Keith Mostov, MD, PhD
Professor
Anatomy
School of Medicine
Formation and regeneration of epithelial organs.
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The Mostov Lab wants to understand how the shape, structure, and size of organs are determined during development, as well as how we can use that knowledge to foster the regeneration of damaged organs. Epithelia are the most common type of tissue in animals. Epithelial cells form sheets of cells that line surfaces and internal cavities. Most internal organs, such as the respiratory, digestive, genito-urinary and vascular systems, consist of a network of tubes that are lined by a single layer of epithelial cells, surrounded by other tissue types, such as muscle, neurons and connective tissue. We are studying how these epithelial tubes form and how they regenerate. We are using as models the tubes in several mammalian organ systems, such as the kidney and digestive system.
We are particularly interested in how the size of tubes is regulated and how this impacts regeneration. For instance, the mammalian small intestine consists of villi that project into the lumen of the intestine to increase the surface area available to absorb nutrients from the intestinal lumen. In between the villi are crypts, outpouchings of the wall of the small intestine. Epithelial stem cells are located at the base of the crypts. Some daughters of the stem cells differentiate and move up the crypts into the villi and are eventually shed from the tips of the villi. A single crypt stem cell can regenerate an entire crypt-villus structure.
The small intestine grows enormously in length both in the embryo and after birth, reaching a length of about 6 meters in the adult human. However, the small intestine never regenerates in length, either in the embryo or after birth. If the small intestine is abnormally short for any reason, such as mutation, injury or surgery, it can never recover in length. This is in stark contrast to the ability of a single stem cell in the base of the crypt to regenerate the entire crypt-villus structure. Almost nothing is known about the mechanisms that control the length of the small intestine. We have found multiple genes that control the length of the small intestine and have used them to uncover several signaling pathways that regulate the length of the small intestine. These genes and pathways open the door to therapies to promote regeneration of the length of the small intestine.
Awards
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- Inaugural Fellow Lifetime Achievement, American Society for Cell Biology, 2017
- MERIT Award, NIH NIAID, 2002-2012
- Established Investigator Award, American Heart Associatio, 1992-1995
- Scholar, Mallinckrodt Foundation, 1991-1994
- Investigator Award, Cancer Research Institute (New York), 1990-1992
- Scholar, Searle Foundation, 1989-1992
- Scholar, Hood Foundation, 1985-1988
- Rhodes Scholar, Rhodes Trust, 1976-1977
- National Merit Scholar, National Merit Foundation, 1972-1976
Education & Training
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- Diversity, Equity and Inclusion Training University of California 2020
- MD Medicine Cornell Medical
- Oxford Rhodes Scholar
- PhD Cell Biology Rockefeller (Guenter Blobel)
- AB University of Chicago
- Whitehead Institute - PI
Interests
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- Short Bowel Syndrome
- Crypt-Villus Axis
- Small Intestine
- Acute Kidney Injury
- Regeneration
- Host-pathogen interaction
- Tubulogenesis
- Epithelium
- Pseudomonas aeruginosa
- Kidney
- Hedgehog
- Intestinal Cell Kinase
- Enteric Nervous System
- Cilia
Websites
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- DSCB Graduate Program (dscb.ucsf.edu)
- UCSF Department of Anatomy Profile (mostovlab.ucsf.edu)
- BMS Graduate Program (bms.ucsf.edu)
- Tetrad Graduate Program (tetrad.ucsf.edu)
Videos
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- Control of Epithelial Tube Length by Hedgehog (youtube.com)
Publications (208)
Top publication keywords:
Receptors, Polymeric ImmunoglobulinEpithelial CellsOrganogenesisCell MembraneHepatocyte Growth FactorKidney TubulesExocytosisMorphogenesisCell PolarityReceptors, FcEndocytosisSecretory ComponentEpitheliumImmunoglobulin ADogs
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Simple Rules Determine Distinct Patterns of Branching Morphogenesis.
Cell systems 2019 Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE -
p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway.
