Karen Rabin, MD, PhD
Professor
Pediatrics
School of Medicine

Publications (126)

Top publication keywords:
ChildPrecursor T-Cell Lymphoblastic Leukemia-LymphomaLeukemia, Myeloid, AcuteLymphocyte CountPhiladelphia ChromosomePrecursor Cell Lymphoblastic Leukemia-LymphomaChromosomes, Human, Pair 21Ikaros Transcription FactorAntimetabolites, AntineoplasticLeukemiaLeukemoid ReactionAntineoplastic Combined Chemotherapy ProtocolsDown SyndromeMethotrexatePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma

• An analysis of diagnostic metabolomic profiles associated with hepatotoxicity during childhood ALL induction therapy.
  Blood advances 2025 Mason EJ, Crain AM, Scheurer ME, Lupo PJ, Rabin KR, Taylor OA, Roberts M, Woodhouse JP, Chavana A, Ludwig K, Klesse L, Heym K, Griffin T, Erana R, Bernini JC, Gramatges MM, Yi JS, Pruitt SL, Bernhardt…
• Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome.
  Nature communications 2025 Li Z, Yang W, Wu G, Chang TC, Cheng Z, Devidas M, Shago M, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Sanclemente L, Raetz EA, Hunger SP, Loh ML, Feingold E, Rosser TC, Allen EG, Sherman SL, …
• Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia.
  PloS one 2025 Vrana C, Zhang M, Rochette M, Alozie M, Oviedo H, Gonzalez A, Sherman J, Zorman B, Sumazin P, Rabin KR, Junco JJ
• Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia.
  The oncologist 2025 Harris RD, Taylor OA, Gramatges MM, Hughes AE, Zobeck M, Pruitt S, Bernhardt MB, Chavana A, Huynh V, Ludwig K, Klesse L, Heym K, Griffin T, Erana R, Bernini JC, Choi A, Ohno Y, Richard MA, Morrison AC…
• Genome-Wide Association Studies of Down Syndrome Associated Congenital Heart Defects Suggests a Genetically Heterogeneous Risk for CHD in DS.
  Genetic epidemiology 2025 Feldman ER, Li Y, Cutler DJ, Rosser TC, Wechsler SB, Sanclemente L, Rachubinski AL, Elliott N, Vyas P, Roberts I, Rabin KR, Wagner M, Gelb BD, Espinosa JM, Lupo PJ, de Smith AJ, Sherman SL, Leslie-…

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• Performance of Two-Phase Designs for the Time-to-Event Outcome and a Case Study Assessing the Relapse Risk Associated With B-ALL Subtypes.
  JCO clinical cancer informatics 2025 Chen W, Chang TC, Rabin KR, Raetz EA, Devidas M, Hunger SP, Ramirez NC, Mullighan CG, Loh ML, Wu G
• All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome.
  Leukemia 2025 Hsu CJ, Schraw JM, Desrosiers TA, Janitz AE, Kirby RS, Nestoridi E, Nembhard WN, Salemi JL, Shumate C, Tanner JP, Yazdy MM, Scheurer ME, Rabin KR, Lupo PJ
• The impact of Indigenous American-like ancestry on risk of acute lymphoblastic leukemia in Hispanic/Latino children.
  medRxiv : the preprint server for health sciences 2025 Langie J, Chan TF, Yang W, Kang AY, Morimoto L, Stram DO, Mancuso N, Ma X, Metayer C, Lupo PJ, Rabin KR, Scheurer ME, Wiemels JL, Yang JJ, de Smith AJ, Chiang CWK
• Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model.
  Nature communications 2025 Iqbal M, McLennan AL, Mukhamedshin A, Dinh MTP, Liu Q, Junco JJ, Mohan A, Srivaths PR, Rabin KR, Fogarty TP, Gifford SC, Shevkoplyas SS, Lam FW
• Erratum: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR.
  JCO clinical cancer informatics 2025 Miller TP, Getz KD, Krause E, Jo YG, Charapala S, Gramatges MM, Rabin K, Scheurer ME, Wilkes JJ, Fisher BT, Aplenc R
• Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.
  Neuromolecular medicine 2025 Flores-Aguilar L, Hamlett ED, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, Chan L, Christian B, Costa ACS, Costanzo F, Del Hoyo Soriano L, Dierssen M, Eichler EE, Fisher E, Galbraith M, Ghosh…
• Evaluation of methotrexate Pharmacogenomic variation to predict acute neurotoxicity in children with acute lymphoblastic leukemia.
  Pharmacotherapy 2024 Harris RD, Taylor OA, Gramatges MM, Hughes AE, Zobeck M, Pruitt S, Bernhardt MB, Chavana A, Huynh V, Ludwig K, Klesse L, Heym K, Griffin T, Erana R, Bernini JC, Choi A, Ohno Y, Richard MA, Morrison AC…
• Reply to: Accurate Determinants of Outcome in ALL.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2024 Chang TC, Chen W, Qu C, Cheng Z, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, …
• Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia.
  Leukemia 2024 Balestra T, Niswander LM, Bagashev A, Loftus JP, Ross SL, Chen RK, McClellan SM, Junco JJ, Bárcenas López DA, Rabin KR, Fry TJ, Tasian SK
• Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children.
  The New England journal of medicine 2024 Gupta S, Rau RE, Kairalla JA, Rabin KR, Wang C, Angiolillo AL, Alexander S, Carroll AJ, Conway S, Gore L, Kirsch I, Kubaney HR, Li AM, McNeer JL, Militano O, Miller TP, Moyer Y, O'Brien MM, Okada M, …
• A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities.
  Haematologica 2024 Junco JJ, Rochette M, Alozie M, Rashid R, Terrell M, Zorman B, Sumazin P, Rowland L, Dettorre G, Powell RT, Stephan CC, Davies PJ, Martinez-Moczygemba M, Yang JJ, Rabin KR
• Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR.
  JCO clinical cancer informatics 2024 Miller TP, Getz KD, Krause E, Jo YG, Charapala S, Gramatages MM, Rabin K, Scheurer ME, Wilkes JJ, Fisher BT, Aplenc R
• Delayed excretion of high-dose methotrexate in pediatric acute leukemia correlates with laxative and constipation management.
  Pediatric blood & cancer 2024 Belsky JA, Chavana A, Banerjee A, Zobeck M, Schafer ES, Rabin KR, Gramatges M, Sim A, Leisinger A, Reddy T, Parod MJ, Lupo P, Scheurer M, Brown AL, Bernhardt MB
• Cerebral Sinus Venous Thrombosis in Pediatric Acute Lymphoblastic Leukemia: Incidence, Clinical Characteristics, and Long-term Neurologic Outcomes.
  Journal of child neurology 2024 Johnson-Bishop L, Karakas C, Kralik SF, Cohen CT, Zobeck M, Park N, Rabin K, Pehlivan D, Bhar S
• Genome-wide association studies of Down syndrome associated congenital heart defects.
  medRxiv : the preprint server for health sciences 2024 Feldman ER, Li Y, Cutler DJ, Rosser TC, Wechsler SB, Sanclemente L, Rachubinski AL, Elliott N, Vyas P, Roberts I, Rabin KR, Wagner M, Gelb BD, Espinosa JM, Lupo PJ, de Smith AJ, Sherman SL, Leslie EJ
• Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2024 Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey…
• Episodes of acute methotrexate-related neurotoxicity linked to compromised long-term neurocognitive function.
  Pediatric blood & cancer 2024 Harris RD, Taylor OA, Raghubar KP, Matheus Gonzalez M, Zobeck M, Gramatges MM, Rabin KR, Scheurer ME, Brown AL
• Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children's Oncology Group Report.
  Leukemia 2024 DelRocco NJ, Loh ML, Borowitz MJ, Gupta S, Rabin KR, Zweidler-McKay P, Maloney KW, Mattano LA, Larsen E, Angiolillo A, Schore RJ, Burke MJ, Salzer WL, Wood BL, Carroll AJ, Heerema NA, Reshmi SC, …
• Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children's Oncology Group study.
  Blood 2023 Wood BL, Devidas M, Summers RJ, Chen Z, Asselin B, Rabin KR, Zweidler-McKay PA, Winick NJ, Borowitz MJ, Carroll WL, Raetz EA, Loh ML, Hunger SP, Dunsmore KP, Teachey DT, Winter SS
• Survival outcomes of children with relapsed or refractory myeloid leukemia associated with Down syndrome.
  Blood advances 2023 Raghuram N, Hasegawa D, Nakashima K, Rahman S, Antoniou E, Skajaa T, Merli P, Verma A, Rabin KR, Aftandilian C, Kotecha RS, Cheuk D, Jahnukainen K, Kolenova A, Balwierz W, Norton A, O'Brien M, Cellot …
• Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 Rabin KR, Devidas M, Chen Z, Ji L, Kairalla J, Hitzler JK, Yang JJ, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Roberts KG, Mullighan CG, Harvey RC, Chen IM, Willman CL, Reshmi SC, Gastier-Foster JM…
• Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia.
  Pediatric blood & cancer 2023 Winestone LE, Getz KD, Li Y, Burrows E, Scheurer ME, Tam V, Gramatges MM, Wilkes JJ, Miller TP, Seif AE, Rabin KR, Fisher BT, Aplenc R
• Down syndrome and leukemia: from basic mechanisms to clinical advances.
  Haematologica 2023 Baruchel A, Bourquin JP, Crispino J, Cuartero S, Hasle H, Hitzler J, Klusmann JH, Izraeli S, Lane AA, Malinge S, Rabin KR, Roberts I, Ryeom S, Tasian SK, Wagenblast E
• Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
  Pediatric blood & cancer 2023 Hsiao W, Li Y, Getz K, Cao L, Krause E, Ramos M, Lee J, Gramatges MM, Rabin KR, Scheurer ME, Aplenc R, Denburg M, Miller TP
• Management of Down Syndrome-Associated Leukemias: A Review.
  JAMA oncology 2023 Verma A, Lupo PJ, Shah NN, Hitzler J, Rabin KR
• Insights into the genomics of iAMP21-ALL.
  Blood 2023 Rabin KR
• Flow cytometric assessment of leukemia-associated monocytes in childhood B-cell acute lymphoblastic leukemia outcome.
  Blood advances 2023 Contreras Yametti GP, Evensen NA, Schloss JM, Aldebert C, Duan E, Zhang Y, Hu J, Chambers TM, Scheurer ME, Teachey DT, Rabin KR, Raetz EA, Aifantis I, Carroll WL, Witkowski MT
• Children's Oncology Group blueprint for research: Acute lymphoblastic leukemia.
  Pediatric blood & cancer 2023 Raetz EA, Bhojwani D, Devidas M, Gore L, Rabin KR, Tasian SK, Teachey DT, Loh ML
• Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.
  Blood 2023 Li Z, Chang TC, Junco JJ, Devidas M, Li Y, Yang W, Huang X, Hedges DJ, Cheng Z, Shago M, Carroll AJ, Heerema NA, Gastier-Foster J, Wood BL, Borowitz MJ, Sanclemente L, Raetz EA, Hunger SP, Feingold E,…
• Correction: Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932.
  Leukemia 2023 Schore RJ, Angiolillo AL, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, Borowitz MJ, Wood B, Carroll AJ, Heerema NA, Relling MV, Hitzler J, Kadan-Lottick NS, Maloney K, Wang C, Carroll WL, …
• SARS-CoV-2 infections in patients enrolled on the Children's Oncology Group standard-risk B-cell acute lymphoblastic leukemia trial, AALL1731.
  EJHaem 2023 Elgarten CW, Kairalla JA, Thompson JC, Miller TP, Wang C, Conway S, Loh ML, Raetz EA, Gupta S, Rau RE, Angiolillo A, Rabin KR, Alexander S
• Central nervous system status is prognostic in T-cell acute lymphoblastic leukemia: a Children's Oncology Group report.
  Blood 2023 Gossai NP, Devidas M, Chen Z, Wood BL, Zweidler-McKay PA, Rabin KR, Loh ML, Raetz EA, Winick NJ, Burke MJ, Carroll AJ, Esiashvili N, Heerema NA, Carroll WL, Hunger SP, Dunsmore KP, Winter SS, Teachey …
• Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932.
  Leukemia 2023 Schore RJ, Angiolillo AL, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, Borowitz MJ, Wood B, Carroll AJ, Heerema NA, Relling MV, Hitzler J, Kadan-Lottick NS, Maloney K, Wang C, Carroll WL, …
• Prognostic impact of pretreatment immunoglobulin clonal composition in pediatric B-lymphoblastic leukemia.
  Haematologica 2023 Fries C, Lee LW, Devidas M, Dai Y, Rabin KR, Gupta S, Loh ML, Kirsch IR, Wood B, Rau RE
• Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.
  Pharmacotherapy 2023 Zobeck M, Bernhardt MB, Kamdar KY, Rabin KR, Lupo PJ, Scheurer ME
• Patients with Down syndrome can be included in early phase clinical trials- a report from the T2016-003 Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) study.
  Leukemia 2023 Gossai N, Bhojwani D, Schafer ES, Chang BH, Pommert L, Verma A, Malvar J, Chi YY, Hitzler J, Burke MJ, Rabin KR
• Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia.
  Blood advances 2023 Bridges CS, Chen TJ, Puppi M, Rabin KR, Lacorazza HD
• Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials.
  The Lancet. Haematology 2023 Gupta S, Dai Y, Chen Z, Winestone LE, Teachey DT, Bona K, Aplenc R, Rabin KR, Zweidler-McKay P, Carroll AJ, Heerema NA, Gastier-Foster J, Borowitz MJ, Wood BL, Maloney KW, Mattano LA, Larsen EC, …
• Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate.
  Cancer 2023 Harris RD, Bernhardt MB, Zobeck MC, Taylor OA, Gramatges MM, Schafer ES, Lupo PJ, Rabin KR, Scheurer ME, Brown AL
• Absolute lymphocyte count recovery following initial acute myelogenous leukemia therapy: Implications for adoptive cell therapy.
  Pediatric blood & cancer 2022 Molina JC, Li Y, Otto WR, Miller TP, Getz KD, Mccoubrey C, Ramos M, Krause E, Cao L, Gramatges MM, Rabin K, Scheurer M, Elgarten CW, Myers RM, Seif AE, Fisher BT, Shah NN, Aplenc R
• Improving infectious adverse event reporting for children and adolescents enrolled in clinical trials for acute lymphoblastic leukemia: A report from the Children's Oncology Group.
  Pediatric blood & cancer 2022 Elgarten CW, Thompson JC, Angiolillo A, Chen Z, Conway S, Devidas M, Gupta S, Kairalla JA, McNeer JL, O'Brien MM, Rabin KR, Rau RE, Rheingold SR, Wang C, Wood C, Raetz EA, Loh ML, Alexander S, Miller …
• The genomic landscape of pediatric acute lymphoblastic leukemia.
  Nature genetics 2022 Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, …
• Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome.
  Blood advances 2022 Li S, Sok P, Xu K, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Metayer C, Ma X, Mueller BA, Roy A, Roberts I, Rabin KR, Brown AL, Lupo PJ, Wiemels JL, de Smith AJ
• Rates of laboratory adverse events by course in paediatric leukaemia ascertained with automated electronic health record extraction: a retrospective cohort study from the Children's Oncology Group.
  The Lancet. Haematology 2022 Miller TP, Getz KD, Li Y, Demissei BG, Adamson PC, Alonzo TA, Burrows E, Cao L, Castellino SM, Daves MH, Fisher BT, Gerbing R, Grundmeier RW, Krause EM, Lee J, Lupo PJ, Rabin KR, Ramos M, Scheurer ME,…
• A report from the Leukemia Electronic Abstraction of Records Network on risk of hepatotoxicity during pediatric acute lymphoblastic leukemia treatment.
  Haematologica 2022 Yi JS, Chambers TM, Getz KD, Miller TP, Burrows E, Daves MH, Lupo PJ, Scheurer ME, Aplenc R, Rabin KR, Gramatges MM
• An updated assessment of 43,110 patients enrolled in the Childhood Cancer Research Network: A Children's Oncology Group report.
  Cancer 2022 Brown AL, Sok P, Scheurer ME, Rabin KR, Marcotte EL, Hawkins DS, Spector LG, Lupo PJ
• CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome.
  Experimental hematology 2022 Junco JJ, Zorman B, Gant VU, Muñoz J, Lacorazza HD, Sumazin P, Rabin KR
• Residence in a Latinx enclave and end-induction minimal residual disease positivity among children with acute lymphoblastic leukemia.
  Pediatric hematology and oncology 2022 Muñiz JP, Woodhouse JP, Hughes AE, Pruitt SL, Rabin KR, Scheurer ME, Lupo PJ, Schraw JM
• Genetic Ancestry and Childhood Acute Lymphoblastic Leukemia Subtypes and Outcomes in the Genomic Era.
  JAMA oncology 2022 Rabin KR
• Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report.
  Cancer 2022 Gupta S, Teachey DT, Chen Z, Rabin KR, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA, Winter SS, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Winick NJ, Loh ML, Hunger SP, …
• Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children's Oncology Group Study AALL0232.
  Leukemia 2021 Burke MJ, Devidas M, Chen Z, Salzer WL, Raetz EA, Rabin KR, Heerema NA, Carroll AJ, Gastier-Foster JM, Borowitz MJ, Wood BL, Winick NJ, Carroll WL, Hunger SP, Loh ML, Larsen EC
• Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia.
  Scientific reports 2021 Schraw JM, Woodhouse JP, Bernhardt MB, Taylor OA, Horton TM, Scheurer ME, Okcu MF, Rabin KR, Lupo PJ, Brown AL
• Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.
  JAMA oncology 2021 Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, …
• Risk stratification for Down syndrome and acute lymphocytic leukaemia: one size does not fit all.
  The Lancet. Haematology 2021 Rabin KR
• Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.
  Oncotarget 2021 Chen TJ, Du W, Junco JJ, Bridges CS, Shen Y, Puppi M, Rabin KR, Lacorazza HD
• An evidence-based, risk-adapted algorithm for antifungal prophylaxis reduces risk for invasive mold infections in children with hematologic malignancies.
  Pediatric blood & cancer 2021 Dutta A, Ikwuezunma A, Castellanos MI, Brackett J, Reddy K, Mahajan P, Marshburn AM, Kamdar K, Paek H, Palazzi DL, Rabin KR, Scheurer ME, Gramatges MM
• Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia.
  The Journal of clinical investigation 2021 Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, Zhang R, Gastier-Foster JM, Raetz EA, Carroll WL, Li C, Liu PP, Rabin KR, Sanda T, Mullighan CG, Nichols …
• Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis.
  Nature biomedical engineering 2021 Koldobskiy MA, Jenkinson G, Abante J, Rodriguez DiBlasi VA, Zhou W, Pujadas E, Idrizi A, Tryggvadottir R, Callahan C, Bonifant CL, Rabin KR, Brown PA, Ji H, Goutsias J, Feinberg AP
• Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.
  Pediatric blood & cancer 2021 Zobeck MC, Bernhardt MB, Kamdar KY, Rabin KR, Lupo PJ, Scheurer ME
• Prognostic impact of minimal residual disease at the end of consolidation in NCI standard-risk B-lymphoblastic leukemia: A report from the Children's Oncology Group.
  Pediatric blood & cancer 2021 Rau RE, Dai Y, Devidas M, Rabin KR, Zweidler-McKay P, Angiolillo A, Schore RJ, Burke MJ, Salzer WL, Heerema NA, Carroll AJ, Winick NJ, Hunger SP, Raetz EA, Loh ML, Wood BL, Borowitz MJ
• Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia.
  Blood 2021 Nishii R, Baskin-Doerfler R, Yang W, Oak N, Zhao X, Yang W, Hoshitsuki K, Bloom M, Verbist K, Burns M, Li Z, Lin TN, Qian M, Moriyama T, Gastier-Foster JM, Rabin KR, Raetz E, Mullighan C, Pui CH, Yeoh…
• Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds.
  PloS one 2021 Gant VU, Junco JJ, Terrell M, Rashid R, Rabin KR
• Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2021 Angiolillo AL, Schore RJ, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, Borowitz MJ, Wood B, Carroll AJ, Heerema NA, Relling MV, Hitzler J, Lane AR, Maloney KW, Wang C, Bassal M, Carroll WL, …
• An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance.
  Leukemia 2020 Junco JJ, Chen T, Rashid R, Terrell M, Gant VU, Miller M, Rau R, Lacorazza HD, Rabin KR
• The relationship between chronic health conditions and cognitive deficits in children, adolescents, and young adults with down syndrome: A systematic review.
  PloS one 2020 Gandy KC, Castillo HA, Ouellette L, Castillo J, Lupo PJ, Jacola LM, Rabin KR, Raghubar KP, Gramatges MM
• Aberrant leukemia-associated immunophenotype as potential harbinger of lineage switch in KMT2A-rearranged leukemia: a case series.
  Leukemia & lymphoma 2020 Yost CM, Gaikwad AS, Parsons DW, Rabin KR, Gant VU, Fisher KE, Marcogliese AN, Schafer ES
• Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Dunsmore KP, Winter SS, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Rabin KR, Zweidler-Mckay PA, Raetz EA, Loh …
• Area deprivation is associated with poorer overall survival in children with acute lymphoblastic leukemia.
  Pediatric blood & cancer 2020 Schraw JM, Peckham-Gregory EC, Rabin KR, Scheurer ME, Lupo PJ, Oluyomi A
• Impact of Intrathecal Triple Therapy Versus Intrathecal Methotrexate on Disease-Free Survival for High-Risk B-Lymphoblastic Leukemia: Children's Oncology Group Study AALL1131.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Salzer WL, Burke MJ, Devidas M, Dai Y, Hardy KK, Kairalla JA, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz EA, Loh…
• Six Candidate miRNAs Associated With Early Relapse in Pediatric B-Cell Acute Lymphoblastic Leukemia.
  Anticancer research 2020 Amankwah EK, Devidas M, Teachey DT, Rabin KR, Brown PA
• Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
  Cancer cell 2020 Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, …
• Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment.
  Pediatric blood & cancer 2020 Cahen VC, Li Y, Getz KD, Elgarten CW, DiNofia AM, Wilkes JJ, Winestone LE, Huang YV, Miller TP, Gramatges MM, Rabin KR, Fisher BT, Aplenc R, Seif AE
• Optimizing Targeted Therapy for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
  JAMA oncology 2020 Rabin KR
• Utilization of archived neonatal dried blood spots for genome-wide genotyping.
  PloS one 2020 Sok P, Lupo PJ, Richard MA, Rabin KR, Ehli EA, Kallsen NA, Davies GE, Scheurer ME, Brown AL
• Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study.
  Leukemia 2020 Oberley MJ, Raikar SS, Wertheim GB, Malvar J, Sposto R, Rabin KR, Punia JN, Seif AE, Cahen VC, Schore RJ, Luca DC, Guinipero T, Woods WG, O'Gorman MRG, Orgel E
• Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.
  Journal of the National Cancer Institute 2019 Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay …
• Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
  Cancer 2019 Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-…
• Metabolomic profiling identifies pathways associated with minimal residual disease in childhood acute lymphoblastic leukaemia.
  EBioMedicine 2019 Schraw JM, Junco JJ, Brown AL, Scheurer ME, Rabin KR, Lupo PJ
• Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome.
  Blood 2019 Brown AL, de Smith AJ, Gant VU, Yang W, Scheurer ME, Walsh KM, Chernus JM, Kallsen NA, Peyton SA, Davies GE, Ehli EA, Winick N, Heerema NA, Carroll AJ, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, …
• Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children's Oncology Group.
  Blood advances 2019 Matloub Y, Rabin KR, Ji L, Devidas M, Hitzler J, Xu X, Bostrom BC, Stork LC, Winick N, Gastier-Foster JM, Heerema NA, Stonerock E, Carroll WL, Hunger SP, Gaynon PS
• Maternal Residential Proximity to Major Roadways and the Risk of Childhood Acute Leukemia: A Population-Based Case-Control Study in Texas, 1995-2011.
  International journal of environmental research and public health 2019 Peckham-Gregory EC, Ton M, Rabin KR, Danysh HE, Scheurer ME, Lupo PJ
• Need for new thinking: Treatment of relapsed leukemia in children with Down syndrome.
  Pediatric blood & cancer 2019 Rabin K, Izraeli S, Hijiya N, Hitzler J
• PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia.
  Nature genetics 2019 Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, …
• Replacing cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide/etoposide during consolidation/delayed intensification does not improve outcome for pediatric B-cell acute lymphoblastic leukemia: a report from the COG.
  Haematologica 2018 Burke MJ, Salzer WL, Devidas M, Dai Y, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz EA, Loh ML, Hunger SP
• PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
  The Journal of experimental medicine 2018 Ariës IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, …
• Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Winter SS, Dunsmore KP, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Gaynon PS, Borowitz MJ, Loh ML, Rabin KR, …
• Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.
  PloS one 2018 Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME
• An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016.
  Pediatric hematology and oncology 2018 Scheurer ME, Lupo PJ, Schüz J, Spector LG, Wiemels JL, Aplenc R, Gramatges MM, Schiffman JD, Pombo-de-Oliveira MS, Yang JJ, Heck JE, Metayer C, Orjuela-Grimm MA, Bona K, Aristizabal P, Austin MT, …
• International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
  Blood 2018 Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, …
• Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.
  Blood 2018 Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang …
• Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Gore L, Kearns PR, de Martino ML, De Souza CA, Bertrand Y, Hijiya N, Stork LC, Chung NG, Cardos RC, Saikia T, Fagioli F, Seo JJ, Landman-Parker J, Lancaster D, Place AE, Rabin KR, Sacchi M, Swanink R,…
• Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.
  PloS one 2017 Archer NP, Perez-Andreu V, Stoltze U, Scheurer ME, Wilkinson AV, Lin TN, Qian M, Goodings C, Swartz MD, Ranjit N, Rabin KR, Peckham-Gregory EC, Plon SE, de Alarcon PA, Zabriskie RC, Antillon-Klussmann…
• Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
  Blood 2017 Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll …
• Self-reported adherence in ALL: true or false?
  Blood 2017 Rabin KR
• Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia.
  Pediatric blood & cancer 2017 Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR
• Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.
  Leukemia 2016 Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JPP, Lacorazza HD
• Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics.
  Cancer 2016 Archer NP, Perez-Andreu V, Scheurer ME, Rabin KR, Peckham-Gregory EC, Plon SE, Zabriskie RC, De Alarcon PA, Fernandez KS, Najera CR, Yang JJ, Antillon-Klussmann F, Lupo PJ
• The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia.
  Leukemia 2015 Rouce RH, Shaim H, Sekine T, Weber G, Ballard B, Ku S, Barese C, Murali V, Wu MF, Liu H, Shpall EJ, Bollard CM, Rabin KR, Rezvani K
• Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.
