Katalin Medzihradszky, PhD
Professor
Pharmaceutical Chemistry
School of Pharmacy

Publications (175)

Top publication keywords:
Sequence Analysis, ProteinChromatography, AffinityPhosphopeptidesMass SpectrometryMucin-1Tandem Mass SpectrometryGlycopeptidesGlycoproteinsProtein Processing, Post-TranslationalChromatography, LiquidGlycosylationProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetylglucosamineSpectrometry, Mass, Electrospray Ionization

• PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.
  Science advances 2023 Alber S, Di Matteo P, Zdradzinski MD, Dalla Costa I, Medzihradszky KF, Kawaguchi R, Di Pizio A, Freund P, Panayotis N, Marvaldi L, Doron-Mandel E, Okladnikov N, Rishal I, Nevo R, Coppola G, Lee SJ, …
• Cross-Linking Mass Spectrometry on P-Glycoprotein.
  International journal of molecular sciences 2023 Gellen G, Klement E, Biwott K, Schlosser G, Kalló G, Csosz É, Medzihradszky KF, Bacso Z
• Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis.
  Molecular neurobiology 2023 Tukacs V, Mittli D, Hunyadi-Gulyás É, Hlatky D, Medzihradszky KF, Darula Z, Nyitrai G, Czurkó A, Juhász G, Kardos J, Kékesi KA
• Multiple Layers of Complexity in O-Glycosylation Illustrated with the Urinary Glycoproteome.
  Molecular & cellular proteomics : MCP 2022 Pap A, Kiraly IE, Folkl Medzihradszky K, Darula Z
• Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
  Nature methods 2022 Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley RJ, Cheng K, Choo MS, Edwards N, Goldman R, Hoffmann M, Hu Y, Huang Y, Kim JY, Kletter D, Liquet B, Liu M, Mechref Y, Meng B, Neelamegham S,…

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• Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis.
  Nature methods 2021 Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley RJ, Cheng K, Choo MS, Edwards N, Goldman R, Hoffmann M, Hu Y, Huang Y, Kim JY, Kletter D, Liquet B, Liu M, Mechref Y, Meng B, Neelamegham S,…
• Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants.
  eLife 2021 Schwenk P, Sheerin DJ, Ponnu J, Staudt AM, Lesch KL, Lichtenberg E, Medzihradszky KF, Hoecker U, Klement E, Viczián A, Hiltbrunner A
• Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
  Frontiers in immunology 2021 Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, Homolya L, Juhász G, Kékesi KA, Józsi M, Györffy BA, Kardos J
• The effectiveness of filtering glycopeptide peak list files for Y ions.
  Molecular omics 2020 Chalkley RJ, Medzihradszky KF, Darula Z, Pap A, Baker PR
• Novel O-linked sialoglycan structures in human urinary glycoproteins.
  Molecular omics 2020 Pap A, Tasnadi E, Medzihradszky KF, Darula Z
• CRK5 Protein Kinase Contributes to the Progression of Embryogenesis of Arabidopsis thaliana.
  International journal of molecular sciences 2019 Baba AI, Valkai I, Labhane NM, Koczka L, Andrási N, Klement É, Darula Z, Medzihradszky KF, Szabados L, Fehér A, Rigó G, Cséplo Á
• A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.
  Cell 2019 Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D
• AtCRK5 Protein Kinase Exhibits a Regulatory Role in Hypocotyl Hook Development during Skotomorphogenesis.
  International journal of molecular sciences 2019 Baba AI, Andrási N, Valkai I, Gorcsa T, Koczka L, Darula Z, Medzihradszky KF, Szabados L, Fehér A, Rigó G, Cséplo Á
• Characterization of Site-Specific N-Glycosylation.
  Methods in molecular biology (Clifton, N.J.) 2019 Hevér H, Darula Z, Medzihradszky KF
• Extended Sialylated O-Glycan Repertoire of Human Urinary Glycoproteins Discovered and Characterized Using Electron-Transfer/Higher-Energy Collision Dissociation.
  Journal of proteome research 2018 Darula Z, Pap Á, Medzihradszky KF
• Translatome Regulation in Neuronal Injury and Axon Regrowth.
  eNeuro 2018 Rozenbaum M, Rajman M, Rishal I, Koppel I, Koley S, Medzihradszky KF, Oses-Prieto JA, Kawaguchi R, Amieux PS, Burlingame AL, Coppola G, Fainzilber M
• Status Report on the High-Throughput Characterization of Complex Intact O-Glycopeptide Mixtures.
  Journal of the American Society for Mass Spectrometry 2018 Pap A, Klement E, Hunyadi-Gulyas E, Darula Z, Medzihradszky KF
• Microtubule organization in presynaptic boutons relies on the formin DAAM.