Journal of cell science 2015 Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE -
A molecular switch for the orientation of epithelial cell polarization.
Developmental cell 2014 Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE -
Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth.
Current biology : CB 2014 Kwon SH, Liu KD, Mostov KE -
Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A.
International journal of molecular sciences 2022 Nedvetsky PI, Cornelissen I, Mathivet T, Bouleti C, Ou P, Baatsen P, Zhao X, Schuit F, Stanchi F, Mostov KE, Gerhardt H
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Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.
Nature communications 2021 Yang Y, Paivinen P, Xie C, Krup AL, Makela TP, Mostov KE, Reiter JF -
Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition.
Nature reviews. Molecular cell biology 2021 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, … -
Intussusceptive Angiogenesis in Human Metastatic Malignant Melanoma.
The American journal of pathology 2021 Pandita A, Ekstrand M, Bjursten S, Zhao Z, Fogelstrand P, Le Gal K, Ny L, Bergo MO, Karlsson J, Nilsson JA, Akyürek LM, Levin MC, Borén J, Ewald AJ, Mostov KE, Levin M -
A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis.
iScience 2020 Wang T, Kwon SH, Peng X, Urdy S, Lu Z, Schmitz RJ, Dalton S, Mostov KE, Zhao S -
Guidelines and definitions for research on epithelial-mesenchymal transition.
Nature reviews. Molecular cell biology 2020 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, … -
The phospholipid PI(3,4)P2 is an apical identity determinant.
Nature communications 2018 Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM -
Adaptor protein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein trafficking through the Golgi complex.
The Journal of biological chemistry 2017 Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH -
Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition.
Cellular signalling 2017 Datta A, Sandilands E, Mostov KE, Bryant DM -
Afadin orients cell division to position the tubule lumen in developing renal tubules.
Development (Cambridge, England) 2017 Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK -
Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity.
Molecular biology of the cell 2016 Ruch TR, Bryant DM, Mostov KE, Engel JN -
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.
The Journal of biological chemistry 2016 Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH -
cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner.
Development (Cambridge, England) 2016 Nedvetsky PI, Zhao X, Mathivet T, Aspalter IM, Stanchi F, Metzger RJ, Mostov KE, Gerhardt H -
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization.
Nature communications 2015 Peng J, Awad A, Sar S, Komaiha OH, Moyano R, Rayal A, Samuel D, Shewan A, Vanhaesebroeck B, Mostov K, Gassama-Diagne A -
Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
Developmental cell 2014 Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM -
Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.
Cell host & microbe 2014 Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN -
Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures.
The Journal of cell biology 2013 Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A -
Apical targeting of the formin Diaphanous in Drosophila tubular epithelia.
eLife 2013 Rousso T, Shewan AM, Mostov KE, Schejter ED, Shilo BZ -
Polarity in mammalian epithelial morphogenesis.
Cold Spring Harbor perspectives in biology 2013 Roignot J, Peng X, Mostov K -
Cell height: Tao rising.
The Journal of cell biology 2012 Cai L, Mostov KE -
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.
Nature cell biology 2012 Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-… -
Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.
Molecular biology of the cell 2012 Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N -
Cyclic AMP regulates formation of mammary epithelial acini in vitro.
Molecular biology of the cell 2012 Nedvetsky PI, Kwon SH, Debnath J, Mostov KE -
Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90.
Journal of cell science 2012 Eastburn DJ, Zegers MM, Mostov KE -
Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma.
The Journal of biological chemistry 2011 Su T, Chapin SJ, Bryant DM, Shewan AM, Young K, Mostov KE -
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Developmental biology 2011 Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY -
Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism.
Cellular microbiology 2011 Lepanto P, Bryant DM, Rossello J, Datta A, Mostov KE, Kierbel A -
p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.
Development (Cambridge, England) 2011 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF -
MDCK cystogenesis driven by cell stabilization within computational analogues.
PLoS computational biology 2011 Engelberg JA, Datta A, Mostov KE, Hunt CA -
Molecular regulation of lumen morphogenesis.
