimica et biophysica acta 2013 Elias PM, Williams ML, Choi EH, Feingold KR
• Role of lipids in the formation and maintenance of the cutaneous permeability barrier.
  Biochimica et biophysica acta 2013 Feingold KR, Elias PM
• Diabetes and risk of hospitalized fall injury among older adults.
  Diabetes care 2013 Yau RK, Strotmeyer ES, Resnick HE, Sellmeyer DE, Feingold KR, Cauley JA, Vittinghoff E, De Rekeneire N, Harris TB, Nevitt MC, Cummings SR, Shorr RI, Schwartz AV
• Innate immunity stimulates permeability barrier homeostasis.
  The Journal of investigative dermatology 2013 Feingold KR
• Ceramides stimulate caspase-14 expression in human keratinocytes.
  Experimental dermatology 2013 Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR
• Lipids: a key player in the battle between the host and microorganisms.
  Journal of lipid research 2012 Feingold KR, Grunfeld C
• Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
  The Journal of investigative dermatology 2012 Lin TK, Man MQ, Santiago JL, Park K, Roelandt T, Oda Y, Hupe M, Crumrine D, Lee HJ, Gschwandtner M, Thyssen JP, Trullas C, Tschachler E, Feingold KR, Elias PM
• Tight junction properties change during epidermis development.
  Experimental dermatology 2012 Celli A, Zhai Y, Jiang YJ, Crumrine D, Elias PM, Feingold KR, Mauro TM
• Lamellar bodies: the key to cutaneous barrier function.
  The Journal of investigative dermatology 2012 Feingold KR
• Mechanisms of triglyceride accumulation in activated macrophages.
  Journal of leukocyte biology 2012 Feingold KR, Shigenaga JK, Kazemi MR, McDonald CM, Patzek SM, Cross AS, Moser A, Grunfeld C
• Psoriasis: it's more than just the skin.
  Journal of lipid research 2012 Feingold KR, Grunfeld C
• Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders.
  Clinics in dermatology 2012 Elias PM, Williams ML, Feingold KR
• Regulation of permeability barrier homeostasis.
  Clinics in dermatology 2012 Feingold KR, Denda M
• Angiopoietin like protein 4 expression is decreased in activated macrophages.
  Biochemical and biophysical research communications 2012 Feingold KR, Shigenaga JK, Cross AS, Moser A, Grunfeld C
• FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
  Endocrinology 2012 Feingold KR, Grunfeld C, Heuer JG, Gupta A, Cramer M, Zhang T, Shigenaga JK, Patzek SM, Chan ZW, Moser A, Bina H, Kharitonenkov A
• Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis.
  International journal of dermatology 2011 Man W, Man M, Hupe M, Martin-Ezquerra G, Feingold KR, Elias PM, Man MQ
• Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.
  Inflammation 2011 Lu B, Xu FY, Taylor WA, Feingold KR, Hatch GM
• Inflammation inhibits GPR81 expression in adipose tissue.
  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011 Feingold KR, Moser A, Shigenaga JK, Grunfeld C
• Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.
  The Journal of investigative dermatology 2011 Hatano Y, Elias PM, Crumrine D, Feingold KR, Katagiri K, Fujiwara S
• PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis.
  Experimental dermatology 2011 Jiang YJ, Kim P, Lu YF, Feingold KR
• Lipid metabolism in the epidermis.
  Dermato-endocrinology 2011 Feingold KR
• The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes/epidermis.
  Dermato-endocrinology 2011 Jiang YJ, Feingold KR
• The mechanisms by which lipids coordinately regulate the formation of the protein and lipid domains of the stratum corneum: Role of fatty acids, oxysterols, cholesterol sulfate and ceramides as signaling molecules.
  Dermato-endocrinology 2011 Feingold KR, Jiang YJ
• Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue.
  Innate immunity 2011 Feingold KR, Moser A, Shigenaga JK, Grunfeld C
• A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin.
  Experimental dermatology 2011 Man M, Hupe M, Mackenzie D, Kim H, Oda Y, Crumrine D, Lee SH, Martin-Ezquerra G, Trullas C, Mauro TM, Feingold KR, Elias PM, Man MQ
• The role of HDL in innate immunity.
  Journal of lipid research 2010 Feingold KR, Grunfeld C
• Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.
  Journal of lipid research 2010 Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR
• IL-6 stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation.
  Experimental dermatology 2010 Jiang YJ, Lu B, Crumrine D, Elias PM, Feingold KR
• Regulation of ABCG1 expression in human keratinocytes and murine epidermis.
  Journal of lipid research 2010 Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR
• Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?
  The Journal of investigative dermatology 2010 Fluhr JW, Elias PM, Man MQ, Hupe M, Selden C, Sundberg JP, Tschachler E, Eckhart L, Mauro TM, Feingold KR
• Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
  Innate immunity 2010 Feingold KR, Shigenaga JK, Patzek SM, Chui LG, Moser A, Grunfeld C
• The acute phase response inhibits reverse cholesterol transport.
  Journal of lipid research 2010 Feingold KR, Grunfeld C
• The acute phase response stimulates the expression of angiopoietin like protein 4.
  Biochemical and biophysical research communications 2009 Lu B, Moser A, Shigenaga JK, Grunfeld C, Feingold KR
• Does inhibition of apolipoprotein B synthesis produce foie gras?
  Journal of lipid research 2009 Feingold KR
• Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.
  The Journal of allergy and clinical immunology 2009 Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM
• Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.
  The Journal of investigative dermatology 2009 Hachem JP, Roelandt T, Schürer N, Pu X, Fluhr J, Giddelo C, Man MQ, Crumrine D, Roseeuw D, Feingold KR, Mauro T, Elias PM
• ADRP/ADFP and Mal1 expression are increased in macrophages treated with TLR agonists.
  Atherosclerosis 2009 Feingold KR, Kazemi MR, Magra AL, McDonald CM, Chui LG, Shigenaga JK, Patzek SM, Chan ZW, Londos C, Grunfeld C
• Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
  The Journal of allergy and clinical immunology 2009 Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM
• PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation.
  The Journal of investigative dermatology 2009 Jiang YJ, Barish G, Lu B, Evans RM, Crumrine D, Schmuth M, Elias PM, Feingold KR
• Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm.
  Journal of lipid research 2009 Feingold KR, Moser A, Patzek SM, Shigenaga JK, Grunfeld C
• Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes.
  The Journal of biological chemistry 2009 Jiang YJ, Uchida Y, Lu B, Kim P, Mao C, Akiyama M, Elias PM, Holleran WM, Grunfeld C, Feingold KR
• Pentosidine and increased fracture risk in older adults with type 2 diabetes.
  The Journal of clinical endocrinology and metabolism 2009 Schwartz AV, Garnero P, Hillier TA, Sellmeyer DE, Strotmeyer ES, Feingold KR, Resnick HE, Tylavsky FA, Black DM, Cummings SR, Harris TB, Bauer DC, Health, Aging, and Body Composition Study
• The role of CD44 in cutaneous inflammation.
  Experimental dermatology 2009 Man M, Elias PM, Man W, Wu Y, Bourguignon LY, Feingold KR, Man MQ
• Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.
  Experimental dermatology 2009 Demerjian M, Choi EH, Man MQ, Chang S, Elias PM, Feingold KR
• IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development.
  Journal of dermatological science 2009 Jiang YJ, Lu B, Crumrine D, Man MQ, Elias PM, Feingold KR
• Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.
  The Journal of investigative dermatology 2009 Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM
• pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.
  The Journal of investigative dermatology 2009 Gunathilake R, Schurer NY, Shoo BA, Celli A, Hachem JP, Crumrine D, Sirimanna G, Feingold KR, Mauro TM, Elias PM
• The "caveolae brake hypothesis" and the epidermal barrier.
  The Journal of investigative dermatology 2008 Roelandt T, Giddelo C, Heughebaert C, Denecker G, Hupe M, Crumrine D, Kusuma A, Haftek M, Roseeuw D, Declercq W, Feingold KR, Elias PM, Hachem JP
• The outer frontier: the importance of lipid metabolism in the skin.
  Journal of lipid research 2008 Feingold KR
• Endotoxin in the gut and chylomicrons: translocation or transportation?
  Journal of lipid research 2008 Grunfeld C, Feingold KR
• LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes.
  American journal of physiology. Endocrinology and metabolism 2008 Lu B, Lu Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
  The Journal of investigative dermatology 2008 Fluhr JW, Man MQ, Hachem JP, Crumrine D, Mauro TM, Elias PM, Feingold KR
• Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis.