  Development (Cambridge, England) 2018 Migh E, Götz T, Földi I, Szikora S, Gombos R, Darula Z, Medzihradszky KF, Maléth J, Hegyi P, Sigrist S, Mihály J
• Salivary proteome profiling of oral squamous cell carcinoma in a Hungarian population.
  FEBS open bio 2018 Csosz É, Márkus B, Darula Z, Medzihradszky KF, Nemes J, Szabó E, Tozsér J, Kiss C, Márton I
• Analysis of Mammalian O-Glycopeptides-We Have Made a Good Start, but There is a Long Way to Go.
  Molecular & cellular proteomics : MCP 2017 Darula Z, Medzihradszky KF
• Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D
• Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins.
  Scientific reports 2017 Langó T, Róna G, Hunyadi-Gulyás É, Turiák L, Varga J, Dobson L, Várady G, Drahos L, Vértessy BG, Medzihradszky KF, Szakács G, Tusnády GE
• Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
  Scientific reports 2017 Sipos A, Iván J, Bécsi B, Darula Z, Tamás I, Horváth D, Medzihradszky KF, Erdodi F, Lontay B
• Extracellular Protein Phosphorylation, the Neglected Side of the Modification.
  Molecular & cellular proteomics : MCP 2016 Klement E, Medzihradszky KF
• Using "spectral families" to assess the reproducibility of glycopeptide enrichment: human serum O-glycosylation revisited.
  Analytical and bioanalytical chemistry 2016 Pap A, Medzihradszky KF, Darula Z
• Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals.
  Molecular & cellular proteomics : MCP 2016 Maynard JC, Burlingame AL, Medzihradszky KF
• Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.
  Cell reports 2016 Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, …
• Immobilized metal affinity chromatography optimized for the analysis of extracellular phosphorylation.
  Proteomics 2016 Klement E, Raffai T, Medzihradszky KF
• MiniCORVET is a Vps8-containing early endosomal tether in Drosophila.
  eLife 2016 Lorincz P, Lakatos Z, Varga Á, Maruzs T, Simon-Vecsei Z, Darula Z, Benko P, Csordás G, Lippai M, Andó I, Hegedus K, Medzihradszky KF, Takáts S, Juhász G
• Maternal alterations in the proteome of the medial prefrontal cortex in rat.
  Journal of proteomics 2016 Völgyi K, Udvari EB, Szabó ÉR, Györffy BA, Hunyadi-Gulyás É, Medzihradszky K, Juhász G, Kékesi KA, Dobolyi Á
• Photoactivatable protein labeling by singlet oxygen mediated reactions.
  Bioorganic & medicinal chemistry letters 2016 To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X
• N-Glycopeptide Profiling in Arabidopsis Inflorescence.
  Molecular & cellular proteomics : MCP 2016 Xu SL, Medzihradszky KF, Wang ZY, Burlingame AL, Chalkley RJ
• O-glycosylation sites identified from mucin core-1 type glycopeptides from human serum.
  Glycoconjugate journal 2016 Darula Z, Sarnyai F, Medzihradszky KF
• Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model.
  American journal of cancer research 2015 Nagy Z, Baghy K, Hunyadi-Gulyás É, Micsik T, Nyíro G, Rácz G, Butz H, Perge P, Kovalszky I, Medzihradszky KF, Rácz K, Patócs A, Igaz P
• Isolation and analyses of axonal ribonucleoprotein complexes.
  Methods in cell biology 2015 Doron-Mandel E, Alber S, Oses JA, Medzihradszky KF, Burlingame AL, Fainzilber M, Twiss JL, Lee SJ
• Carbamidomethylation Side Reactions May Lead to Glycan Misassignments in Glycopeptide Analysis.
  Analytical chemistry 2015 Darula Z, Medzihradszky KF
• Tissue-Specific Glycosylation at the Glycopeptide Level.
  Molecular & cellular proteomics : MCP 2015 Medzihradszky KF, Kaasik K, Chalkley RJ
• Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades.
  The Biochemical journal 2015 Nagy SK, Darula Z, Kállai BM, Bögre L, Bánhegyi G, Medzihradszky KF, Horváth GV, Mészáros T
• Identification of nodule-specific cysteine-rich plant peptides in endosymbiotic bacteria.
  Proteomics 2015 Durgo H, Klement E, Hunyadi-Gulyas E, Szucs A, Kereszt A, Medzihradszky KF, Kondorosi E
• Structure-function analysis of peroxidasin provides insight into the mechanism of collagen IV crosslinking.
  Free radical biology & medicine 2015 Lázár E, Péterfi Z, Sirokmány G, Kovács HA, Klement E, Medzihradszky KF, Geiszt M
• Characterizing sialic acid variants at the glycopeptide level.
