Katherine Scangos, MD, PhD
Assistant Professor
Psychiatry
School of Medicine

Grants and Projects

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• Distributed networks underlying depression in epilepsy: a computational circuit-based approach to biomarker development, NIH, 2019-2024
• Deciphering principles of network dynamics underlying depression symptom severity from multi-day intracranial recordings in patients with major depression, NIH, 2021-2022

Publications (38)

Top publication keywords:
Subthalamic NucleusMental DisordersHaloperidolElectroconvulsive TherapyElectrocorticographyDrug Resistant EpilepsyFeedbackDeep Brain StimulationLimbic SystemDepressive Disorder, MajorPsychiatryMovementAffectBenzodiazepinesElectric Stimulation

• Stereoelectroencephalography Electrode Implantation for Inpatient Workup of Treatment-Resistant Depression.
  Neurosurgery 2024 Clara Kwon Starkweather, Leo P. Sugrue, Iahn Cajigas, Benjamin Speidel, Andrew D. Krystal, Katherine Scangos, Edward F. Chang
• Deep brain stimulation for refractory major depressive disorder: a comprehensive review.
  Molecular psychiatry 2024 Johnson KA, Okun MS, Scangos KW, Mayberg HS, de Hemptinne C
• Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.
  Journal of visualized experiments : JoVE 2023 Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.
  Brain stimulation 2023 Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD
• 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression.
  Biological Psychiatry 2023 Joshua Cohen, Joline M. Fan, Kristin K. Sellers, Ankit N. Khambhati, Heather E. Dawes, Katherine W. Scangos, Vikram R. Rao, Leo P. Sugrue, Philip A. Starr, Edward F. Chang, Andrew D. Krystal

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• New and emerging approaches to treat psychiatric disorders.
  Nature medicine 2023 Scangos KW, State MW, Miller AH, Baker JT, Williams LM
• Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.
  Brain stimulation 2023 Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD
• Changes in intracranial neurophysiology associated with acute COVID-19 infection.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2023 Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Identification of a personalized intracranial biomarker of depression and response to DBS therapy.
  Brain Stimulation 2023 Adam Frank, Katherine Scangos, Paul Larson, Tenzin Norbu, Anthony Lee, A. Moses Lee
• Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression.
  Nature medicine 2022 Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD
• Identification of a Personalized Intracranial Biomarker of Depression and Response to DBS Therapy.
  Brain Stimulation 2021 Adam Frank, Katherine Scangos, Paul Larson, Tenzin Norbu, Anthony Lee, Moses Lee
• Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.
  Frontiers in human neuroscience 2021 Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF
• Closed-loop neuromodulation in an individual with treatment-resistant depression.
  Nature medicine 2021 Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF
• Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
  Frontiers in human neuroscience 2021 Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, …
• 2 Personalized closed-loop neurostimulation for depression.
  Journal of Neurology Neurosurgery & Psychiatry 2021 Katherine Scangos
• Identification of a personalized intracranial biomarker of depression and response to DBS therapy.
  Brain stimulation 2021 Frank AC, Scangos KW, Larson PS, Norbu T, Lee AT, Lee AM
• Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
  Frontiers in human neuroscience 2021 Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, …
• State-dependent responses to intracranial brain stimulation in a patient with depression.
  Nature medicine 2021 Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD
• A Gaussian Process Model of Human Electrocorticographic Data.
  Cerebral cortex (New York, N.Y. : 1991) 2020 Owen LLW, Muntianu TA, Heusser AC, Daly PM, Scangos KW, Manning JR
• Using prefrontal transcranial direct current stimulation (tDCS) to enhance proactive cognitive control in schizophrenia.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Boudewyn MA, Scangos K, Ranganath C, Carter CS
• Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression.
  Biological Psychiatry 2020 Katherine Scangos, Ghassan Makhoul, Ankit N. Khambhati, Kristin K. Sellers, Edward F. Chang, Andrew D. Krystal
• Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.
  Frontiers in human neuroscience 2020 Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, Walker HC, Little SJ, Gilron R, …
• Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.
  The Journal of neuropsychiatry and clinical neurosciences 2019 Scangos KW, Ahmad HS, Shafi A, Sellers KK, Dawes HE, Krystal A, Chang EF
• An Electrophysiological Biomarker That May Predict Treatment Response to ECT.
  The journal of ECT 2019 Scangos KW, Weiner RD, Coffey EC, Krystal AD
• O20. Resting State Whole Brain Network Activity in Depression From Intracranial EEG Signals.
  Biological Psychiatry 2019 Katherine Scangos, Ankit N. Khambhati, Patrick Daly, Alia Shafi, Heather Dawes, Andrew Krystal, Edward F. Chang
• Effects of acute and subacute stimulation of ventral subthalamic nucleus on cognition and perceptual decision-making in patients with Parkinson’s disease.
  Brain Stimulation 2019 F. Girgis, A. Prabhu, I. Saez, K. Scangos, G. Gurkoff, K. O'Connor, J. Ditterich, C. Carter, J. Smucny, K. Shahlaie
• What We've Got Here Is Failure to Communicate: Improving Interventional Psychiatry With Closed-Loop Stimulation.
  Biological psychiatry 2018 Scangos KW, Ross DA
• F85. An Electrophysiological Biomarker That Predicts Treatment Response to ECT.
  Biological Psychiatry 2018 Katherine Scangos, Richard Weiner, Edward Coffey, Andrew Krystal
• Effect of Short-Term Theta Frequency Stimulation of the Vagus Nerve on Cognition among Patients with Refractory Epilepsy: A Pilot Study.
  The FASEB Journal 2018 E. Brandon Strong, Katherine Scangos, Anthony Mefford, Darrin Lee, Kiarash Shahlaie
• A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease.
  Brain stimulation 2017 Scangos KW, Carter CS, Gurkoff G, Zhang L, Shahlaie K
• 545 Effects of tDCS on Cognitive Control and Cortical Network Oscillations in Schizophrenia.
  Biological Psychiatry 2017 Katherine Scangos, Brooke Roberts, J. Daniel Ragland, Charan Ranganath, Cameron S. Carter
• Acute Frequency-Dependent Hypomania Induced by Ventral Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Case Report.
  Biological psychiatry 2016 Scangos KW, Shahlaie K
• Multiple Long-Acting Injectable Antipsychotics for Treatment-Resistant Schizophrenia: Case Report.
  Journal of clinical psychopharmacology 2016 Scangos KW, Caton M, Newman WJ
• Performance monitoring by presupplementary and supplementary motor area during an arm movement countermanding task.
  Journal of neurophysiology 2013 Scangos KW, Aronberg R, Stuphorn V
• Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans.
  Genetics 2011 Hale VA, Guiney EL, Goldberg LY, Haduong JH, Kwartler CS, Scangos KW, Goutte C
• Supplementary motor area exerts proactive and reactive control of arm movements.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Chen X, Scangos KW, Stuphorn V
• Medial frontal cortex motivates but does not control movement initiation in the countermanding task.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Scangos KW, Stuphorn V
• A chemical-genetic approach to studying neurotrophin signaling.
  Neuron 2005 Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD