Kathleen Liu, MD, PhD
Professor
Medicine
School of Medicine

College: Harvard University, AB Medical/Graduate School: University of California, San Francisco, MD, PhD

RESEARCH

My current research areas of interest focus on the predictive and pathogenetic role of biomarkers for both acute and chronic disease states. My long term goal is to identify and validate novel biomarkers of organ injury (specifically, the kidney and lung) that may have predictive value for disease outcomes as well as shed important insight into disease pathogenesis. In addition, I have a major interest in clinical trials in the Intensive Care Unit, with a particular focus on acute lung injury and acute kidney injury.

• Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
  American journal of respiratory and critical care medicine 2024 Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee…
• Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL).
  Intensive care medicine 2024 Pickkers P, Angus DC, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle MH, Doi K, Doig CJ, Ferrer R, Francois B, Gammelager H, Pedersen UG, Hoste E, Iversen S, Joannidis M, Kellum JA, Liu K, …
• A New Global Definition of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF,…
• Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial.
  Intensive care medicine 2023 Wald R, Gaudry S, da Costa BR, Adhikari NKJ, Bellomo R, Du B, Gallagher MP, Hoste EA, Lamontagne F, Joannidis M, Liu KD, McAuley DF, McGuinness SP, Nichol AD, Ostermann M, Palevsky PM, Qiu H, Pettilä …
• The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events.
  Kidney international 2023 Menez S, Wen Y, Xu L, Moledina DG, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju PK, Ikizler TA, Siew ED, Chinchilli VM, Garg AX, Go AS, Liu KD, Kaufman JS, Kimmel PL, Himmelfarb J, Coca SG, Cantley …
• Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
  The Lancet. Respiratory medicine 2023 Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, …
• Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study.
  Annals of internal medicine 2023 Muiru AN, Hsu JY, Zhang X, Appel LJ, Chen J, Cohen DL, Drawz PE, Freedman BI, Go AS, He J, Horwitz EJ, Hsu RK, Lash JP, Liu KD, McCoy IE, Porter A, Rao P, Ricardo AC, Rincon-Choles H, Sondheimer J, …
• Subgroups of Patients with Distinct Health Utility Profiles after AKI.
  Kidney360 2023 Kwong YD, Liu KD, Hsu CY, Cooper B, Palevsky PM, Kellum JA, Johansen KL, Miaskowski C
• Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
  Critical care (London, England) 2023 Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, …
• Longitudinal biomarkers and kidney disease progression after acute kidney injury.
  JCI insight 2023 Wen Y, Xu L, Melchinger I, Thiessen-Philbrook H, Moledina DG, Coca SG, Hsu CY, Go AS, Liu KD, Siew ED, Ikizler TA, Chinchilli VM, Kaufman JS, Kimmel PL, Himmelfarb J, Cantley LG, Parikh CR, ASSESS-AKI…
• Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes.
  Clinical journal of the American Society of Nephrology : CJASN 2023 McCoy IE, Hsu JY, Zhang X, Diamantidis CJ, Taliercio J, Go AS, Liu KD, Drawz P, Srivastava A, Horwitz EJ, He J, Chen J, Lash JP, Weir MR, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) Study …
• Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury.
  BMJ open 2023 Pickkers P, Angus DC, Arend J, Bellomo R, van den Berg E, Bernholz J, Bestle M, Broglio K, Carlsen J, Doig CJ, Ferrer R, Joannidis M, Francois B, Doi K, Kellum JA, Laterre PF, Liu K, Mehta RL, Murray …
• Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes.
  Clinical journal of the American Society of Nephrology : CJASN 2023 Vasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour SG, Moledina DG, Gulamali FF, Siew ED, Garg AX, Sarder P, Chinchilli VM, Kaufman JS, Hsu CY, Liu KD, Kimmel PL, Go AS, Wurfel MM, Himmelfarb J, Parikh …
• Care of the Hospitalized Patients with Kidney Failure during COVID-19 Pandemic: Lessons Learned.
  Clinical journal of the American Society of Nephrology : CJASN 2023 Liu K, Koyner JL, Heung M, Vijayan A
• Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
  The New England journal of medicine 2023 National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinic, Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, …
• Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2023 Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS
• Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes.
  Annals of surgery 2022 Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators
• Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial.
  Critical care (London, England) 2022 Wald R, Kirkham B, daCosta BR, Ghamarian E, Adhikari NKJ, Beaubien-Souligny W, Bellomo R, Gallagher MP, Goldstein S, Hoste EAJ, Liu KD, Neyra JA, Ostermann M, Palevsky PM, Schneider A, Vaara ST, …
• Overview of the Medical Management of the Critically Ill Patient.
  Clinical journal of the American Society of Nephrology : CJASN 2022 Martinez RH, Liu KD, Aldrich JM
• Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
  Nature microbiology 2022 Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, …
• Informed consent process in the ISPY COVID trial is ethically acceptable.
  European journal of internal medicine 2022 Files DC, Esserman L, Liu KD, Calfee CS
• The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.
  Critical care (London, England) 2022 Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network
• Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Journal of the Endocrine Society 2022 Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL
• Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
  Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, …
• Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study.
  BMC nephrology 2022 McCoy IE, Hsu JY, Bonventre JV, Parikh CR, Go AS, Liu KD, Ricardo AC, Srivastava A, Cohen DL, He J, Chen J, Rao PS, Muiru AN, Hsu CY
• Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2022 Coca SG, Vasquez-Rios G, Mansour SG, Moledina DG, Thiessen-Philbrook H, Wurfel MM, Bhatraju P, Himmelfarb J, Siew E, Garg AX, Hsu CY, Liu KD, Kimmel PL, Chinchilli VM, Kaufman JS, Wilson M, Banks RE, …
• Subphenotypes in acute kidney injury: a narrative review.
  Critical care (London, England) 2022 Vaara ST, Bhatraju PK, Stanski NL, McMahon BA, Liu K, Joannidis M, Bagshaw SM
• Optimizing the Design and Analysis of Future AKI Trials.
  Journal of the American Society of Nephrology : JASN 2022 Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, …
• I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.
  BMJ open 2022 Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, …
• Factors associated with risk and prognosis of intensive care unit admission in patients with acute leukemia: a Danish nationwide cohort study.
  Leukemia & lymphoma 2022 Maeng CV, Christiansen CF, Liu KD, Kamper P, Christensen S, Medeiros BC, Østgård LSG
• Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy.
  Clinical journal of the American Society of Nephrology : CJASN 2022 Thompson Bastin ML, Stromberg AJ, Nerusu SN, Liu LJ, Mayer KP, Liu KD, Bagshaw SM, Wald R, Morris PE, Neyra JA
• Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
  American journal of respiratory and critical care medicine 2022 Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, …
• Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2022 Muiru AN, Yang J, Derebail VK, Liu KD, Feldman HI, Srivastava A, Bhat Z, Saraf SL, Chen TK, He J, Estrella MM, Go AS, Hsu CY, CRIC Study Investigators
• Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury.
  Kidney international reports 2022 Wen Y, Thiessen-Philbrook H, Moledina DG, Kaufman JS, Reeves WB, Ghahramani N, Ikizler TA, Go AS, Liu KD, Siew ED, Himmelfarb J, Kimmel PL, Hsu CY, Parikh CR
• Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study.
  Journal of the American Society of Nephrology : JASN 2022 McCoy IE, Hsu JY, Bonventre JV, Parikh CR, Go AS, Liu KD, Ricardo AC, Srivastava A, Cohen DL, He J, Chen J, Rao PS, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
• Introduction to Critical Care Nephrology and Acute Kidney Injury.
  Clinical journal of the American Society of Nephrology : CJASN 2022 Liu KD, Palevsky PM
• Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
  Shock (Augusta, Ga.) 2022 Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA
• Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury.
  Journal of the American Society of Nephrology : JASN 2022 Mansour SG, Bhatraju PK, Coca SG, Obeid W, Wilson FP, Stanaway IB, Jia Y, Thiessen-Philbrook H, Go AS, Ikizler TA, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Reeves WB, Liu KD, Kimmel PL, Kaufman JS, …
• Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
  The Lancet. Respiratory medicine 2022 Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz …
• Kidney Dysfunction After Acute Heart Failure: Is Acute Kidney Disease the New Acute Kidney Injury?
  Kidney international reports 2021 Kwong YD, Liu KD, Hsu RK
• Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells.
  The European respiratory journal 2021 Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ
• Preface.
  Critical care clinics 2021 Matthay MA, Liu KD
• Recovery after Critical Illness and Acute Kidney Injury.
  Clinical journal of the American Society of Nephrology : CJASN 2021 Vijayan A, Abdel-Rahman EM, Liu KD, Goldstein SL, Agarwal A, Okusa MD, Cerda J, AKI!NOW Steering Committee
• Identifying the Sickest During Triage: Using Point-of-Care Severity Scores to Predict Prognosis in Emergency Department Patients With Suspected Sepsis.
  Journal of hospital medicine 2021 Prasad PA, Fang MC, Martinez SP, Liu KD, Kangelaris KN
• Achieved blood pressure post-acute kidney injury and risk of adverse outcomes after AKI: A prospective parallel cohort study.
  BMC nephrology 2021 McCoy I, Brar S, Liu KD, Go AS, Hsu RK, Chinchilli VM, Coca SG, Garg AX, Himmelfarb J, Ikizler TA, Kaufman J, Kimmel PL, Lewis JB, Parikh CR, Siew ED, Ware LB, Zeng H, Hsu CY, Assessment, Serial …
• Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
  Critical care explorations 2021 Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA
• Association Between Kidney Dysfunction Types and Mortality Among Hospitalized Patients with Cirrhosis.
  Digestive diseases and sciences 2021 Cullaro G, Rubin JB, Fortune BE, Crawford CV, Verna EC, Hsu CY, Liu KD, Brown RS, Lai JC, Rosenblatt R
• Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
  Thorax 2021 Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB…
• Kidney Replacement Therapy in the ICU: Less Is More (Death)?
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Legrand M, Liu KD
• Pathophysiology of COVID-19-associated acute kidney injury.
  Nature reviews. Nephrology 2021 Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V
• Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Schmidt IM, Srivastava A, Sabbisetti V, McMahon GM, He J, Chen J, Kusek JW, Taliercio J, Ricardo AC, Hsu CY, Kimmel PL, Liu KD, Mifflin TE, Nelson RG, Vasan RS, Xie D, Zhang X, Palsson R, Stillman IE,…
• Changes in intensive care unit admission rates, organ support, and mortality in patients with acute myeloid leukaemia over a 12-year period: a Danish nationwide cohort study.
  British journal of haematology 2021 Maeng CV, Østgård LSG, Christiansen CF, Liu KD
• Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.
  Nature reviews. Nephrology 2021 Prowle JR, Forni LG, Bell M, Chew MS, Edwards M, Grams ME, Grocott MPW, Liu KD, McIlroy D, Murray PT, Ostermann M, Zarbock A, Bagshaw SM, Bartz R, Bell S, Bihorac A, Gan TJ, Hobson CE, Joannidis M, …
• Outpatient Dietary Management of Electrolyte Disorders During COVID-19: Food as Medicine.
  JAMA internal medicine 2021 Kwong YD, Liu KD, Lo LJ
• Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data.
  PLoS medicine 2021 Ku E, Hsu RK, Johansen KL, McCulloch CE, Mitsnefes M, Grimes BA, Liu KD
• Biomarkers of inflammation and repair in kidney disease progression.
  The Journal of clinical investigation 2021 Puthumana J, Thiessen-Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J, Bhatraju PK, Ikizler TA, Siew ED, Ware LB, Liu KD, Go AS, Kaufman JS, Kimmel PL, Chinchilli VM, Cantley LG, Parikh CR
• Survey of Current Practices of Outpatient Hemodialysis for AKI Patients.
  Kidney international reports 2021 Ortiz-Soriano V, Butler CR, Levy M, Huen SC, Castaneda JL, Sakhuja A, Basu RK, Liu KD, Cerda J, Neyra JA
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury.
  Clinical journal of the American Society of Nephrology : CJASN 2020 Brar S, Liu KD, Go AS, Hsu RK, Chinchilli VM, Coca SG, Garg AX, Himmelfarb J, Ikizler TA, Kaufman J, Kimmel PL, Parikh CR, Siew ED, Ware LB, Zeng H, Hsu CY, ASsessment, Serial Evaluation, and …
• Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains.
  Critical care medicine 2020 Legrand M, Liu K
• Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2020 Matthay MA, Leligdowicz A, Liu KD
• Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
  JAMA 2020 Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, …
• Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
  Nature reviews. Nephrology 2020 Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, …
• Alternative Tobacco Product Use in Critically Ill Patients.
  International journal of environmental research and public health 2020 Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS
• The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.
  Transplantation 2020 Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D
• AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.
  Journal of the American Society of Nephrology : JASN 2020 Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, …
• COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
  Nature reviews. Nephrology 2020 Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, …
• Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
  American journal of physiology. Renal physiology 2020 Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD
• Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.
  American journal of respiratory and critical care medicine 2020 Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N
• Improving Care for Patients after Hospitalization with AKI.
  Journal of the American Society of Nephrology : JASN 2020 Siew ED, Liu KD, Bonn J, Chinchilli V, Dember LM, Girard TD, Greene T, Hernandez AF, Ikizler TA, James MT, Kampschroer K, Kopp JB, Levy M, Palevsky PM, Pannu N, Parikh CR, Rocco MV, Silver SA, …
• Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
  American journal of physiology. Lung cellular and molecular physiology 2020 Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, …
• Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury.
  Kidney diseases (Basel, Switzerland) 2020 Dae MW, Liu KD, Solomon RJ, Gao DW, Stillson CA
• Need for Additional Trials of Vitamin C for Sepsis.
  JAMA 2020 Files DC, Liu KD, Matthay M
• Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
  Pediatric pulmonology 2020 Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR
• Recovery of Kidney Function Among Patients With Glomerular Disease Starting Maintenance Dialysis.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2020 Kwong YD, Liu KD, Hsu RK, Johansen KL, McCulloch CE, Seth D, Fallahzadeh MK, Grimes BA, Ku E
• Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions.
  Kidney international reports 2020 Liu KD, Forni LG, Heung M, Wu VC, Kellum JA, Mehta RL, Ronco C, Kashani K, Rosner MH, Haase M, Koyner JL, Acute Disease Quality Initiative Investigators
• A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death.
  Kidney international 2020 Ikizler TA, Parikh CR, Himmelfarb J, Chinchilli VM, Liu KD, Coca SG, Garg AX, Hsu CY, Siew ED, Wurfel MM, Ware LB, Faulkner GB, Tan TC, Kaufman JS, Kimmel PL, Go AS, ASSESS-AKI Study Investigators
• Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
  BMC nephrology 2020 Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM
• Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.
  The New England journal of medicine 2020 STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology…
• Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy.