  Analytical chemistry 2015 Medzihradszky KF, Kaasik K, Chalkley RJ
• Lessons in de novo peptide sequencing by tandem mass spectrometry.
  Mass spectrometry reviews 2015 Medzihradszky KF, Chalkley RJ
• The B″ regulatory subunit of protein phosphatase 2A mediates the dephosphorylation of rice retinoblastoma-related protein-1.
  Plant molecular biology 2014 Ábrahám E, Yu P, Farkas I, Darula Z, Varga E, Lukács N, Ayaydin F, Medzihradszky KF, Dombrádi V, Dudits D, Horváth GV
• Noncovalent dimer formation in liquid chromatography-mass spectrometry analysis.
  Analytical chemistry 2014 Medzihradszky KF
• The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6.
  Plant physiology 2014 Pérez-Salamó I, Papdi C, Rigó G, Zsigmond L, Vilela B, Lumbreras V, Nagy I, Horváth B, Domoki M, Darula Z, Medzihradszky K, Bögre L, Koncz C, Szabados L
• Glycan side reaction may compromise ETD-based glycopeptide identification.
  Journal of the American Society for Mass Spectrometry 2014 Darula Z, Medzihradszky KF
• Medicago truncatula symbiotic peptide NCR247 contributes to bacteroid differentiation through multiple mechanisms.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Farkas A, Maróti G, Durgo H, Györgypál Z, Lima RM, Medzihradszky KF, Kereszt A, Mergaert P, Kondorosi É
• A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development.
  The Biochemical journal 2013 Lipinszki Z, Klement E, Hunyadi-Gulyas E, Medzihradszky KF, Márkus R, Pál M, Deák P, Udvardy A
• N- and O-glycosylation in the murine synaptosome.
  Molecular & cellular proteomics : MCP 2013 Trinidad JC, Schoepfer R, Burlingame AL, Medzihradszky KF
• Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.
  The FEBS journal 2013 Nagy GN, Marton L, Krámos B, Oláh J, Révész Á, Vékey K, Delsuc F, Hunyadi-Gulyás É, Medzihradszky KF, Lavigne M, Vial H, Cerdan R, Vértessy BG
• Inactivation of plasma membrane-localized CDPK-RELATED KINASE5 decelerates PIN2 exocytosis and root gravitropic response in Arabidopsis.
  The Plant cell 2013 Rigó G, Ayaydin F, Tietz O, Zsigmond L, Kovács H, Páy A, Salchert K, Darula Z, Medzihradszky KF, Szabados L, Palme K, Koncz C, Cséplo A
• Phosphorylation of phytochrome B inhibits light-induced signaling via accelerated dark reversion in Arabidopsis.
  The Plant cell 2013 Medzihradszky M, Bindics J, Ádám É, Viczián A, Klement É, Lorrain S, Gyula P, Mérai Z, Fankhauser C, Medzihradszky KF, Kunkel T, Schäfer E, Nagy F
• Altered functional protein networks in the prefrontal cortex and amygdala of victims of suicide.
  PloS one 2012 Kékesi KA, Juhász G, Simor A, Gulyássy P, Szego EM, Hunyadi-Gulyás E, Darula Z, Medzihradszky KF, Palkovits M, Penke B, Czurkó A
• Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.
  Journal of the American Chemical Society 2012 McCusker KP, Medzihradszky KF, Shiver AL, Nichols RJ, Yan F, Maltby DA, Gross CA, Fujimori DG
• How to dig deeper? Improved enrichment methods for mucin core-1 type glycopeptides.
  Molecular & cellular proteomics : MCP 2012 Darula Z, Sherman J, Medzihradszky KF
• Partial de novo sequencing and unusual CID fragmentation of a 7 kDa, disulfide-bridged toxin.
  Journal of the American Society for Mass Spectrometry 2012 Medzihradszky KF, Bohlen CJ
• A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.
  Nature 2011 Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D
• Removal of nonspecific binding proteins from cell and tissue extracts using 2-aminobenzimidazole-tethered affinity resin.
  Die Pharmazie 2011 Molnár E, Fábián G, Klem J, Darula Z, Hunyadi-Gulyás E, Medgyesi A, Medzihradszky KF, Puskás LG
• Unusual fragmentation of Pro-Ser/Thr-containing peptides detected in collision-induced dissociation spectra.
  Journal of the American Society for Mass Spectrometry 2011 Medzihradszky KF, Trinidad JC
• Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide.
  PloS one 2011 Bozóky Z, Róna G, Klement É, Medzihradszky KF, Merényi G, Vértessy BG, Friedrich P
• A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid.
  Biochemistry 2011 Sivaramakrishnan S, Ouellet H, Du J, McLean KJ, Medzihradszky KF, Dawson JH, Munro AW, Ortiz de Montellano PR
• Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding.
