Kathy Ivey, PhD
Assistant Professor
Pediatrics
School of Medicine

Publications (37)

Top publication keywords:
Myocytes, CardiacTranscription Factor AP-2OsteogenesisHeartFibroblastsCell LineageGene Expression Regulation, DevelopmentalBranchial RegionEndothelin-1MicroRNAsInduced Pluripotent Stem CellsBasic Helix-Loop-Helix Transcription FactorsCell DifferentiationDuctus ArteriosusRNA-Induced Silencing Complex

• AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy.
  Communications medicine 2024 Wu I, Zeng A, Greer-Short A, Aycinena JA, Tefera AE, Shenwai R, Farshidfar F, Van Pell M, Xu E, Reid C, Rodriguez N, Lim B, Chung TW, Woods J, Scott A, Jones S, Dee-Hoskins C, Gutierrez CG, Madariaga …
• The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
  Stem cell reports 2023 Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, …
• Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus.
  Circulation 2023 Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon EC, Qureshi TN, Reid CA, Nettesheim ER, Xu E, Duclos Z, Mohamed TMA, Farshidfar F, Fejes A, Liu J, Jones S, Feathers C, Chung TW, Jing F, Prince WS, Lin J…
• Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
  Circulation 2022 Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, …
• Physiological Biomimetic Culture System for Pig and Human Heart Slices.
  Circulation research 2019 Ou Q, Jacobson Z, Abouleisa RRE, Tang XL, Hindi SM, Kumar A, Ivey KN, Giridharan G, El-Baz A, Brittian K, Rood B, Lin YH, Watson SA, Perbellini F, McKinsey TA, Hill BG, Jones SP, Terracciano CM, Bolli…

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• Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.
  Cell stem cell 2019 Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D
• Oligogenic inheritance of a human heart disease involving a genetic modifier.
  Science (New York, N.Y.) 2019 Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D
• The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.
  Development (Cambridge, England) 2017 Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN
• A Heart of Stone: Cardiac Fibroblasts Turn to Bone in Calcified Hearts.
  Cell stem cell 2017 Ivey KN
• Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.
  Circulation 2016 Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D
• Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells.
  Current protocols in human genetics 2015 Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K
• microRNAs as Developmental Regulators.
  Cold Spring Harbor perspectives in biology 2015 Ivey KN, Srivastava D
• NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.
  Journal of molecular and cellular cardiology 2015 White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D
• The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
  The Journal of biological chemistry 2014 King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN
• microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.
  eLife 2013 Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D
• Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells.
  Stem cells translational medicine 2013 Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I
• Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
  Stem cells (Dayton, Ohio) 2013 White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D
• MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.
  Circulation research 2012 Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D
• Hand2 function in second heart field progenitors is essential for cardiogenesis.
  Developmental biology 2010 Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
• The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch.
  Development (Cambridge, England) 2010 Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D
• skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D
• MicroRNAs as regulators of differentiation and cell fate decisions.
  Cell stem cell 2010 Ivey KN, Srivastava D
• MicroRNAs in cardiac development.
  Pediatric cardiology 2010 Cordes KR, Srivastava D, Ivey KN
• miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.
  Nature 2009 Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D
• Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.
  Developmental cell 2009 Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D
• Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ
• microRNA-138 modulates cardiac patterning during embryonic development.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D
• miR-126 regulates angiogenic signaling and vascular integrity.
  Developmental cell 2008 Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D
• Transcriptional regulation during development of the ductus arteriosus.
  Circulation research 2008 Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D
• MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
  Cell stem cell 2008 Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D
• The paradoxical patent ductus arteriosus.
  The Journal of clinical investigation 2006 Ivey KN, Srivastava D
• Potential of stem-cell-based therapies for heart disease.
  Nature 2006 Srivastava D, Ivey KN
• Sonic hedgehog is essential for first pharyngeal arch development.
  Pediatric research 2006 Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D
• Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
  Developmental biology 2003 Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM
• A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L.
  Mechanisms of development 2001 Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D
• shl, a New set of Arabidopsis mutants with exaggerated developmental responses to available red, far-red, and blue light.
  Plant physiology 2001 Pepper AE, Seong-Kim M, Hebst SM, Ivey KN, Kwak SJ, Broyles DE
• Cell surface monkey CD9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity.
  The Journal of biological chemistry 2000 Cha JH, Brooke JS, Ivey KN, Eidels L