  Critical care (London, England) 2020 Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD
• Renin-angiotensin system blockers and 1-year mortality in patients with post-operative acute kidney injury.
  Acta anaesthesiologica Scandinavica 2020 Slagelse C, Gammelager H, Iversen LH, Liu KD, Sørensen HT, Christiansen CF
• Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
  Critical care medicine 2020 Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS
• The attributable mortality of acute respiratory distress syndrome.
  Intensive care medicine 2020 Auriemma CL, Delucchi K, Liu KD, Calfee CS
• Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
  Kidney international 2020 Ostermann M, Bellomo R, Burdmann EA, Doi K, Endre ZH, Goldstein SL, Kane-Gill SL, Liu KD, Prowle JR, Shaw AD, Srisawat N, Cheung M, Jadoul M, Winkelmayer WC, Kellum JA, Conference Participants
• AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI.
  Clinical journal of the American Society of Nephrology : CJASN 2020 Liu KD, Goldstein SL, Vijayan A, Parikh CR, Kashani K, Okusa MD, Agarwal A, Cerdá J, AKI!Now Initiative of the American Society of Nephrology
• Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes.
  JAMA network open 2020 Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM
• Gender Differences in Authorship of Critical Care Literature.
  American journal of respiratory and critical care medicine 2020 Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ
• Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
  Intensive care medicine 2020 Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS
• Clinical Trials for AKI: Lessons Learned From the ARDS Network.
  Seminars in nephrology 2020 Liu KD
• Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study.
  JAMA internal medicine 2020 Hsu CY, Chinchilli VM, Coca S, Devarajan P, Ghahramani N, Go AS, Hsu RK, Ikizler TA, Kaufman J, Liu KD, Parikh CR, Reeves WB, Wurfel M, Zappitelli M, Kimmel PL, Siew ED, ASSESS-AKI Investigators
• Exciting developments in the field of acute kidney injury.
  Nature reviews. Nephrology 2020 Huang CT, Liu KD
• Critical Care Nephrology: Core Curriculum 2020.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2020 Griffin BR, Liu KD, Teixeira JP
• Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
  The European respiratory journal 2020 Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ
• Renin-Angiotensin System Blockade after Acute Kidney Injury (AKI) and Risk of Recurrent AKI.
  Clinical journal of the American Society of Nephrology : CJASN 2019 Hsu CY, Liu KD, Yang J, Glidden DV, Tan TC, Pravoverov L, Zheng S, Go AS
• Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
  Critical care (London, England) 2019 Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, …
• The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury.
  PloS one 2019 Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD
• Renin-angiotensin system blocker use and the risk of acute kidney injury after colorectal cancer surgery: a population-based cohort study.
  BMJ open 2019 Slagelse C, Gammelager H, Iversen LH, Liu KD, Sørensen HTT, Christiansen CF
• Lung inflammatory environments differentially alter mesenchymal stromal cell behavior.
  American journal of physiology. Lung cellular and molecular physiology 2019 Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, …
• Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.
  Critical care medicine 2019 Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM
• Impact of AKI on Urinary Protein Excretion: Analysis of Two Prospective Cohorts.
  Journal of the American Society of Nephrology : JASN 2019 Hsu CY, Hsu RK, Liu KD, Yang J, Anderson A, Chen J, Chinchilli VM, Feldman HI, Garg AX, Hamm L, Himmelfarb J, Kaufman JS, Kusek JW, Parikh CR, Ricardo AC, Rosas SE, Saab G, Sha D, Siew ED, Sondheimer …
• Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.
  Clinical kidney journal 2019 Hsu RK, Hsu CY, McCulloch CE, Yang J, Anderson AH, Chen J, Feldman HI, He J, Liu KD, Navaneethan SD, Porter AC, Rahman M, Tan TC, Wilson FP, Xie D, Zhang X, Go AS, Chronic Renal Insufficiency Cohort (…
• Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
  The New England journal of medicine 2019 National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, …
• Quality Improvement Goals for Acute Kidney Injury.
  Clinical journal of the American Society of Nephrology : CJASN 2019 Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo …
• Fluid Management in Acute Kidney Injury.
  Chest 2019 Ostermann M, Liu K, Kashani K
• Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
  American journal of respiratory and critical care medicine 2019 Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, …
• Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019 Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A
• Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
  The Lancet. Respiratory medicine 2019 Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS
• Prediction Models for AKI: Will They Result in Improved Outcomes for AKI?
  Clinical journal of the American Society of Nephrology : CJASN 2019 Kwong YD, Liu KD
• Management of hyperkalemia in the acutely ill patient.
  Annals of intensive care 2019 Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M
• Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury.
  Kidney international reports 2019 Lee BJ, Hsu CY, Parikh R, McCulloch CE, Tan TC, Liu KD, Hsu RK, Pravoverov L, Zheng S, Go AS
• Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA
• Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
  The Lancet. Respiratory medicine 2018 Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, …
• Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS.
  Transfusion 2018 Huppert LA, Liu KD, Matthay MA
• Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 Liu KD, Yang J, Tan TC, Glidden DV, Zheng S, Pravoverov L, Hsu CY, Go AS
• Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.
