Karen Smith-Mccune, MD, PhD
Recall Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

Education & Training

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• M.D. School of Medicine Stanford University 1986

Grants and Projects

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• Reproductive Tract Effects of the Intrauterine Device: Implications for HIV Risk, NIH, 2014-2018
• Exploring HIV-Host Interactions in the Female Reproductive Tract, NIH, 2009-2015
• General Clinical Research Center, NIH, 1974-2009
• Molecular Approaches to Cervical Cancer Screening, NIH, 2000-2003
• Correlation of Anal and Cervical Hpv Disease in Women, NIH, 1996-2000
• Cervical Dysplasia--Analysis of Molecular Events, NIH, 1994-1997
• Transformation by Hpv16--Cellular Events Mediated by E7, NIH, 1994-1995

Publications (81)

Top publication keywords:
EndometriumVirus SheddingNonoxynolPapillomavirus InfectionsUterine Cervical NeoplasmsCervix UteriVaginal SmearsPapillomavirus VaccinesIntrauterine Devices, CopperLevonorgestrelUterine Cervical DysplasiaAlphapapillomavirusMedroxyprogesterone AcetatePapillomaviridaeVaginal Creams, Foams, and Jellies

• Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women.
  Vaccine 2020 Silverberg MJ, Leyden WA, Lam JO, Chao CR, Gregorich SE, Huchko MJ, Kulasingam S, Kuppermann M, Smith-McCune KK, Sawaya GF
• Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Shanmugasundaram U, Critchfield JW, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL
• Differential Effects of the Hormonal and Copper Intrauterine Device on the Endometrial Transcriptome.
  Scientific reports 2020 Smith-McCune K, Thomas R, Averbach S, Seidman D, Takeda M, Houshdaran S, Giudice LC
• Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions.
  International journal of molecular sciences 2020 Houshdaran S, Chen JC, Vallvé-Juanico J, Balayan S, Vo KC, Smith-McCune K, Greenblatt RM, Irwin JC, Giudice LC
• Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo.
  PloS one 2019 Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K

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• Estimated Quality of Life and Economic Outcomes Associated With 12 Cervical Cancer Screening Strategies: A Cost-effectiveness Analysis.
  JAMA internal medicine 2019 Sawaya GF, Sanstead E, Alarid-Escudero F, Smith-McCune K, Gregorich SE, Silverberg MJ, Leyden W, Huchko MJ, Kuppermann M, Kulasingam S
• Cervical Cancer Screening: More Choices in 2019.
  JAMA 2019 Sawaya GF, Smith-McCune K, Kuppermann M
• Menstrual cycle-dependent alterations in glycosylation: a roadmap for defining biomarkers of favorable and unfavorable mucus.
  Journal of assisted reproduction and genetics 2019 Reynoso-Prieto M, Takeda M, Prakobphol A, Seidman D, Averbach S, Fisher S, Smith-McCune K
• Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study.
  The Lancet. Child & adolescent health 2018 Silverberg MJ, Leyden WA, Lam JO, Gregorich SE, Huchko MJ, Kulasingam S, Kuppermann M, Smith-McCune KK, Sawaya GF
• Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer.
  Contraception 2018 Averbach S, Silverberg MJ, Leyden W, Smith-McCune K, Raine-Bennett T, Sawaya GF
• Human Immunodeficiency Virus (HIV)- and Non-HIV-Associated Immunosuppression and Risk of Cervical Neoplasia.
  Obstetrics and gynecology 2018 Silverberg MJ, Leyden WA, Chi A, Gregorich S, Huchko MJ, Kulasingam S, Kuppermann M, Seto A, Smith-McCune KK, Sawaya GF
• Effect of professional society recommendations on women's desire for a routine pelvic examination.
  American journal of obstetrics and gynecology 2017 Sawaya GF, Smith-McCune KK, Gregorich SE, Moghadassi M, Kuppermann M
• Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology.