  American journal of clinical pathology 2015 Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X
• A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011).
  Pediatric blood & cancer 2015 Loh ML, Tasian SK, Rabin KR, Brown P, Magoon D, Reid JM, Chen X, Ahern CH, Weigel BJ, Blaney SM
• Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: a multi-institution, multi-platform microarray study.
  Cancer genetics 2014 Baughn LB, Biegel JA, South ST, Smolarek TA, Volkert S, Carroll AJ, Heerema NA, Rabin KR, Zweidler-McKay PA, Loh M, Hirsch B
• First do no harm: infectious deaths in pediatric ALL.
  Blood 2014 Rabin KR
• G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol.
  Leukemia research 2013 Yamada T, Park CS, Shen Y, Rabin KR, Lacorazza HD
• Reply to "Peripheral blood lymphocyte recovery and overall survival in pediatric acute lymphoblastic leukemia".
  Pediatric blood & cancer 2013 Rabin KR, Gramatges MM, Margolin JF, Zweidler-McKay PA
• The adolescent and young adult with cancer: state of the art-- acute leukemias.
  Current oncology reports 2013 Gramatges MM, Rabin KR
• Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Weber G, Caruana I, Rouce RH, Barrett AJ, Gerdemann U, Leen AM, Rabin KR, Bollard CM
• Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant.
  Leukemia 2013 Weber G, Gerdemann U, Caruana I, Savoldo B, Hensel NF, Rabin KR, Shpall EJ, Melenhorst JJ, Leen AM, Barrett AJ, Bollard CM
• Pediatric Hodgkin lymphoma: are we over-scanning our patients?
  Pediatric hematology and oncology 2012 Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM
• Attacking remaining challenges in childhood leukemia.
  The New England journal of medicine 2012 Rabin KR
• Myelosuppression and infectious complications in children with Down syndrome and acute lymphoblastic leukemia.
  Pediatric blood & cancer 2011 Rabin KR, Smith J, Kozinetz CA
• Absolute lymphocyte counts refine minimal residual disease-based risk stratification in childhood acute lymphoblastic leukemia.
  Pediatric blood & cancer 2011 Rabin KR, Gramatges MM, Borowitz MJ, Palla SL, Shi X, Margolin JF, Zweidler-McKay PA
• Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles.
  Leukemia 2011 Loudin MG, Wang J, Leung HC, Gurusiddappa S, Meyer J, Condos G, Morrison D, Tsimelzon A, Devidas M, Heerema NA, Carroll AJ, Plon SE, Hunger SP, Basso G, Pession A, Bhojwani D, Carroll WL, Rabin KR
• Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.
  Leukemia 2011 Blink M, Buitenkamp TD, van den Heuvel-Eibrink MM, Danen-van Oorschot AA, de Haas V, Reinhardt D, Klusmann JH, Zimmermann M, Devidas M, Carroll AJ, Basso G, Pession A, Hasle H, Pieters R, Rabin KR, …
• Management strategies in acute lymphoblastic leukemia.
  Oncology (Williston Park, N.Y.) 2011 Rabin KR, Poplack DG
• Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
  Nature genetics 2009 Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, …
• Malignancy in children with trisomy 21.
  The oncologist 2009 Rabin KR, Whitlock JA
• Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
  British journal of haematology 2008 Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR
• Differential in vitro cytotoxicity does not explain increased host toxicities from chemotherapy in Down syndrome acute lymphoblastic leukemia.
  Leukemia research 2008 Valle M, Plon SE, Rabin KR
• Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia.
  Pediatric blood & cancer 2008 Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC
• Personalized care of pediatric cancer patients.
  Nestle Nutrition workshop series. Paediatric programme 2008 Rabin K, Man TK, Lau CC
• Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.
  Seminars in cancer biology 2004 Giuriato S, Rabin K, Fan AC, Shachaf CM, Felsher DW