  Canadian journal of kidney health and disease 2018 Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD
• Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2018 Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA
• Biological Variability of Estimated GFR and Albuminuria in CKD.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 Waikar SS, Rebholz CM, Zheng Z, Hurwitz S, Hsu CY, Feldman HI, Xie D, Liu KD, Mifflin TE, Eckfeldt JH, Kimmel PL, Vasan RS, Bonventre JV, Inker LA, Coresh J, Chronic Kidney Disease Biomarkers …
• Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials.
  Respiratory care 2018 Pais FM, Sinha P, Liu KD, Matthay MA
• Selection of Intravenous Fluids.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 Kwong YD, Liu KD
• Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study.
  BMC nephrology 2018 Lee BJ, Hsu CY, Parikh RV, Leong TK, Tan TC, Walia S, Liu KD, Hsu RK, Go AS
• Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.
  Journal of the American Heart Association 2018 Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, …
• Remote organ failure in acute kidney injury.
  Journal of the Formosan Medical Association = Taiwan yi zhi 2018 Kao CC, Yang WS, Fang JT, Liu KD, Wu VC
• Acute Kidney Injury and Risk of Heart Failure and Atherosclerotic Events.
  Clinical journal of the American Society of Nephrology : CJASN 2018 Go AS, Hsu CY, Yang J, Tan TC, Zheng S, Ordonez JD, Liu KD
• Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.
  Annals of emergency medicine 2018 Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, …
• Contrast-Induced Acute Kidney Injury in the PRESERVE Trial: Lessons Learned.
  Clinical journal of the American Society of Nephrology : CJASN 2018 Siew ED, Liu KD
• Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.
  Clinical journal of the American Society of Nephrology : CJASN 2018 Zuk A, Palevsky PM, Fried L, Harrell FE, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, …
• Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.
  American journal of medical quality : the official journal of the American College of Medical Quality 2018 Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD
• Duration of acute kidney injury in critically ill patients.
  Annals of intensive care 2018 Federspiel CK, Itenov TS, Mehta K, Hsu RK, Bestle MH, Liu KD
• Management of Acute Kidney Injury: Core Curriculum 2018.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 Moore PK, Hsu RK, Liu KD
• Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury.
  Kidney international 2018 Lee BJ, Go AS, Parikh R, Leong TK, Tan TC, Walia S, Hsu RK, Liu KD, Hsu CY
• Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.
  American journal of critical care : an official publication, American Association of Critical-Care Nurses 2018 Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA
• Acute Respiratory Distress Syndrome.
  The New England journal of medicine 2017 Thompson BT, Chambers RC, Liu KD
• Pathophysiology of AKI.
  Best practice & research. Clinical anaesthesiology 2017 Ostermann M, Liu K
• Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families.
  Critical care medicine 2017 Thornton KC, Schwarz JJ, Gross AK, Anderson WG, Liu KD, Romig MC, Schell-Chaple H, Pronovost PJ, Sapirstein A, Gropper MA, Lipshutz AKM, Project Emerge Collaborators
• Acute Kidney Injury Ascertainment Is Affected by the Use of First Inpatient Versus Outpatient Baseline Serum Creatinine.
  Kidney international reports 2017 Liu KD, Hsu CY, Yang J, Tan TC, Zheng S, Ordonez JD, Go AS
• Acute Respiratory Distress Syndrome.
  The New England journal of medicine 2017 Thompson BT, Chambers RC, Liu KD
• No impact of surviving sepsis campaign care bundles in reducing sepsis-associated acute kidney injury
.
  Clinical nephrology 2017 Pérez-Fernández X, Sabater-Riera J, Ballus-Noguera J, Cárdenas-Campos P, Moreno-González G, Alonso-Juste V, Corral-Velez V, Gutierrez-Arámbula D, Gumucio-Sanguino V, Betbesé-Roig A, Liu KD
• Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
  Critical care medicine 2017 Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA
• AKI Adjudication: Do We Need It.
  Nephron 2017 Kwong YD, Liu KD
• What endpoints should not be used for clinical studies of acute kidney injury?
  Intensive care medicine 2017 Palevsky PM, Liu KD
• The ten barriers for translation of animal data on AKI to the clinical setting.
  Intensive care medicine 2017 Liu KD, Humphreys BD, Endre ZH
• Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study.
  Clinical journal of the American Society of Nephrology : CJASN 2017 Park M, Hsu CY, Go AS, Feldman HI, Xie D, Zhang X, Mifflin T, Waikar SS, Sabbisetti VS, Bonventre JV, Coresh J, Nelson RG, Kimmel PL, Kusek JW, Rahman M, Schelling JR, Vasan RS, Liu KD, Chronic Renal …
• Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.
  Nature reviews. Nephrology 2017 Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu KD, Macedo E, Mehta R, Murray P, Nadim M,…
• Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
  American journal of physiology. Lung cellular and molecular physiology 2017 Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, NHLBI ARDS Network
• Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.
  American journal of respiratory and critical care medicine 2017 Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS, ARDS Network
• Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome.
