Kara Lynch, PhD
Professor
Laboratory Medicine
School of Medicine

Her research laboratory primarily focuses on identifying and quantifying endogenous and exogenous compounds in biological specimens using novel diagnostic technologies, such as mass spectrometry and biolayer interferometry, and correlating the findings with clinical pathologies. They are involved in translational research studies aimed at the clinical evaluation of novel biomarkers or biomarker panels to diagnosis, treat and monitor disease. The Lynch lab has developed numerous liquid-chromatography tandem mass spectrometry (LC-MS/MS), liquid-chromatography quadrupole time-of-flight (LC-QTOF) mass spectrometry, and label-free immunoassay methods for the detection and quantitation of small molecules and proteins in biological specimens. The methods they develop are used to investigate perturbations in metabolic pathways caused by disease and toxicological exposure. They aim to translate results into information that can be used in clinical practice bridging laboratory research and clinical research through multidisciplinary collaboration and methodologies.

• Comparison of liquid chromatography-high-resolution tandem mass spectrometry (MS2) and multi-stage mass spectrometry (MS3) for screening toxic natural products.
  Journal of mass spectrometry and advances in the clinical lab 2023 Luo RY, Comstock K, Ding C, Wu AHB, Lynch KL
• Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.
  bioRxiv : the preprint server for biology 2023 Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young K, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S…
• A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.
  Nature 2023 Augusto DG, Murdolo LD, Chatzileontiadou DSM, Sabatino JJ, Yusufali T, Peyser ND, Butcher X, Kizer K, Guthrie K, Murray VW, Pae V, Sarvadhavabhatla S, Beltran F, Gill GS, Lynch KL, Yun C, Maguire CT, …
• Assessment of Adverse Reactions, Antibody Patterns, and 12-month Outcomes in the Mother-Infant Dyad After COVID-19 mRNA Vaccination in Pregnancy.
  JAMA network open 2023 Cassidy AG, Li L, Golan Y, Gay C, Lin CY, Jigmeddagva U, Chidboy MA, Ilala M, Buarpung S, Gonzalez VJ, Basilio E, Duck M, Murtha AP, Wu AHB, Lynch KL, Asiodu IV, Prahl MK, Gaw SL
• Predictive Value of ABCC2 and UGT1A1 Polymorphisms on Irinotecan-Related Toxicities in Patients with Cancer.
  Genetic testing and molecular biomarkers 2023 Aoullay Z, Smith A, Slaoui M, El Bouchikhi I, Ghazal H, Al Idrissi N, Meddah B, Lynch KL, Cherrah Y, Wu AHB
• A case series evaluation of comprehensive drug testing in the pediatric acute care setting.
  Journal of mass spectrometry and advances in the clinical lab 2023 Lynch KL
• Unexpected Fentanyl Detection during a Liver Transplant Evaluation.
  Clinical chemistry 2023 Fitch BA, Lynch KL, Liao HC
• Multiple substance use and blood pressure in women experiencing homelessness.
  Addictive behaviors reports 2023 Suen LW, Vittinghoff E, Wu AHB, Ravi A, Coffin PO, Hsue P, Lynch KL, Kazi DS, Riley ED
• Development of a Machine Learning Algorithm for Drug Screening Analysis on High-Resolution UPLC-MSE/QTOF Mass Spectrometry.
  The journal of applied laboratory medicine 2023 Hao Y, Lynch K, Fan P, Jurtschenko C, Cid M, Zhao Z, Yang HS
• Detection of IgM, IgG, IgA and neutralizing antibody responses to SARS-CoV-2 infection and mRNA vaccination.
  Journal of medical microbiology 2023 Fleischmann CJ, Bulman CA, Yun C, Lynch KL, Wu AHB, Whitman JD
• Transient expression of antinuclear RNP-A antibodies in patients with acute COVID-19 infection.
  Journal of translational autoimmunity 2022 Zhou S, Kaul R, Lynch KL, Wu AHB, Walker RP
• An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results.
  The journal of applied laboratory medicine 2022 Geno KA, Badea A, Lynch KL, Jannetto P, Hubbard JA, Nerenz RD, Cervinski MA
• Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq.
  eLife 2022 Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Proekt I, Yu D, Mandel-Brehm C, Wang CY, Miao B, Sowa G, Zorn K, Chan AY…
• Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.
  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2022 Riley ED, Kazi DS, Coffin PO, Vittinghoff E, Wade AN, Bulfone TC, Lynch KL, Atai Z, Wu AHB
• Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Journal of the Endocrine Society 2022 Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL
• Differences in Post-mRNA Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Immunoglobulin G (IgG) Concentrations and Surrogate Virus Neutralization Test Response by Human Immunodeficiency Virus (HIV) Status and Type of Vaccine: A Matched Case-Control Observational Study.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Spinelli MA, Peluso MJ, Lynch KL, Yun C, Glidden DV, Henrich TJ, Deeks SG, Gandhi M
• Abstract P3005: Cannabinoid Receptor 1 Antagonist Genistein Attenuates Marijuana-Induced Vascular Inflammation.
  Circulation Research 2022 Mark Chandy, Tzu-tang T Wei, Masataka Nishiga, Angela Zhang, Kaavya K Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne M Justesen, Ian Y Chen, Hung-Ta Wo, Johnson Y Yang, Saereh Khanamiri, …
• Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
  Nature communications 2022 Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Lin CY, Gonzalez VJ, Chidboy MA, Warrier L, Buarpung S, Murtha AP, Flaherman VJ, Greene WC, Wu AHB, Lynch KL, Rajan J,…
• The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites.
  Journal of psychoactive drugs 2022 Wolfson P, Cole R, Lynch K, Yun C, Wallach J, Andries J, Whippo M
• Development and application of a High-Resolution mass spectrometry method for the detection of fentanyl analogs in urine and serum.
  Journal of mass spectrometry and advances in the clinical lab 2022 Zhang Y, Halifax JC, Tangsombatvisit C, Yun C, Pang S, Hooshfar S, Wu AHB, Lynch KL
• Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection.
  AIDS (London, England) 2022 Peluso MJ, Spinelli MA, Deveau TM, Forman CA, Munter SE, Mathur S, Tang AF, Lu S, Goldberg SA, Arreguin MI, Hoh R, Tai V, Chen JY, Martinez EO, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Sette A, …
• Multiple substance use, inflammation and cardiac stretch in women living with HIV.
  Drug and alcohol dependence 2022 Riley ED, Kizer JR, Tien PC, Vittinghoff E, Lynch KL, Wu AHB, Coffin PO, Beck-Engeser G, Braun C, Hunt PW
• Increased Serum IgG Antibody, Avidity, and Surrogate Virus Neutralization Response after a Third Dose for the BNT162b2 mRNA Vaccine to SARS-CoV-2.
  The journal of applied laboratory medicine 2022 Wu AHB, Lynch KL
• Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test.
  Clinical chemistry 2022 Lynch KL, Zhou S, Kaul R, Walker R, Wu AH
• Adequate Antibody Response to COVID-19 Vaccine in Patients with Monoclonal Gammopathies and Light Chain Amyloidosis.
  Laboratory medicine 2022 Wu AHB, Wang CC, Ong CM, Lynch KL
• Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.
  Cell 2022 Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, …
• Establishment of a High-Resolution Liquid Chromatography-Mass Spectrometry Spectral Library for Screening Toxic Natural Products.
  Journal of analytical toxicology 2022 Luo YR, Goodnough R, Yun C, Wu AHB, Lynch KL
• Rate of Serum SARS-CoV-2 Antibody Decline for Two mRNA Vaccines.
  The journal of applied laboratory medicine 2022 Wu AHB, Nguyen ED, Ong CM, Yun C, Lynch KL
• Longitudinal SARS-CoV-2 Antibody Avidity Responses in a SARS-CoV-2 Pregnancy Cohort.
  American Journal of Obstetrics and Gynecology 2022 Arianna Cassidy, Mary Prahl, Dongli Song, Priya Jegatheesan, Kara Lynch, Stephanie Gaw
• Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations.
  Laboratory medicine 2022 Aoullay Z, Van Wijk XMR, Yanhui M, Meddah B, Lynch KL, Cherrah Y, Wu AHB
• Development of a high-throughput differential mobility separation-tandem mass spectrometry (DMS-MS/MS) method for clinical urine drug testing.
  Journal of mass spectrometry and advances in the clinical lab 2022 Hooshfar S, Tchu S, Yun C, Lynch KL
• Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection.
  Clinical chemistry 2021 Zhang Y, Ong CM, Yun C, Mo W, Whitman JD, Lynch KL, Wu AHB
• Refractory vasodilatory shock secondary to metformin overdose supported with VA ECMO.
  Toxicology reports 2021 Ives Tallman C, Zhang Y, Black N, Lynch K, Fayed M, Armenian P
• Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy.
  Research square 2021 Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Lin CY, Gonzalez VJ, Chidboy MA, Warrier L, Buarpung S, Murtha AP, Flaherman VJ, Greene WC, Wu AHB, Lynch KL, Rajan J,…
• Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy.
  medRxiv : the preprint server for health sciences 2021 Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Lin CY, Gonzalez VJ, Chidboy MA, Warrier L, Buarpung S, Murtha AP, Flaherman VJ, Greene WC, Wu AHB, Lynch KL, Rajan J,…
• LB8. Lower SARS-CoV-2 IgG and Pseudovirus Neutralization Titers Post-mRNA Vaccination among People Living with HIV.
  Open Forum Infectious Diseases 2021 Matthew A Spinelli, Michael J Peluso, Kara Lynch, Cassandra Yun, David V Glidden, Timothy J Henrich, Steve Deeks, Monica Gandhi
• Mistaken identity: acute respiratory arrest from accidental ingestion of poison hemlock.
  Clinical toxicology (Philadelphia, Pa.) 2021 Li K, Bassett H, Fitch B, Lynch K
• Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Luo YR, Chakraborty I, Yun C, Wu AHB, Lynch KL
• The Reference Range for the Anion Gap Is Dependent on the Instrument's Electrolyte Assay.
  The journal of applied laboratory medicine 2021 Wu AHB, Jankowski T, Zhang Y, Lynch KL
• Longitudinal Study of SARS-CoV-2 Antibody Characteristics Using Label-Free Immunoassays.
  American Journal of Clinical Pathology 2021 Y R Luo, C Yun, A H Wu, K L Lynch, I Chakraborty
• SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.
  bioRxiv : the preprint server for biology 2021 Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K
• Ongoing tobacco use in women who experience homelessness and unstable housing: A prospective study to inform tobacco cessation interventions and policies.
  Addictive Behaviors 2021 Elise D. Riley, Kevin Delucchi, Sara Rubin, Sheri D. Weiser, Maya Vijayaraghavan, Kara Lynch, Janice Y. Tsoh
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
  Open forum infectious diseases 2021 Peluso MJ, Munter SE, Lynch KL, Yun C, Torres L, Iyer NS, Donatelli J, Ryan L, Deitchman AN, Deeks SG, Rutishauser RL, Henrich TJ
• Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019.
  Open forum infectious diseases 2021 Bainbridge ED, Hsue PY, Esensten JH, Lynch KL, Hendrickson CM, Doernberg SB, Fung M, Chin-Hong P, Di Germanio C, Norris PJ, Simmons G, Glidden DV, Luetkemeyer AF
• Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19.
  Cell reports 2021 Neidleman J, Luo X, George AF, McGregor M, Yang J, Yun C, Murray V, Gill G, Greene WC, Vasquez J, Lee SA, Ghosn E, Lynch KL, Roan NR
• A SARS-CoV-2 Label-Free Surrogate Virus Neutralization Test and a Longitudinal Study of Antibody Characteristics in COVID-19 Patients.
  Journal of clinical microbiology 2021 Luo YR, Yun C, Chakraborty I, Wu AHB, Lynch KL
• Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records.
  Nature communications 2021 Routledge I, Epstein A, Takahashi S, Janson O, Hakim J, Duarte E, Turcios K, Vinden J, Sujishi K, Rangel J, Coh M, Besana L, Ho WK, Oon CY, Ong CM, Yun C, Lynch K, Wu AHB, Wu W, Karlon W, Thornborrow …
• Lacosamide induced Brugada I morphology in the setting of septicemia: A case report.
  Medicine 2021 Goodnough R, Badea A, Geier C, Lynch KL, LeSaint KT
• Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality.
  The journal of applied laboratory medicine 2021 van Wijk XMR, Yun C, Lynch KL
• SARS-CoV-2 seroprevalence, and IgG concentration and pseudovirus neutralising antibody titres after infection, compared by HIV status: a matched case-control observational study.
