Keith Yamamoto, PhD
Professor
Cellular Molecular Pharmacology
School of Medicine

Dr. Yamamoto currently serves as the Vice Chancellor for Science Policy and Strategy and the Director of Precision Medicine at UCSF.

In 2022, Yamamoto was elected president of the American Association for the Advancement of Science, the largest multidisciplinary scientific society in the world.

• Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.
  Leukemia 2020 Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing …
• A New Tool for Inducible Gene Expression in Caenorhabditis elegans.
  Genetics 2018 Monsalve GC, Yamamoto KR, Ward JD
• Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.
  Nature 2018 Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, …
• Internship Experiences Contribute to Confident Career Decision Making for Doctoral Students in the Life Sciences.
  CBE life sciences education 2018 Schnoes AM, Caliendo A, Morand J, Dillinger T, Naffziger-Hirsch M, Moses B, Gibeling JC, Yamamoto KR, Lindstaedt B, McGee R, O'Brien TC
• Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation.
  Nucleic acids research 2017 Love MI, Huska MR, Jurk M, Schöpflin R, Starick SR, Schwahn K, Cooper SB, Yamamoto KR, Thomas-Chollier M, Vingron M, Meijsing SH
• Metabolic gatekeeper function of B-lymphoid transcription factors.
  Nature 2017 Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, …
• Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
  Nature reviews. Molecular cell biology 2017 Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR
• Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions.
  Cell 2016 Walter P, Yamamoto KR
• Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations.
  Worm 2016 Ratnappan R, Ward JD, Yamamoto KR, Ghazi A
• Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).
  The Journal of biological chemistry 2016 Pack LR, Yamamoto KR, Fujimori DG
• Precision medicine: Beyond the inflection point.
  Science translational medicine 2015 Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR
• Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms.
  Advances in experimental medicine and biology 2015 Granner DK, Wang JC, Yamamoto KR
• Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.
  PLoS genetics 2014 Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, Ghazi A
• Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes.
  Genome biology 2014 Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR
• SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation.
  Worm 2014 Ward JD, Yamamoto KR, Asahina M
• Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses.
  PloS one 2014 Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR
• Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR
• Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development.
  PLoS genetics 2013 Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR
• A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto KR, Meijsing SH
• The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals.
  Nature structural & molecular biology 2013 Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR
• Commentary: Team science.
  Academic medicine : journal of the Association of American Medical Colleges 2013 O'Brien T, Yamamoto K, Hawgood S
• Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Chen SH, Masuno K, Cooper SB, Yamamoto KR
• Leveraging crowdsourcing to facilitate the discovery of new medicines.
  Science translational medicine 2011 Norman TC, Bountra C, Edwards AM, Yamamoto KR, Friend SH
• The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner.
  Molecular and cellular biology 2011 Engel KB, Yamamoto KR
• Occupancy of chromatin organizers in the Epstein-Barr virus genome.
  Virology 2011 Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ
• A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression.
  Molecular cancer research : MCR 2011 Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR
• Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC
• Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate.
  The Journal of biological chemistry 2011 Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ
• Reciprocal intronic and exonic histone modification regions in humans.
  Nature structural & molecular biology 2010 Huff JT, Plocik AM, Guthrie C, Yamamoto KR
• Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.
  Genome research 2010 DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L…
• Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.
  Molecular systems biology 2010 Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ
• Nuclear hormone receptors in nematodes: evolution and function.
  Molecular and cellular endocrinology 2010 Taubert S, Ward JD, Yamamoto KR
• Integrated biology and undergraduate science education: a new biology education for the twenty-first century?
  CBE life sciences education 2010 Labov JB, Reid AH, Yamamoto KR
• Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.
  Endocrine reviews 2009 Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto KR, Haegeman G, De Bosscher K
• Glucocorticoid regulation of the circadian clock modulates glucose homeostasis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ
• DNA binding site sequence directs glucocorticoid receptor structure and activity.
  Science (New York, N.Y.) 2009 Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR
• Non-competitive androgen receptor inhibition in vitro and in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI
• Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro.
  Molecular biology of the cell 2008 Pantoja C, Huff JT, Yamamoto KR
• Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes.
  Proceedings of the National Academy of Sciences of the United States of America 2008 So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR
• The Mediator subunit MDT-15 confers metabolic adaptation to ingested material.
  PLoS genetics 2008 Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR
• Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV
• Cell- and gene-specific regulation of primary target genes by the androgen receptor.
  Genes & development 2007 Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto KR
• Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor.
  PLoS genetics 2007 So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR
• The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release.
