Julius Guccione, PhD
Professor Emeritus
Surgery
School of Medicine

He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. In 2012, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

Dr. Guccione also is CTO at 3DT HOLDINGS, LLC

• Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images.
  Bioengineering (Basel, Switzerland) 2024 Fan L, Choy JS, Cai C, Teague SD, Guccione J, Lee LC, Kassab GS
• Temporal evolution of ascending aortic aneurysm wall stress predicts all-cause mortality.
  Interdisciplinary cardiovascular and thoracic surgery 2024 Zamirpour S, Gulati A, Xuan Y, Leach JR, Saloner DA, Guccione JM, Boskovski MT, Ge L, Tseng EE
• Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.
  International journal of cardiology. Heart & vasculature 2024 Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach JR, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE
• A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation
  JACC: ADVANCES 2023 Dabiri Y, Mahadevan V, Guccione JM, Kassab GS
• Imaging and Computational Modeling of Tricuspid Regurgitation and Repair
  Vessel Plus 2023 Morgan AE, Howell K, Chen S, Serrone RO, Zhang Y, Wang VY, Kim JJ, Grossi E, Selzman CH, Guccione JM, Sharma V, MacLeod R; Ratcliffe MB
• On the Role of Ionic Model in the Signature of Cardiac Arrhythmias for Healthy and Diseased Hearts
  Mathematics 2023 Ramirez WA, Gizzi A, Sack KL, Filippi S, Guccione JM, Hurtado DE
• On the Severity of Aortic Stenosis in Ascending Aortic Aneurysm A Computational Tool to Examine Ventricular-Arterial Interaction and Aortic Wall Stress
  Mechanics Research Communications 2023 Cosentino F, Giuseppe M, Agnese V, Gentile G, Raffa GM, Wisneski A, Guccione J, Pilato M, Pasta S
• Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms.
  The Journal of thoracic and cardiovascular surgery 2023 Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE
• Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population.
  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2023 Gulati A, Zamirpour S, Leach J, Khan A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE
• Machine learning used for simulation of MitraClip intervention: A proof-of-concept study.
  Frontiers in genetics 2023 Dabiri Y, Mahadevan VS, Guccione JM, Kassab GS
• Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.
  Scientific reports 2023 Mojumder J, Fan L, Nguyen T, Campbell KS, Wenk JF, Guccione JM, Abraham T, Lee LC
• Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction.
  Journal of the mechanical behavior of biomedical materials 2022 Xuan Y, Wang Z, Guccione JM, Tseng EE, Ge L
• Numerical simulation of transcatheter mitral valve replacement: The dynamic implication of LVOT obstruction in the valve-in-ring case.
  Journal of biomechanics 2022 Pasta S, Catalano C, Cannata S, Guccione JM, Gandolfo C
• Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans.
  Seminars in thoracic and cardiovascular surgery 2022 Zamirpour S, Xuan Y, Wang Z, Gomez A, Hope MD, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE
• Regional wall stress differences on tricuspid aortic valve-associated ascending aortic aneurysms.
  Interactive cardiovascular and thoracic surgery 2022 Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE
• Inversion of Left Atrial Appendage Will Cause Compressive Stresses in the Tissue: Simulation Study of Potential Therapy.
  Journal of personalized medicine 2022 Pasta S, Guccione JM, Kassab GS
• A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation.
  JACC. Advances 2022 Dabiri Y, Mahadevan VS, Guccione JM, Kassab GS
• Mitral Valve Atlas for Artificial Intelligence Predictions of MitraClip Intervention Outcomes.
  Frontiers in cardiovascular medicine 2021 Dabiri Y, Yao J, Mahadevan VS, Gruber D, Arnaout R, Gentzsch W, Guccione JM, Kassab GS
• Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model.
  Bioengineering (Basel, Switzerland) 2021 Cutugno S, Agnese V, Gentile G, Raffa GM, Wisneski AD, Guccione JM, Pilato M, Pasta S
• Regional biomechanical and failure properties of healthy human ascending aorta and root.
  Journal of the mechanical behavior of biomedical materials 2021 Xuan Y, Wisneski AD, Wang Z, Lum M, Kumar S, Pallone J, Flores N, Inman J, Lai L, Lin J, Guccione JM, Tseng EE, Ge L
• Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms.
  The Journal of thoracic and cardiovascular surgery 2021 Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE
• A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction.
  Magnetic resonance in medicine 2021 Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe …
• Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction.