Current biology : CB 2011 Datta A, Bryant DM, Mostov KE -
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
Proceedings of the National Academy of Sciences of the United States of America 2011 Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR -
Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis.
Current biology : CB 2011 Kwon SH, Nedvetsky PI, Mostov KE -
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
Nature cell biology 2010 Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE -
Cse1l is a negative regulator of CFTR-dependent fluid secretion.
Current biology : CB 2010 Bagnat M, Navis A, Herbstreith S, Brand-Arzamendi K, Curado S, Gabriel S, Mostov K, Huisken J, Stainier DY -
A molecular network for de novo generation of the apical surface and lumen.
Nature cell biology 2010 Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, Mostov KE -
STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis.
Molecular biology of the cell 2010 Kim M, O'Brien LE, Kwon SH, Mostov KE -
The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.
The Journal of cell biology 2010 Rodriguez-Fraticelli AE, Vergarajauregui S, Eastburn DJ, Datta A, Alonso MA, Mostov K, Martín-Belmonte F -
Laying the foundation for epithelia: insights into polarized basement membrane deposition.
EMBO reports 2010 Eastburn DJ, Mostov KE -
Simulation of lung alveolar epithelial wound healing in vitro.
Journal of the Royal Society, Interface 2010 Kim SH, Matthay MA, Mostov K, Hunt CA -
Medical applications of shortwave FM radar: remote monitoring of cardiac and respiratory motion.
Medical physics 2010 Mostov K, Liptsen E, Boutchko R -
A computational approach to resolve cell level contributions to early glandular epithelial cancer progression.
BMC systems biology 2009 Kim SH, Debnath J, Mostov K, Park S, Hunt CA -
Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium.
Infection and immunity 2009 Bucior I, Mostov K, Engel JN -
Polarity is destiny.
Cell 2009 Cai L, Mostov K -
Computational investigation of epithelial cell dynamic phenotype in vitro.
Theoretical biology & medical modelling 2009 Kim SH, Park S, Mostov K, Debnath J, Hunt CA -
Identification of a cytoplasmic signal for apical transcytosis.
Traffic (Copenhagen, Denmark) 2009 Luton F, Hexham MJ, Zhang M, Mostov KE -
Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis.
Molecular biology of the cell 2009 Tanimizu N, Miyajima A, Mostov KE -
A computational approach to understand in vitro alveolar morphogenesis.
PloS one 2009 Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA -
Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
American journal of physiology. Renal physiology 2008 Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE -
From cells to organs: building polarized tissue.
Nature reviews. Molecular cell biology 2008 Bryant DM, Mostov KE -
Focal adhesion components are essential for mammalian cell cytokinesis.
Cell cycle (Georgetown, Tex.) 2008 Shafikhani SH, Mostov K, Engel J -
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
EMBO reports 2008 Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE -
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.
Current biology : CB 2008 Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Ewald A, Werb Z, Alonso MA, Mostov K -
Regulation of cell polarity during epithelial morphogenesis.
Current opinion in cell biology 2008 Martin-Belmonte F, Mostov K -
In silico simulation of epithelial cell tubulogenesis.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2008 Engelberg JA, Kim M, Mostov KE, Hunt CA -
Development: inflationary pressures.
Nature 2007 Bryant D, Mostov K -
Catch the KIF5B train to the apical surface.
Developmental cell 2007 Jacobson C, Mostov K -
Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
American journal of physiology. Renal physiology 2007 Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE -
Genetic control of single lumen formation in the zebrafish gut.
Nature cell biology 2007 Bagnat M, Cheung ID, Mostov KE, Stainier DY -
Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.
Journal of cell science 2007 Kim M, Datta A, Brakeman P, Yu W, Mostov KE -
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation.
Stem cells (Dayton, Ohio) 2007 Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ -
Phosphoinositides control epithelial development.
Cell cycle (Georgetown, Tex.) 2007 Martin-Belmonte F, Mostov K -
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.
Journal of cell science 2007 Bryant DM, Kerr MC, Hammond LA, Joseph SR, Mostov KE, Teasdale RD, Stow JL -
Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane.
The Journal of cell biology 2007 Kierbel A, Gassama-Diagne A, Rocha C, Radoshevich L, Olson J, Mostov K, Engel J -
Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.
Molecular biology of the cell 2007 Leroy P, Mostov KE -
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
Molecular biology of the cell 2007 Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K -
Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.
Molecular biology of the cell 2007 Tanimizu N, Miyajima A, Mostov KE -
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.
Cell 2007 Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K -
A model of intussusceptive angiogenesis.
Novartis Foundation symposium 2007 Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K -
Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle.
Proceedings of the National Academy of Sciences of the United States of America 2006 Reiter JF, Mostov K -
Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor.
Experimental cell research 2006 Vergés M, Sebastián I, Mostov KE -
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells.
Nature cell biology 2006 Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K -
Simulating properties of in vitro epithelial cell morphogenesis.
PLoS computational biology 2006 Grant MR, Mostov KE, Tlsty TD, Hunt CA -
Developmental biology: the hole picture.
Nature 2006 Mostov K, Martin-Belmonte F -
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer cell 2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA -
mTOR is out of control in polycystic kidney disease.
Proceedings of the National Academy of Sciences of the United States of America 2006 Mostov KE -
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures.
Methods in enzymology 2006 O'Brien LE, Yu W, Tang K, Jou TS, Zegers MM, Mostov KE -
The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells.
Molecular biology of the cell 2005 ter Beest MB, Chapin SJ, Avrahami D, Mostov KE -
The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization.
Molecular biology of the cell 2005 Kierbel A, Gassama-Diagne A, Mostov K, Engel JN -
Formation of multicellular epithelial structures.
Novartis Foundation symposium 2005 Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W -
Beta1-integrin orients epithelial polarity via Rac1 and laminin.
Molecular biology of the cell 2004 Yu W, Datta A, Leroy P, O'Brien LE, Mak G, Jou TS, Matlin KS, Mostov KE, Zegers MM -
Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts.
Journal of cell science 2004 Tanimizu N, Saito H, Mostov K, Miyajima A -
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Nature cell biology 2004 Vergés M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov KE -
ERK and MMPs sequentially regulate distinct stages of epithelial tubule development.
Developmental cell 2004 O'Brien LE, Tang K, Kats ES, Schutz-Geschwender A, Lipschutz JH, Mostov KE -
Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2004 Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME -
Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa.
Molecular biology of the cell 2003 Kazmierczak BI, Mostov K, Engel JN -
Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity.
American journal of physiology. Cell physiology 2003 Pollack AL, Apodaca G, Mostov KE -
Pak1 and PIX regulate contact inhibition during epithelial wound healing.
The EMBO journal 2003 Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH -
Epithelial polarity and morphogenesis.
Methods (San Diego, Calif.) 2003 Mostov KE -
An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling.
American journal of physiology. Cell physiology 2003 Lai JF, Juang SH, Hung YM, Cheng HY, Cheng TL, Mostov KE, Jou TS -
Epithelial polarity and tubulogenesis in vitro.
Trends in cell biology 2003 Zegers MM, O'Brien LE, Yu W, Datta A, Mostov KE -
Polarized epithelial membrane traffic: conservation and plasticity.
Nature cell biology 2003 Mostov K, Su T, ter Beest M -
The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum.
The Journal of biological chemistry 2003 Lipschutz JH, Lingappa VR, Mostov KE -
Cell biology: Just mix and patch.
Nature 2003 Mostov K, Zegers M -
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures.
Molecular biology of the cell 2003 Yu W, O'Brien LE, Wang F, Bourne H, Mostov KE, Zegers MM -
Role of rab proteins in epithelial membrane traffic.
International review of cytology 2003 van Ijzendoorn SC, Mostov KE, Hoekstra D -
Opinion: Building epithelial architecture: insights from three-dimensional culture models.