  Annals of the American Thoracic Society 2017 Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu KD, Talmor DS, Yealy DM, Reevaluation of Systemic Early …
• Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
  Critical care (London, England) 2016 Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM
• Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.
  Kidney international 2016 Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman …
• Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study.
  PloS one 2016 Liu KD, Siew ED, Reeves WB, Himmelfarb J, Go AS, Hsu CY, Bennett MR, Devarajan P, Ikizler TA, Kaufman JS, Kimmel PL, Chinchilli VM, Parikh CR, ASSESS-AKI Study Investigators
• Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.
  The New England journal of medicine 2016 Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu KD, Ashby D
• Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR
• RRT in AKI: Start Early or Wait?
  Clinical journal of the American Society of Nephrology : CJASN 2016 Liu KD, Palevsky PM
• Statistical Methods for Cohort Studies of CKD: Prediction Modeling.
  Clinical journal of the American Society of Nephrology : CJASN 2016 Roy J, Shou H, Xie D, Hsu JY, Yang W, Anderson AH, Landis JR, Jepson C, He J, Liu KD, Hsu CY, Feldman HI, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
• Does Changing the Volume Matter? The Relationship of Urine Volume and Dialysis Intensity.
  Clinical journal of the American Society of Nephrology : CJASN 2016 Federspiel CK, Liu KD
• Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016 Liu KD, Vijayan A, Rosner MH, Shi J, Chawla LS, Kellum JA
• Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016 Waikar SS, Sabbisetti V, Ärnlöv J, Carlsson AC, Coresh J, Feldman HI, Foster MC, Fufaa GD, Helmersson-Karlqvist J, Hsu CY, Kimmel PL, Larsson A, Liu Y, Lind L, Liu KD, Mifflin TE, Nelson RG, Risérus U…
• The acute respiratory distress syndrome following isolated severe traumatic brain injury.
  The journal of trauma and acute care surgery 2016 Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ
• Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
  Critical care (London, England) 2016 Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network
• ATS Core Curriculum 2016: Part II. Adult Critical Care Medicine.
  Annals of the American Thoracic Society 2016 McSparron JI, Hayes MM, Poston JT, Thomson CC, Fessler HE, Stapleton RD, Carlos WG, Hinkle L, Liu K, Shieh S, Ali A, Rogers A, Shah NG, Slack D, Patel B, Wolfe K, Schweickert WD, Bakhru RN, Shin S, …
• Changing Faces of Critical Care Nephrology.
  Advances in chronic kidney disease 2016 Liu KD
• Critical Care Updates for the Nephrologist, 2016.
  Advances in chronic kidney disease 2016 Pérez XL, Liu KD
• Acute kidney injury: Clinical trials in AKI: is the end in sight?
  Nature reviews. Nephrology 2016 Parks M, Liu KD
• Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient.
  Clinics in chest medicine 2016 Weyker PD, Pérez XL, Liu KD
• Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2016 Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A, American Society of Nephrology Acute Kidney Injury Advisory Group
• New Strategies for Effective Therapeutics in Critically Ill Patients.
  JAMA 2016 Matthay MA, Liu KD
• Bridging Translation by Improving Preclinical Study Design in AKI.
  Journal of the American Society of Nephrology : JASN 2015 de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S, ASN AKI Advisory Group
• Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial.
  Journal of the American Society of Nephrology : JASN 2015 Bansal N, Carpenter MA, Weiner DE, Levey AS, Pfeffer M, Kusek JW, Cai J, Hunsicker LG, Park M, Bennett M, Liu KD, Hsu CY
• The authors reply.
  Critical care medicine 2015 Ghannoum M, Calello DP, Lavergne V, Gosselin S, Liu KD, Roberts DM
• Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study.
  Clinical journal of the American Society of Nephrology : CJASN 2015 Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman HI, Vasan RS, Kimmel PL, Hsu CY, Liu KD, CKD Biomarkers Consortium
• What a Nephrologist Needs to Know About Acute Liver Failure.
  Advances in chronic kidney disease 2015 Leventhal TM, Liu KD
• Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.
  Critical care medicine 2015 Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M, Extracorporeal Treatments in Poisoning Workgroup
• Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care.
  Clinical journal of the American Society of Nephrology : CJASN 2015 Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A, American Society of Nephrology Acute Kidney Injury Advisory Group
• Promoting Kidney Function Recovery in Patients with AKI Requiring RRT.
  Clinical journal of the American Society of Nephrology : CJASN 2015 Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S, AKI Advisory Group of the American Society of Nephrology
• When change is not a good thing.
  Clinical chemistry 2015 Liu KD, Hsu CY
• Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.
  Critical care medicine 2015 Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A
• Finding the key to dialysis catheter lock.
  American journal of respiratory and critical care medicine 2015 Shieh SC, Liu KD
• Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.
  The Lancet. Respiratory medicine 2015 Wilson J, McKenna D, Liu KD, Matthay MA
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium.
  Clinical journal of the American Society of Nephrology : CJASN 2015 Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM,…
• Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network
• Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup.
  Clinical toxicology (Philadelphia, Pa.) 2015 Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS, EXTRIP workgroup
• Preparing for renal replacement therapy in patients with the Ebola virus disease.