  The lancet. HIV 2021 Spinelli MA, Lynch KL, Yun C, Glidden DV, Peluso MJ, Henrich TJ, Gandhi M, Brown LB
• Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma.
  American journal of clinical pathology 2021 Balcerek J, Trejo E, Levine K, Couey P, Kornberg ZV, Rogine C, Young C, Li PJ, Shy BR, Taylor JE, Bakhtary S, Friedlander T, Lynch KL, Bern C, Esensten JH
• Lack of Cross-Reactivity of Tianeptine with Tricyclic Antidepressant Immunoassays.
  Journal of analytical toxicology 2021 Badea A, Ghosh R, Lynch KL, Wu AHB
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2021 Riley ED, Chow FC, Josephson SA, Dilworth SE, Lynch KL, Wade AN, Braun C, Hess CP
• Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB
• 496. Higher SARS-CoV-2 RT-PCR Cycle Threshold (Ct) Values Associated with Longer Symptom Duration Among Patients Hospitalized with COVID-19.
  Open Forum Infectious Diseases 2020 Lillian B Brown, Lisa Gail Winston, Barbara Haller, Phong Pham, Beatrice Marcelo, Wendy Cheung, Kara Lynch, Vivek Jain
• A High-Resolution Liquid Chromatography-Mass Spectrometry Method for Identification of Toxic Natural Products in Clinical Cases.
  American Journal of Clinical Pathology 2020 Y R Luo, C Yun, K L Lynch, K Comstock
• Development of Label-Free Immunoassays as Novel Solutions for the Measurement of Monoclonal Antibody Drugs and Antidrug Antibodies.
  Clinical chemistry 2020 Luo YR, Chakraborty I, Lazar-Molnar E, Wu AHB, Lynch KL
• Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women.
  Drug and alcohol dependence 2020 Riley ED, Vittinghoff E, Wu AHB, Coffin PO, Hsue PY, Kazi DS, Wade A, Braun C, Lynch KL
• Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
  Nature biotechnology 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong …
• Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB
• Challenges of High-Resolution Mass Spectrometry For Detecting Designer Drugs.
  Clinical chemistry 2020 Strathmann FG, Lynch KL, Krotulski A, Negri P, Cichelli J, Meyer MR
• Upper reference limits and percent measurable concentrations using a universal sample bank for high sensitivity cardiac troponin I using a point-of-care assay.
  Clinical biochemistry 2020 Wu AHB, Lynch K, Sexter A, Apple FS
• Test performance evaluation of SARS-CoV-2 serological assays.
  medRxiv : the preprint server for health sciences 2020 Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong …
• AACC Guidance Document on Biotin Interference in Laboratory Tests.
  The journal of applied laboratory medicine 2020 Li D, Ferguson A, Cervinski MA, Lynch KL, Kyle PB
• A case of unexplained duodenal ulcer and massive gastrointestinal bleed.
  Clinica chimica acta; international journal of clinical chemistry 2020 Luo YR, Goodnough R, Menza R, Badea A, Luu HY, Kornblith LZ, Lynch KL
• Addressing overdose risk among unstably housed women in San Francisco, California: an examination of potential fentanyl contamination of multiple substances.
  Harm reduction journal 2020 Meacham MC, Lynch KL, Coffin PO, Wade A, Wheeler E, Riley ED
• Real-time comprehensive toxicology testing in the clinical management of accidental pediatric capecitabine ingestion.
  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2020 Gintjee TJ, Goodnough R, Li K, Badea A, Lynch KL, Garcia E, Repplinger D
• A thin-film interferometry-based label-free immunoassay for the detection of daratumumab interference in serum protein electrophoresis.
  Clinica chimica acta; international journal of clinical chemistry 2019 Luo YR, Chakraborty I, Zuk RF, Lynch KL, Wu AHB
• Quantitative biochemical screening for marijuana use and concordance with tobacco use in urban adolescents.
  Drug and alcohol dependence 2019 Benowitz N, Nardone N, St Helen G, Addo N, Jacob P, Liakoni E, Jain S, Hooshfar S, Lynch K
• Notes from the Field: Unintentional Fentanyl Overdoses Among Persons Who Thought They Were Snorting Cocaine - Fresno, California, January 7, 2019.
