Kathy Giacomini, PhD
Dean-School of Phrmcy/AssocVC
Dean's Office
School of Pharmacy

Major questions addressed in the laboratory include: What is the function of orphan membrane transporters? What is the in vivo role of membrane transporters in the disposition of endogenous solutes as well as in drug disposition and response? How does genetic variation in membrane transporters affect solute disposition, human disease and drug response? What are the structural determinants of specificity?

Dr. Kathy Giacomini is leading an effort to deorphan transporters in the Solute Carrier 22 Family, and to determine the clinical implications of specific genetic variants in membrane transporters. Research ventures, ranging from basic discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to differences in drug response in ethnically diverse populations. Ultimately, these studies will increase our knowledge of the genetic basis underlying drug response and will contribute to advancing the era of personalized medicine. Furthermore, our studies will elucidate the genetic mechanisms of decreased drug response and, ultimately, contribute to improving drug design for safe and effective treatments of subgroups of patients who do not respond to standard treatments.

Research in the laboratory focuses on drugs used in the treatment of diseases associated with metabolic syndrome. We are particularly interested in identifying the genetic determinants of the anti-diabetic drugs, metformin and sulfonylureas, highly prescribed drugs. In particular, our research focuses on discovering functional genetic variants that underlie variation in response to these drugs in large ethnically diverse patient populations. Finally, Kathy Giacomini and her collaborator, Russ Altman of Stanford University are the Co-PIs of the UCSF–Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) funded by the Food and Drug Administration (FDA). Established in 2014 and renewed in 2021, the UCSF-Stanford CERSI aims to advance the field of regulatory sciences and improve the development and evaluation of diagnostics, therapeutics and medical devices. The UCSF-Stanford CERSI is the first FDA funded CERSI on the west coast and seeks to address key challenges related to education and research that will advance the discovery and development of medical products.

DEI Statement: As a biracial woman faculty member with ancestries in the Philippines and Europe, I am deeply committed to issues of diversity, equity and inclusion. I am a strong advocate for graduate students and postdocs of diverse ancestries and particularly under-represented minorities (URM). In my career, I have been the academic advisor for students who are URMs and who now have vibrant careers in academia and industry. My mentoring style is very personal. That is, I tailor my advising of each trainee to their career goals and aspirations, helping them to achieve these goals. On the recommendation of my students, I have institute diversity presentations as part of our regularly scheduled research group meetings. We begin each research group meeting with a diversity presentation, given by an individual group member, who describes some aspect of their cultural background. These are fun and educational and build an inclusive and welcoming environment in my laboratory. As the co-PI of the UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation, CERSI, we established a CERSI Diversity Scholars Program in 2021 and have now made four awards to the scholars (students or postdocs) at UCSF from diverse ethnic backgrounds. My personal goal is to promote diversity, equity and inclusion at UCSF.

• Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials.
  Clinical pharmacology and therapeutics 2023 Smith DM, Minichmayr IK, Standing JF, Giacomini KM, van der Graaf PH, Peck RW
• Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
  Research square 2023 Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, …
• TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters.
  Clinical pharmacology and therapeutics 2023 Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT
• Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
  bioRxiv : the preprint server for biology 2023 Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, …
• Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
  Diabetes 2023 Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn…
• The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse.
  Metabolites 2023 Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW
• Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
  Nature chemical biology 2023 Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R
• Trends in Clinical Pharmacology and Therapeutics.
  Clinical pharmacology and therapeutics 2023 Minichmayr IK, Smith DM, Giacomini KM, van der Graaf PH
• The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
  bioRxiv : the preprint server for biology 2023 Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W
• The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction.
  Clinical pharmacology and therapeutics 2023 Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM
• Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
  Pediatric diabetes 2023 Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson …
• Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
  Journal of veterinary pharmacology and therapeutics 2023 Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM
• Biomarkers Come of Age in Clinical Pharmacology.
  Clinical pharmacology and therapeutics 2023 Giacomini KM
• Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All.
  Clinical pharmacology and therapeutics 2023 Venkatakrishnan K, Brown KE, Giacomini KM, van der Graaf PH
• Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM
• More Than Pharmacokinetics: Transporters in Clinical Pharmacology.
  Clinical pharmacology and therapeutics 2022 Giacomini KM, Huang SM
• New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2022 Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X
• A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption.
  The AAPS journal 2022 Martinez MN, Sinko B, Wu F, Flanagan T, Borbás E, Tsakalozou E, Giacomini KM
• Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682.
  Diabetes care 2022 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
  Clinical pharmacology and therapeutics 2022 Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A,…
• The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology.
  Clinical pharmacology and therapeutics 2022 Giacomini KM, van der Graaf PH
• High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
  Pharmaceutical research 2022 Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM
• Emerging Roles of the Human Solute Carrier 22 Family.
  Drug metabolism and disposition: the biological fate of chemicals 2021 Yee SW, Giacomini KM
• Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
  Diabetes care 2021 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.
  The AAPS journal 2021 Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL
• Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.
  Clinical pharmacology and therapeutics 2021 Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M
• Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.
  Clinical pharmacology and therapeutics 2021 Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM
• Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.
  Clinical and translational science 2021 Vora B, Brackman DJ, Zou L, Garcia-Cremades M, Sirota M, Savic RM, Giacomini KM
• Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.
  American journal of human genetics 2021 McInnes G, Sharo AG, Koleske ML, Brown JEH, Norstad M, Adhikari AN, Wang S, Brenner SE, Halpern J, Koenig BA, Magnus DC, Gallagher RC, Giacomini KM, Altman RB
• The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.
  The AAPS journal 2021 Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM
• A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring.
  Clinical pharmacology and therapeutics 2021 Lavertu A, Vora B, Giacomini KM, Altman R, Rensi S
• Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
  British journal of pharmacology 2021 Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT
• Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM
• A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
  Journal of pharmaceutical sciences 2020 Matsson P, Baranczewski P, Giacomini KM, Andersson TB, Palm J, Palm K, Charman WN, Bergström CAS
• Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
  Journal of pharmaceutical sciences 2020 Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM
• Scientific considerations for global drug development.
  Science translational medicine 2020 Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, …
• The activities of drug inactive ingredients on biological targets.
  Science (New York, N.Y.) 2020 Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, Berg EL, Giacomini KM, Roth BL, …
• Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
  Genes & development 2020 Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K
• COVID-19: A Defining Moment for Clinical Pharmacology?
  Clinical pharmacology and therapeutics 2020 van der Graaf PH, Giacomini KM
• Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ
• Oral Anticoagulants and Precision Medicine: Something Old, Something New.
  Clinical pharmacology and therapeutics 2020 Shahin MH, Giacomini KM
• Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response.
  Clinical pharmacology and therapeutics 2020 Giacomini KM
• GenEpi: gene-based epistasis discovery using machine learning.
  BMC bioinformatics 2020 Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY, Alzheimer’s Disease Neuroimaging Initiative
• Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.
  Molecular pharmaceutics 2020 Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM
• Clinical Pharmacology & Therapeutics 2030.
  Clinical pharmacology and therapeutics 2020 van der Graaf PH, Giacomini KM
• Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3).
  The American journal of clinical nutrition 2020 Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM
• Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
  Clinical pharmacology and therapeutics 2019 Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM
• Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.
  Clinical pharmacology and therapeutics 2019 Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF
• Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
  PLoS genetics 2019 Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM
• A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
  PLoS genetics 2019 Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P
• A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.
  Clinical pharmacology and therapeutics 2019 Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN
• l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
  Bioorganic & medicinal chemistry letters 2019 Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA
• Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
  Clinical pharmacology and therapeutics 2019 Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM
• Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
  Human mutation 2019 Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM
• Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
  Clinical and translational science 2019 Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM
• Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.
  Clinical pharmacology and therapeutics 2019 Giacomini KM, Lin L, Altman RB
• Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.
  Clinical pharmacology and therapeutics 2019 Zou L, Ni Z, Tsakalozou E, Giacomini KM
• Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
  PLoS biology 2019 Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L
• Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2018 Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L, International Transporter Consortium
• The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development.
  Clinical pharmacology and therapeutics 2018 Giacomini KM, Galetin A, Huang SM
• Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
  Journal of medicinal chemistry 2018 Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, …
• Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
  Clinical pharmacology and therapeutics 2018 Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y, International Transporter Consortium
• Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2018 Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM
• ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
  Clinical pharmacology and therapeutics 2018 Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L, International Transporter Consortium
• Pharmacogenetics of Antidiabetic Drugs.
  Advances in pharmacology (San Diego, Calif.) 2018 Srinivasan S, Yee SW, Giacomini KM
• Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
  Molecular pharmacology 2018 Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM
• Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
  PLoS biology 2018 Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM
• Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.
  Diabetes 2018 Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger…
• Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.
  Clinical pharmacology and therapeutics 2017 Zamek-Gliszczynski MJ, Giacomini KM, Zhang L
• Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
  Clinical pharmacology and therapeutics 2017 Brackman DJ, Giacomini KM
• PharmGKB summary: very important pharmacogene information for ABCG2.
  Pharmacogenetics and genomics 2017 Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE
• New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
  Clinical pharmacology and therapeutics 2017 Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM
• PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters.
  Clinical pharmacology and therapeutics 2017 Hsueh CH, Hsu V, Zhao P, Zhang L, Giacomini KM, Huang SM
• Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.
  Biochemistry 2017 Stecula A, Schlessinger A, Giacomini KM, Sali A
• Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.