  Molecular and cellular biology 2007 Meijsing SH, Elbi C, Luecke HF, Hager GL, Yamamoto KR
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Feldman BJ, Streeper RS, Farese RV, Yamamoto KR
• A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans.
  Genes & development 2006 Taubert S, Van Gilst MR, Hansen M, Yamamoto KR
• Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.
  Genes & development 2006 Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR
• A new era in the ethics of human embryonic stem cell research.
  Stem cells (Dayton, Ohio) 2005 Lo B, Zettler P, Cedars MI, Gates E, Kriegstein AR, Oberman M, Reijo Pera R, Wagner RM, Wuerth MT, Wolf LE, Yamamoto KR
• A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Van Gilst MR, Hadjivassiliou H, Yamamoto KR
• The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.
  Genes & development 2005 Luecke HF, Yamamoto KR
• Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
  PLoS biology 2005 Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR
• Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain.
  The Journal of biological chemistry 2004 Shostak Y, Yamamoto KR
• Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR
• Bankrolling stem-cell research with California dollars.
  The New England journal of medicine 2004 Yamamoto KR
• Identification of C. elegans DAF-12-binding sites, response elements, and target genes.
  Genes & development 2004 Shostak Y, Van Gilst MR, Antebi A, Yamamoto KR
• Informed consent in human oocyte, embryo, and embryonic stem cell research.
  Fertility and sterility 2004 Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR
• The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.
  The Journal of biological chemistry 2004 Wang JC, Walker A, Blackwell TK, Yamamoto KR
• Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.
  Molecular biology of the cell 2004 Freedman ND, Yamamoto KR
• Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.
  Molecular biology of the cell 2003 Tee MK, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto KR, Leitman DC
• Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR
• Medicine. Consent from donors for embryo and stem cell research.
  Science (New York, N.Y.) 2003 Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR
• Statement on scientific publication and security.
  Science (New York, N.Y.) 2003 Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse …
• Statement on the consideration of biodefence and biosecurity.
  Nature 2003 Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse …
• Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Rogatsky I, Luecke HF, Leitman DC, Yamamoto KR
• Disassembly of transcriptional regulatory complexes by molecular chaperones.
  Science (New York, N.Y.) 2002 Freeman BC, Yamamoto KR
• Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA.
  Journal of molecular biology 2000 van Tilborg MA, Lefstin JA, Kruiskamp M, Teuben J, Boelens R, Yamamoto KR, Kaptein R
• Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health.
  Science (New York, N.Y.) 1999 Alberts BM, Ayala FJ, Botstein D, Frank E, Holmes EW, Lee RD, Macagno ER, Marrack P, Oparil S, Orkin SH, Rubenstein AH, Slayman CW, Sparling PF, Squire LR, von Hippel PH, Yamamoto KR
• Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.
  Molecular and cellular biology 1996 Miller ME, Cairns BR, Levinson RS, Yamamoto KR, Engel DA, Smith MM
• Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains.
  The Journal of biological chemistry 1996 Xu M, Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS
• Hold 'em and fold 'em: chaperones and signal transduction.
  Science (New York, N.Y.) 1995 Bohen SP, Kralli A, Yamamoto KR
• Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations.
  Journal of molecular biology 1995 van Tilborg MA, Bonvin AM, Hård K, Davis AL, Maler B, Boelens R, Yamamoto KR, Kaptein R
• Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.
  Biochemistry 1993 Scherrer LC, Picard D, Massa E, Harmon JM, Simons SS, Yamamoto KR, Pratt WB
• Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.
  The Journal of biological chemistry 1993 Imai E, Miner JN, Mitchell JA, Yamamoto KR, Granner DK
• Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.
  The Journal of biological chemistry 1992 Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS
• The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors.
  Molecular endocrinology (Baltimore, Md.) 1992 Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR
• 1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element.
  Biochemistry 1991 Remerowski ML, Kellenbach E, Boelens R, van der Marel GA, van Boom JH, Maler BA, Yamamoto KR, Kaptein R
• Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain.
  The Journal of biological chemistry 1991 Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS
• Identification of the metal coordinating residues in the DNA binding domain of the glucocorticoid receptor by 113Cd-1H heteronuclear NMR spectroscopy.
  FEBS letters 1991 Kellenbach E, Maler BA, Yamamoto KR, Boelens R, Kaptein R
• Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.
  Nature 1991 Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB
• Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements.
  Journal of biomolecular NMR 1991 Kellenbach E, Härd T, Boelens R, Dahlman K, Carlstedt-Duke J, Gustafsson JA, van der Marel GA, van Boom JH, Maler B, Yamamoto KR
• Vectors for constitutive and inducible gene expression in yeast.
  Methods in enzymology 1991 Schena M, Picard D, Yamamoto KR
• The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast.
  Cell 1990 Privalsky ML, Sharif M, Yamamoto KR
• Mapping the HSP90 binding region of the glucocorticoid receptor.
  The Journal of biological chemistry 1990 Howard KJ, Holley SJ, Yamamoto KR, Distelhorst CW
• Solution structure of the glucocorticoid receptor DNA-binding domain.
  Science (New York, N.Y.) 1990 Härd T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA, Kaptein R
• Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.
  Genes & development 1989 Schena M, Freedman LP, Yamamoto KR
• Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells.
  Nature 1989 Eilers M, Picard D, Yamamoto KR, Bishop JM
• More fingers in hand.
  Cell 1988 Freedman LP, Yamamoto KR, Luisi BF, Sigler PB
• Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.
  The EMBO journal 1987 Rusconi S, Yamamoto KR