Kate Alfieri, PhD
Director of Research Development and Training
Anesthesia
School of Medicine

Kate provides scientific and organizational oversight of the Department of Anesthesia's research enterprise and works with faculty leadership to develop, implement, and evaluate initiatives to address faculty and trainee research needs.

Awards

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• Graduate Research Fellowship, National Science Foundation, 2010

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California, San Francisco 2019
• Ph.D. Chemistry - Biophysical Chemistry University of California, Berkeley 2015
• B.S. Chemistry - Biochemistry Haverford College 2010

Grants and Projects

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• Comprehensive Anesthesia Research Training, NIH/NIGMS, 1995-2027

Publications (6)

Top publication keywords:
Major Histocompatibility ComplexCysteineLipid BilayersThiocyanatesLymphocyte ActivationCD28 AntigensSpectroscopy, Fourier Transform InfraredT-LymphocytesReceptors, Antigen, T-CellCircular DichroismAntigensAntimicrobial Cationic PeptidesPeptidesB7-1 AntigenLauric Acids

• Membrane Association Transforms an Inert Anti-TCRβ Fab' Ligand into a Potent T Cell Receptor Agonist.
  Biophysical journal 2020 Lin JJ, O'Donoghue GP, Wilhelm KB, Coyle MP, Low-Nam ST, Fay NC, Alfieri KN, Groves JT
• Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.
  Science signaling 2019 Lin JJY, Low-Nam ST, Alfieri KN, McAffee DB, Fay NC, Groves JT
• Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Pielak RM, O'Donoghue GP, Lin JJ, Alfieri KN, Fay NC, Low-Nam ST, Groves JT
• Using infrared spectroscopy of cyanylated cysteine to map the membrane binding structure and orientation of the hybrid antimicrobial peptide CM15.
  Biochemistry 2011 Alfieri KN, Vienneau AR, Londergan CH
• Polyglutamine fibrils are formed using a simple designed beta-hairpin model.
  Proteins 2010 Smith MH, Miles TF, Sheehan M, Alfieri KN, Kokona B, Fairman R
• Cyanylated Cysteine: A Covalently Attached Vibrational Probe of Protein-Lipid Contacts.
  The journal of physical chemistry letters 2010 McMahon HA, Alfieri KN, Clark KA, Londergan CH