  Journal of chemical information and modeling 2017 Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM
• Transporters Involved in Metformin Pharmacokinetics and Treatment Response.
  Journal of pharmaceutical sciences 2017 Liang X, Giacomini KM
• The Effect of Uremic Solutes on the Organic Cation Transporter 2.
  Journal of pharmaceutical sciences 2017 Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM
• Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
  Journal of medicinal chemistry 2017 Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM
• Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
  Clinical pharmacology and therapeutics 2017 Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimcáková L, Pirags V,…
• Genomic Characterization of Metformin Hepatic Response.
  PLoS genetics 2016 Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N
• Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
  Nature reviews. Drug discovery 2016 Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M
• The use of drug transporters as therapeutic targets.
  Clinical advances in hematology & oncology : H&O 2016 Giacomini KM
• A Molecular Basis for Innovation in Drug Excipients.
  Clinical pharmacology and therapeutics 2016 Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM
• A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
  Clinical pharmacology and therapeutics 2016 Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM
• Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
  Clinical pharmacology and therapeutics 2016 Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM
• LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
  Bioorganic & medicinal chemistry letters 2016 Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA
• Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.
  Molecular pharmaceutics 2016 Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM
• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
  Nature genetics 2016 Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M…
• Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
  Clinical pharmacology and therapeutics 2016 Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M
• Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
  European journal of nuclear medicine and molecular imaging 2016 Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG
• Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.
  Frontiers in pharmacology 2016 Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R
• The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.
  Clinical pharmacokinetics 2016 Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM
• A research roadmap for next-generation sequencing informatics.
  Science translational medicine 2016 Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, …
• LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.
  Bioorganic & medicinal chemistry letters 2016 Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA
• The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
  Clinical pharmacokinetics 2016 Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM
• Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
  The pharmacogenomics journal 2016 Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA…
• Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
  Drug metabolism and disposition: the biological fate of chemicals 2015 Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM
• Unmet needs: Research helps regulators do their jobs.
  Science translational medicine 2015 Altman RB, Khuri N, Salit M, Giacomini KM
• Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
  Molecular pharmaceutics 2015 Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM
• Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
  European journal of nuclear medicine and molecular imaging 2015 Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG
• Prediction and validation of enzyme and transporter off-targets for metformin.
  Journal of pharmacokinetics and pharmacodynamics 2015 Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM
• SLC transporters as therapeutic targets: emerging opportunities.
  Nature reviews. Drug discovery 2015 Lin L, Yee SW, Kim RB, Giacomini KM
• Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
  Molecular pharmacology 2015 Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM
• Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
  Clinical pharmacology and therapeutics 2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM
• Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao…
• A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
  Pharmacogenetics and genomics 2015 Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM
• OCT1 in hepatic steatosis and thiamine disposition.
  Cell cycle (Georgetown, Tex.) 2015 Chen L, Yee SW, Giacomini KM
• Genome-wide discovery of drug-dependent human liver regulatory elements.
  PLoS genetics 2014 Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N
• Metformin pharmacogenomics: current status and future directions.
  Diabetes 2014 Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC
• OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
• PharmGKB summary: very important pharmacogene information for SLC22A1.
  Pharmacogenetics and genomics 2014 Goswami S, Gong L, Giacomini K, Altman RB, Klein TE
• Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM
• Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.
  Clinical pharmacology and therapeutics 2014 Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM, Clinical Pharmacogenetics Implementation Consortium
• Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.
  Clinical pharmacokinetics 2014 Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM
• Profiling solute carrier transporters in the human blood-brain barrier.
  Clinical pharmacology and therapeutics 2013 Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM
• A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
  The Journal of allergy and clinical immunology 2013 Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, …
• International Transporter Consortium commentary on clinically important transporter polymorphisms.
  Clinical pharmacology and therapeutics 2013 Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M, International Transporter Consortium
• SLC classification: an update.
  Clinical pharmacology and therapeutics 2013 Schlessinger A, Yee SW, Sali A, Giacomini KM
• Transporters in drug development and clinical pharmacology.
  Clinical pharmacology and therapeutics 2013 Giacomini KM, Huang SM
• Special Section on Pharmacogenomics: recent advances and future directions.
  Journal of human genetics 2013 Mushiroda T, Giacomini KM, Kubo M
• Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
  Journal of human genetics 2013 Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C
• Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
  Journal of pharmaceutical sciences 2013 Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM
• Emerging transporters of clinical importance: an update from the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2013 Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L, International Transporter Consortium
• Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM
• Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.
  Molecular pharmaceutics 2013 Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM
• Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
  Journal of medicinal chemistry 2013 Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM
• Molecular modeling and ligand docking for solute carrier (SLC) transporters.
  Current topics in medicinal chemistry 2013 Schlessinger A, Khuri N, Giacomini KM, Sali A
• Renal transporters in drug development.