  The FEBS journal 2010 Bekesi A, Pukancsik M, Haasz P, Felfoldi L, Leveles I, Muha V, Hunyadi-Gulyas E, Erdei A, Medzihradszky KF, Vertessy BG
• The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion.
  The Journal of biological chemistry 2010 Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH
• Protein PTMs: post-translational modifications or pesky trouble makers?
  Journal of mass spectrometry : JMS 2010 Bradshaw RA, Medzihradszky KF, Chalkley RJ
• Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.
  Fungal genetics and biology : FG & B 2010 Pusztahelyi T, Klement E, Szajli E, Klem J, Miskei M, Karányi Z, Emri T, Kovács S, Orosz G, Kovács KL, Medzihradszky KF, Prade RA, Pócsi I
• Improved identification of O-linked glycopeptides from ETD data with optimized scoring for different charge states and cleavage specificities.
  Amino acids 2010 Darula Z, Chalkley RJ, Lynn A, Baker PR, Medzihradszky KF
• Signaling to transcription networks in the neuronal retrograde injury response.
  Science signaling 2010 Michaelevski I, Segal-Ruder Y, Rozenbaum M, Medzihradszky KF, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan SY, Rishal I, Geschwind DH, Pilpel Y, Burlingame AL, Fainzilber M
• BspRI restriction endonuclease: cloning, expression in Escherichia coli and sequential cleavage mechanism.
  Nucleic acids research 2010 Raskó T, Dér A, Klement E, Slaska-Kiss K, Pósfai E, Medzihradszky KF, Marshak DR, Roberts RJ, Kiss A
• Identification of β-lactamases in human and bovine isolates of Staphylococcus aureus strains having borderline resistance to penicillinase-resistant penicillins (PRPs) with proteomic methods.
  Veterinary microbiology 2010 Keseru JS, Szabó I, Gál Z, Massidda O, Mingoia M, Kaszanyitzky E, Jánosi S, Hulvely J, Csorba A, Buzás K, Hunyadi-Gulyás E, Medzihradszky KF, Biró S
• Improving software performance for peptide electron transfer dissociation data analysis by implementation of charge state- and sequence-dependent scoring.
  Molecular & cellular proteomics : MCP 2010 Baker PR, Medzihradszky KF, Chalkley RJ
• Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach.
  Journal of proteome research 2010 Klement E, Lipinszki Z, Kupihár Z, Udvardy A, Medzihradszky KF
• The genome of Beet cryptic virus 1 shows high homology to certain cryptoviruses present in phylogenetically distant hosts.
  Virus genes 2010 Szego A, Enünlü N, Deshmukh SD, Veliceasa D, Hunyadi-Gulyás E, Kühne T, Ilyés P, Potyondi L, Medzihradszky K, Lukács N
• Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
  Protein science : a publication of the Protein Society 2010 Cade CE, Dlouhy AC, Medzihradszky KF, Salas-Castillo SP, Ghiladi RA
• Axoplasm isolation from peripheral nerve.
  Developmental neurobiology 2010 Rishal I, Michaelevski I, Rozenbaum M, Shinder V, Medzihradszky KF, Burlingame AL, Fainzilber M
• Physiological truncation and domain organization of a novel uracil-DNA-degrading factor.
  The FEBS journal 2010 Pukáncsik M, Békési A, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kosinski J, Bujnicki JM, Alfonso C, Rivas G, Vértessy BG
• Statistical analysis of Peptide electron transfer dissociation fragmentation mass spectrometry.
  Analytical chemistry 2010 Chalkley RJ, Medzihradszky KF, Lynn AJ, Baker PR, Burlingame AL
• Mass spectrometric analysis, automated identification and complete annotation of O-linked glycopeptides.
  European journal of mass spectrometry (Chichester, England) 2010 Darula Z, Chalkley RJ, Baker P, Burlingame AL, Medzihradszky KF
• Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve.
  Molecular & cellular proteomics : MCP 2009 Michaelevski I, Medzihradszky KF, Lynn A, Burlingame AL, Fainzilber M
• Affinity enrichment and characterization of mucin core-1 type glycopeptides from bovine serum.
  Molecular & cellular proteomics : MCP 2009 Darula Z, Medzihradszky KF
• Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster.
  Journal of cell science 2009 Lipinszki Z, Kiss P, Pál M, Deák P, Szabó A, Hunyadi-Gulyas E, Klement E, Medzihradszky KF, Udvardy A
• Regulation of calpain B from Drosophila melanogaster by phosphorylation.