  International journal of cancer 2017 Ho D, Drake TK, Smith-McCune KK, Darragh TM, Hwang LY, Wax A
• Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility.
  Mucosal immunology 2017 Smith-McCune KK, Hilton JF, Shanmugasundaram U, Critchfield JW, Greenblatt RM, Seidman D, Averbach S, Giudice LC, Shacklett BL
• The effect of intrauterine devices on acquisition and clearance of human papillomavirus.
  American journal of obstetrics and gynecology 2016 Averbach SH, Ma Y, Smith-McCune K, Shiboski S, Moscicki AB
• Performance of p16INK4a ELISA as a primary cervical cancer screening test among a large cohort of HIV-infected women in western Kenya: a 2-year cross-sectional study.
  BMJ open 2016 Wu TJ, Smith-McCune K, Reuschenbach M, von Knebel Doeberitz M, Maloba M, Huchko MJ
• Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2016 Shanmugasundaram U, Hilton JF, Critchfield JW, Greenblatt RM, Giudice LC, Averbach S, Seidman D, Shacklett BL, Smith-McCune K
• Emerging Technologies to Prevent Pregnancy and Sexually Transmitted Infections in Women.
  Seminars in reproductive medicine 2016 Seidman D, Hemmerling A, Smith-McCune K
• Cervical Cancer Screening.
  Obstetrics and gynecology 2016 Sawaya GF, Smith-McCune K
• Interpretation, communication, and mechanisms of associations between injectable contraception and HIV risk.
  The lancet. HIV 2015 Seidman D, Averbach S, Smith-McCune K, Darney P
• Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study.
  PloS one 2015 Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC
• A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women.
  PloS one 2015 Huchko MJ, Sneden J, Zakaras JM, Smith-McCune K, Sawaya G, Maloba M, Bukusi EA, Cohen CR
• Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix.
  Reproductive sciences (Thousand Oaks, Calif.) 2015 Goldfien GA, Barragan F, Chen J, Takeda M, Irwin JC, Perry J, Greenblatt RM, Smith-McCune KK, Giudice LC
• Choosing a screening method for cervical cancer: Papanicolaou testing alone or with human papillomavirus testing.
  JAMA internal medicine 2014 Smith-McCune K
• Accuracy of visual inspection with acetic acid to detect cervical cancer precursors among HIV-infected women in Kenya.
  International journal of cancer 2014 Huchko MJ, Sneden J, Sawaya G, Smith-McCune K, Maloba M, Abdulrahim N, Bukusi EA, Cohen CR
• Treatment of cervical precancers: back to basics.
  Obstetrics and gynecology 2014 Khan MJ, Smith-McCune KK
• Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages.
  The Journal of infectious diseases 2014 Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, …
• Does treatment for cervical and vulvar dysplasia impact women's sexual health?
  American journal of obstetrics and gynecology 2014 Cendejas BR, Smith-McCune KK, Khan MJ
• Authors' reply: Impact of loop electrosurgical excision procedure for cervical intraepithelial neoplasia on HIV-1 genital shedding: a prospective cohort study: population and statistical queries.
  BJOG : an international journal of obstetrics and gynaecology 2014 Huchko MJ, Leslie HH, Smith-McCune K
• Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2013 Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL
• A novel breath test to directly measure use of vaginal gel and condoms.
  AIDS and behavior 2013 van der Straten A, Cheng H, Wasdo S, Montgomery L, Smith-McCune K, Booth M, Gonzalez D, Derendorf H, Morey TE, Dennis DM
• Is there an association between HIV-1 genital shedding and cervical intraepithelial neoplasia 2/3 among women on antiretroviral therapy?
  Journal of lower genital tract disease 2013 Huchko MJ, Woo V, Liegler T, Leddy A, Smith-McCune K, Sawaya GF, Bukusi EA, Cohen CR
• Association of cervical biopsy with HIV type 1 genital shedding among women on highly active antiretroviral therapy.
  AIDS research and human retroviruses 2013 Woo VG, Liegler T, Cohen CR, Sawaya GF, Smith-McCune K, Bukusi EA, Huchko MJ
• Impact of loop electrosurgical excision procedure for cervical intraepithelial neoplasia on HIV-1 genital shedding: a prospective cohort study.
  BJOG : an international journal of obstetrics and gynaecology 2013 Huchko MJ, Woo VG, Liegler T, Leslie H, Smith-McCune K, Sawaya GF, Bukusi EA, Cohen CR
• Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
  International journal of cancer 2012 Chan PK, Zhang C, Park JS, Smith-McCune KK, Palefsky JM, Giovannelli L, Coutlée F, Hibbitts S, Konno R, Settheetham-Ishida W, Chu TY, Ferrera A, Alejandra Picconi M, De Marco F, Woo YL, Raiol T, Piña-…
• A systematic review of randomized trials assessing human papillomavirus testing in cervical cancer screening.
  American journal of obstetrics and gynecology 2012 Patanwala IY, Bauer HM, Miyamoto J, Park IU, Huchko MJ, Smith-McCune KK
• Human papillomavirus infection and increased risk of HIV acquisition. A systematic review and meta-analysis.
  AIDS (London, England) 2012 Houlihan CF, Larke NL, Watson-Jones D, Smith-McCune KK, Shiboski S, Gravitt PE, Smith JS, Kuhn L, Wang C, Hayes R
• Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.
  British journal of cancer 2012 Abkevich V, Timms KM, Hennessy BT, Potter J, Carey MS, Meyer LA, Smith-McCune K, Broaddus R, Lu KH, Chen J, Tran TV, Williams D, Iliev D, Jammulapati S, FitzGerald LM, Krivak T, DeLoia JA, Gutin A, …
• Direct human papillomavirus E6 whole-cell enzyme-linked immunosorbent assay for objective measurement of E6 oncoproteins in cytology samples.
  Clinical and vaccine immunology : CVI 2012 Yang YS, Smith-McCune K, Darragh TM, Lai Y, Lin JH, Chang TC, Guo HY, Kesler T, Carter A, Castle PE, Cheng S
• Investigating Potential Associations between Cervical Procedures and HIV Acquisition.
  ISRN obstetrics and gynecology 2011 Diouf K, Sawaya GF, Shiboski S, Magure T, Makunike-Mutasa R, Darragh TM, Tuveson J, Chipato T, Palefsky JM, Moscicki AB, Chirenje M, Smith-McCune K
• Identification of human papillomavirus type 58 lineages and the distribution worldwide.
  The Journal of infectious diseases 2011 Chan PK, Luk AC, Park JS, Smith-McCune KK, Palefsky JM, Konno R, Giovannelli L, Coutlée F, Hibbitts S, Chu TY, Settheetham-Ishida W, Picconi MA, Ferrera A, De Marco F, Woo YL, Raiol T, Piña-Sánchez P,…
• Cervical cancer screening.
  Journal of the National Comprehensive Cancer Network : JNCCN 2010 Partridge EE, Abu-Rustum NR, Campos SM, Fahey PJ, Farmer M, Garcia RL, Giuliano A, Jones HW, Lele SM, Lieberman RW, Massad SL, Morgan MA, Reynolds RK, Rhodes HE, Singh DK, Smith-McCune K, Teng N, …
• Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator.
  Cancer cell 2010 Ishida S, McCormick F, Smith-McCune K, Hanahan D
• Quadrivalent HPV vaccine administered to women who became pregnant during trials did not appear to adversely affect pregnancy outcome; however, use during pregnancy is not recommended.
  Evidence-based medicine 2010 Smith-McCune K
• Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections.
  PloS one 2010 Smith-McCune KK, Shiboski S, Chirenje MZ, Magure T, Tuveson J, Ma Y, Da Costa M, Moscicki AB, Palefsky JM, Makunike-Mutasa R, Chipato T, van der Straten A, Sawaya GF
• Update on quadrivalent human papillomavirus vaccination and pregnancy outcomes: is contraception advisable?
  Obstetrics and gynecology 2009
• In vivo effects of nonoxynol-9 on endometrial immune cell populations.
  Journal of acquired immune deficiency syndromes (1999) 2009 Rahangdale L, Greenblatt RM, Perry J, Darragh TM, Kobayashi A, Smith-McCune KK
• Cervical human papillomavirus incidence and persistence in a cohort of HIV-negative women in Zimbabwe.
  Sexually transmitted diseases 2009 Fukuchi E, Sawaya GF, Chirenje M, Magure T, Tuveson J, Ma Y, Shiboski S, Da Costa M, Palefsky J, Moscicki AB, Makunike-Mutasa R, Chipato T, Smith-McCune KK
• Effect of diaphragm and lubricant gel provision on human papillomavirus infection among women provided with condoms: a randomized controlled trial.
  Obstetrics and gynecology 2008 Sawaya GF, Chirenje MZ, Magure MT, Tuveson JL, Ma Y, Shiboski SC, Da Costa MM, Palefsky JM, Moscicki AB, Mutasa RM, Chipato T, Smith-McCune KK
• The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection.
  Journal of virology 2008 Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC
• Human papillomavirus vaccine efficacy: aligning expectations with reality.
  Gynecologic oncology 2008 Smith-McCune KK
• Evolving immunosuppressive microenvironment during human cervical carcinogenesis.
  Mucosal immunology 2008 Kobayashi A, Weinberg V, Darragh T, Smith-McCune K
• Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
  Molecular oncology 2008 Nanjundan M, Cheng KW, Zhang F, Lahad J, Kuo WL, Schmandt R, Smith-McCune K, Fishman D, Gray JW, Mills GB
• Cervical cancer screening.
  Journal of the National Comprehensive Cancer Network : JNCCN 2008 Partridge EE, Abu-Rustum N, Campos S, Fahey PJ, Greer BE, Lele SM, Lieberman RW, Lipscomb GH, Morgan M, Nava ME, Reynolds RK, Singh DK, Smith-McCune K, Teng N, Trimble CL, Valea F, Wilczynski S, …
• HPV vaccination--more answers, more questions.
  The New England journal of medicine 2007 Sawaya GF, Smith-McCune K
• Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
  Cancer research 2007 Nanjundan M, Nakayama Y, Cheng KW, Lahad J, Liu J, Lu K, Kuo WL, Smith-McCune K, Fishman D, Gray JW, Mills GB
• Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
  Oncogene 2006 Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, Mills GB
• Effect of Replens gel used with a diaphragm on tests for human papillomavirus and other lower genital tract infections.
  Journal of lower genital tract disease 2006 Smith-McCune KK, Tuveson JL, Rubin MM, Da Costa MM, Darragh TM, Shiboski SC, Van Der Pol B, Moscicki AB, Palefsky JM, Sawaya GF
• Cervical cancer screening clinical practice guidelines in oncology.
  Journal of the National Comprehensive Cancer Network : JNCCN 2004 Partridge EE, Abu-Rustum NR, Campos S, Edelson M, Fahey PJ, Fiorica J, Greer BE, Lieberman RW, Likes W, Molpus KL, Nava ME, Reynolds RK, Singh DK, Smith-McCune K, Soper J, Teng N, Trimble CL, …
• The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
  Nature medicine 2004 Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB
• Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection.
  Cancer research 2004 Kobayashi A, Greenblatt RM, Anastos K, Minkoff H, Massad LS, Young M, Levine AM, Darragh TM, Weinberg V, Smith-McCune KK
• Aqueous extract of herba Scutellaria barbatae, a chinese herb used for ovarian cancer, induces apoptosis of ovarian cancer cell lines.
  Gynecologic oncology 2003 Powell CB, Fung P, Jackson J, Dall'Era J, Lewkowicz D, Cohen I, Smith-McCune K
• Participants at the ASCCP 2000 Biennial Meeting adhere to published guidelines in their management of atypical squamous cells and atypical glandular cells on pap test.