  Annual review of pharmacology and toxicology 2012 Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM
• Highlights from the International Transporter Consortium second workshop.
  Clinical pharmacology and therapeutics 2012 Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM
• Metformin pathways: pharmacokinetics and pharmacodynamics.
  Pharmacogenetics and genomics 2012 Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE
• The UCSF-FDA TransPortal: a public drug transporter database.
  Clinical pharmacology and therapeutics 2012 Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM
• The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2012 Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM
• Pharmacogenomics and patient care: one size does not fit all.
  Science translational medicine 2012 Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y
• Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
  International journal of molecular imaging 2012 Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK
• High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.
  The Journal of biological chemistry 2012 Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A
• Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!
  Pharmaceutical research 2012 Smith DE, Rowland M, Giacomini KM, Amidon GL
• The role of ATM in response to metformin treatment and activation of AMPK.
  Nature genetics 2012 Yee SW, Chen L, Giacomini KM
• Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.
  The pharmacogenomics journal 2012 Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM
• Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
  Genome research 2011 Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV
• A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, …
• PharmGKB summary: methotrexate pathway.
  Pharmacogenetics and genomics 2011 Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB
• A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
  Clinical pharmacology and therapeutics 2011 Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke …
• Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A
• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
  Journal of medicinal chemistry 2011 Kido Y, Matsson P, Giacomini KM
• Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.
  Xenobiotica; the fate of foreign compounds in biological systems 2011 Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P
• Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM
• Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
  The pharmacogenomics journal 2011 Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM
• Functional characterization of liver enhancers that regulate drug-associated transporters.
  Clinical pharmacology and therapeutics 2011 Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N
• Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.
  Molecular cancer therapeutics 2011 Minematsu T, Giacomini KM
• GABAA receptor open-state conformation determines non-competitive antagonist binding.
  Toxicology and applied pharmacology 2010 Chen L, Xue L, Giacomini KM, Casida JE
• Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.
  Pharmaceutical research 2010 Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM
• Consequences of POR mutations and polymorphisms.
  Molecular and cellular endocrinology 2010 Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM
• Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
  Pharmacogenetics and genomics 2010 Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL
• Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
  Pharmacogenetics and genomics 2010 Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM
• SLC19A1 pharmacogenomics summary.
  Pharmacogenetics and genomics 2010 Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB
• Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.
  Pharmacogenetics and genomics 2010 Agrawal V, Choi JH, Giacomini KM, Miller WL
• Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
  American journal of physiology. Renal physiology 2010 Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM
• Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.
  The Journal of pharmacology and experimental therapeutics 2010 Chen L, Takizawa M, Chen E, Schlessinger A, Segenthelar J, Choi JH, Sali A, Kubo M, Nakamura S, Iwamoto Y, Iwasaki N, Giacomini KM
• Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM
• Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.
  The pharmacogenomics journal 2010 Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P
• Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
  Molecular cancer therapeutics 2010 More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM
• Pharmacogenomics of membrane transporters: past, present and future.
  Pharmacogenomics 2010 Yee SW, Chen L, Giacomini KM
• Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.
  Molecular bioSystems 2010 Ianculescu AG, Friesema EC, Visser TJ, Giacomini KM, Scanlan TS
• Comparison of human solute carriers.
  Protein science : a publication of the Protein Society 2010 Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A
• Membrane transporters in drug development.
  Nature reviews. Drug discovery 2010 International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, …
• The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA.
  Clinical pharmacology and therapeutics 2010 Huang SM, Zhang L, Giacomini KM
• The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
  Clinical pharmacology and therapeutics 2009 Kroetz DL, Yee SW, Giacomini KM
• Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009 Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV
• The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.
  Clinical pharmacology and therapeutics 2009 Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P
• Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
  Pharmacogenetics and genomics 2009 Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM
• Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
  Pharmacogenomics 2009 Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM
• A survey of integral alpha-helical membrane proteins.
  Journal of structural and functional genomics 2009 Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A
• Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
  PloS one 2009 Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, …
• Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
  Pharmacogenetics and genomics 2009 Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM
• The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
  Journal of cardiovascular pharmacology 2009 McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM
• Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.
  The pharmacogenomics journal 2009 Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM
• Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).
  The Journal of pharmacology and experimental therapeutics 2009 Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM
• Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
  The Journal of pharmacology and experimental therapeutics 2008 Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM
• Identification and characterization of 3-iodothyronamine intracellular transport.
  Endocrinology 2008 Ianculescu AG, Giacomini KM, Scanlan TS
• Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
  Journal of molecular biology 2008 Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM
• Genetic variation in human P450 oxidoreductase.
  Molecular and cellular endocrinology 2008 Miller WL, Huang N, Agrawal V, Giacomini KM
• Genetic variation in human aquaporins and effects on phenotypes of water homeostasis.
  Human mutation 2008 Sorani MD, Manley GT, Giacomini KM
• Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research.