  Journal of cardiovascular translational research 2021 Shavik SM, Wall S, Sundnes J, Guccione JM, Sengupta P, Solomon SD, Burkhoff D, Lee LC
• Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain.
  Journal of the mechanical behavior of biomedical materials 2021 Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB
• Precision medicine in human heart modeling : Perspectives, challenges, and opportunities.
  Biomechanics and modeling in mechanobiology 2021 Peirlinck M, Costabal FS, Yao J, Guccione JM, Tripathy S, Wang Y, Ozturk D, Segars P, Morrison TM, Levine S, Kuhl E
• Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics.
  Scientific reports 2020 Dabiri Y, Van der Velden A, Sack KL, Choy JS, Guccione JM, Kassab GS
• Impact of Transcatheter Aortic Valve Size on Leaflet Stresses: Implications for Durability and Optimal Grey Zone Sizing.
  AsiaIntervention 2020 Xuan Y, Dvir D, Wisneski AD, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE
• Commentary: Fast and accurate surrogate of finite-element analysis: For bench to bedside, we need it now!
  JTCVS techniques 2020 Wisneski AD, Guccione JM
• In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy.
  Scientific reports 2020 Ramírez WA, Gizzi A, Sack KL, Guccione JM, Hurtado DE
• Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep.
  PloS one 2020 Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB
• Stent and leaflet stresses across generations of balloon-expandable transcatheter aortic valves.
  Interactive cardiovascular and thoracic surgery 2020 Xuan Y, Dvir D, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE
• A Novel MRI-Based Finite Element Modeling Method for Calculation of Myocardial Ischemia Effect in Patients With Functional Mitral Regurgitation.
  Frontiers in physiology 2020 Zhang Y, Wang VY, Morgan AE, Kim J, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB
• Wall Stress Distribution in Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysms.
  The Annals of thoracic surgery 2020 Gomez A, Wang Z, Xuan Y, Wisneski AD, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE
• Wall stress analyses in patients with ≥5 cm versus <5 cm ascending thoracic aortic aneurysm.
  The Journal of thoracic and cardiovascular surgery 2020 Wang Z, Flores N, Lum M, Wisneski AD, Xuan Y, Inman J, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE
• Numerical Simulations of MitraClip Placement: Clinical Implications.
  Scientific reports 2019 Kamakoti R, Dabiri Y, Wang DD, Guccione J, Kassab GS
• Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study.
  PloS one 2019 Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB
• Editorial: Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic.
  Frontiers in physiology 2019 Kassab G, Guccione J
• Prediction of Left Ventricular Mechanics Using Machine Learning.
  Frontiers in physics 2019 Dabiri Y, Van der Velden A, Sack KL, Choy JS, Kassab GS, Guccione JM
• Finite elastic wrinkling deformations of incompressible fiber-reinforced plates.
  International journal of engineering science 2019 Taylor M, Shirani M, Dabiri Y, Guccione JM, Steigmann DJ
• Using machine learning to characterize heart failure across the scales.
  Biomechanics and modeling in mechanobiology 2019 Peirlinck M, Sahli Costabal F, Sack KL, Choy JS, Kassab GS, Guccione JM, De Beule M, Segers P, Kuhl E
• Tricuspid Valve Regurgitation Decreases after MitraClip Implantation: Fluid Structure Interaction Simulation.
  Mechanics research communications 2019 Dabiri Y, Yao J, Sack KL, Kassab GS, Guccione JM
• Reply to Letter to Editor by S Tong, L Zhang, J Joseph, and X Jiang "A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR".
  International journal of cardiology 2019 Kassab GS, Choy JS, Guccione JM
• Multiscale characterization of heart failure.
  Acta biomaterialia 2019 Sahli Costabal F, Choy JS, Sack KL, Guccione JM, Kassab GS, Kuhl E
• Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach.
  Molecular & cellular biomechanics : MCB 2019 Dabiri Y, Sack KL, Shaul S, Acevedo-Bolton G, Choy JS, Kassab GS, Guccione JM
• Range of Pulmonary Autograft Responses to Systemic Pressure Immediately After Ross Procedure.
  The Journal of heart valve disease 2019 Wisneski AD, Wang Z, Xuan Y, Guccione JM, Ge L, Tseng EE
• Diffusion and swelling in a bio-elastic cylinder.
  Mechanics research communications 2018 Tartibi M, Guccione JM, Steigmann DJ
• Relationship of Transmural Variations in Myofiber Contractility to Left Ventricular Ejection Fraction: Implications for Modeling Heart Failure Phenotype With Preserved Ejection Fraction.