Nature reviews. Molecular cell biology 2002 O'Brien LE, Zegers MM, Mostov KE -
Exocytosis: the many masters of the exocyst.
Current biology : CB 2002 Lipschutz JH, Mostov KE -
Signal transduction. A new thread in an intricate web.
Science (New York, N.Y.) 2001 von Zastrow M, Mostov K -
Analysis of membrane traffic in polarized epithelial cells.
Current protocols in cell biology 2001 Lipschutz JH, O'Brien LE, Altschuler Y, Avrahami D, Nguyen Y, Tang K, Mostov KE -
Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line.
American journal of physiology. Renal physiology 2001 Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM -
Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells.
Cellular microbiology 2001 Kazmierczak BI, Jou TS, Mostov K, Engel JN -
Interaction of bacterial pathogens with polarized epithelium.
Annual review of microbiology 2001 Kazmierczak BI, Mostov K, Engel JN -
Connecting apical endocytosis to the intracellular traffic infrastructure in polarized hepatocytes.
Gastroenterology 2000 van Ijzendoorn SC, Mostov KE -
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins.
Molecular biology of the cell 2000 Lipschutz JH, Guo W, O'Brien LE, Nguyen YH, Novick P, Mostov KE -
Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis.
Cellular microbiology 2000 van Ooij C, Kalman L, Nishijima M, Hanada K, Mostov K, Engel JN -
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.
Molecular and cellular biology 2000 Hansen SH, Zegers MM, Woodrow M, Rodriguez-Viciana P, Chardin P, Mostov KE, McMahon M -
Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation.
Biochemistry 2000 Razani B, Altschuler Y, Zhu L, Pestell RG, Mostov KE, Lisanti MP -
Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits.
The Journal of biological chemistry 2000 Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR -
The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells.
Cell 2000 Zhang JR, Mostov KE, Lamm ME, Nanno M, Shimida S, Ohwaki M, Tuomanen E -
Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity.
Molecular biology of the cell 2000 Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T -
Membrane traffic in polarized epithelial cells.
Current opinion in cell biology 2000 Mostov KE, Verges M, Altschuler Y -
Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.
The Journal of biological chemistry 2000 Zhang W, Razani B, Altschuler Y, Bouzahzah B, Mostov KE, Pestell RG, Lisanti MP -
Catch the mu1B train to the basolateral surface.
Cell 1999 Mostov K, ter Beest MB, Chapin SJ -
ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells.
The Journal of cell biology 1999 Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K -
The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo.
Molecular cell 1999 Luton F, Vergés M, Vaerman JP, Sudol M, Mostov KE -
A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default.
Proceedings of the National Academy of Sciences of the United States of America 1999 Vergés M, Havel RJ, Mostov KE -
Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa.
Infection and immunity 1999 Comolli JC, Waite LL, Mostov KE, Engel JN -
Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals.
Molecular biology of the cell 1999 Luton F, Mostov KE -
Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms.
The Journal of cell biology 1998 Altschuler Y, Barbas SM, Terlecky LJ, Tang K, Hardy S, Mostov KE, Schmid SL -
Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.
Developmental biology 1998 Pollack AL, Runyan RB, Mostov KE -
Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis.
Journal of autoimmunity 1998 Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J -
A model for structural similarity between different SNARE complexes based on sequence relationships.
Trends in cell biology 1998 Weimbs T, Mostov K, Low SH, Hofmann K -
Role of tyrosine phosphorylation in ligand-induced regulation of transcytosis of the polymeric Ig receptor.
Molecular biology of the cell 1998 Luton F, Cardone MH, Zhang M, Mostov KE -
Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor.
Infection and immunity 1998 Fleiszig SM, Vallas V, Jun CH, Mok L, Balkovetz DF, Roth MG, Mostov KE -
The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells.
The Journal of cell biology 1998 Low SH, Chapin SJ, Wimmer C, Whiteheart SW, Kömüves LG, Mostov KE, Weimbs T -
Brefeldin A (BFA) inhibits basolateral membrane (BLM) delivery and dimerization of transcobalamin II receptor in human intestinal epithelial Caco-2 cells. BFA effects on BLM cholesterol content.
The Journal of biological chemistry 1998 Bose S, Chapin SJ, Seetharam S, Feix J, Mostov KE, Seetharam B -
Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells.
Infection and immunity 1998 Hauser AR, Fleiszig S, Kang PJ, Mostov K, Engel JN -
Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking.
Molecular biology of the cell 1998 Singer KL, Mostov KE -
Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells.
The Journal of biological chemistry 1998 Low SH, Roche PA, Anderson HA, van Ijzendoorn SC, Zhang M, Mostov KE, Weimbs T -
Apical targeting in polarized epithelial cells: There's more afloat than rafts.
Trends in cell biology 1997 Weimbs T, Low SH, Chapin SJ, Mostov KE -
Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity.
Infection and immunity 1997 Fleiszig SM, Evans DJ, Do N, Vallas V, Shin S, Mostov KE -
Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis.
The Journal of cell biology 1997 Pollack AL, Barth AI, Altschuler Y, Nelson WJ, Mostov KE -
Identification of Pseudomonas aeruginosa genes required for epithelial cell injury.
Molecular microbiology 1997 Kang PJ, Hauser AR, Apodaca G, Fleiszig SM, Wiener-Kronish J, Mostov K, Engel JN -
Journey across the osteoclast.
Science (New York, N.Y.) 1997 Mostov K, Werb Z -
A conserved domain is present in different families of vesicular fusion proteins: a new superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1997 Weimbs T, Low SH, Chapin SJ, Mostov KE, Bucher P, Hofmann K -
NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion.
The Journal of cell biology 1997 Barth AI, Pollack AL, Altschuler Y, Mostov KE, Nelson WJ -
Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers.
The Journal of biological chemistry 1997 Balkovetz DF, Pollack AL, Mostov KE -
Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S.
Infection and immunity 1997 Fleiszig SM, Wiener-Kronish JP, Miyazaki H, Vallas V, Mostov KE, Kanada D, Sawa T, Yen TS, Frank DW -
Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells.
Molecular biology of the cell 1996 Low SH, Chapin SJ, Weimbs T, Kömüves LG, Bennett MK, Mostov KE -
The basolateral sorting signal of the polymeric immunoglobulin receptor contains two functional domains.
Journal of cell science 1996 Reich V, Mostov K, Aroeti B -
Calmodulin regulates the intracellular trafficking in epithelial cells.
Zeitschrift fur Gastroenterologie 1996 Enrich C, Apodaca G, Mostov KE -
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.
The Journal of cell biology 1996 Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE -
Reconstitution of transcytosis in SLO-permeabilized MDCK cells: existence of an NSF-dependent fusion mechanism with the apical surface of MDCK cells.
The EMBO journal 1996 Apodaca G, Cardone MH, Whiteheart SW, DasGupta BR, Mostov KE -
Calmodulin binds to the basolateral targeting signal of the polymeric immunoglobulin receptor.
The Journal of biological chemistry 1996 Chapin SJ, Enrich C, Aroeti B, Havel RJ, Mostov KE -
Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor.
FEBS letters 1995 Cardone M, Mostov K -
Dimeric and tetrameric IgA are transcytosed equally by the polymeric Ig receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995 Song W, Vaerman JP, Mostov KE -
Generation and assembly of secretory antibodies in plants.
Science (New York, N.Y.) 1995 Ma JK, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T -
Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing.
Infection and immunity 1995 Apodaca G, Bomsel M, Lindstedt R, Engel J, Frank D, Mostov KE, Wiener-Kronish J -
Regulation of protein traffic in polarized epithelial cells.
Histology and histopathology 1995 Mostov KE -
Regulation of protein traffic in polarized epithelial cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995 Mostov KE, Cardone MH -
Regulation of protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor model.