  Journal of lower genital tract disease 2003 Ancheta E, Perry J, Bernard-Pearl L, Paul S, Darragh T, Smith-McCune K
• Identification of cervical cancer markers by cDNA and tissue microarrays.
  Cancer research 2003 Chen Y, Miller C, Mosher R, Zhao X, Deeds J, Morrissey M, Bryant B, Yang D, Meyer R, Cronin F, Gostout BS, Smith-McCune K, Schlegel R
• Treatment of women with low-grade squamous intraepithelial lesions on cytologic evidence or biopsy results by board-certified gynecologists.
  American journal of obstetrics and gynecology 2003 Lee C, Mancuso V, Contant T, Jackson R, Smith-Mccune K
• Specific keynote: genome copy number abnormalities in ovarian cancer.
  Gynecologic oncology 2003 Gray JW, Suzuki S, Kuo WL, Polikoff D, Deavers M, Smith-McCune K, Berchuck A, Pinkel D, Albertson D, Mills GB
• Testing for human papillomavirus in women with abnormal pap smear results.
  JAMA 2002 Sawaya GF, Smith-McCune K
• Measurements of human papillomavirus transcripts by real time quantitative reverse transcription-polymerase chain reaction in samples collected for cervical cancer screening.
  The Journal of molecular diagnostics : JMD 2002 Lamarcq L, Deeds J, Ginzinger D, Perry J, Padmanabha S, Smith-McCune K
• Lymphoid follicles are generated in high-grade cervical dysplasia and have differing characteristics depending on HIV status.
  The American journal of pathology 2002 Kobayashi A, Darragh T, Herndier B, Anastos K, Minkoff H, Cohen M, Young M, Levine A, Grant LA, Hyun W, Weinberg V, Greenblatt R, Smith-McCune K
• Management of women with atypical Papanicolaou tests of undetermined significance by board-certified gynecologists: discrepancies with published guidelines.
  American journal of obstetrics and gynecology 2001 Smith-McCune K, Mancuso V, Contant T, Jackson R
• Recent developments in understanding the immune response to human papilloma virus infection and cervical neoplasia.
  Oncology nursing forum 2000 Kobayashi A, Miaskowski C, Wallhagen M, Smith-McCune K
• Follow-up of unsatisfactory Papanicolaou test results.
  JAMA 2000 McGaraghan A, Smith-McCune K
• Angiogenesis, proliferation, and apoptosis in anal high-grade squamous intraepithelial lesions.
  Diseases of the colon and rectum 2000 Litle VR, Leavenworth JD, Darragh TM, Kosinski LA, Moore DH, Smith-McCune KK, Warren RS, Palefsky JM, Welton ML
• Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, Bishop JM
• Angiogenesis in histologically benign squamous mucosa is a sensitive marker for nearby cervical intraepithelial neoplasia.
  Journal of lower genital tract disease 1999 Smith-McCune K, Zhu YH, Darragh T
• Atypical squamous cells of undetermined significance: management patterns at an academic medical center.
  Journal of lower genital tract disease 1999 Suh-Burgmann E, Darragh T, Smith-McCune K
• Atypical squamous cells of undetermined significance: management patterns at an academic medical center.
  American journal of obstetrics and gynecology 1998 Suh-Burgmann E, Darragh T, Smith-McCune K
• Angiogenesis in histologically benign squamous mucosa is a sensitive marker for nearby cervical intraepithelial neoplasia.
  Angiogenesis 1998 Smith-McCune KK, Zhu Y, Darragh T
• Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice.
  Cancer research 1997 Smith-McCune K, Zhu YH, Hanahan D, Arbeit J
• Angiogenesis in squamous cell carcinoma in situ and microinvasive carcinoma of the uterine cervix.
  Obstetrics and gynecology 1997 Smith-McCune K
• Demonstration and characterization of the angiogenic properties of cervical dysplasia.
  Cancer research 1994 Smith-McCune KK, Weidner N