  Pharmacotherapy 2008 Figg WD, Chau CH, Okita R, Preusch P, Tracy TS, McLeod H, Reed M, Pieper J, Knoell D, Miller K, Speedie M, Blouin R, Kroboth P, Koda-Kimble MA, Taylor P, Cohen J, Giacomini K
• cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ
• Creating and evaluating genetic tests predictive of drug response.
  Nature reviews. Drug discovery 2008 Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA, Ratain MJ, Giacomini KM
• Genetic variation in drug transporters in ethnic populations.
  Clinical pharmacology and therapeutics 2008 Cropp CD, Yee SW, Giacomini KM
• Novel variants in human Aquaporin-4 reduce cellular water permeability.
  Human molecular genetics 2008 Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT
• Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system.
  Journal of neurotrauma 2008 Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT
• The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
  The Journal of pharmacology and experimental therapeutics 2008 Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL
• Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Huang N, Agrawal V, Giacomini KM, Miller WL
• Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.
  Molecular pharmacology 2008 Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM
• Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.
  Nature reviews. Drug discovery 2007 Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM
• Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).
  Pharmacogenetics and genomics 2007 Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM
• Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
  Clinical pharmacology and therapeutics 2007 Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM
• Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.
  Clinical pharmacology and therapeutics 2007 Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM
• Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.
  The Journal of pharmacology and experimental therapeutics 2007 Chen Y, Zhang S, Sorani M, Giacomini KM
• Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
  The Journal of clinical investigation 2007 Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM
• Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
  Pharmacogenomics 2007 Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, Roden D, Krauss RM, Ratain M
• When good drugs go bad.
  Nature 2007 Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y
• The pharmacogenetics research network: from SNP discovery to clinical drug response.
  Clinical pharmacology and therapeutics 2007 Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA,…
• Pharmacogenomics: challenges and opportunities.
  Annals of internal medicine 2006 Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST, Pharmacogenetics Research …
• Organic cation transporters are determinants of oxaliplatin cytotoxicity.
  Cancer research 2006 Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM
• Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).
  Molecular pharmacology 2006 Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM
• Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.
  The Journal of biological chemistry 2006 Owen RP, Badagnani I, Giacomini KM
• Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
  The Journal of pharmacology and experimental therapeutics 2006 Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM
• PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
  Pharmacological reviews 2006 Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL
• PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
  Pharmacological reviews 2006 Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard …
• PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
  Pharmacological reviews 2006 Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini …
• Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.
  Journal of pharmaceutical sciences 2006 Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM
• Functional genomics of membrane transporters in human populations.
  Genome research 2005 Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM
• The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
  American journal of physiology. Renal physiology 2005 Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM
• Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.
  Drug metabolism and disposition: the biological fate of chemicals 2005 Owen RP, Lagpacan LL, Taylor TR, De La Cruz M, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM
• Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
  Pharmacogenetics and genomics 2005 Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM
• Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.
  Pharmacogenetics and genomics 2005 Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM
• Enhancing data sharing in collaborative research projects with DASH.
  Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2005 Ferrin TE, Huang CC, Greenblatt DM, Stryke D, Giacomini KM, Morris JH
• Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).
  The pharmacogenomics journal 2005 Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM
• Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease.
  Inflammatory bowel diseases 2005 Urban TJ, Giacomini KM, Risch N
• PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.
  Pharmacological reviews 2004 Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM
• Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.
  Molecular pharmacology 2004 Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM
• Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.
  European journal of pharmacology 2003 Mangravite LM, Badagnani I, Giacomini KM
• Estimating the contribution of genes and environment to variation in renal drug clearance.
  Pharmacogenetics 2003 Leabman MK, Giacomini KM
• Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
  Pharmacogenetics 2003 Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG, Pharmacogenetics of Membrane …
• PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).
  Pharmacological reviews 2003 Leabman MK, Huang CC, Stryke D, Johns SJ, Kawamoto M, Ferrin TE, DeYoung J, Taylor TR, De La Cruz M, Herskowitz I, Giacomini KM
• The concentrative nucleoside transporter family, SLC28.
  Pflugers Archiv : European journal of physiology 2003 Gray JH, Owen RP, Giacomini KM
• Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1.
  Pharmacogenetics 2003 Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I, Giacomini KM
• Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM, Pharmacogenetics Of Membrane Transporters Investigators
• Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM, Pharmacogenetics Of…
• Sorting of rat SPNT in renal epithelium is independent of N-glycosylation.
  Pharmaceutical research 2003 Mangravite LM, Giacomini KM
• Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.
  American journal of physiology. Renal physiology 2003 Mangravite LM, Xiao G, Giacomini KM
• SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project.
  Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2003 Stryke D, Huang CC, Kawamoto M, Johns SJ, Carlson EJ, Deyoung JA, Leabman MK, Herskowitz I, Giacomini KM, Ferrin TE
• Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).
  Pharmaceutical research 2002 Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM
• Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.
  American journal of physiology. Renal physiology 2002 Gerstin KM, Dresser MJ, Giacomini KM
• Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.
  Biochemistry 2002 Feng B, Shu Y, Giacomini KM
• Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
  Pharmacogenetics 2002 Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM, Pharmacogenetics of Membrane Transporters Investigators
• Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.
  The Journal of pharmacology and experimental therapeutics 2001 Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM
• Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.
  Biochemistry 2001 Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM
• Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line.
  American journal of physiology. Renal physiology 2001 Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM
• Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.
  Nature genetics 2001 Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB
• Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.
  Journal of pharmaceutical sciences 2001 Dresser MJ, Leabman MK, Giacomini KM
• A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans.
  Molecular pharmacology 2001 Xiao G, Wang J, Tangen T, Giacomini KM
• Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.
  Drug metabolism and disposition: the biological fate of chemicals 2000 Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM
• Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine.
  Pharmaceutical research 2000 Gerstin KM, Dresser MJ, Wang J, Giacomini KM
• Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.
  Drug metabolism and disposition: the biological fate of chemicals 2000 Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM
• Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).
  The Journal of pharmacology and experimental therapeutics 2000 Dresser MJ, Gray AT, Giacomini KM
• Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system.
  The Journal of pharmacology and experimental therapeutics 1999 Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM
• The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.
  The Journal of pharmacology and experimental therapeutics 1999 Zhang L, Gorset W, Dresser MJ, Giacomini KM
• Characterization of a bioengineered chimeric Na+-nucleoside transporter.
  Molecular pharmacology 1999 Wang J, Giacomini KM
• Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter.
  The Journal of biological chemistry 1999 Wang J, Giacomini KM
• Molecular and functional characteristics of cloned human organic cation transporters.
  Pharmaceutical biotechnology 1999 Dresser MJ, Zhang L, Giacomini KM
• Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
  The Journal of pharmacology and experimental therapeutics 1998 Zhang L, Schaner ME, Giacomini KM
• Nucleoside transport in isolated human and rhesus choroid plexus tissue slices.
  Pharmaceutical research 1998 Washington CB, Giacomini KM, Brett CM
• Nicotine transport in a human choriocarcinoma cell line (JAR).
  Journal of pharmaceutical sciences 1998 Zevin S, Schaner ME, Giacomini KM
• Molecular cloning and functional expression of a rabbit renal organic cation transporter.
  Biochimica et biophysica acta 1998 Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM
• Role of organic cation transporters in drug absorption and elimination.
  Annual review of pharmacology and toxicology 1998 Zhang L, Brett CM, Giacomini KM
• Membrane transporters in drug disposition.
  Journal of pharmacokinetics and biopharmaceutics 1997 Giacomini KM
• Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.
  The American journal of physiology 1997 Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM
• Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters.
  The Journal of biological chemistry 1997 Wang J, Giacomini KM
• Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit.
  Biochimica et biophysica acta 1997 Ramanathan VK, Brett CM, Giacomini KM
• Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.
  Pharmaceutical research 1997 Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM
• Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa).
  Pharmaceutical research 1997 Schaner ME, Wang J, Zevin S, Gerstin KM, Giacomini KM
• Characterization of guanidine transport in human renal brush border membranes.
  Pharmaceutical research 1997 Chun JK, Zhang L, Piquette-Miller M, Lau E, Tong LQ, Giacomini KM
• Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
  The Journal of biological chemistry 1997 Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM
• Cloning and functional expression of a human liver organic cation transporter.
  Molecular pharmacology 1997 Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM
• Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.
  Journal of pharmaceutical sciences 1997 Chun JK, Piquette-Miller M, Zhang L, Giacomini KM
• Guanidine transport in a human choriocarcinoma cell line (JAR).
  Pharmaceutical research 1997 Zevin S, Schaner ME, Illsley NP, Giacomini KM
• Taurine transport in cultured choroid plexus.
  Pharmaceutical research 1997 Ramanathan VK, Chung SJ, Giacomini KM, Brett CM
• Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices.
  Pharmaceutical research 1996 Washington CB, Giacomini KM
• Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport.
  Pharmaceutical research 1996 Ramanathan VK, Hui AC, Brett CM, Giacomini KM
• Saturable disposition of taurine in the rat cerebrospinal fluid.
  The Journal of pharmacology and experimental therapeutics 1996 Chung SJ, Ramanathan VK, Brett CM, Giacomini KM
• Isolated renal brush border and basolateral membrane vesicles and cultured renal cells.
  Pharmaceutical biotechnology 1996 Gutierrez MM, Brett CM, Giacomini KM
• Methods of study drug transport in isolated choroid plexus tissue and cultured cells.