Cold Spring Harbor symposia on quantitative biology 1995 Mostov KE, Altschuler Y, Chapin SJ, Enrich C, Low SH, Luton F, Richman-Eisenstat J, Singer KL, Tang K, Weimbs T -
The polymeric immunoglobulin receptor accumulates in specialized endosomes but not synaptic vesicles within the neurites of transfected neuroendocrine PC12 cells.
The Journal of cell biology 1994 Bonzelius F, Herman GA, Cardone MH, Mostov KE, Kelly RB -
Transcytosis of the polymeric immunoglobulin receptor is regulated in multiple intracellular compartments.
The Journal of biological chemistry 1994 Song W, Apodaca G, Mostov K -
The calmodulin antagonist, W-13, alters transcytosis, recycling, and the morphology of the endocytic pathway in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1994 Apodaca G, Enrich C, Mostov KE -
Rapid internalization of the polymeric immunoglobulin receptor requires phosphorylated serine 726.
The Journal of biological chemistry 1994 Okamoto CT, Song W, Bomsel M, Mostov KE -
Polarized sorting of the polymeric immunoglobulin receptor in the exocytotic and endocytotic pathways is controlled by the same amino acids.
The EMBO journal 1994 Aroeti B, Mostov KE -
Both the Gs alpha and beta gamma subunits of the heterotrimeric G protein, Gs, control the sorting of the polymeric immunoglobulin receptor into transcytotic vesicles.
Biochemical Society transactions 1994 Bomsel M, Mostov KE -
Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes.
The Journal of cell biology 1994 Apodaca G, Katz LA, Mostov KE -
Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells.
The Journal of cell biology 1994 Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM -
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.
The Journal of cell biology 1994 Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE -
Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA.
Proceedings of the National Academy of Sciences of the United States of America 1994 Song W, Bomsel M, Casanova J, Vaerman JP, Mostov K -
Transepithelial transport of immunoglobulins.
Annual review of immunology 1994 Mostov KE -
Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.
The Journal of biological chemistry 1993 Bomsel M, Mostov KE -
Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor.
The Journal of cell biology 1993 Aroeti B, Kosen PA, Kuntz ID, Cohen FE, Mostov KE -
Transcytosis of placental alkaline phosphatase-polymeric immunoglobulin receptor fusion proteins is regulated by mutations of Ser664.
The Journal of biological chemistry 1993 Apodaca G, Mostov KE -
Brefeldin-A inhibits the delivery of the polymeric immunoglobulin receptor to the basolateral surface of MDCK cells.
The Journal of biological chemistry 1993 Apodaca G, Aroeti B, Tang K, Mostov KE -
Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway.
The Journal of biological chemistry 1993 Lindstedt R, Apodaca G, Barondes SH, Mostov KE, Leffler H -
Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits.
The EMBO journal 1993 Chang MP, Mallet WG, Mostov KE, Brodsky FM -
Protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor as a model system.
Journal of cell science. Supplement 1993 Mostov K -
Role of heterotrimeric G proteins in membrane traffic.
Molecular biology of the cell 1992 Bomsel M, Mostov K -
The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal.
The Journal of biological chemistry 1992 Okamoto CT, Shia SP, Bird C, Mostov KE, Roth MG -
Plasma membrane protein sorting in polarized epithelial cells.
The Journal of cell biology 1992 Mostov K, Apodaca G, Aroeti B, Okamoto C -
Polymeric immunoglobulin receptor.
International review of cytology 1992 Aroeti B, Casanova J, Okamoto C, Cardone M, Pollack A, Tang K, Mostov K -
Direct apical sorting of rat liver dipeptidylpeptidase IV expressed in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1991 Casanova JE, Mishumi Y, Ikehara Y, Hubbard AL, Mostov KE -
The polymeric immunoglobulin receptor.
Seminars in cell biology 1991 Mostov K -
Sorting of plasma membrane proteins in epithelial cells.