  The American journal of pathology 2008 Elias PM, Arbiser J, Brown BE, Rossiter H, Man MQ, Cerimele F, Crumrine D, Gunathilake R, Choi EH, Uchida Y, Tschachler E, Feingold KR
• Inflammation stimulates the expression of PCSK9.
  Biochemical and biophysical research communications 2008 Feingold KR, Moser AH, Shigenaga JK, Patzek SM, Grunfeld C
• LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney.
  Journal of lipid research 2008 Feingold KR, Wang Y, Moser A, Shigenaga JK, Grunfeld C
• Skin as an endocrine organ: implications for its function.
  Drug discovery today. Disease mechanisms 2008 Slominski A, Wortsman J, Paus R, Elias PM, Tobin DJ, Feingold KR
• HDL and innate immunity: a tale of two apolipoproteins.
  Journal of lipid research 2008 Grunfeld C, Feingold KR
• Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti-inflammatory activity in murine disease models.
  Experimental dermatology 2008 Man MQ, Shi Y, Man M, Lee SH, Demerjian M, Chang S, Feingold KR, Elias PM
• Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.
  Journal of lipid research 2008 Schmuth M, Jiang YJ, Dubrac S, Elias PM, Feingold KR
• Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2.
  The American journal of pathology 2007 Demerjian M, Hachem JP, Tschachler E, Denecker G, Declercq W, Vandenabeele P, Mauro T, Hupe M, Crumrine D, Roelandt T, Houben E, Elias PM, Feingold KR
• Diabetes-related complications, glycemic control, and falls in older adults.
  Diabetes care 2007 Schwartz AV, Vittinghoff E, Sellmeyer DE, Feingold KR, de Rekeneire N, Strotmeyer ES, Shorr RI, Vinik AI, Odden MC, Park SW, Faulkner KA, Harris TB, Health, Aging, and Body Composition Study
• Infection and inflammation decrease apolipoprotein M expression.
  Atherosclerosis 2007 Feingold KR, Shigenaga JK, Chui LG, Moser A, Khovidhunkit W, Grunfeld C
• Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.
  The Journal of clinical investigation 2007 Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM
• Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.
  The Journal of investigative dermatology 2007 Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schröder JM, Feingold KR, Elias PM
• Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis.
  Journal of lipid research 2007 Feingold KR
• Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.
  The Journal of investigative dermatology 2007 Man MQ, Barish GD, Schmuth M, Crumrine D, Barak Y, Chang S, Jiang Y, Evans RM, Elias PM, Feingold KR
• Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.
  The Journal of investigative dermatology 2007 Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM
• PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
  The Journal of investigative dermatology 2007 Jiang YJ, Lu B, Kim P, Paragh G, Schmitz G, Elias PM, Feingold KR
• The regulation of permeability barrier homeostasis.
  The Journal of investigative dermatology 2007 Feingold KR, Schmuth M, Elias PM
• Stratum corneum acidification is impaired in moderately aged human and murine skin.
  The Journal of investigative dermatology 2007 Choi EH, Man MQ, Xu P, Xin S, Liu Z, Crumrine DA, Jiang YJ, Fluhr JW, Feingold KR, Elias PM, Mauro TM
• Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
  The American journal of pathology 2007 Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM
• Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.
  Biochimica et biophysica acta 2007 Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
  Metabolism: clinical and experimental 2007 Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, Feingold KR
• Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells.
  The Biochemical journal 2007 Van Q, Liu J, Lu B, Feingold KR, Shi Y, Lee RM, Hatch GM
• Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins.
  Journal of lipid research 2006 Staprans I, Pan XM, Rapp JH, Moser AH, Feingold KR
• Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function.
  American journal of physiology. Regulatory, integrative and comparative physiology 2006 Choi EH, Demerjian M, Crumrine D, Brown BE, Mauro T, Elias PM, Feingold KR
• Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.
  Journal of lipid research 2006 Lu B, Moser AH, Shigenaga JK, Feingold KR, Grunfeld C
• Regulation of ABCA1 expression in human keratinocytes and murine epidermis.
  Journal of lipid research 2006 Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR
• Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models.
  Experimental dermatology 2006 Fluhr JW, Feingold KR, Elias PM
• Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis.
  The Journal of investigative dermatology 2006 Bourguignon LY, Ramez M, Gilad E, Singleton PA, Man MQ, Crumrine DA, Elias PM, Feingold KR
• Serine protease signaling of epidermal permeability barrier homeostasis.
  The Journal of investigative dermatology 2006 Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR, Elias PM
• FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.
  Molecular and cellular biology 2006 Wu Q, Ortegon AM, Tsang B, Doege H, Feingold KR, Stahl A
• Thiazolidinedione use and bone loss in older diabetic adults.
  The Journal of clinical endocrinology and metabolism 2006 Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR, Strotmeyer ES, Resnick HE, Carbone L, Beamer BA, Park SW, Lane NE, Harris TB, Cummings SR
• Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome.
  The Journal of investigative dermatology 2006 Hachem JP, Wagberg F, Schmuth M, Crumrine D, Lissens W, Jayakumar A, Houben E, Mauro TM, Leonardsson G, Brattsand M, Egelrud T, Roseeuw D, Clayman GL, Feingold KR, Williams ML, Elias PM
• Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).
  Journal of lipid research 2006 Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR
• Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model.
  Experimental dermatology 2006 Demerjian M, Man MQ, Choi EH, Brown BE, Crumrine D, Chang S, Mauro T, Elias PM, Feingold KR
• Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing.
  The Journal of investigative dermatology 2006 Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM, Holleran WM, Feingold KR
• Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy.
  American journal of physiology. Endocrinology and metabolism 2006 Sweeney TR, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Differential expression of fatty acid transport proteins in epidermis and skin appendages.
  The Journal of investigative dermatology 2005 Schmuth M, Ortegon AM, Mao-Qiang M, Elias PM, Feingold KR, Stahl A
• Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate.
  The Journal of investigative dermatology 2005 Fluhr JW, Crumrine D, Mao-Qiang M, Moskowitz DG, Elias PM, Feingold KR
• The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis.
  Molecular nutrition & food research 2005 Staprans I, Pan XM, Rapp JH, Feingold KR
• Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.
  Journal of lipid research 2005 Lu B, Jiang YJ, Man MQ, Brown B, Elias PM, Feingold KR
• LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes.
  Journal of lipid research 2005 Jiang YJ, Kim P, Elias PM, Feingold KR
• Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.
  The Journal of investigative dermatology 2005 Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM
• Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.
  Journal of lipid research 2005 Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Is endogenous glycerol a determinant of stratum corneum hydration in humans?
  The Journal of investigative dermatology 2005 Choi EH, Man MQ, Wang F, Zhang X, Brown BE, Feingold KR, Elias PM
• Suppression of estrogen-related receptor alpha and medium-chain acyl-coenzyme A dehydrogenase in the acute-phase response.
  Journal of lipid research 2005 Kim MS, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C
• Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity.
  The Journal of investigative dermatology 2005 Choi EH, Brown BE, Crumrine D, Chang S, Man MQ, Elias PM, Feingold KR
• Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists.
  Arteriosclerosis, thrombosis, and vascular biology 2005 Kazemi MR, McDonald CM, Shigenaga JK, Grunfeld C, Feingold KR
• Parotid secretory protein is an HDL-associated protein with anticandidal activity.
  American journal of physiology. Regulatory, integrative and comparative physiology 2005 Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C
• Diabetes and bone loss at the hip in older black and white adults.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Schwartz AV, Sellmeyer DE, Strotmeyer ES, Tylavsky FA, Feingold KR, Resnick HE, Shorr RI, Nevitt MC, Black DM, Cauley JA, Cummings SR, Harris TB, Health ABC Study
• Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL.
  Atherosclerosis 2004 Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR
• Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis.
  The Journal of investigative dermatology 2004 Presland RB, Coulombe PA, Eckert RL, Mao-Qiang M, Feingold KR, Elias PM
• Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.
  The Journal of investigative dermatology 2004 Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE, Moser AH, Michalik L, Desvergne B, Wahli W, Li M, Metzger D, Chambon PH, Elias PM, Feingold KR
• Functional consequences of a neutral pH in neonatal rat stratum corneum.
  The Journal of investigative dermatology 2004 Fluhr JW, Mao-Qiang M, Brown BE, Hachem JP, Moskowitz DG, Demerjian M, Haftek M, Serre G, Crumrine D, Mauro TM, Elias PM, Feingold KR
• The effect of LXR activators on AP-1 proteins in keratinocytes.
  The Journal of investigative dermatology 2004 Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR
• Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.
