Ken Nakamura, MD, PhD
Professor
Neurology
School of Medicine

He also runs a research laboratory at the Gladstone Institutes, where he investigates how disruptions of mitochondria—the “power centers” of cells that convert nutrients into energy—contribute to the development and progression of Parkinson’s disease and Alzheimer’s disease.

Nakamura earned a bachelor’s degree in chemistry and biological sciences from Cornell University, and an MD and PhD in neurobiology from the University of Chicago. His thesis work focused on the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson’s disease. Nakamura then completed an internship in internal medicine and a residency in neurology at UCSF, and a clinical fellowship in movement disorders at UCSF and the San Francisco VA Medical Center. He also completed a research fellowship at UCSF, during which he investigated how alpha-synuclein disrupts mitochondrial morphology and function and contributes to the development of Parkinson’s disease. He has received several awards, including a Burroughs Wellcome Fund Career Award for Medical Scientists.

• Effectiveness of Corticosteroids on Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Patients with Septic Shock: A Retrospective Claims Database Study.
  Journal of intensive care medicine 2025 Takano H, Kanda N, Ohbe H, Yoshida M, Nakamura K
• Prognostic evaluation of GLIM-defined severe malnutrition via skeletal muscle mass index in critically ill adults: A comparative analysis.
  JPEN. Journal of parenteral and enteral nutrition 2025 Miyagi T, Yoshida M, Suganuma S, Nakamura K, Takaki S
• Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis.
  Bioconjugate chemistry 2025 Iwamoto N, Ohno S, Nakamura K, Naito T, Miura S, Inuki S, Ohno H, Hayashi G, Murakami H, Oishi S
• Evaluation of the course of improvement with molnupiravir treatment for feline infectious peritonitis.
  The Canadian veterinary journal = La revue veterinaire canadienne 2025 Yoshida S, Sugawara-Suda M, Sasaoka K, Sasaki N, Yokoyama N, Nakamura K, Morishita K, Kim S, Sunaga T, Takiguchi M
• Single Case of a Cat Suspected of Having Congenital Biliary Dilatation Associated with Pancreaticobiliary Maljunction.
  Journal of the American Animal Hospital Association 2025 Fujimoto S, Torisu S, Nakatani K, Amiya R, Hosaka Y, Kaneko Y, Nakamura K, Tanabe M
• Use of C-Reactive Protein in Global Leadership Initiative on Malnutrition (GLIM) Etiologic Criteria for Critically Ill Patients: A Retrospective Claims Database Study.
  Nutrients 2025 Suganuma S, Kanda N, Yoshida M, Miyagi T, Nakamura K
• Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study.
  Frontiers in immunology 2025 Takano H, Kanda N, Wakimoto Y, Ohbe H, Nakamura K
• Fat-free oral nutritional supplements for patients after acute illness: a prospective observational study.
  Journal of clinical biochemistry and nutrition 2024 Nakamura K, Takahashi Y, Yanai Y, Miyagi T, Nakano H, Koyama Y, Hashimoto H
• Letter to the Editor-"Effects of early enteral nutrition on persistent inflammation, immunosuppression, and catabolism syndrome in critically ill patients".
  Clinical nutrition (Edinburgh, Scotland) 2024 Kashiwagi S, Kanda N, Nakamura K
• The polymyxin-B direct hemoperfusion OPTimal Initiation timing with Catecholamine PMX-OPTIC study: A multicenter retrospective observational study.
  Artificial organs 2024 Nakamura K, Okazaki T, Tampo A, Mochizuki K, Kanda N, Ono T, Yanagita K, Shimomura T, Murase T, Saito K, Hirayama T, Ito T, Ogawa K, Nakamura M, Oda T, Morishima T, Fukushima T, Yasui H, Akashi N, …
• Regional Collaboration for Heart Failure Patients Certified as Needing Support or Care in Long-Term Care Insurance System.
  Circulation journal : official journal of the Japanese Circulation Society 2024 Kinugasa Y, Nakamura K, Hirai M, Manba M, Ishiga N, Sota T, Nakayama N, Ota T, Kato M, Adachi T, Fukuki M, Hirota Y, Mizuta E, Mura E, Nozaka Y, Omodani H, Tanaka H, Tanaka Y, Watanabe I, Mikami M, …
• Relationship between very early enteral nutrition and persistent inflammation, immunosuppression, and catabolism syndrome in cardiovascular surgery patients: a propensity score-matched study.
  The American journal of clinical nutrition 2024 Yoshida M, Kanda N, Kashiwagi S, Wakimoto Y, Ohbe H, Nakamura K
• The water imbalance of skeletal muscle and muscle weakness in patients with heart failure.
  ESC heart failure 2024 Nakamura K, Kinugasa Y, Sota T, Hirai M, Kato M, Yamamoto K
• Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates.
  PloS one 2024 Sue M, Tsubaki T, Ishimoto Y, Hayashi S, Ishida S, Otsuka T, Isumi Y, Kawase Y, Yamaguchi J, Nakada T, Ishiguro J, Nakamura K, Kawaida R, Ohtsuka T, Wada T, Agatsuma T, Kawasaki N
• Acute muscle loss assessed using panoramic ultrasound in critically ill adults: a prospective observational study.
  Journal of medical ultrasonics (2001) 2024 Ikechi D, Nakano H, Nakanishi N, Fujita T, Watanabe N, Koyama Y, Hashimoto H, Nakamura K
• Effects of mechanical insufflation-exsufflation on ventilator-free days in intensive care unit subjects with sputum retention; a randomized clinical trial.
  PloS one 2024 Kubota S, Hashimoto H, Yoshikawa Y, Hiwatashi K, Ono T, Mochizuki M, Naraba H, Nakano H, Takahashi Y, Sonoo T, Nakamura K
• Association of a Transitional Heart Failure Management Program With Readmission and End-of-Life Care in Rural Japan.
  Circulation reports 2024 Kinugasa Y, Nakamura K, Hirai M, Manba M, Ishiga N, Sota T, Nakayama N, Ohta T, Kato M, Adachi T, Fukuki M, Hirota Y, Mizuta E, Mura E, Nozaka Y, Omodani H, Tanaka H, Tanaka Y, Watanabe I, Mikami M, …
• A de novo nonsense variant in the DMD gene associated with X-linked dystrophin-deficient muscular dystrophy in a cat.
  Journal of veterinary internal medicine 2024 Yokoyama N, Matsumoto Y, Yamaguchi T, Okada K, Kinoshita R, Shimbo G, Ukawa H, Ishii R, Nakamura K, Yamazaki J, Takiguchi M
• Predictor of A4 amplitude using preprocedural electrocardiography in patients with leadless pacemakers.
  Heart rhythm 2024 Kawatani S, Kotake Y, Takami A, Nakamura K, Tomomori T, Okamura A, Kato M, Yamamoto K
• Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Bennett NK, Lee M, Orr AL, Nakamura K
• NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
  Nature communications 2023 Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R…
• Role of dopamine neuron activity in Parkinson's disease pathophysiology.
  Experimental neurology 2023 Rademacher K, Nakamura K
• Successful treatment of sclerosing encapsulating peritonitis in a cat using bioresorbable hyaluronate-carboxymethylcellulose membrane after surgical adhesiolysis and long-term prednisolone.
  JFMS open reports 2023 Yokoyama N, Kinoshita R, Ohta H, Okada K, Shimbo G, Sasaoka K, Nagata N, Sasaki N, Morishita K, Nakamura K, Kagawa Y, Takiguchi M
• Effectiveness of Minitracheostomy After Extubation in Patients with Pneumonia at High Risk of Reintubation: A Case Series.
  Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) 2023 Ouchi A, Takahashi Y, Nakano H, Mochizuki M, Okamoto S, Sakuramoto H, Nakamura K
• Explorative Clustering of the Nitrogen Balance Trajectory in Critically Ill Patients: A Preliminary post hoc Analysis of a Single-Center Prospective Observational Study.
  Annals of nutrition & metabolism 2023 Nakamura K, Ogura K, Nakano H, Ikechi D, Mochizuki M, Takahashi Y, Goto T
• Protocol to combine brain sections from multiple mice into a single block for spatial transcriptomic analyses.
  STAR protocols 2023 Sei YJ, Chaumeil MM, Nakamura K
• Impact of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome during Intensive Care Admission on Each Post-Intensive Care Syndrome Component in a PICS Clinic.
  Journal of clinical medicine 2023 Suganuma S, Idei M, Nakano H, Koyama Y, Hashimoto H, Yokoyama N, Takaki S, Nakamura K
• Ultrasound-based upper limb muscle thickness is useful for screening low muscularity during intensive care unit admission: A retrospective study.
  Clinical nutrition ESPEN 2023 Nakanishi N, Inoue S, Ono Y, Sugiyama J, Takayama K, Arai Y, Nakamura K, Oto J, Kotani J
• The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study.
  Critical care (London, England) 2023 Nakamura K, Nakano H, Ikechi D, Mochizuki M, Takahashi Y, Koyama Y, Hashimoto H, Abe T, Hayakawa M, Yamakawa K
• Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure.
  Geriatrics & gerontology international 2023 Kinugasa Y, Sota T, Nakamura K, Hirai M, Kato M, Yamamoto K
• Investigation of the therapeutic effects, predictors, and complications of long-term immunosuppressive therapy in dogs with precursor-targeted immune-mediated anemia.
  The Journal of veterinary medical science 2023 Sugawara-Suda M, Morishita K, Iwanaga Y, Yamazaki J, Kagawa Y, Yokoyama N, Sasaki N, Ohta H, Nakamura K, Takiguchi M
• Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy.
  PloS one 2023 Sugawara-Suda M, Morishita K, Ichii O, Namba T, Aoshima K, Kagawa Y, Kim S, Hosoya K, Yokoyama N, Sasaki N, Nakamura K, Yamazaki J, Takiguchi M
• Neurons require glucose uptake and glycolysis in vivo.
  Cell reports 2023 Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura…
• Two cyanobacterial response regulators with diguanylate cyclase activity, Rre2 and Rre8, participate in biofilm formation.
  Molecular microbiology 2023 Kobayashi A, Nakamura M, Tsujii M, Makino K, Nagayama T, Nakamura K, Nanatani K, Kota K, Furuuchi Y, Kayamori S, Furuta T, Suzuki I, Hayakawa Y, Tanudjaja E, Ishimaru Y, Uozumi N
• Verifying the Japanese version of the Healthy Aging Brain Care Monitor self-report tool for evaluating post-intensive care syndrome.
  Australian critical care : official journal of the Confederation of Australian Critical Care Nurses 2023 Matsuishi Y, Hoshino H, Enomoto Y, Shimojo N, Ikeda M, Kotani M, Kobayashi S, Kido T, Mathis BJ, Nakamura K, Nakano H, Okubo N, Inoue Y
• The prognostic utility of prehospital qSOFA in addition to emergency department qSOFA for sepsis in patients with suspected infection: A retrospective cohort study.
  PloS one 2023 Saito A, Osawa I, Shibata J, Sonoo T, Nakamura K, Goto T
• Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling.
  Life science alliance 2023 Goel S, Oliva R, Jeganathan S, Bader V, Krause LJ, Kriegler S, Stender ID, Christine CW, Nakamura K, Hoffmann JE, Winter R, Tatzelt J, Winklhofer KF
• Coagulopathy correlates with muscle titin injury in critically ill patients.
  Journal of critical care 2022 Nakamura K, Nakano H, Ikechi D, Mochizuki M, Takahashi Y, Ogawa Y, Matsuishi Y, Shimojo N, Inoue Y
• Clinical Criteria for Persistent Inflammation, Immunosuppression, and Catabolism Syndrome: An Exploratory Analysis of Optimal Cut-Off Values for Biomarkers.
  Journal of clinical medicine 2022 Nakamura K, Ogura K, Ohbe H, Goto T
• Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
  Cell 2022 Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-…
• Serum steroid profiling of hepatocellular carcinoma associated with hyperadrenocorticism in dogs: A preliminary study.
  Frontiers in veterinary science 2022 Oo T, Sasaki N, Ikenaka Y, Ichise T, Nagata N, Yokoyama N, Sasaoka K, Morishita K, Nakamura K, Takiguchi M
• Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function.
  PLoS biology 2022 Bennett NK, Nakaoka HJ, Laurent D, Okimoto RA, Sei Y, Horvai AE, Bivona TG, Ten Hoeve J, Graeber TG, Nakamura K, Nakamura JL
• Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy.
  Human mutation 2022 Rius R, Bennett NK, Bhattacharya K, Riley LG, Yüksel Z, Formosa LE, Compton AG, Dale RC, Cowley MJ, Gayevskiy V, Al Tala SM, Almehery AA, Ryan MT, Thorburn DR, Nakamura K, Christodoulou J
• Reply to WH Hartl.
  The American journal of clinical nutrition 2022 Nakamura K, Kanda N, Hatakeyama J
• Reader Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
  Neurology 2022 Kang UJ, Nakamura K, Zhuang X
• Post-Intensive Care Syndrome-10 Years after Its Proposal and Future Directions.
  Journal of clinical medicine 2022 Inoue S, Nakanishi N, Nakamura K
• Evaluation of Right Ventricular Function and Dyssynchrony in a Dog Model of Acute Pulmonary Embolism: Diagnostic Utility and Reversibility.
  Frontiers in veterinary science 2022 Morita T, Nakamura K, Osuga T, Kawamoto S, Miki S, Takiguchi M
• Early ICU mobilisation predicting functional impairment at hospital discharge. Author's reply.
  Intensive care medicine 2022 Ohbe H, Goto T, Nakamura K, Matsui H, Yasunaga H
• Isoflurane inhibition of endocytosis is an anesthetic mechanism of action.
  Current biology : CB 2022 Jung S, Zimin PI, Woods CB, Kayser EB, Haddad D, Reczek CR, Nakamura K, Ramirez JM, Sedensky MM, Morgan PG
• Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism.
  The Journal of veterinary medical science 2022 Nagata N, Sawamura H, Morishita K, Hosoya K, Yokoyama N, Sasaoka K, Sasaki N, Nakamura K, Ikenaka Y, Takiguchi M
• Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds.
  The Journal of veterinary medical science 2022 Nagata N, Ohta H, Yokoyama N, Teoh YB, Sasaki N, Nakamura K, Takiguchi M
• Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
  Human molecular genetics 2022 Nguyen MK, McAvoy K, Liao SC, Doric Z, Lo I, Li H, Manfredi G, Nakamura K
• Performance of the new FilmArray Blood Culture Identification 2 panel and its potential impact on clinical use in patients with Gram-negative bacteremia.