Current opinion in cell biology 1991 Bomsel M, Mostov K -
An autonomous signal for basolateral sorting in the cytoplasmic domain of the polymeric immunoglobulin receptor.
Cell 1991 Casanova JE, Apodaca G, Mostov KE -
The polymeric immunoglobulin receptor. A model protein to study transcytosis.
The Journal of clinical investigation 1991 Apodaca G, Bomsel M, Arden J, Breitfeld PP, Tang K, Mostov KE -
Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells.
The Journal of cell biology 1990 Breitfeld PP, McKinnon WC, Mostov KE -
Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.
The Journal of biological chemistry 1990 Breitfeld PP, Casanova JE, McKinnon WC, Mostov KE -
Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis.
Science (New York, N.Y.) 1990 Casanova JE, Breitfeld PP, Ross SA, Mostov KE -
Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells.
The Journal of cell biology 1990 Le Bivic A, Sambuy Y, Mostov K, Rodriguez-Boulan E -
Transepithelial transport of immunoglobulins: a model of protein sorting and transcytosis.
American journal of respiratory cell and molecular biology 1989 Breitfeld PP, Casanova JE, Simister NE, Ross SA, McKinnon WC, Mostov KE -
Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells.
The Journal of cell biology 1989 Breitfeld PP, Harris JM, Mostov KE -
Sorting signals.
Current opinion in cell biology 1989 Breitfeld PP, Casanova JE, Simister NE, Ross SA, McKinnon WC, Mostov KE -
An Fc receptor structurally related to MHC class I antigens.
Nature 1989 Simister NE, Mostov KE -
Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog.
Cold Spring Harbor symposia on quantitative biology 1989 Simister NE, Mostov KE -
Expression and analysis of the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells using retroviral vectors.
Methods in cell biology 1989 Breitfeld PP, Casanova JE, Harris JM, Simister NE, Mostov KE -
Cell biology of the IgA receptor in polarized epithelia.
Monographs in allergy 1988 Breitfeld PP, Harris JM, Mostov KE -
An anchor-minus form of the polymeric immunoglobulin receptor is secreted predominantly apically in Madin-Darby canine kidney cells.
The Journal of cell biology 1987 Mostov KE, Breitfeld P, Harris JM -
Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis.
Cell 1986 Mostov KE, de Bruyn Kops A, Deitcher DL -
Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA.
Cell 1986 Mostov KE, Deitcher DL -
Alternate splicing of rabbit polymeric immunoglobulin receptor.
Molecular and cellular biology 1986 Deitcher DL, Mostov KE -
Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts.
The Journal of cell biology 1986 Deitcher DL, Neutra MR, Mostov KE -
Structure and function of the receptor for polymeric immunoglobulins.
Biochemical Society symposium 1986 Mostov KE, Friedlander M, Blobel G -
Transcytosis.
Cell 1985 Mostov KE, Simister NE -
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains.
Nature 1984 Mostov KE, Friedlander M, Blobel G -
Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.
Proceedings of the National Academy of Sciences of the United States of America 1983 Anderson DJ, Mostov KE, Blobel G -
Transcellular transport of polymeric immunoglobulin by secretory component: a model system for studying intracellular protein sorting.
Annals of the New York Academy of Sciences 1983 Mostov KE, Blobel G -
Biosynthesis, processing, and function of secretory component.
Methods in enzymology 1983 Mostov KE, Blobel G -
A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins.
The Journal of biological chemistry 1982 Mostov KE, Blobel G -
In vitro translation and processing of a precursor form of favin, a lectin from Vicia faba.
The Journal of biological chemistry 1982 Hemperly JJ, Mostov KE, Cunningham BA -
Co-translational membrane integration of calcium pump protein without signal sequence cleavage.
Nature 1981 Mostov KE, DeFoor P, Fleischer S, Blobel G -
Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms.
Proceedings of the National Academy of Sciences of the United States of America 1980 Mostov KE, Kraehenbuhl JP, Blobel G