Kenneth Drasner, MD
Professor Emeritus
Anesthesia
School of Medicine

Grants and Projects

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• Local Anesthetic Neurotoxicity, NIH, 1996-2001

Publications (41)

Top publication keywords:
Soybean OilBupivacaineAnesthetics, LocalAnalgesia, ObstetricalInjections, SpinalAnestheticsNerve Compression SyndromesProcaineMorphineCauda EquinaAnalgesicsLidocaineAnesthesia, SpinalFat Emulsions, IntravenousAnesthesia, Epidural

• A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion.
  Anesthesiology 2012 Ruan W, French D, Wong A, Drasner K, Wu AH
• Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies.
  Clinical toxicology (Philadelphia, Pa.) 2011 French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH
• Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose.
  Clinical toxicology (Philadelphia, Pa.) 2011 French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH
• Anesthetic effects on the developing nervous system: if you aren't concerned, you haven't been paying attention.
  Anesthesiology 2010 Drasner K
• Safety of ultrasound-guided regional anesthesia.
  Anesthesiology 2010 Gray AT, Drasner K

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• ASRA practice advisory on local anesthetic systemic toxicity.
  Regional anesthesia and pain medicine 2010 Neal JM, Bernards CM, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL
• Local anesthetic systemic toxicity: a historical perspective.
  Regional anesthesia and pain medicine 2010 Drasner K
• Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats.
  Regional anesthesia and pain medicine 2010 Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL
• Continuous spinal analgesia for labor and delivery: a born-again technique?
  Anesthesiology 2008 Drasner K, Smiley R
• Epidural chloroprocaine-standard of care for postpartum bilateral tubal ligation.
  Anesthesia and analgesia 2005 Drasner K
• Chloroprocaine spinal anesthesia: back to the future?
  Anesthesia and analgesia 2005 Drasner K
• Thoracic epidural anesthesia: asleep at the wheal?
  Anesthesia and analgesia 2004 Drasner K
• Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity?
  Anesthesiology 2004 Taniguchi M, Bollen AW, Drasner K
• Low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular but not intrathecal morphine.
  Anesthesiology 2001 Drasner K
• Comparative toxicity of glucose and lidocaine administered intrathecally in the rat.
  Regional anesthesia and pain medicine 1998 Hashimoto K, Sakura S, Bollen AW, Ciriales R, Drasner K
• Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients.
  Anesthesiology 1998 Freedman JM, Li DK, Drasner K, Jaskela MC, Larsen B, Wi S
• Lidocaine toxicity in primary afferent neurons from the rat.
  The Journal of pharmacology and experimental therapeutics 1998 Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD
• A comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia.
  Regional anesthesia and pain medicine 1998 Chan VW, Garcia J, Al-Kaisy A, Drasner K
• Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine.
  Anesthesiology 1998 Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, Harms C, Seeberger M, Schneider MC, Drasner K
• The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine.
  Anesthesiology 1997 Sakura S, Sumi M, Sakaguchi Y, Saito Y, Kosaka Y, Drasner K
• Lidocaine spinal anesthesia: a vanishing therapeutic index?
  Anesthesiology 1997 Drasner K
• A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine.
  Anesthesia and analgesia 1996 Hampl KF, Schneider MC, Pargger H, Gut J, Drewe J, Drasner K
• Intrathecal catheterization in the rat. Improved technique for morphologic analysis of drug-induced injury.
  Anesthesiology 1996 Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K
• Spontaneous intracranial hypotension: a series.
  Anesthesiology 1996 Weitz SR, Drasner K
• [Neurologic sequelae of spinal anesthesia: local anesthetic toxicity].
  Masui. The Japanese journal of anesthesiology 1996 Sakura S, Drasner K
• Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels.
  Anesthesia and analgesia 1995 Sakura S, Bollen AW, Ciriales R, Drasner K
• Local anesthetic test dose as a predictor of effective epidural opioid analgesia.
  Anesthesiology 1995 Weitz SR, Drasner K
• Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group.
  Anesthesiology 1995 Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT
• The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat.
  Anesthesiology 1995 Sakura S, Chan VW, Ciriales R, Drasner K
• Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat.
  Anesthesiology 1994 Drasner K, Sakura S, Chan VW, Bollen AW, Ciriales R
• Models for local anesthetic toxicity from continuous spinal anesthesia.
  Regional anesthesia 1993 Drasner K
• Cauda equina syndrome following intended epidural anesthesia.
  Anesthesiology 1992 Drasner K, Rigler ML, Sessler DI, Stoller ML
• Distribution of catheter-injected local anesthetic in a model of the subarachnoid space.
  Anesthesiology 1991 Rigler ML, Drasner K
• Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla.
  Brain research 1991 Heinricher MM, Drasner K
• Cauda equina syndrome after continuous spinal anesthesia.
  Anesthesia and analgesia 1991 Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D
• Hypotension during transfusion of autologous blood.
  Anesthesiology 1991 Miller AC, Scherba-Krugliak L, Toy PT, Drasner K
• Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat?
  Anesthesia and analgesia 1990 Fassoulaki A, Drasner K, Eger EI
• Preoperative laboratory testing of children undergoing elective surgery.
  Anesthesia and analgesia 1990 O'Connor ME, Drasner K
• Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
  Brain research 1989 Fang FG, Haws CM, Drasner K, Williamson A, Fields HL
• Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans.
  Anesthesiology 1988 Drasner K, Bernards CM, Ozanne GM
• Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat.
  Pain 1988 Drasner K, Fields HL