  The FEBS journal 2009 Kovács L, Alexa A, Klement E, Kókai E, Tantos A, Gógl G, Sperka T, Medzihradszky KF, Tözsér J, Dombrádi V, Friedrich P
• Lack of A-factor production induces the expression of nutrient scavenging and stress-related proteins in Streptomyces griseus.
  Molecular & cellular proteomics : MCP 2009 Birkó Z, Swiatek M, Szájli E, Medzihradszky KF, Vijgenboom E, Penyige A, Keseru J, van Wezel GP, Biró S
• Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling.
  Journal of medicinal chemistry 2009 Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P
• Spin scavenging analysis of myoglobin protein-centered radicals using stable nitroxide radicals: characterization of oxoammonium cation-induced modifications.
  Chemical research in toxicology 2009 Lardinois OM, Maltby DA, Medzihradszky KF, de Montellano PR, Tomer KB, Mason RP, Deterding LJ
• Mutator transposon activity reprograms the transcriptomes and proteomes of developing maize anthers.
  The Plant journal : for cell and molecular biology 2009 Skibbe DS, Fernandes JF, Medzihradszky KF, Burlingame AL, Walbot V
• Identification of new p53 acetylation sites in COS-1 cells.
  Molecular & cellular proteomics : MCP 2009 Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL
• Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.
  Journal of inorganic biochemistry 2008 Jiang Y, Trnka MJ, Medzihradszky KF, Ouellet H, Wang Y, Ortiz de Montellano PR
• Electron-transfer subunits of the NiFe hydrogenases in Thiocapsa roseopersicina BBS.
  The FEBS journal 2008 Palágyi-Mészáros LS, Maróti J, Latinovics D, Balogh T, Klement E, Medzihradszky KF, Rákhely G, Kovács KL
• Identifying calpain substrates in intact S2 cells of Drosophila.
  Archives of biochemistry and biophysics 2008 Bozoky Z, Alexa A, Dancsok J, Gogl G, Klement E, Medzihradszky KF, Friedrich P
• Cloning and characterization of the DNA region responsible for Megacin A-216 production in Bacillus megaterium 216.
  Journal of bacteriology 2008 Kiss A, Balikó G, Csorba A, Chuluunbaatar T, Medzihradszky KF, Alföldi L
• In-depth analysis of tandem mass spectrometry data from disparate instrument types.
  Molecular & cellular proteomics : MCP 2008 Chalkley RJ, Baker PR, Medzihradszky KF, Lynn AJ, Burlingame AL
• Investigating the quantitative nature of MALDI-TOF MS.
  Molecular & cellular proteomics : MCP 2008 Szájli E, Fehér T, Medzihradszky KF
• Proteomic analysis of skin invasion by blood fluke larvae.
  PLoS neglected tropical diseases 2008 Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH
• Intrinsic structural disorder of DF31, a Drosophila protein of chromatin decondensation and remodeling activities.
  Journal of proteome research 2008 Szollosi E, Bokor M, Bodor A, Perczel A, Klement E, Medzihradszky KF, Tompa K, Tompa P
• Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport.
  Plant physiology 2008 Zsigmond L, Rigó G, Szarka A, Székely G, Otvös K, Darula Z, Medzihradszky KF, Koncz C, Koncz Z, Szabados L
• Atypical nicotinic agonist bound conformations conferring subtype selectivity.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE
• Characterization of site-specific N-glycosylation.
  Methods in molecular biology (Clifton, N.J.) 2008 Medzihradszky KF
• Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
  FEBS letters 2007 Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Tölgyesi F, Fidy J, Vértessy BG
• Differential use of protease families for invasion by schistosome cercariae.
  Biochimie 2007 Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH
• Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells.
  Cell biology international 2007 Hutamekalin P, Farkas AE, Orbók A, Wilhelm I, Nagyoszi P, Veszelka S, Deli MA, Buzás K, Hunyadi-Gulyás E, Medzihradszky KF, Meksuriyen D, Krizbai IA
• Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor.
  The Journal of pharmacology and experimental therapeutics 2007 Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA
• Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases.
  The Journal of biological chemistry 2007 Hlavanda E, Klement E, Kókai E, Kovács J, Vincze O, Tökési N, Orosz F, Medzihradszky KF, Dombrádi V, Ovádi J
• Defining nicotinic agonist binding surfaces through photoaffinity labeling.
  Biochemistry 2007 Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, Casida JE
• Sulfopeptide fragmentation in electron-capture and electron-transfer dissociation.
  Journal of the American Society for Mass Spectrometry 2007 Medzihradszky KF, Guan S, Maltby DA, Burlingame AL
• Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
  Biochemistry 2007 Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA
• Mapping the elusive neonicotinoid binding site.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE
• The secreted signaling protein factor C triggers the A-factor response regulon in Streptomyces griseus: overlapping signaling routes.