  Blood purification 2015 Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ
• Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network
• Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.
  Critical care medicine 2015 Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR, Morris AH, National Heart Lung and Blood Institute Acute Respiratory Distress…
• Body temperature and mortality in patients with acute respiratory distress syndrome.
  American journal of critical care : an official publication, American Association of Critical-Care Nurses 2015 Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
• Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
  The Lancet. Respiratory medicine 2014 Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA
• Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.
  Diabetologia 2014 Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD, Chronic Kidney Disease Biomarkers…
• Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2014 Liu KD, Yang W, Go AS, Anderson AH, Feldman HI, Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, Miller ER, Rosas SE, Steigerwalt S, Tao K, Weir MR, Hsu CY, CRIC Study Investigators
• Therapeutic strategies for clinical trials targeting renal recovery.
  Nephron. Clinical practice 2014 Liu KD
• Rosuvastatin for sepsis-associated ARDS.
  The New England journal of medicine 2014 Liu KD, Dong N, Truwit JD
• Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
  Critical care medicine 2014 Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood …
• Propofol as a panacea for acute kidney injury?
  Kidney international 2014 Huddleston LL, Liu KD
• Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2014 Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
  Journal of intensive care 2014 Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS
• An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial.
  Trials 2014 Orme RM, Perkins GD, McAuley DF, Liu KD, Mason AJ, Morelli A, Singer M, Ashby D, Gordon AC
• Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia.
  Thorax 2014 Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P
• Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
  The New England journal of medicine 2014 National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP…
• The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2014 Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S, Acute Kidney Injury Advisory Group of the American Society of Nephrology
• Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
  Journal of critical care 2014 Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS
• Cardiovascular events after AKI: a new dimension.
  Journal of the American Society of Nephrology : JASN 2014 Hsu CY, Liu KD
• Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance.
  The Journal of thoracic and cardiovascular surgery 2014 Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M
• Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth.
  Current biology : CB 2014 Kwon SH, Liu KD, Mostov KE
• The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
  Respiratory care 2013 Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA, National Heart Lung and Blood Institute ARDS Network Investigators
• Evolving practices in critical care and their influence on acute kidney injury.
  Current opinion in critical care 2013 Wilson JG, Butcher BW, Liu KD
• Urine stability studies for novel biomarkers of acute kidney injury.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2013 Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu KD, ASSESS-AKI Study Investigators
• AKI: a path forward.
  Clinical journal of the American Society of Nephrology : CJASN 2013 Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA, Kidney Research National Dialogue (KRND)
• The authors reply.
  Kidney international 2013 Liu KD, Yang W, Hsu CY
• Acute kidney injury: an increasing global concern.
  Lancet (London, England) 2013 Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W, Vanholder R
• Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
  American journal of respiratory and critical care medicine 2013 Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS
• KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2013 Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD
• Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation.
  Biomarker insights 2013 Park M, Vittinghoff E, Liu KD, Shlipak MG, Hsu CY
• Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease.
  Kidney international 2013 Liu KD, Yang W, Anderson AH, Feldman HI, Demirjian S, Hamano T, He J, Lash J, Lustigova E, Rosas SE, Simonson MS, Tao K, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) study investigators
• Critical care nephrology: update in critical care for the nephrologist.
  Advances in chronic kidney disease 2013 Liu KD
• Fluid overload in AKI: epiphenomenon or putative effect on mortality?
  Current opinion in critical care 2012 Butcher BW, Liu KD
• Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.
  American journal of physiology. Lung cellular and molecular physiology 2012 Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD
• Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup.
  Clinical journal of the American Society of Nephrology : CJASN 2012 Ghannoum M, Nolin TD, Goldfarb DS, Roberts DM, Mactier R, Mowry JB, Dargan PI, Maclaren R, Hoegberg LC, Laliberté M, Calello D, Kielstein JT, Anseeuw K, Winchester JF, Burdmann EA, Bunchman TE, Li Y, …
• The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology.
  Clinical toxicology (Philadelphia, Pa.) 2012 Lavergne V, Nolin TD, Hoffman RS, Roberts D, Gosselin S, Goldfarb DS, Kielstein JT, Mactier R, Maclaren R, Mowry JB, Bunchman TE, Juurlink D, Megarbane B, Anseeuw K, Winchester JF, Dargan PI, Liu KD, …
• Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings.
  Clinical journal of the American Society of Nephrology : CJASN 2012 Molitoris BA, Okusa MD, Palevsky PM, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Faubel SG, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS,…
• Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials.
  Clinical journal of the American Society of Nephrology : CJASN 2012 Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, …
• Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology.
  Clinical journal of the American Society of Nephrology : CJASN 2012 Palevsky PM, Molitoris BA, Okusa MD, Levin A, Waikar SS, Wald R, Chertow GM, Murray PT, Parikh CR, Shaw AD, Go AS, Faubel SG, Kellum JA, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Chawla LS, …
• Ongoing clinical trials in AKI.
  Clinical journal of the American Society of Nephrology : CJASN 2012 Faubel S, Chawla LS, Chertow GM, Goldstein SL, Jaber BL, Liu KD, Acute Kidney Injury Advisory Group of the American Society of Nephrology
• The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
  Chest 2011 Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.
  Critical care medicine 2011 Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD, National Institutes of Health National Heart, Lung, and Blood …
• Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.
  American journal of respiratory and critical care medicine 2011 National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, …
• The value of positive end-expiratory pressure and Fio₂ criteria in the definition of the acute respiratory distress syndrome.
  Critical care medicine 2011 Britos M, Smoot E, Liu KD, Thompson BT, Checkley W, Brower RG, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators
• FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.
  Annals of intensive care 2011 Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD
• Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study.
  Annals of intensive care 2011 Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD
• Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
  Critical care research and practice 2011 Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA
• Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.
  American journal of respiratory and critical care medicine 2011 Matthay MA, Liu KD
• Fluid balance, diuretic use, and mortality in acute kidney injury.
  Clinical journal of the American Society of Nephrology : CJASN 2011 Grams ME, Estrella MM, Coresh J, Brower RG, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
• Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA, DOGMATIC Study Investigators
• Curbing the use of ultrasonography in the diagnosis of acute kidney injury: Penny wise or pound foolish?: Comment on "Renal ultrasonography in the evaluation of acute kidney injury".
  Archives of internal medicine 2010 Liu KD, Chertow GM
• Therapeutic potential of mesenchymal stem cells for severe acute lung injury.
  Chest 2010 Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW
• Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.
  Critical care medicine 2010 Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD
• The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.
  BMC nephrology 2010 Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB, …
• Acute kidney injury: is acute kidney injury a risk factor for long-term mortality?
  Nature reviews. Nephrology 2010 Liu KD
• Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury?
  Clinical journal of the American Society of Nephrology : CJASN 2010 Johnson XD, Liu KD
• Clinical trials for acute kidney injury: design challenges and possible solutions.
  Current drug targets 2009 Liu KD, Glidden DV
• Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.
  American journal of physiology. Lung cellular and molecular physiology 2009 Brown LM, Liu KD, Matthay MA
• Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study.
  Critical care (London, England) 2009 Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S
• Inhaled activated protein C: a novel therapy for acute lung injury?
  Critical care (London, England) 2009 Liu KD, Looney MR, Matthay MA
• Protective mechanisms of activated protein C in severe inflammatory disorders.
  British journal of pharmacology 2009 Neyrinck AP, Liu KD, Howard JP, Matthay MA
• Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2009 Church GD, Matthay MA, Liu K, Milet M, Flori HR
• Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.
  Pediatric pulmonology 2009 Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD
• Some methodological issues in studying the long-term renal sequelae of acute kidney injury.
  Current opinion in nephrology and hypertension 2009 Liu KD, Lo L, Hsu CY
• Long-term outcomes after acute kidney injury: where we stand and how we can move forward.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Lo L, Liu KD, Hsu CY
• Critical care nephrology: Core Curriculum 2009.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Liu KD
• Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
  American journal of physiology. Renal physiology 2008 Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE
• Impact of acute kidney injury on lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2008 Liu KD
• Randomized clinical trial of activated protein C for the treatment of acute lung injury.
  American journal of respiratory and critical care medicine 2008 Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA
• Protein C as a surrogate end-point for clinical trials of sepsis.
  Critical care (London, England) 2008 Liu KD, Matthay MA
• Renal repair and recovery.
  Critical care medicine 2008 Liu KD, Brakeman PR
• Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
  The Journal of biological chemistry 2008 Lindemann MJ, Hu Z, Benczik M, Liu KD, Gaffen SL
• Diagnosis, epidemiology and outcomes of acute kidney injury.
  Clinical journal of the American Society of Nephrology : CJASN 2008 Waikar SS, Liu KD, Chertow GM
• Advances in critical care for the nephrologist: acute lung injury/ARDS.
  Clinical journal of the American Society of Nephrology : CJASN 2008 Liu KD, Matthay MA
• Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.
  Critical care medicine 2007 Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group
• Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
  American journal of physiology. Renal physiology 2007 Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE
• Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury.
  Chest 2007 Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA
• The incidence and prognostic significance of acute kidney injury.
  Current opinion in nephrology and hypertension 2007 Waikar SS, Liu KD, Chertow GM
• Timing of initiation of dialysis in critically ill patients with acute kidney injury.
  Clinical journal of the American Society of Nephrology : CJASN 2006 Liu KD, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM
• Evolving practices in critical care and potential implications for management of acute kidney injury.
  Clinical journal of the American Society of Nephrology : CJASN 2006 Liu KD, Matthay MA, Chertow GM
• Formation of multicellular epithelial structures.
  Novartis Foundation symposium 2005 Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W
• Overview of interleukin-2 function, production and clinical applications.
  Cytokine 2004 Gaffen SL, Liu KD
• Management of acidosis during lung-protective ventilation in acute respiratory distress syndrome.
  Respiratory care clinics of North America 2003 Kallet RH, Liu K, Tang J
• Molecular mechanisms of recovery from acute renal failure.
  Critical care medicine 2003 Liu KD