Kaitlin Schaefer, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy

Publications (24)

Top publication keywords:
LigasesStaphylococcus aureusbeta-LactamsPeptidoglycanCell MembraneBacterial ProteinsAntibodies, NeutralizingCell WallSpike Glycoprotein, CoronavirusPeptidyl TransferasesUridine Diphosphate N-Acetylmuramic AcidEosine Yellowish-(YS)Penicillin-Binding ProteinsTeichoic AcidsHydrolases

• Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells.
  Science (New York, N.Y.) 2024 Lin Z, Schaefer K, Lui I, Yao Z, Fossati A, Swaney DL, Palar A, Sali A, Wells JA
• Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells.
  bioRxiv : the preprint server for biology 2023 Lin Z, Schaefer K, Lui I, Yao Z, Fossati A, Swaney DL, Palar A, Sali A, Wells JA
• Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase.
  ACS central science 2022 Schaefer K, Lui I, Byrnes JR, Kang E, Zhou J, Weeks AM, Wells JA
• Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
  Nature chemical biology 2022 Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …

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• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
  bioRxiv : the preprint server for biology 2021 Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Kumar GR, Ott M, Baker D, El-Samad H
• Lipoteichoic acid polymer length is determined by competition between free starter units.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Hesser AR, Schaefer K, Lee W, Walker S
• Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.
  Nature microbiology 2020 Schaefer K, Owens TW, Page JE, Santiago M, Kahne D, Walker S
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
  Nature chemical biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.
  bioRxiv : the preprint server for biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan.
  Nature microbiology 2020 Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S
• Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases.
  Journal of the American Chemical Society 2019 Welsh MA, Schaefer K, Taguchi A, Kahne D, Walker S
• MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis.
  eLife 2018 Hussain S, Wivagg CN, Szwedziak P, Wong F, Schaefer K, Izoré T, Renner LD, Holmes MJ, Sun Y, Bisson-Filho AW, Walker S, Amir A, Löwe J, Garner EC
• Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus.
  Journal of the American Chemical Society 2018 Schaefer K, Owens TW, Kahne D, Walker S
• Identification of a Functionally Unique Family of Penicillin-Binding Proteins.
  Journal of the American Chemical Society 2017 Welsh MA, Taguchi A, Schaefer K, Van Tyne D, Lebreton F, Gilmore MS, Kahne D, Walker S
• Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections.
  Journal of the American Chemical Society 2017 Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S
• Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams.
  Nature chemical biology 2017 Qiao Y, Srisuknimit V, Rubino F, Schaefer K, Ruiz N, Walker S, Kahne D
• In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins.
  Nature chemical biology 2017 Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S
• The Mechanism of Action of Lysobactin.
  Journal of the American Chemical Society 2015 Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S
• Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction.
  Journal of the American Chemical Society 2014 Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S