Karthik Srinivasan, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• PhD Structural, Biophysical, and Computational Biology Purdue University 08/2023
• M.Sc. (Hons.) Biological Sciences BITS Pilani 08/2017
• B.E. (Hons.) Mechanical Engineering BITS Pilani 08/2017

Publications (11)

Top publication keywords:
Scattering, Small AngleUbiquitinsBacterial Outer Membrane ProteinsSmall Molecule LibrariesPolypharmacologyMolecular Docking SimulationAnalgesicsX-Ray DiffractionMiddle East Respiratory Syndrome CoronavirusHealth PlanningProtein PrecursorsArabidopsis ProteinsChloroplastsPlant ProteinsArabidopsis

• Hypervariable loop profiling decodes sequence determinants of antibody stability.
  Nature structural & molecular biology 2026 Wan Y, Liang J, Dai Y, Srinivasan K, Billesbølle C, Zhu JF, Shin JE, Paul S, Marks D, Song YS, Myers BR, Koehl A, Manglik A
• Large Library Docking for Polypharmacology.
  Journal of medicinal chemistry 2026 Wu Y, Vigneron S, Braz J, Srinivasan K, Fink EA, Huang XP, Xu X, Huebner H, Kim JY, Wang J, Pfeiffer T, Sakamoto K, Radchenko DS, Rodriguiz RM, Moroz YS, Irwin JJ, Gmeiner P, Billesboelle C, Roth BL, …
• Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects.
  ACS central science 2025 Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbølle CB, Srinivasan K, Bhardwaj K, Irwin JJ, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
• Radar for Europa Assessment and Sounding: Ocean to Near-Surface (REASON).
  Space science reviews 2024 Blankenship DD, Moussessian A, Chapin E, Young DA, Wesley Patterson G, Plaut JJ, Freedman AP, Schroeder DM, Grima C, Steinbrügge G, Soderlund KM, Ray T, Richter TG, Jones-Wilson L, Wolfenbarger NS, …
• Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID.
  Cell reports. Medicine 2023 Wang K, Khoramjoo M, Srinivasan K, Gordon PMK, Mandal R, Jackson D, Sligl W, Grant MB, Penninger JM, Borchers CH, Wishart DS, Prasad V, Oudit GY

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• Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
  Structure (London, England : 1993) 2023 Srinivasan K, Erramilli SK, Chakravarthy S, Gonzalez A, Kossiakoff A, Noinaj N
• Discovery of associative patterns between workplace sound level and physiological wellbeing using wearable devices and empirical Bayes modeling.
  NPJ digital medicine 2023 Srinivasan K, Currim F, Lindberg CM, Razjouyan J, Gilligan B, Lee H, Canada KJ, Goebel N, Mehl MR, Lunden MM, Heerwagen J, Najafi B, Sternberg EM, Kampschroer K, Ram S
• Structure Determination of Membrane Proteins Using X-Ray Crystallography.
  Methods in molecular biology (Clifton, N.J.) 2021 Billings E, Lundquist K, Overly C, Srinivasan K, Noinaj N
• Preparing for an Increased Need for Abortion Access in India during and after COVID-19: Challenges and Strategies.
  Studies in family planning 2020 Chandrasekaran S, Diamond-Smith N, Srinivasan K, Dalvie S
• Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
  Journal of medicinal chemistry 2020 Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R
• Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease.
  Antiviral research 2019 Clasman JR, Everett RK, Srinivasan K, Mesecar AD