  Molecular & cellular proteomics : MCP 2007 Birkó Z, Bialek S, Buzás K, Szájli E, Traag BA, Medzihradszky KF, Rigali S, Vijgenboom E, Penyige A, Kele Z, van Wezel GP, Biró S
• A novel fruitfly protein under developmental control degrades uracil-DNA.
  Biochemical and biophysical research communications 2007 Békési A, Pukáncsik M, Muha V, Zagyva I, Leveles I, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Kele Z, Erdei A, Felföldi F, Kónya E, Vértessy BG
• High mobility group box 1 protein induction by Mycobacterium bovis BCG.
  Mediators of inflammation 2007 Hofner P, Seprényi G, Miczák A, Buzás K, Gyulai Z, Medzihradszky KF, Rouhiainen A, Rauvala H, Mándi Y
• Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
  Nucleic acids research 2006 Németh-Pongrácz V, Barabás O, Fuxreiter M, Simon I, Pichová I, Rumlová M, Zábranská H, Svergun D, Petoukhov M, Harmat V, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kónya E, Vértessy BG
• Evidence for an extended interacting surface between beta-amyloid and serum amyloid P component.
  Neuroscience letters 2006 Likó I, Mák M, Klement E, Hunyadi-Gulyás E, Pázmány T, Medzihradszky KF, Urbányi Z
• Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
  Biochemistry 2006 Vincze O, Tökési N, Oláh J, Hlavanda E, Zotter A, Horváth I, Lehotzky A, Tirián L, Medzihradszky KF, Kovács J, Orosz F, Ovádi J
• Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.
  FEBS letters 2006 Oláh J, Tokési N, Vincze O, Horváth I, Lehotzky A, Erdei A, Szájli E, Medzihradszky KF, Orosz F, Kovács GG, Ovádi J
• Novel extracellular chitinases rapidly and specifically induced by general bacterial elicitors and suppressed by virulent bacteria as a marker of early basal resistance in tobacco.
  Molecular plant-microbe interactions : MPMI 2006 Ott PG, Varga GJ, Szatmári A, Bozsó Z, Klement E, Medzihradszky KF, Besenyei E, Czelleng A, Klement Z
• O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.
  Molecular & cellular proteomics : MCP 2006 Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL
• Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I).
  Biochemistry 2005 Ghiladi RA, Medzihradszky KF, Ortiz de Montellano PR
• Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome.
  The Biochemical journal 2005 Kiss P, Szabó A, Hunyadi-Gulyás E, Medzihradszky KF, Lipinszki Z, Pál M, Udvardy A
• Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG.
  Journal of the American Chemical Society 2005 Ghiladi RA, Medzihradszky KF, Rusnak FM, Ortiz de Montellano PR
• Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
  Biological chemistry 2005 Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T
• Proteomic analysis of Schistosoma mansoni cercarial secretions.
  Molecular & cellular proteomics : MCP 2005 Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH
• Identification of synaptic plasma membrane proteins co-precipitated with fibrillar beta-amyloid peptide.
  Journal of neurochemistry 2005 Verdier Y, Huszár E, Penke B, Penke Z, Woffendin G, Scigelova M, Fülöp L, Szucs M, Medzihradszky K, Janáky T
• Comprehensive analysis of a multidimensional liquid chromatography mass spectrometry dataset acquired on a quadrupole selecting, quadrupole collision cell, time-of-flight mass spectrometer: I. How much of the data is theoretically interpretable by search engines?
  Molecular & cellular proteomics : MCP 2005 Chalkley RJ, Baker PR, Hansen KC, Medzihradszky KF, Allen NP, Rexach M, Burlingame AL
• The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.
  The Journal of biological chemistry 2005 Ghiladi RA, Knudsen GM, Medzihradszky KF, Ortiz de Montellano PR
• Primary contact sites in intrinsically unstructured proteins: the case of calpastatin and microtubule-associated protein 2.
  Biochemistry 2005 Csizmók V, Bokor M, Bánki P, Klement E, Medzihradszky KF, Friedrich P, Tompa K, Tompa P
• Parotid secretory protein is an HDL-associated protein with anticandidal activity.
  American journal of physiology. Regulatory, integrative and comparative physiology 2005 Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C
• Characterization of protein N-glycosylation.
  Methods in enzymology 2005 Medzihradszky KF
• In-solution digestion of proteins for mass spectrometry.
  Methods in enzymology 2005 Medzihradszky KF
• Peptide sequence analysis.
  Methods in enzymology 2005 Medzihradszky KF
• Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL.
  Atherosclerosis 2004 Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR
• An antibiotic factory caught in action.
  Nature structural & molecular biology 2004 Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM
• Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS).
  Molecular & cellular proteomics : MCP 2004 Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL
• Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones.
  Biological chemistry 2004 Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M
• Developmental regulation of dUTPase in Drosophila melanogaster.
