Kelly Wentworth, MD
Assistant Professor
Medicine
School of Medicine

My research focuses on understanding the role of Gs-protein coupled receptor signaling in skeletal development, with a focused interest in craniofacial fibrous dysplasia of the bone (FD) and McCune-Albright syndrome (MAS).

Education & Training

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• non-ACGME Endocrinology Research Fellowship University of California 2019
• Fellowship- Diabetes, Endocrinology and Metabolism University of California 2017
• Residency-Internal Medicine University of Washington 2011
• MD Medicine University of Connecticut School of Medicine 2008
• BA Biology University of Rochester 2003

Grants and Projects

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• Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone, NIH, 2024-2026
• ASBMR Rising Star Award, American Society of Bone and Mineral Research, 2021-2024
• Dissecting the Cellular and Molecular Mechanisms Contributing to Craniofacial Fibrous Dysplasia, NIH, 2019-2024
• Identification and Signaling Characterization of GNAS R201H/C Selective Inhibitors for FD/MAS, University of Pennsylvania/Million Dollar Bike Ride Program, 2022-2023
• Elucidating the Role of GNAS Mosaicism in Fibrous Dysplastic Lesions, Million Dollar Bike Ride Grant Program, 2019-2020
• A Human Pluripotent Stem Cell Model for Elucidating Cell Fate Defects in McCune-Albright Syndrome, NIH, 2017-2019
• , Eli and Edythe Broad Stem Cell Fellowship, 2016-2017

Publications (20)

Top publication keywords:
High-Throughput Screening AssaysDrug DiscoveryAzathioprineMyositis OssificansBone RemodelingOsteoporosisActivin Receptors, Type IPyrazolesBone and BonesStilbenesDrug HypersensitivityHypoparathyroidismOssification, HeterotopicSirolimusArthroplasty, Replacement, Hip

• Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS
• AI is a viable alternative to high throughput screening: a 318-target study.
  Scientific reports 2024 Atomwise AIMS Program
• Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.
  JBMR plus 2024 Lung H, Wentworth KL, Moody T, Zamarioli A, Ram A, Ganesh G, Kang M, Ho S, Hsiao EC
• Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM
• Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor KE, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC

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• Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.
  The Journal of clinical endocrinology and metabolism 2022 Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL
• ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
  Pain 2022 Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC
• Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
  Orphanet journal of rare diseases 2022 Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC
• Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.
  Orphanet journal of rare diseases 2020 Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC
• Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-γ agonist palovarotene: a case report.
  BMC musculoskeletal disorders 2020 Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC
• Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.
  Frontiers in endocrinology 2020 Lung H, Hsiao EC, Wentworth KL
• New Frontiers in Osteoporosis Therapy.
  Annual review of medicine 2019 Cheng C, Wentworth K, Shoback DM
• Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken.
  JAMA internal medicine 2019 Wentworth K, Shoback D
• Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.
  British journal of clinical pharmacology 2019 Wentworth KL, Masharani U, Hsiao EC
• NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
  JCI insight 2018 Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC
• Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva.
  Bone 2017 Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC
• A Novel T55A Variant of Gs α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.
  Case reports in endocrinology 2016 Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC
• Pocket change: a simple educational intervention increases hospitalist documentation of comorbidities and improves hospital quality performance measures.
  Quality management in health care 2015 Sparks R, Salskov AH, Chang AS, Wentworth KL, Gupta PP, Staiger TO, Anawalt BD
• Three hospital admissions in 9 days to diagnose azathioprine hypersensitivity in a patient with Crohn's disease.
  American journal of therapeutics 2015 Mookherjee S, Narayanan M, Uchiyama T, Wentworth KL
• Faculty development for hospitalists: structured peer observation of teaching.
  Journal of hospital medicine 2014 Mookherjee S, Monash B, Wentworth KL, Sharpe BA