  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2022 Kanda N, Hashimoto H, Suzuki T, Nakamura K
• Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission.
  Intensive care medicine 2022 Ohbe H, Goto T, Nakamura K, Matsui H, Yasunaga H
• Evaluation of Intravascular Volume Using the Internal Jugular Vein Cardiac Collapse Index in the Emergency Department: A Preliminary Prospective Observational Study.
  Ultrasound in medicine & biology 2022 Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Nakamura K
• The efficacy and safety of nurse-initiated sedation management in an intensive care unit: A two-phase prospective study in Japan.
  Japan journal of nursing science : JJNS 2022 Kanda N, Nakano H, Naraba H, Kawasaki A, Ohno N, Yoshikawa Y, Sakuramoto H, Takahashi Y, Sonoo T, Hashimoto H, Nakamura K
• A Case of Suspected COVID-19 Vaccine-related Thrombophlebitis.
  Internal medicine (Tokyo, Japan) 2022 Ikechi D, Hashimoto H, Nakano H, Nakamura K
• Effectiveness of early rehabilitation following aortic surgery: a nationwide inpatient database study.
  General thoracic and cardiovascular surgery 2022 Nakamura K, Ohbe H, Uda K, Matsui H, Yasunaga H
• Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives.
  Marine drugs 2022 Casalme LO, Katayama K, Hayakawa Y, Nakamura K, Yamauchi A, Nogata Y, Yoshimura E, Matsuda F, Umezawa T
• Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction.
  ESC heart failure 2022 Kinugasa Y, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Nagai T, Yoshikawa T, Saito Y, Takeishi Y, Yamamoto K, Anzai T
• Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle.
  Critical care (London, England) 2021 Nakano H, Naraba H, Hashimoto H, Mochizuki M, Takahashi Y, Sonoo T, Ogawa Y, Matsuishi Y, Shimojo N, Inoue Y, Nakamura K
• The PINK1 advantage: recycling mitochondria in times of trouble?
  Autophagy 2021 Doric Z, Li H, Nakamura K
• Mice with disrupted mitochondria used to model Parkinson's disease.
  Nature 2021 Doric Z, Nakamura K
• Author's reply.
  Journal of cardiology 2021 Nakamura K, Ohbe H, Yasunaga H
• Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.
  Nature communications 2021 Linsley JW, Shah K, Castello N, Chan M, Haddad D, Doric Z, Wang S, Leks W, Mancini J, Oza V, Javaherian A, Nakamura K, Kokel D, Finkbeiner S
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).
  Acute medicine & surgery 2021 Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N,…
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).
  Journal of intensive care 2021 Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N,…
• Whole-Genome Analysis Reveals That the Nucleoid Protein IHF Predominantly Binds to the Replication Origin oriC Specifically at the Time of Initiation.
  Frontiers in microbiology 2021 Kasho K, Oshima T, Chumsakul O, Nakamura K, Fukamachi K, Katayama T
• Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation.
  Science advances 2021 Li H, Doric Z, Berthet A, Jorgens DM, Nguyen MK, Hsieh I, Margulis J, Fang R, Debnath J, Sesaki H, Finkbeiner S, Huang E, Nakamura K
• Early rehabilitation after acute myocardial infarction: A nationwide inpatient database study.
  Journal of cardiology 2021 Nakamura K, Ohbe H, Uda K, Fushimi K, Yasunaga H
• Cardiovascular effects of dose escalating of norepinephrine in healthy dogs anesthetized with isoflurane.
  Veterinary anaesthesia and analgesia 2021 Kojima K, Ishizuka T, Sasaki N, Nakamura K, Takiguchi M
• Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology.
  Journal of veterinary internal medicine 2021 Fujimoto S, Torisu S, Kaneko Y, Mizutani S, Yamamoto S, Naganobu K, Nakamura K
• Accuracy and Stability of a Subcutaneous Flash Glucose Monitoring System in Critically Ill Patients.
  Journal of diabetes science and technology 2021 Naraba H, Goto T, Tokuda M, Sonoo T, Nakano H, Takahashi Y, Hashimoto H, Nakamura K
• Child ego state and self-care behavior change in heart failure patients.
  Journal of cardiology 2021 Yanagihara K, Kinugasa Y, Kunimi T, Kaneko S, Haruki N, Nakamura K, Kamitani H, Hirai M, Kato M, Yamamoto K
• Time in blood glucose range 70 to 180 mg/dL and survival rate in critically ill patients: A retrospective cohort study.
  PloS one 2021 Naraba H, Goto T, Shirakawa T, Sonoo T, Kanda N, Nakano H, Takahashi Y, Hashimoto H, Nakamura K
• Vasopressin Loading for Refractory Septic Shock: A Preliminary Analysis of a Case Series.
  Frontiers in medicine 2021 Nakamura K, Nakano H, Naraba H, Mochizuki M, Takahashi Y, Sonoo T, Hashimoto H, Abe T, Hayakawa M, Yamakawa K
• Block-cyclic stochastic coordinate descent for deep neural networks.
  Neural networks : the official journal of the International Neural Network Society 2021 Nakamura K, Soatto S, Hong BW
• Case of hereditary angioedema with lupus erythematosus tumidus-like eruption.
  The Australasian journal of dermatology 2021 Honda R, Nakamura K, Ito S
• Trimethylamine N-oxide and outcomes in patients hospitalized with acute heart failure and preserved ejection fraction.
  ESC heart failure 2021 Kinugasa Y, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Yamamoto K
• SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
  Science translational medicine 2021 Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC
• Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.
  Nutrients 2021 Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Matsuishi Y, Ogawa Y, Shimojo N, Inoue Y, Nakamura K
• Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
  The Journal of biological chemistry 2021 Shields LY, Li H, Nguyen K, Kim H, Doric Z, Garcia JH, Gill TM, Haddad D, Vossel K, Calvert M, Nakamura K
• Urine Titin N-Fragment as a Biomarker of Muscle Injury for Critical Illness Myopathy.
  American journal of respiratory and critical care medicine 2021 Nakano H, Hashimoto H, Mochizuki M, Naraba H, Takahashi Y, Sonoo T, Matsubara T, Yamakawa K, Nakamura K
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
  Autophagy 2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, …
• Effect of Early Rehabilitation on Physical Function in Patients Undergoing Coronary Artery Bypass Grafting: A Nationwide Inpatient Database Study.
  Journal of clinical medicine 2021 Ohbe H, Nakamura K, Uda K, Matsui H, Yasunaga H
• Cardiac Variation of Internal Jugular Vein as a Marker of Volume Change in Hemorrhagic Shock.
  Shock (Augusta, Ga.) 2020 Tokunaga K, Nakamura K, Inokuchi R, Hayase N, Terada R, Tomioka Y, Ikeda T, Kobayashi E, Okazaki H, Sakuma I, Doi K, Morimura N
• Institution-Specific Machine Learning Models for Prehospital Assessment to Predict Hospital Admission: Prediction Model Development Study.
  JMIR medical informatics 2020 Shirakawa T, Sonoo T, Ogura K, Fujimori R, Hara K, Goto T, Hashimoto H, Takahashi Y, Naraba H, Nakamura K
• l-Carnitine supplementation in heart failure patients with preserved ejection fraction; a pilot study.
  Geriatrics & gerontology international 2020 Kinugasa Y, Sota T, Ishiga N, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Yamamoto K
• Diagnostic Value of Serum Procalcitonin in Patients with Convulsion in Emergency Department, an Observational Study.
  Antibiotics (Basel, Switzerland) 2020 Murakami H, Naraba H, Gondo T, Mochizuki M, Nakano H, Takahashi Y, Sonoo T, Hashimoto H, Nakamura K
• SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
  bioRxiv : the preprint server for biology 2020 Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC
• Defining the ATPome reveals cross-optimization of metabolic pathways.
  Nature communications 2020 Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K
• Validation of chief complaints, medical history, medications, and physician diagnoses structured with an integrated emergency department information system in Japan: the Next Stage ER system.
  Acute medicine & surgery 2020 Goto T, Hara K, Hashimoto K, Soeno S, Shirakawa T, Sonoo T, Nakamura K
• Home-based Inspiratory Muscle Training in Patients With Heart Failure and Preserved Ejection Fraction: A Preliminary Study.
  Journal of cardiac failure 2020 Kinugasa Y, Sota T, Ishiga N, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Yamamoto K
• Disseminated Intravascular Coagulopathy Is Associated with the Outcome of Persistent Inflammation, Immunosuppression and Catabolism Syndrome.
  Journal of clinical medicine 2020 Nakamura K, Ogura K, Nakano H, Naraba H, Takahashi Y, Sonoo T, Hashimoto H, Goto T
• High protein versus medium protein delivery under equal total energy delivery in critical care: A randomized controlled trial.
  Clinical nutrition (Edinburgh, Scotland) 2020 Nakamura K, Nakano H, Naraba H, Mochizuki M, Takahashi Y, Sonoo T, Hashimoto H, Morimura N
• Gram-negative Organisms from Patients with Community-Acquired Urinary Tract Infections and Associated Risk Factors for Antimicrobial Resistance: A Single-Center Retrospective Observational Study in Japan.
  Antibiotics (Basel, Switzerland) 2020 Kanda N, Hashimoto H, Sonoo T, Naraba H, Takahashi Y, Nakamura K, Hatakeyama S
• Levetiracetam vs. Fosphenytoin for Second-Line Treatment of Status Epilepticus: Propensity Score Matching Analysis Using a Nationwide Inpatient Database.
  Frontiers in neurology 2020 Nakamura K, Ohbe H, Matsui H, Takahashi Y, Marushima A, Inoue Y, Fushimi K, Yasunaga H
• Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study.
  Critical care (London, England) 2020 Nakano H, Matsubara T, Yamakawa K, Nakamura K
• Changes in Real-world Practice Patterns of Antiepileptic Drugs for Status Epilepticus: A Nationwide Observational Study in Japan.
  Neurologia medico-chirurgica 2020 Nakamura K, Ohbe H, Matsui H, Takahashi Y, Marushima A, Inoue Y, Fushimi K, Yasunaga H
• C-reactive protein clustering to clarify persistent inflammation, immunosuppression and catabolism syndrome.
  Intensive care medicine 2020 Nakamura K, Ogura K, Nakano H, Naraba H, Takahashi Y, Sonoo T, Hashimoto H, Morimura N
• Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Zhang J, Shang Y, Kamiya S, Kotowski SJ, Nakamura K, Huang EJ
• Podoplanin expression on endothelial cells promotes superficial erosive injury and thrombus formation in rat carotid artery: Implications for plaque erosion.
  Thrombosis research 2019 Furukoji E, Yamashita A, Nakamura K, Hirai T, Asada Y
• To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.
  Brain communications 2019 de Haas R, Heltzel LCMW, Tax D, van den Broek P, Steenbreker H, Verheij MMM, Russel FGM, Orr AL, Nakamura K, Smeitink JAM
• Change in right ventricular function in an American cocker spaniel with acute pulmonary thromboembolism.
  The Journal of veterinary medical science 2019 Morita T, Nakamura K, Osuga T, Hanazono K, Morishita K, Takiguchi M
• Findings of contrast-enhanced ultrasonography with Sonazoid for cholangiocellular adenoma in three dogs.
  The Journal of veterinary medical science 2019 Tamura M, Nakamura K, Osuga T, Shimbo G, Sasaki N, Morishita K, Ohta H, Takiguchi M
• Polypharmacy and taste disorders in heart failure patients.
  European journal of preventive cardiology 2019 Kinugasa Y, Nakayama N, Sugihara S, Mizuta E, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Yamamoto K
• β-Hydroxy-β-methylbutyrate, Arginine, and Glutamine Complex on Muscle Volume Loss in Critically Ill Patients: A Randomized Control Trial.
  JPEN. Journal of parenteral and enteral nutrition 2019 Nakamura K, Kihata A, Naraba H, Kanda N, Takahashi Y, Sonoo T, Hashimoto H, Morimura N
• Effect of acute volume loading on left atrial strain values derived from two-dimensional speckle tracking echocardiography in dogs.
  The Journal of veterinary medical science 2019 Dermlim A, Osuga T, Nakamura K, Morita T, Nisa K, Sasaoka K, Leela-Arporn R, Nagata N, Tamura M, Sasaki N, Ohta H, Takiguchi M
• Predictive factors of malignancy in dogs with focal liver lesions using clinical data and ultrasonographic features.
  The Journal of veterinary medical science 2019 Leela-Arporn R, Ohta H, Tamura M, Nagata N, Sasaoka K, Dermlim A, Nisa K, Morishita K, Sasaki N, Nakamura K, Takagi S, Hosoya K, Takiguchi M
• Pectin-containing liquid enteral nutrition for critical care: a historical control and propensity score matched study.
  Asia Pacific journal of clinical nutrition 2019 Nakamura K, Inokuchi R, Fukushima K, Naraba H, Takahashi Y, Sonoo T, Hashimoto H, Doi K, Morimura N
• Independent Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Syndrome Clones in a Patient With Complete Bone Marrow Failure.
  HemaSphere 2018 Mita M, Shichishima T, Noji H, Takahashi H, Nakamura KI, Ikezoe T
• Effects of immunosuppressive prednisolone therapy on pancreatic tissue and concentration of canine pancreatic lipase immunoreactivity in healthy dogs.
  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 2018 Ohta H, Kojima K, Yokoyama N, Sasaki N, Kagawa Y, Hanazono K, Ishizuka T, Morishita K, Nakamura K, Takagi S, Takiguchi M
• Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis.
  Geriatrics & gerontology international 2018 Tomita KI, Aida J, Izumiyama-Shimomura N, Nakamura KI, Ishikawa N, Matsuda Y, Arai T, Ishiwata T, Kumasaka T, Takahashi-Fujigasaki J, Hiraishi N, Yamada M, Fujiwara M, Takubo K
• Mapping the Genetic Landscape of Human Cells.
  Cell 2018 Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA
• Pulmonary hypertension due to unclassified interstitial lung disease in a Pembroke Welsh corgi.
  The Journal of veterinary medical science 2018 Morita T, Nakamura K, Osuga T, Kobayashi A, Ichii O, Yabuki A, Takiguchi M
• Generation of efficient mutants of endoglycosidase from Streptococcus pyogenes and their application in a novel one-pot transglycosylation reaction for antibody modification.