  MMWR. Morbidity and mortality weekly report 2019 Armenian P, Whitman JD, Badea A, Johnson W, Drake C, Dhillon SS, Rivera M, Brandehoff N, Lynch KL
• Correlation of Breath and Blood Δ9-Tetrahydrocannabinol Concentrations and Release Kinetics Following Controlled Administration of Smoked Cannabis.
  Clinical chemistry 2019 Lynch KL, Luo YR, Hooshfar S, Yun C
• Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I.
  Clinical biochemistry 2019 van Wijk XMR, Claassen S, Enea NS, Li P, Yang S, Brouwer MA, Cramer GE, Zuk R, Lynch KL, Wu AHB
• Quantitation of Cannabinoids in Breath Samples Using a Novel Derivatization LC-MS/MS Assay with Ultra-High Sensitivity.
  Journal of analytical toxicology 2019 Luo YR, Yun C, Lynch KL
• A fatal ranolazine overdose after an intentional ingestion.
  Clinical toxicology (Philadelphia, Pa.) 2019 Goodnough R, Kim-Katz S, Badea A, Lynch KL, Cotter LE, Smollin CG
• A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines.
  Journal of analytical toxicology 2019 van Wijk XMR, Yun C, Hooshfar S, Arens AM, Lung D, Wu AHB, Lynch KL
• Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window Acquisition of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology.
  Clinical chemistry 2019 Whitman JD, Lynch KL
• Azo coupling-based derivatization method for high-sensitivity liquid chromatography-tandem mass spectrometry analysis of tetrahydrocannabinol and other aromatic compounds.
  Journal of chromatography. A 2019 Luo YR, Han J, Yun C, Lynch KL
• Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day).
  Clinical toxicology (Philadelphia, Pa.) 2019 Goodnough R, Nomura M, Badea A, Lynch KL, Benowitz NL, Tsutaoka B
• Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry.
  Methods in molecular biology (Clifton, N.J.) 2019 Colby JM, Lynch KL
• Case of brodifacoum-contaminated synthetic cannabinoid.
  Clinical toxicology (Philadelphia, Pa.) 2018 Riley SB, Sochat M, Moser K, Lynch KL, Tochtrop R, Isbell TS, Scalzo A
• Accreditation and Quality Assurance for Clinical Liquid Chromatography-Mass Spectrometry Laboratories.
  Clinics in laboratory medicine 2018 Lynch KL
• Notes from the Field: Toxic Leukoencephalopathy Associated with Tianeptine Misuse - California, 2017.
  MMWR. Morbidity and mortality weekly report 2018 Goodnough R, Li K, Fouladkou F, Lynch KL, Shah M, Smollin CG, Blanc PD
• Suspect Screening Using LC-QqTOF Is a Useful Tool for Detecting Drugs in Biological Samples.
  Journal of analytical toxicology 2018 Colby JM, Thoren KL, Lynch KL
• Evaluation of Intraosseous Fluid as an Alternative Biological Specimen in Postmortem Toxicology.
  Journal of analytical toxicology 2018 Rodda LN, Volk JA, Moffat E, Williams CM, Lynch KL, Wu AHB
• Reproducibility Assessment for a Broad Spectrum Drug Screening Method from Urine using Liquid Chromatography Time-of-Flight Mass Spectrometry.
  Clinical Mass Spectrometry 2018 Imir G. Metushi, Michael R. Wakefield, Kara Lynch, Judy Stone, Robert L. Fitzgerald
• Quantitation of Infliximab and Detection of Antidrug Antibodies in Serum by Use of Surface Plasmon Resonance.
  The Journal of Applied Laboratory Medicine 2018 Katie L. Thoren, Brian Pasi, Julio C. Delgado, Alan H.B. Wu, Kara L. Lynch
• Quantitation of Infliximab and Detection of Antidrug Antibodies in Serum by Use of Surface Plasmon Resonance.
  The journal of applied laboratory medicine 2018 Thoren KL, Pasi B, Delgado JC, Wu AHB, Lynch KL
• Specimen Validity Testing: Is it "Valid" for Drug Testing in Pain Management?
  The journal of applied laboratory medicine 2018 Lynch KL
• Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol.
  Annals of emergency medicine 2017 Vo KT, Horng H, Li K, Ho RY, Wu AHB, Lynch KL, Smollin CG
• Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review.
  Neuropharmacology 2017 Armenian P, Vo KT, Barr-Walker J, Lynch KL
• Commentary.