  The Journal of biological chemistry 2004 Békési A, Zagyva I, Hunyadi-Gulyás E, Pongrácz V, Kovári J, Nagy AO, Erdei A, Medzihradszky KF, Vértessy BG
• Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury.
  Molecular & cellular proteomics : MCP 2004 Perlson E, Medzihradszky KF, Darula Z, Munno DW, Syed NI, Burlingame AL, Fainzilber M
• From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons.
  Journal of neurobiology 2004 Perlson E, Hanz S, Medzihradszky KF, Burlingame AL, Fainzilber M
• Modular broad-host-range expression vectors for single-protein and protein complex purification.
  Applied and environmental microbiology 2004 Fodor BD, Kovács AT, Csáki R, Hunyadi-Gulyás E, Klement E, Maróti G, Mészáros LS, Medzihradszky KF, Rákhely G, Kovács KL
• O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.
  Molecular & cellular proteomics : MCP 2004 Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL
• Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer.
  The Journal of biological chemistry 2004 Dubrovay Z, Gáspári Z, Hunyadi-Gulyás E, Medzihradszky KF, Perczel A, Vértessy BG
• 26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster.
  Biochemical and biophysical research communications 2003 Sümegi M, Hunyadi-Gulyás E, Medzihradszky KF, Udvardy A
• Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein.
  Glycobiology 2003 Medzihradszky KF, Spencer DI, Sharma SK, Bhatia J, Pedley RB, Read DA, Begent RH, Chester KA
• Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, …
• Synthesis of the C-terminal domain of the tissue inhibitor of metalloproteinases-1 (TIMP-1).
  Journal of peptide science : an official publication of the European Peptide Society 2003 Bódi J, Mihala N, Hajnal A, Medzihradszky KF, Süli-Vargha H
• Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations.
  Biochemistry 2002 Hlavanda E, Kovács J, Oláh J, Orosz F, Medzihradszky KF, Ovádi J
• The identification of protein-protein interactions of the nuclear pore complex of Saccharomyces cerevisiae using high throughput matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry.
  Molecular & cellular proteomics : MCP 2002 Huang L, Baldwin MA, Maltby DA, Medzihradszky KF, Baker PR, Allen N, Rexach M, Edmondson RD, Campbell J, Juhasz P, Martin SA, Vestal ML, Burlingame AL
• Characterization of site-specific glycosylation.
  Methods in molecular biology (Clifton, N.J.) 2002 Medzihradszky KF
• Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides.
  Biochemistry 2001 Wang X, Medzihradszky KF, Maltby D, Correia MA
• Matrix-assisted laser desorption/ionization coupled with quadrupole/orthogonal acceleration time-of-flight mass spectrometry for protein discovery, identification, and structural analysis.
  Analytical chemistry 2001 Baldwin MA, Medzihradszky KF, Lock CM, Fisher B, Settineri TA, Burlingame AL
• Protein identification by in-gel digestion, high-performance liquid chromatography, and mass spectrometry: peptide analysis by complementary ionization techniques.
  Journal of the American Society for Mass Spectrometry 2001 Medzihradszky KF, Leffler H, Baldwin MA, Burlingame AL
• Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
  Chemistry & biology 2000 Greenbaum D, Medzihradszky KF, Burlingame A, Bogyo M
• The characteristics of peptide collision-induced dissociation using a high-performance MALDI-TOF/TOF tandem mass spectrometer.
  Analytical chemistry 2000 Medzihradszky KF, Campbell JM, Baldwin MA, Falick AM, Juhasz P, Vestal ML, Burlingame AL
• Spin trapping and protein cross-linking of the lactoperoxidase protein radical.
  The Journal of biological chemistry 1999 Lardinois OM, Medzihradszky KF, Ortiz de Montellano PR
• Study on the synthesis and characterization of peptides containing phosphorylated tyrosine.
  The journal of peptide research : official journal of the American Peptide Society 1999 Bonewald LF, Bibbs L, Kates SA, Khatri A, McMurray JS, Medzihradszky KF, Weintraub ST
• Fragmentation and sequencing of cyclic peptides by matrix-assisted laser desorption/ionization post-source decay mass spectrometry.
  Rapid communications in mass spectrometry : RCM 1999 Schilling B, Wang W, McMurray JS, Medzihradszky KF
• Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.
  Biochemistry 1998 Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ
• Heme oxygenase active-site residues identified by heme-protein cross-linking during reduction of CBrCl3.
  Biochemistry 1998 Wilks A, Medzihradszky KF, Ortiz de Montellano PR
• Reverse-phase capillary high performance liquid chromatography/high performance electrospray ionization mass spectrometry: an essential tool for the characterization of complex glycoprotein digests.