  PloS one 2018 Iwamoto M, Sekiguchi Y, Nakamura K, Kawaguchi Y, Honda T, Hasegawa J
• The effect of sedation with a combination of butorphanol and midazolam on quantitative contrast-enhanced ultrasonography of duodenum in healthy dogs.
  The Journal of veterinary medical science 2018 Nisa K, Lim SY, Osuga T, Yokoyama N, Tamura M, Nagata N, Sasaoka K, Dermlim A, Leela-Arporn R, Morita T, Sasaki N, Morishita K, Nakamura K, Ohta H, Takiguchi M
• Correction to: Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization.
  Journal of gastroenterology 2018 Aoki Y, Aida J, Kawano Y, Nakamura KI, Izumiyama-Shimomura N, Ishikawa N, Arai T, Nakamura Y, Taniai N, Uchida E, Takubo K, Ishiwata T
• Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model.
  PloS one 2017 Sasaki N, Ishi K, Kudo N, Nakayama SMM, Nakamura K, Morishita K, Ohta H, Ishizuka M, Takiguchi M
• Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization.
  Journal of gastroenterology 2017 Aoki Y, Aida J, Kawano Y, Nakamura KI, Izumiyama-Shimomura N, Ishikawa N, Arai T, Nakamura Y, Taniai N, Uchida E, Takubo K, Ishiwata T
• A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
  Cell systems 2017 Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster …
• Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog.
  The Canadian veterinary journal = La revue veterinaire canadienne 2017 Osuga T, Nakamura K, Morita T, Kagawa Y, Ohta H, Takiguchi M
• Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs.
  The Journal of veterinary medical science 2017 Nisa K, Lim SY, Shinohara M, Nagata N, Sasaoka K, Dermlim A, Leela-Arporn R, Morita T, Yokoyama N, Osuga T, Sasaki N, Morishita K, Nakamura K, Ohta H, Takiguchi M
• Genome-Wide Analysis of ResD, NsrR, and Fur Binding in Bacillus subtilis during Anaerobic Fermentative Growth by In Vivo Footprinting.
  Journal of bacteriology 2017 Chumsakul O, Anantsri DP, Quirke T, Oshima T, Nakamura K, Ishikawa S, Nakano MM
• Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.
  Medicine 2017 Nakamura K, Inokuchi R, Daidoji H, Naraba H, Sonoo T, Hashimoto H, Tokunaga K, Hiruma T, Doi K, Morimura N
• Stimulation of colorectal biopsies from miniature dachshunds with inflammatory colorectal polyps with toll-like receptor ligands: A pilot study.
  Veterinary immunology and immunopathology 2017 Yokoyama N, Ohta H, Kagawa Y, Nagata N, Nisa K, Morita T, Osuga T, Sasaki N, Morishita K, Nakamura K, Takiguchi M
• Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload.
  Echocardiography (Mount Kisco, N.Y.) 2017 Morita T, Nakamura K, Osuga T, Yokoyama N, Morishita K, Sasaki N, Ohta H, Takiguchi M
• Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
  Neurochemistry international 2017 Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K
• PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.
  Cell chemical biology 2017 Haddad D, Nakamura K
• Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps.
  The Journal of veterinary medical science 2017 Yokoyama N, Ohta H, Kagawa Y, Leela-Arporn R, Dermlim A, Nisa K, Morita T, Osuga T, Sasaki N, Morishita K, Nakamura K, Takiguchi M
• Reply: Novel Interest About Cardiac Variation of Internal Jugular Vein for the Evaluation of the Hemodynamics.
  Ultrasound in medicine & biology 2016 Nakamura K
• Reply: Postpartum high fever and imitators of HELLP syndrome.
  The American journal of emergency medicine 2016 Nakamura K
• Synthesis, Structure, Optical, and Electrochemical Properties of Triple- and Quadruple-Decker Co-facial Tetrathiafulvalene Arrays.
  Chemistry (Weinheim an der Bergstrasse, Germany) 2016 Hasegawa M, Nakamura K, Tokunaga S, Baba Y, Shiba R, Shirahata T, Mazaki Y, Misaki Y
• Switching therapy from intravenous beta blocker to bisoprolol transdermal patch for atrial fibrillation tachycardia.
  Journal of anesthesia 2016 Nakamura K, Inokuchi R, Hiruma T, Tokunaga K, Doi K, Nakajima S
• Hypercalcemia in a Dog with Chronic Ingestion of Maxacalcitol Ointment.
  Journal of the American Animal Hospital Association 2016 Nakamura K, Tohyama N, Yamasaki M, Ohta H, Morishita K, Takiguchi M
• Recombinant thrombomodulin for secondary thrombotic thrombocytopenic purpura.
  Medicine 2016 Nakamura K, Inokuchi R, Hiruma T, Ohshima K, Sonoo T, Tokunaga K, Doi K, Nakajima S
• Telomere attrition in beta and alpha cells with age.
  Age (Dordrecht, Netherlands) 2016 Tamura Y, Izumiyama-Shimomura N, Kimbara Y, Nakamura K, Ishikawa N, Aida J, Chiba Y, Matsuda Y, Mori S, Arai T, Fujiwara M, Poon SS, Ishizaki T, Araki A, Takubo K, Ito H
• Late postpartum HELLP syndrome over 10 days after delivery.
  The American journal of emergency medicine 2016 Nakamura K, Inokuchi R, Sonoo T, Hiruma T, Tokunaga K, Doi K
• Cardiac Variation of Internal Jugular Vein for the Evaluation of Hemodynamics.
  Ultrasound in medicine & biology 2016 Nakamura K, Qian K, Ando T, Inokuchi R, Doi K, Kobayashi E, Sakuma I, Nakajima S, Yahagi N
• Efficacy of non-vitamin K antagonist oral anticoagulants for Lemierre syndrome.
  The American journal of emergency medicine 2016 Kubota M, Daidoji H, Takaya N, Tokunaga K, Sonoo T, Nakamura K
• Changes of telomere status with aging: An update.
  Geriatrics & gerontology international 2016 Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Matsuda Y, Arai T, Takubo K
• Continuous veno-venous hemodialysis and filtration for extensive burn with severe hypernatremia.
  Acute medicine & surgery 2015 Nakamura K, Inokuchi R, Hiruma T, Omura T, Ohshima K, Tokunaga K, Ueda A, Doi K
• Severe Hemorrhage from Cervical Cancer Managed with Foley Catheter Balloon Tamponade.
  The western journal of emergency medicine 2015 Sonoo T, Inokuchi R, Yamamoto M, Nakamura K, Nakajima S, Yahagi N
• Prospective analysis of cardiac collapsibility of inferior vena cava using ultrasonography.
  Journal of critical care 2015 Sonoo T, Nakamura K, Ando T, Sen K, Maeda A, Kobayashi E, Sakuma I, Doi K, Nakajima S, Yahagi N
• Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.
  Cell death & disease 2015 Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K
• Crowned dens syndrome.
  The spine journal : official journal of the North American Spine Society 2015 Inokuchi R, Ohshima K, Yamamoto M, Fukuda T, Nakamura K
• A Melanocytic Lesion Extending From the Right Ear to the Nasopharynx in a Pediatric Patient: A Case Report.