  Clinical chemistry 2017 Lynch KL
• Anticholinergic toxicity associated with ingestion of water containing lupini bean extract.
  Clinical toxicology (Philadelphia, Pa.) 2017 Li K, van Wijk XMR, Hayashi S, Lynch KL, Wu AHB, Smollin CG
• Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.
  Clinical biochemistry 2017 van Wijk XMR, Vittinghoff E, Wu AHB, Lynch KL, Riley ED
• ASSOCIATION OF COCAINE AND AMPHETAMINE USE WITH TROPONIN I CONCENTRATIONS.
  Journal of the American College of Cardiology 2017 Peter Moore, Kara L. Lynch, Alan H.B. Wu, Yifei Ma, Rebecca Scherzer, Danny Li, Elise D. Riley
• Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.
  MMWR. Morbidity and mortality weekly report 2017 Tomassoni AJ, Hawk KF, Jubanyik K, Nogee DP, Durant T, Lynch KL, Patel R, Dinh D, Ulrich A, D'Onofrio G
• Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease.
  Drug and alcohol dependence 2017 Riley ED, Hsue PY, Vittinghoff E, Wu AH, Coffin PO, Moore PK, Lynch KL
• Chapter 6 Toxicology: liquid chromatography mass spectrometry.
  Mass Spectrometry for the Clinical Laboratory 2017 K.L. Lynch
• Improvement of drug identification in urine by LC-QqTOF using a probability-based library search algorithm.
  Clinical Mass Spectrometry 2017 Jennifer M. Colby, Jeffery Rivera, Lyle Burton, Dave Cox, Kara L. Lynch
• Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse.
  Clinical toxicology (Philadelphia, Pa.) 2016 Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY
• A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase.
  Clinica chimica acta; international journal of clinical chemistry 2016 van Wijk XMR, Magee CA, Wu AHB, Tana MM, Lynch KL
• Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters.
  Journal of analytical toxicology 2016 Colby JM, Thoren KL, Lynch KL
• Adverse Effects From Counterfeit Alprazolam Tablets.
  JAMA internal medicine 2016 Arens AM, van Wijk XM, Vo KT, Lynch KL, Wu AH, Smollin CG
• Collaboration at the Heart of Innovation.
  Clinical Chemistry 2016 Kara L Lynch
• A two-week pilot study of intranasal oxytocin for cocaine-dependent individuals receiving methadone maintenance treatment for opioid use disorder.
  Addiction research & theory 2016 Stauffer CS, Musinipally V, Suen A, Lynch KL, Shapiro B, Woolley JD
• Levamisole-Contaminated Cocaine Use in HIV-Infected and Uninfected Unstably Housed Women.
  Journal of women's health (2002) 2016 Riley ED, Kral AH, Cohen J, Dilworth SE, Shumway M, Lynch KL
• Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016.
  MMWR. Morbidity and mortality weekly report 2016 Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG
• Development and Validation of a Novel LC-MS/MS Opioid Confirmation Assay: Evaluation of β-glucuronidase Enzymes and Sample Cleanup Methods.
  Journal of analytical toxicology 2016 Yang HS, Wu AH, Lynch KL
• Development and validation of an LC-MS/MS sulfonylurea assay for hypoglycemia cases in the emergency department.
  Clinica chimica acta; international journal of clinical chemistry 2016 Yang HS, Wu AH, Johnson-Davis KL, Lynch KL
• Clenbuterol causing non-ST-segment elevation myocardial infarction in a teenage female desiring to lose weight: case and brief literature review.
  The American journal of emergency medicine 2016 Quinley KE, Chen HY, Yang HS, Lynch KL, Olson KR
• Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening.
  Clinical chemistry 2015 Thoren KL, Colby JM, Shugarts SB, Wu AH, Lynch KL
• CLSI C62-A: A New Standard for Clinical Mass Spectrometry.
  Clinical chemistry 2015 Lynch KL
• Analysis of codeine positivity in urine of pain management patients.
  Journal of analytical toxicology 2015 Colby JM, Wu AH, Lynch KL
• Promethazine use among chronic pain patients.
  Drug and alcohol dependence 2015 Lynch KL, Shapiro BJ, Coffa D, Novak SP, Kral AH
• Cross-reactivity of acetylfentanyl and risperidone with a fentanyl immunoassay.