  Rapid communications in mass spectrometry : RCM 1998 Medzihradszky KF, Besman MJ, Burlingame AL
• Structural characterization of site-specific N-glycosylation of recombinant human factor VIII by reversed-phase high-performance liquid chromatography-electrospray ionization mass spectrometry.
  Analytical chemistry 1997 Medzihradszky KF, Besman MJ, Burlingame AL
• Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.
  Journal of medicinal chemistry 1997 Osapay G, Prokai L, Kim HS, Medzihradszky KF, Coy DH, Liapakis G, Reisine T, Melacini G, Zhu Q, Wang SH, Mattern RH, Goodman M
• Synthesis and characterization of histidine-phosphorylated peptides.
  Protein science : a publication of the Protein Society 1997 Medzihradszky KF, Phillipps NJ, Senderowicz L, Wang P, Turck CW
• A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains.
  Science (New York, N.Y.) 1996 Wang SX, Mure M, Medzihradszky KF, Burlingame AL, Brown DE, Dooley DM, Smith AJ, Kagan HM, Klinman JP
• Peptide sequence determination by matrix-assisted laser desorption ionization employing a tandem double focusing magnetic-Orthogonal acceleration time-of-flight mass spectrometer.
  Journal of the American Society for Mass Spectrometry 1996 Medzihradszky KF, Adams GW, Burlingame AL, Bateman RH, Green MR
• Determination of in vivo phosphorylation sites in protein kinase C.
  The Journal of biological chemistry 1995 Tsutakawa SE, Medzihradszky KF, Flint AJ, Burlingame AL, Koshland DE
• Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
  Methods in enzymology 1995 Adams GW, Mayer P, Medzihradszky KF, Burlingame AL
• Complete assignment of disulfide bonds in bovine dopamine beta-hydroxylase.
  Biochemistry 1994 Robertson JG, Adams GW, Medzihradszky KF, Burlingame AL, Villafranca JJ
• Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.
  The EMBO journal 1994 Brown JD, Hann BC, Medzihradszky KF, Niwa M, Burlingame AL, Walter P
• Characterization of protein iv-glycosylation by reversed-phase microbore liquid chromatography / electrospray mass spectrometry, complementary mobile phases, and sequential exoglycosidase digestion.
  Journal of the American Society for Mass Spectrometry 1994 Medzihradszky KF, Maltby DA, Hall SC, Settineri CA, Burlingame AL
• Primary structures for a mammalian cellular and serum copper amine oxidase.
  The Journal of biological chemistry 1994 Mu D, Medzihradszky KF, Adams GW, Mayer P, Hines WM, Burlingame AL, Smith AJ, Cai D, Klinman JP
• Low-mass ions produced from peptides by high-energy collision-induced dissociation in tandem mass spectrometry.
  Journal of the American Society for Mass Spectrometry 1993 Falick AM, Hines WM, Medzihradszky KF, Baldwin MA, Gibson BW
• Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family.
  The Journal of biological chemistry 1992 Wen DX, Livingston BD, Medzihradszky KF, Kelm S, Burlingame AL, Paulson JC
• The active site of creatine kinase. Affinity labeling of cysteine 282 with N-(2,3-epoxypropyl)-N-amidinoglycine.
  The Journal of biological chemistry 1992 Buechter DD, Medzihradszky KF, Burlingame AL, Kenyon GL
• The primary structure of fatty-acid-binding protein from nurse shark liver. Structural and evolutionary relationship to the mammalian fatty-acid-binding protein family.
  European journal of biochemistry 1992 Medzihradszky KF, Gibson BW, Kaur S, Yu ZH, Medzihradszky D, Burlingame AL, Bass NM
• Structure determination of O-linked glycopeptides by tandem mass spectrometry.
  Biomedical & environmental mass spectrometry 1990 Medzihradszky KF, Gillece-Castro BL, Settineri CA, Townsend RR, Masiarz FR, Burlingame AL
• Characterization of O-glycosylation sites in recombinant B-chain of platelet-derived growth factor expressed in yeast using liquid secondary ion mass spectrometry, tandem mass spectrometry and Edman sequence analysis.
  Biomedical & environmental mass spectrometry 1990 Settineri CA, Medzihradszky KF, Masiarz FR, Burlingame AL, Chu C, George-Nascimento C
• Artifacts in four-sector tandem mass spectrometry.
  Rapid communications in mass spectrometry : RCM 1990 Falick AM, Medzihradszky KF, Walls FC
• Met-enkephalin inhibits mineralocorticoid production in isolated human aldosteronoma cells.
  The Journal of clinical endocrinology and metabolism 1982 Rácz K, Varga I, Gláz E, Kiss R, Vida S, Lada G, di Gleria K, Medzihradszky K, Lichtwald K, Vecsei P