  The Annals of otology, rhinology, and laryngology 2015 Saito C, Ishikawa K, Nakamura K, Fujita A, Shimizu M, Fukushima N, Nishino H, Ichimura K
• Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas.
  PloS one 2015 Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, Hamayasu H, Fujiwara M, Tomita K, Hiraishi N, Nakamura K, Ishikawa N, Aida J, Takubo K, Arai T
• Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study.
  Medicine 2015 Inokuchi R, Ohashi-Fukuda N, Nakamura K, Wada T, Gunshin M, Kitsuta Y, Nakajima S, Yahagi N
• Donor age and operational tolerance in living donor liver transplantation.
  Pediatric transplantation 2015 Sanada Y, Kawano Y, Ishikawa N, Aida J, Nakamura K, Izumiyama-Shimomura N, Urahashi T, Ihara Y, Okada N, Yamada N, Hirata Y, Takubo K, Mizuta K
• Linezolid is a novel and effective treatment for septic pulmonary embolism.
  The American journal of emergency medicine 2015 Yasuda M, Inokuchi R, Ohshima K, Yamamoto M, Tokunaga K, Fukuda T, Nakamura K
• Psoriatic erythroderma-induced septicaemia causing Janeway lesions.
  BMJ case reports 2014 Yamamoto M, Inokuchi R, Nakamura K, Yahagi N
• How long should resuscitative efforts be continued in adult out-of-hospital cardiac arrest?
  The Canadian journal of cardiology 2014 Fukuda T, Nakamura K, Fukuda-Ohashi N, Yahagi N
• Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K
• In vitro and in vivo safety and efficacy studies of amphotericin B on Babesia gibsoni.
  Veterinary parasitology 2014 Yamasaki M, Harada E, Tamura Y, Lim SY, Ohsuga T, Yokoyama N, Morishita K, Nakamura K, Ohta H, Takiguchi M
• Recombinant thrombomodulin monotherapy for secondary thrombotic thrombocytopenic purpura.
  The American journal of emergency medicine 2014 Ebisawa K, Fukuda T, Inokuchi R, Nakamura K
• Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease.
  American journal of veterinary research 2014 Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim SY, Tamura Y, Morishita K, Nakamura K, Yamasaki M, Takiguchi M
• Evaluation of selected cytokine gene expression in colonic mucosa from dogs with idiopathic lymphocytic-plasmacytic colitis.
  The Journal of veterinary medical science 2014 Tamura Y, Ohta H, Yokoyama N, Lim SY, Osuga T, Morishita K, Nakamura K, Yamasaki M, Takiguchi M
• Serum Free Light Chain Only Myeloma with Cytoplasmic IgM.
  Case reports in hematology 2014 Ebana H, Nakamura K, Nozawa Y, Seki R, Mita M
• β-cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length.
  The Journal of clinical endocrinology and metabolism 2014 Tamura Y, Izumiyama-Shimomura N, Kimbara Y, Nakamura K, Ishikawa N, Aida J, Chiba Y, Mori S, Arai T, Aizawa T, Araki A, Takubo K, Ito H
• Primary pleomorphic adenoma of the external auditory canal: a case report and review of the literature.
  Case reports in otolaryngology 2014 Saito C, Kanazawa T, Yamaguchi T, Nakamura K, Ichimura K
• Granulocyte colony-stimulating factor-producing lung cancer and acute respiratory distress syndrome.
  The clinical respiratory journal 2014 Inokuchi R, Manabe H, Ohta F, Nakamura K, Nakajima S, Yahagi N
• Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia.
  Transplant international : official journal of the European Society for Organ Transplantation 2014 Sanada Y, Kawano Y, Miki A, Aida J, Nakamura K, Shimomura N, Ishikawa N, Arai T, Hirata Y, Yamada N, Okada N, Wakiya T, Ihara Y, Urahashi T, Yasuda Y, Takubo K, Mizuta K
• Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Skibinski G, Nakamura K, Cookson MR, Finkbeiner S
• CD4⁺ T cell cytokine gene and protein expression in duodenal mucosa of dogs with inflammatory bowel disease.
  The Journal of veterinary medical science 2013 Ohta H, Takada K, Sunden Y, Tamura Y, Osuga T, Lim SY, Murakami M, Sasaki N, Wickramasekara Rajapakshage BK, Nakamura K, Yamasaki M, Takiguchi M
• SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.
  Aging 2013 Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U
• Recurrent hemarthrosis after total knee arthroplasty caused by the impingement of a remnant lateral meniscus: a case report.
  The Knee 2013 Kawata M, Inui H, Taketomi S, Nakamura K, Nakagawa T, Tanaka S
• Clinical outcome of anatomic double-bundle ACL reconstruction and 3D CT model-based validation of femoral socket aperture position.
  Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2013 Taketomi S, Inui H, Nakamura K, Hirota J, Sanada T, Masuda H, Takeda H, Tanaka S, Nakagawa T
• Energy failure: does it contribute to neurodegeneration?
  Annals of neurology 2013 Pathak D, Berthet A, Nakamura K
• Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH.
  Gene 2013 Nakamura K, Ishikawa N, Izumiyama N, Aida J, Kuroiwa M, Hiraishi N, Fujiwara M, Nakao A, Kawakami T, Poon SS, Matsuura M, Sawabe M, Arai T, Takubo K
• Markedly increased expression of interleukin-8 in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds.
  Veterinary immunology and immunopathology 2013 Tamura Y, Ohta H, Torisu S, Yuki M, Yokoyama N, Murakami M, Lim SY, Osuga T, Morishita K, Nakamura K, Yamasaki M, Takiguchi M
• Adult-onset seizures in a patient with Down syndrome and portosystemic shunt.
  Brain & development 2013 Inokuchi R, Nakamura K, Mizuno N, Sato H, Shinohara K, Matsubara T, Doi K, Ishii T, Gunshin M, Nakajima S, Yahagi N
• The proportion of clinically relevant alarms decreases as patient clinical severity decreases in intensive care units: a pilot study.
  BMJ open 2013 Inokuchi R, Sato H, Nanjo Y, Echigo M, Tanaka A, Ishii T, Matsubara T, Doi K, Gunshin M, Hiruma T, Nakamura K, Shinohara K, Kitsuta Y, Nakajima S, Umezu M, Yahagi N
• The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
  Nature 2013 Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS
• Hyperammonemia in idiopathic epileptic seizure.
  The American journal of emergency medicine 2013 Nakamura K, Yamane K, Shinohara K, Doi K, Inokuchi R, Hiruma T, Nakajima S, Noiri E, Yahagi N
• A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.
  Cell 2013 Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM
• Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization.
  Tissue & cell 2013 Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Kuroiwa M, Poon SS, Arai T, Toyoda M, Akutsu H, Umezawa A, Nakamura K, Takubo K
• Specific antibody in IV immunoglobulin for postsplenectomy sepsis.
  Critical care medicine 2013 Nakamura K, Doi K, Okamoto K, Arai S, Ueha S, Matsushima K, Nakajima S, Yahagi N, Noiri E
• Expression of CD4+ T cell cytokine genes in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds.
  Veterinary immunology and immunopathology 2013 Ohta H, Takada K, Torisu S, Yuki M, Tamura Y, Yokoyama N, Osuga T, Lim SY, Murakami M, Sasaki N, Nakamura K, Yamasaki M, Takiguchi M
• Ultrasound image-guided therapy enhances antitumor effect of cisplatin.