  Pharmaceutical biotechnology 1996 Washington CB, Giacomini KM, Brett CM
• Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity.
  The Journal of biological chemistry 1995 Washington CB, Giacomini KM
• The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus.
  The Journal of pharmacology and experimental therapeutics 1995 Washington CB, Brett CM, Wu X, Giacomini KM
• The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy.
  Journal of molecular and cellular cardiology 1995 Lubic SP, Giacomini KM, Giacomini JC
• Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes.
  Biochemical pharmacology 1994 Gutierrez MM, Giacomini KM
• Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy.
  The Journal of pharmacology and experimental therapeutics 1994 Lubic SP, Giacomini KM, Giacomini JC
• Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes.
  Biochemical pharmacology 1994 Wu X, Giacomini KM
• Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus.
  Biochimica et biophysica acta 1994 Chung SJ, Ramanathan V, Giacomini KM, Brett CM
• Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes.
  Pflugers Archiv : European journal of physiology 1994 Giacomini KM, Markovich D, Werner A, Biber J, Wu X, Murer H
• Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit.
  Biochimica et biophysica acta 1994 Wu X, Gutierrez MM, Giacomini KM
• Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells.
  The Journal of pharmacology and experimental therapeutics 1994 Ott RJ, Chan JK, Ramanathan VK, Hui AC, Giacomini KM
• Stereoselective interactions of organic cations with the organic cation transporter in OK cells.
  Pharmaceutical research 1993 Ott RJ, Giacomini KM
• Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.
  Biochimica et biophysica acta 1993 Gutierrez MM, Giacomini KM
• Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine.
  Drug metabolism and disposition: the biological fate of chemicals 1993 Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM
• Formycin B elimination from the cerebrospinal fluid of the rat.
  Pharmaceutical research 1993 Wu X, Hui AC, Giacomini KM
• Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney.
  Pharmaceutical research 1993 Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM
• Caring for the community
  Caring. 1993 Hayes K, Morgan B, Giacomini K, Dockal S.
• Beta-adrenergic blockers as cardioprotective agents.
  The American journal of cardiology 1992 Frishman WH
• Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction.
  The American journal of physiology 1992 Chang SW, Dutton D, Wang HL, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, Voelkel NF
• Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.
  The Journal of biological chemistry 1992 Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM
• Nucleoside transport in brush border membrane vesicles from human kidney.
  Biochimica et biophysica acta 1992 Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM
• Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells.
  The Journal of biological chemistry 1992 Ott RJ, Hui AC, Giacomini KM
• Organic cation transport in human renal brush-border membrane vesicles.
  The American journal of physiology 1991 Ott RJ, Hui AC, Yuan G, Giacomini KM
• Transport of organic cations by a renal epithelial cell line (OK).
  The Journal of biological chemistry 1991 Yuan G, Ott RJ, Salgado C, Giacomini KM
• Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide.
  Journal of clinical pharmacology 1991 Lam YW, Boyd RA, Chin SK, Chang D, Giacomini KM
• Preparation of brush border membrane vesicles from bovine choroid plexus.
  Journal of pharmacological methods 1991 Whittico MT, Hui AC, Giacomini KM
• Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles.
  Biochemical pharmacology 1991 Ott RJ, Hui AC, Wong FM, Hsyu PH, Giacomini KM
• Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus.
  The Journal of pharmacology and experimental therapeutics 1990 Whittico MT, Gang YA, Giacomini KM
• Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles.
  Biochemical pharmacology 1990 Ott RJ, Hai AC, Giacomini KM
• Computer-guided laser for neurosurgery.
  Annales chirurgiae et gynaecologiae 1990 Koivukangas J, Louhisalmi Y
• The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
  Clinical pharmacology and therapeutics 1989 Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM
• High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol.
  Journal of chromatography 1989 Chin SK, Hui AC, Giacomini KM
• The effect of probenecid on the renal elimination of cimetidine.
  Clinical pharmacology and therapeutics 1989 Gisclon LG, Boyd RA, Williams RL, Giacomini KM
• The pharmacokinetics of the enantiomers of atenolol.
  Clinical pharmacology and therapeutics 1989 Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM
• Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium.
  Journal of cardiovascular pharmacology 1988 Boyd RA, Giacomini JC, Giacomini KM
• Cimetidine elimination from the cerebrospinal fluid of the rat.
  Pharmaceutical research 1988 Whittico MT, Giacomini KM
• Renal transport of drugs: an overview of methodology with application to cimetidine.
  Pharmaceutical research 1988 Giacomini KM, Hsyu PH, Gisclon LG
• Stereoselective binding of disopyramide to plasma proteins.
  Pharmaceutical research 1988 Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF
• The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles.
  Drug metabolism and disposition: the biological fate of chemicals 1988 Hsyu PH, Wong FM, Giacomini KM
• Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney.
  Drug metabolism and disposition: the biological fate of chemicals 1988 Gisclon LG, Giacomini KM
• Interactions of organic anions with the organic cation transporter in renal BBMV.
  The American journal of physiology 1988 Hsyu PH, Gisclon LG, Hui AC, Giacomini KM
• Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium.
  The Journal of pharmacology and experimental therapeutics 1987 Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM
• Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney.
  The American journal of physiology 1987 Gisclon L, Wong FM, Giacomini KM
• Essential tyrosine residues in transport of organic cations in renal BBMV.
  The American journal of physiology 1987 Hsyu PH, Giacomini KM
• The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange.
  The Journal of biological chemistry 1987 Hsyu PH, Giacomini KM
• Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.
  Journal of medicinal chemistry 1986 Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC
• The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
  Journal of molecular and cellular cardiology 1986 Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC
• In vivo interaction of the enantiomers of disopyramide in human subjects.
  Journal of pharmacokinetics and biopharmaceutics 1986 Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF
• Posttraumatic complications and inflammatory mediators.
  Archives of surgery (Chicago, Ill. : 1960) 1986 Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ
• High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol.
  Journal of pharmaceutical sciences 1986 Hsyu PH, Giacomini KM
• Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel.
  Biochemical pharmacology 1986 Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM
• Stereoselective renal clearance of pindolol in humans.
  The Journal of clinical investigation 1985 Hsyu PH, Giacomini KM
• Electrophysiology of the enantiomers of disopyramide in dogs.
  Journal of cardiovascular pharmacology 1985 Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF
• The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits.
  Journal of cardiovascular pharmacology 1985 Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM
• Verapamil interacts stereoselectively with the muscarinic receptor.
  Pharmaceutical research 1985 Giacomini JC, Zobrist RH, Dave B, Giacomini KM
• Decreased binding of verapamil to plasma proteins in patients with liver disease.
  Journal of cardiovascular pharmacology 1984 Giacomini KM, Massoud N, Wong FM, Giacomini JC
• Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration.
  Pharmaceutical research 1984 Giacomini KM, Wong FM, Tozer TN
• High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma.
  Journal of chromatography 1984 Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF
• Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide.
  Clinical pharmacokinetics 1984 Giacomini KM, Blaschke TF
• Amitriptyline disposition in young and elderly normal men.
  Clinical pharmacology and therapeutics 1983 Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF
• Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin.
  Therapeutic drug monitoring 1983 Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM
• Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man.
  European journal of clinical pharmacology 1983 Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF
• Calculation of drug concentration in plasma after equilibrium dialysis.
  British journal of clinical pharmacology 1982 Giacomini KM, Abang A, Blaschke TF
• The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study.
  Circulation 1982 Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL
• High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood.
  Journal of pharmaceutical sciences 1982 Smith GA, Schulz P, Giacomini KM, Blaschke TF
• Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography.
  Journal of chromatography 1982 Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF
• The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide.
  Journal of pharmacokinetics and biopharmaceutics 1982 Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF
• Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.
  Journal of medicinal chemistry 1981 Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM
• Evaluation of methods for producing renal dysfunction in rats.
  Journal of pharmaceutical sciences 1981 Giacomini KM, Roberts SM, Levy G
• Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins.
  Biochemical pharmacology 1980 Giacomini KM, Giacomini JC, Blaschke TF
• The stereoselective disposition of disopyramide in the dog.
  Journal of cardiovascular pharmacology 1980 Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF
• Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum.
  Life sciences 1980 Giacomini KM, Cox BM, Blaschke TF
• Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma.
  Life sciences 1980 Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF
• Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt.
  Clinical pharmacology and therapeutics 1980 Giacomini KM, Giacomini JC, Gibson TP, Levy G
• Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs.
  Journal of pharmaceutical sciences 1980 Giacomini KM, Nakeeb SM, Levy G
• Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.
  Clinical pharmacology and therapeutics 1980 Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G
• Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients.
  Clinical pharmacology and therapeutics 1980 Giacomini KM, Gibson TP, Levy G
• Phenylalanine metabolism in uremic and normal man.
  Kidney international 1978 Jones MR, Kopple JD, Swendseid ME
• Rational aspirin dosage regimens.
  Clinical pharmacology and therapeutics 1978 Levy G, Giacomini KM
• Plasma protein binding of d-propoxyphene in normal subjects and anephric patients.
  Journal of clinical pharmacology 1978 Giacomini KM, Gibson TP, Levy G
• A Convenient Method for Repetitive Blood Sampling in the Dog
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• [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease].
  Biomedicine / [publiee pour l'A.A.I.C.I.G.] 1976 Senet JM, Robert R, Mauras G