  Journal of analytical toxicology 2014 Wang BT, Colby JM, Wu AH, Lynch KL
• Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers.
  Clinica chimica acta; international journal of clinical chemistry 2014 Wu AH, Ruan W, Todd J, Lynch KL
• Multi-wavelength spectrophotometric analysis for detection of xanthochromia in cerebrospinal fluid and accuracy for the diagnosis of subarachnoid hemorrhage.
  Clinica chimica acta; international journal of clinical chemistry 2013 Smith A, Wu AH, Lynch KL, Ko N, Grenache DG
• Prolonged ceftriaxone-induced immune thrombocytopenia due to impaired drug clearance: a case report.
  Transfusion 2013 Jacquot C, Moayeri M, Kim B, Shugarts S, Lynch KL, Leavitt AD
• Promethazine misuse among methadone maintenance patients and community-based injection drug users.
  Journal of addiction medicine 2013 Shapiro BJ, Lynch KL, Toochinda T, Lutnick A, Cheng HY, Kral AH
• Cross-reactivity studies and predictive modeling of "Bath Salts" and other amphetamine-type stimulants with amphetamine screening immunoassays.
  Clinical toxicology (Philadelphia, Pa.) 2013 Petrie M, Lynch KL, Ekins S, Chang JS, Goetz RJ, Wu AH, Krasowski MD
• Prescription compliance or illicit designer drug abuse?
  Clinical chemistry 2012 Petrie MS, Lynch KL, Wu AH, Steinhardt AA, Horowitz GL
• Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis.
  Respiratory medicine 2012 Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR
• Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.
  Clinical toxicology (Philadelphia, Pa.) 2012 Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL
• Multifocal inflammatory leukoencephalopathy associated with cocaine abuse: is levamisole responsible?
  Clinical toxicology (Philadelphia, Pa.) 2012 Blanc PD, Chin C, Lynch KL
• Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score.
  Breast cancer research and treatment 2012 Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E
• Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics.
  LC-MS in Drug Bioanalysis 2012 Alan H. B. Wu, Kara L. Lynch
• Therapeutic drug monitoring of tamoxifen using LC-MS/MS.
  Methods in molecular biology (Clifton, N.J.) 2012 Tchu SM, Lynch KL, Wu AH
• Hydrophilic interaction LC-MS/MS analysis of opioids in urine: significance of glucuronide metabolites.
  Bioanalysis 2011 French D, Wu A, Lynch K
• Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine.
  Arthritis and rheumatism 2011 Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J
• Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity.
  Tissue antigens 2011 Kostenko L, Kjer-Nielsen L, Nicholson I, Hudson F, Lucas A, Foley B, Chen K, Lynch K, Nguyen J, Wu AH, Tait BD, Holdsworth R, Mallal S, Rossjohn J, Bharadwaj M, McCluskey J
• Detection of levamisole exposure in cocaine users by liquid chromatography-tandem mass spectrometry.
  Journal of analytical toxicology 2011 Lynch KL, Dominy SS, Graf J, Kral AH
• Images in emergency medicine. Adult female with rash on lower extremities. Vasculopathic purpura and neutropenia caused by levamisole-contaminated cocaine.
  Annals of emergency medicine 2011 Lung D, Lynch K, Agrawal S, Armenian P, Banh K
• Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON® 25-hydroxyvitamin D assay.
  Clinica chimica acta; international journal of clinical chemistry 2010 French D, Gorgi AW, Ihenetu KU, Weeks MA, Lynch KL, Wu AH
• Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening.
  Clinica chimica acta; international journal of clinical chemistry 2010 Lynch KL, Breaud AR, Vandenberghe H, Wu AH, Clarke W
• Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.
  Molecular biology of the cell 2008 Lynch KL, Gerona RR, Kielar DM, Martens S, McMahon HT, Martin TF
• Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis.
  Molecular biology of the cell 2007 Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, Martin TF
• Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells.
  Journal of cell science 2007 Lynch KL, Martin TF
• A second SNARE role for exocytic SNAP25 in endosome fusion.
  Molecular biology of the cell 2006 Aikawa Y, Lynch KL, Boswell KL, Martin TF
• Toward artificial developmental regulators.
  Journal of the American Chemical Society 2003 Arndt HD, Hauschild KE, Sullivan DP, Lake K, Dervan PB, Ansari AZ