  Journal of medical ultrasonics (2001) 2013 Sasaki N, Kudo N, Nakamura K, Lim SY, Murakami M, Kumara WR, Tamura Y, Ohta H, Yamasaki M, Takiguchi M
• α-Synuclein and mitochondria: partners in crime?
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013 Nakamura K
• Repeatability and reproducibility of measurements obtained via two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs.
  American journal of veterinary research 2013 Osuga T, Nakamura K, Lim SY, Tamura Y, Kumara WR, Murakami M, Sasaki N, Morishita K, Ohta H, Yamasaki M, Takiguchi M
• EDTA-dependent pseudothrombocytopenia complicated by eosinophilic pneumonia.
  The American journal of emergency medicine 2013 Ohashi N, Nakamura K, Inokuchi R, Sato H, Tokunaga K, Fukuda T, Nakajima S, Yahagi N
• Putamen hemorrhage occurred simultaneously with Stanford type A acute aortic dissection: a case report.
  The American journal of emergency medicine 2013 Sonoo T, Wada T, Inokuchi R, Nakamura K, Nakajima S, Yahagi N
• Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.
  PloS one 2013 Aida J, Yokoyama A, Shimomura N, Nakamura K, Ishikawa N, Terai M, Poon S, Matsuura M, Fujiwara M, Sawabe M, Arai T, Takubo K
• Cardiac variation of inferior vena cava: new concept in the evaluation of intravascular blood volume.
  Journal of medical ultrasonics (2001) 2013 Nakamura K, Tomida M, Ando T, Sen K, Inokuchi R, Kobayashi E, Nakajima S, Sakuma I, Yahagi N
• Development of information systems and clinical decision support systems for emergency departments: a long road ahead for Japan.
  Emergency medicine journal : EMJ 2013 Inokuchi R, Sato H, Nakajima S, Shinohara K, Nakamura K, Gunshin M, Hiruma T, Ishii T, Matsubara T, Kitsuta Y, Yahagi N
• Bronchial ulceration as a prognostic indicator for varicella pneumonia: case report and systematic literature review.
  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2013 Inokuchi R, Nakamura K, Sato H, Shinohara K, Aoki Y, Doi K, Gunshin M, Ishii T, Matsubara T, Hiruma T, Nakajima S, Yahagi N
• Addition of cyclic ureas and 1-methyl-2-oxazolidone to pyridynes: a new approach to pyridodiazepines, pyridodiazocines, and pyridooxazepines.
  Organic letters 2013 Saito N, Nakamura K, Shibano S, Ide S, Minami M, Sato Y
• Association of telomere shortening in myocardium with heart weight gain and cause of death.
  Scientific reports 2013 Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Sawabe M, Arai T, Fujiwara M, Ishii A, Nakamura K, Takubo K
• Mitochondrial dynamics in neurodegeneration.
  Trends in cell biology 2012 Itoh K, Nakamura K, Iijima M, Sesaki H
• Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro.
  The Japanese journal of veterinary research 2012 Rajapakshage BK, Yamasaki M, Murakami M, Tamura Y, Lim SY, Osuga T, Sasaki N, Nakamura K, Ohta H, Takiguchi M
• Bilateral segmental aplasia with unilateral uterine horn torsion in a Pomeranian bitch.
  Journal of the American Animal Hospital Association 2012 Nakamura K, Yamasaki M, Osaki T, Ohta H, Sasaki N, Aoshima K, Kimura T, Takiguchi M
• Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
  The Journal of biological chemistry 2012 Nakamura K, Man Z, Xie Y, Hanai A, Makyio H, Kawasaki M, Kato R, Shin HW, Nakayama K, Wakatsuki S
• Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturate.
  The Journal of veterinary medical science 2012 Wickramasekara Rajapakshage BK, Yamasaki M, Hwang SJ, Sasaki N, Murakami M, Tamura Y, Lim SY, Nakamura K, Ohta H, Takiguchi M
• Activation of microbubbles by short-pulsed ultrasound enhances the cytotoxic effect of cis-diamminedichloroplatinum (II) in a canine thyroid adenocarcinoma cell line in vitro.
  Ultrasound in medicine & biology 2011 Sasaki N, Kudo N, Nakamura K, Lim SY, Murakami M, Kumara WR, Tamura Y, Ohta H, Yamasaki M, Takiguchi M
• Expression and subcellular localization of apical junction proteins in canine duodenal and colonic mucosa.
  American journal of veterinary research 2011 Ohta H, Yamaguchi T, Rajapakshage BK, Murakami M, Sasaki N, Nakamura K, Hwang SJ, Yamasaki M, Takiguchi M
• Effects and mechanisms of action of polyene macrolide antibiotic nystatin on Babesia gibsoni in vitro.
  The Journal of parasitology 2011 Yamasaki M, Tamura N, Nakamura K, Sasaki N, Murakami M, Rajapakshage W, Kumara B, Tamura Y, Lim SY, Ohta H, Takiguchi M
• Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age.
  Age (Dordrecht, Netherlands) 2011 Ishikawa N, Nakamura K, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K
• Dimeric and trimeric tetrathiafulvalenes with strong intramolecular interactions in the oxidized states.
  Organic letters 2011 Nakamura K, Takashima T, Shirahata T, Hino S, Hasegawa M, Mazaki Y, Misaki Y
• Detection of anti-Babesia gibsoni heat shock protein 70 antibody and anti-canine heat shock protein 70 antibody in sera from Babesia gibsoni-infected dogs.
  Veterinary parasitology 2011 Yamasaki M, Ishida M, Nakamura K, Sasaki N, Murakami M, Kumara WR, Tamura Y, Lim SY, Ohta H, Takiguchi M
• Alcoholics show reduced telomere length in the oesophagus.
  The Journal of pathology 2010 Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
• Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate.
  The Japanese journal of veterinary research 2010 Hwang SJ, Yamasaki M, Nakamura K, Sasaki N, Murakami M, Kumara B, Rajapakshage W, Ohta H, Maede Y, Takiguchi M
• Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence.
  Mechanisms of ageing and development 2010 Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon SS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K
• Babesia gibsoni: detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis.
  Experimental parasitology 2010 Yamasaki M, Kobayashi Y, Nakamura K, Sasaki N, Murakami M, Rajapakshage BK, Ohta H, Yamato O, Maede Y, Takiguchi M
• Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ.
  The Journal of pathology 2010 Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J
• Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
  Neuron 2010 Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH
• Contrast-enhanced ultrasonography for characterization of canine focal liver lesions.
  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 2010 Nakamura K, Takagi S, Sasaki N, Bandula Kumara WR, Murakami M, Ohta H, Yamasaki M, Takiguchi M
• The behavior of alpha-synuclein in neurons.
  Movement disorders : official journal of the Movement Disorder Society 2010 Fortin DL, Nemani VM, Nakamura K, Edwards RH
• Effects and mechanisms of action of ionophorous antibiotics valinomycin and salinomycin-Na on Babesia gibsoni in vitro.
  The Journal of parasitology 2009 Yamasaki M, Nakamura K, Tamura N, Hwang SJ, Yoshikawa M, Sasaki N, Ohta H, Yamato O, Maede Y, Takiguchi M
• Telomere lengths in the oral epithelia with and without carcinoma.