  American journal of physiology. Endocrinology and metabolism 2004 Kim MS, Shigenaga J, Moser A, Grunfeld C, Feingold KR
• Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
  Journal of lipid research 2004 Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C
• Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
  The Journal of investigative dermatology 2004 Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR
• Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis).
  The Journal of investigative dermatology 2004 Schmuth M, Fluhr JW, Crumrine DC, Uchida Y, Hachem JP, Behne M, Moskowitz DG, Christiano AM, Feingold KR, Elias PM
• Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response.
  American journal of physiology. Endocrinology and metabolism 2004 Feingold K, Kim MS, Shigenaga J, Moser A, Grunfeld C
• Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.
  The Journal of investigative dermatology 2004 Elias PM, Crumrine D, Rassner U, Hachem JP, Menon GK, Man W, Choy MH, Leypoldt L, Feingold KR, Williams ML
• Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum.
  The Journal of investigative dermatology 2004 Fluhr JW, Behne MJ, Brown BE, Moskowitz DG, Selden C, Mao-Qiang M, Mauro TM, Elias PM, Feingold KR
• Lipopenia and skin barrier abnormalities in DGAT2-deficient mice.
  The Journal of biological chemistry 2003 Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV
• pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.
  The Journal of investigative dermatology 2003 Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM
• Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.
  Journal of lipid research 2003 Khovidhunkit W, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function.
  The Journal of investigative dermatology 2003 Behne MJ, Barry NP, Hanson KM, Aronchik I, Clegg RW, Gratton E, Feingold K, Holleran WM, Elias PM, Mauro TM
• Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.
  The Journal of investigative dermatology 2003 Fluhr JW, Mao-Qiang M, Brown BE, Wertz PW, Crumrine D, Sundberg JP, Feingold KR, Elias PM
• [Beyond glucocorticoids, retinoids and vitamin D--the evolution of nuclear hormone type transcription factor targeting in the skin].
  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2003 Schmuth M, Elias PM, Feingold KR
• Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.
  The Journal of investigative dermatology 2003 Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, Ahn SK, Brown BE, Elias PM, Feingold KR
• Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
  The Journal of investigative dermatology 2003 Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR
• Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum.
  Journal of lipid research 2003 Staprans I, Pan XM, Rapp JH, Feingold KR
• Repression of farnesoid X receptor during the acute phase response.
  The Journal of biological chemistry 2003 Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C
• Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms.
  The Journal of investigative dermatology 2002 Elias P, Ahn S, Brown B, Crumrine D, Feingold KR
• Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero.
  The Journal of investigative dermatology 2002 Schmuth M, Schoonjans K, Yu QC, Fluhr JW, Crumrine D, Hachem JP, Lau P, Auwerx J, Elias PM, Feingold KR
• The potential of metabolic interventions to enhance transdermal drug delivery.
  The journal of investigative dermatology. Symposium proceedings 2002 Elias PM, Tsai J, Menon GK, Holleran WM, Feingold KR
• Modulations in epidermal calcium regulate the expression of differentiation-specific markers.
  The Journal of investigative dermatology 2002 Elias PM, Ahn SK, Denda M, Brown BE, Crumrine D, Kimutai LK, Kömüves L, Lee SH, Feingold KR
• The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.
  The Journal of investigative dermatology 2002 Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z
• Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis.
  The Journal of investigative dermatology 2002 Sato J, Denda M, Chang S, Elias PM, Feingold KR
• Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver.
  American journal of physiology. Endocrinology and metabolism 2002 Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice.
  Biochemical and biophysical research communications 2002 Nonogaki K, Memon RA, Grunfeld C, Feingold KR, Tecott LH
• Basis for the permeability barrier abnormality in lamellar ichthyosis.
  Experimental dermatology 2002 Elias PM, Schmuth M, Uchida Y, Rice RH, Behne M, Crumrine D, Feingold KR, Holleran WM, Pharm D
• Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.
  Biochemical and biophysical research communications 2002 Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
• Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.
  The Journal of investigative dermatology 2002 Kömüves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ, Moser AH, Lobaccaro JM, Williams ML, Mangelsdorf DJ, Feingold KR
• Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
  The Journal of investigative dermatology 2002 Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J, Fluhr JW, Man MQ, Elias PM, Feingold KR
• Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements.
  The Journal of biological chemistry 2001 Tsuruoka H, Khovidhunkit W, Brown BE, Fluhr JW, Elias PM, Feingold KR