  European journal of cancer (Oxford, England : 1990) 2009 Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fujiwara M, Sawabe M, Arai T, Takubo K
• Primary splenic torsion in a Boston terrier.
  The Journal of veterinary medical science 2009 OHTA H, TAKAGI S, MURAKAMI M, SASAKI N, YOSHIKAWA M, NAKAMURA K, HWANG SJ, YAMASAKI M, TAKIGUCHI M
• [Telomere].
  Nihon rinsho. Japanese journal of clinical medicine 2009 Takubo K, Nakamura K, Shimomura N, Ishikawa N, Aida J
• Quantitative contrast-enhanced ultrasonography of canine spleen.
  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 2009 Nakamura K, Sasaki N, Yoshikawa M, Ohta H, Hwang SJ, Mimura T, Yamasaki M, Takiguchi M
• Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH
• Survey of the distribution of different types of nitrogenases and hydrogenases in heterocyst-forming cyanobacteria.
  Marine biotechnology (New York, N.Y.) 2008 Masukawa H, Zhang X, Yamazaki E, Iwata S, Nakamura K, Mochimaru M, Inoue K, Sakurai H
• Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts.
  Human pathology 2008 Kurabayashi R, Takubo K, Aida J, Honma N, Poon SS, Kammori M, Izumiyama-Shimomura N, Nakamura K, Tsuji E, Matsuura M, Ogawa T, Kaminishi M
• Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.
  Experimental gerontology 2008 Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, Kammori M, Sawabe M, Arai T, Matsuura M, Fujiwara M, Kishimoto H, Takubo K
• The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life.
  Mechanisms of ageing and development 2008 Hatakeyama H, Nakamura K, Izumiyama-Shimomura N, Ishii A, Tsuchida S, Takubo K, Ishikawa N
• Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field.
  International journal of molecular medicine 2007 Kammori M, Poon SS, Nakamura K, Izumiyama N, Ishikawa N, Kobayashi M, Naomoto Y, Takubo K
• Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method.
  Human pathology 2007 Aida J, Izumiyama-Shimomura N, Nakamura K, Ishii A, Ishikawa N, Honma N, Kurabayashi R, Kammori M, Poon SS, Arai T, Takubo K
• Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older.
  Experimental gerontology 2007 Nakamura K, Takubo K, Izumiyama-Shimomura N, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Kato M, Oshimura M, Ishii A, Ishikawa N
• Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.
  Movement disorders : official journal of the Movement Disorder Society 2007 Nakamura K, Christine CW, Starr PA, Marks WJ
• Huntington's disease: clinical characteristics, pathogenesis and therapies.
  Drugs of today (Barcelona, Spain : 1998) 2007 Nakamura K, Aminoff MJ
• Novel mutation (Asp158Val) in H1 domain of keratin 5 gene in a Japanese patient with Köbner-type epidermolysis bullosa simplex.
  The Journal of dermatology 2006 Saeki H, Nakamura K, Tsunemi Y, Komine M, Tamaki K
• Telomere shortening with aging in the human pancreas.
  Experimental gerontology 2006 Ishii A, Nakamura K, Kishimoto H, Honma N, Aida J, Sawabe M, Arai T, Fujiwara M, Takeuchi F, Kato M, Oshimura M, Izumiyama N, Takubo K
• Specific subtelomere loss on chromosome der(11)t(3;11)(q23;q23)x2 in anaplastic thyroid cancer cell line OCUT-1.
  International journal of molecular medicine 2006 Kammori M, Onoda N, Nakamura K, Izumiyama N, Ogisawa K, Kurabayashi R, Ogawa T, Kaminishi M, Poon SS, Takubo K
• Textbook of neural repair and rehabilitation (eds Selzer ME, Cohen L, Gage FH, Clarke S and Duncan PW)
  Trophic factor delivery by gene therapy 2006 Nakamura K Kang UJ
• Expression of human telomerase reverse transcriptase gene and protein, and of estrogen and progesterone receptors, in breast tumors: preliminary data from neo-adjuvant chemotherapy.
  International journal of oncology 2005 Kammori M, Izumiyama N, Hashimoto M, Nakamura K, Okano T, Kurabayashi R, Naoki H, Honma N, Ogawa T, Kaminishi M, Takubo K
• Lipid rafts mediate the synaptic localization of alpha-synuclein.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH
• Vitamin B12 deficiency.
  Archives of neurology 2004 Nakamura K, Mukherjee P, Swanson RA
• Solubilization of dynein from Tetrahymena ssp. axonemes using phosphate analogues.
  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003 Nakamura K, Tanaka M
• Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases.
  Aging clinical and experimental research 2003 Arai T, Nakahara K, Matsuoka H, Sawabe M, Chida K, Matsushita S, Takubo K, Honma N, Nakamura K, Izumiyama N, Esaki Y
• Assay of phosphatase activity and ATP biomass in tideland sediments and classification of the intertidal area using chemical values.
  Marine pollution bulletin 2003 Nakamura K, Takaya C
• Demonstration of human telomerase reverse transcriptase (hTERT) in human parathyroid tumours by in situ hybridization with a new oligonucleotide probe.
  Clinical endocrinology 2003 Kammori M, Nakamura K, Ogawa T, Mafune K, Tatutomi Y, Obara T, Onoda N, Fujiwara M, Izumiyama-Shimomura N, Mori M, Kaminishi M, Takubo K
• Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease.
  Annals of neurology 2003 Kang UJ, Nakamura K
• Proposed mechanism for the reaction catalyzed by a diterpene cyclase, aphidicolan-16beta-ol synthase: experimental results on biomimetic cyclization and examination of the cyclization pathway by ab initio calculations.
  Journal of the American Chemical Society 2002 Oikawa H, Nakamura K, Toshima H, Toyomasu T, Sassa T
• Consistent decrease in telomere length in parathyroid tumors but alteration in telomerase activity limited to malignancies: preliminary report.
  World journal of surgery 2002 Kammori M, Nakamura K, Kanauchi H, Obara T, Kawahara M, Mimura Y, Kaminishi M, Takubo K
• Telomere shortening with aging in human thyroid and parathyroid tissue.
  Experimental gerontology 2002 Kammori M, Nakamura K, Kawahara M, Mimura Y, Kaminishi M, Takubo K
• The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models.
  Cell transplantation 2000 Nakamura K, Ahmed M, Barr E, Leiden JM, Kang UJ
• Preferential resistance of dopaminergic neurons to glutathione depletion in a reconstituted nigrostriatal system.
  Brain research 2000 Nakamura K, Won L, Heller A, Kang UJ
• The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited.
  Molecular pharmacology 2000 Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ
• Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin.
  Journal of neurochemistry 2000 Nakamura K, Wright DA, Wiatr T, Kowlessur D, Milstien S, Lei XG, Kang UJ
• Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys.
  The Journal of clinical endocrinology and metabolism 1999 Brommage R, Hotchkiss CE, Lees CJ, Stancill MW, Hock JM, Jerome CP
• The role of glutathione in dopaminergic neuronal survival.
  Journal of neurochemistry 1997 Nakamura K, Wang W, Kang UJ
• Single core polypeptide in the reaction center of the photosynthetic bacterium Heliobacillus mobilis: structural implications and relations to other photosystems.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Liebl U, Mockensturm-Wilson M, Trost JT, Brune DC, Blankenship RE, Vermaas W