  Frontiers in physiology 2018 Dabiri Y, Sack KL, Shaul S, Sengupta PP, Guccione JM
• Effect of intra-myocardial Algisyl-LVR™ injectates on fibre structure in porcine heart failure.
  Journal of the mechanical behavior of biomedical materials 2018 Sack KL, Aliotta E, Choy JS, Ennis DB, Davies NH, Franz T, Kassab GS, Guccione JM
• Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.
  Frontiers in physiology 2018 Sack KL, Aliotta E, Ennis DB, Choy JS, Kassab GS, Guccione JM, Franz T
• Stent and leaflet stresses in 26-mm, third-generation, balloon-expandable transcatheter aortic valve.
  The Journal of thoracic and cardiovascular surgery 2018 Xuan Y, Dvir D, Wang Z, Mizoguchi T, Ye J, Guccione JM, Ge L, Tseng EE
• Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine.
  International journal of cardiology 2018 Choy JS, Leng S, Acevedo-Bolton G, Shaul S, Fu L, Guo X, Zhong L, Guccione JM, Kassab GS
• Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve.
  The Journal of thoracic and cardiovascular surgery 2018 Xuan Y, Wang Z, Liu R, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng E
• Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium.
  The Annals of thoracic surgery 2018 Morgan AE, Zhang Y, Tartibi M, Goldburg S, Kim JJ, Nguyen TD, Guccione J, Ge L, Weinsaft JW, Ratcliffe MB
• Impact of Patient-Specific Material Properties on Aneurysm Wall Stress: Finite Element Study.
  The Journal of heart valve disease 2018 Wang Z, Xuan Y, Guccione JM, Tseng EE, Ge L
• Stent and Leaflet Stresses in 29-mm Second-Generation Balloon-Expandable Transcatheter Aortic Valve.
  The Annals of thoracic surgery 2017 Xuan Y, Krishnan K, Ye J, Dvir D, Guccione JM, Ge L, Tseng EE
• Leaflet Mechanical Properties of Carpentier-Edwards Perimount Magna Pericardial Aortic Bioprostheses.
  The Journal of heart valve disease 2017 Kuang H, Xuan Y, Lu M, Mookhoek A, Wisneski AD, Guccione JM, Ge L, Tseng EE
• Stent and leaflet stresses in a 26-mm first-generation balloon-expandable transcatheter aortic valve.
  The Journal of thoracic and cardiovascular surgery 2016 Xuan Y, Krishnan K, Ye J, Dvir D, Guccione JM, Ge L, Tseng EE
• Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.
  Heart failure reviews 2016 Sack KL, Davies NH, Guccione JM, Franz T
• Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico.
  The International journal of artificial organs 2016 Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM
• Suture Forces for Closure of Transapical Transcatheter Aortic Valve Replacement: A Mathematical Model.
  The Journal of heart valve disease 2016 Ge L, Haraldsson H, Hope MD, Saloner D, Guccione JM, Ratcliffe MB, Tseng EE
• A New Twist on Mitral Regurgitation.
  JACC. Basic to translational science 2016 Burkhoff D, Guccione J
• Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.
  Annals of biomedical engineering 2016 Kassab GS, An G, Sander EA, Miga MI, Guccione JM, Ji S, Vodovotz Y
• Mathematical modeling of cardiac growth and remodeling.
  Wiley interdisciplinary reviews. Systems biology and medicine 2016 Lee LC, Kassab GS, Guccione JM
• Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone.
  The Annals of thoracic surgery 2016 Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB
• Finite Element Modeling of Mitral Valve Repair.
  Journal of biomechanical engineering 2016 Morgan AE, Pantoja JL, Weinsaft J, Grossi E, Guccione JM, Ge L, Ratcliffe M
• Measuring cardiac efficiency using PET/MRI.
  EJNMMI physics 2015 Gullberg G, Aparici CM, Brooks G, Liu J, Guccione J, Saloner D, Seo AY, Ordovas KG
• Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysm: Patient-Specific Finite Element Analysis.
  The Journal of heart valve disease 2015 Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE
• Residual Stress Impairs Pump Function After Surgical Ventricular Remodeling: A Finite Element Analysis.
  The Annals of thoracic surgery 2015 Pantoja JL, Zhang Z, Tartibi M, Sun K, Macmillan W, Guccione JM, Ge L, Ratcliffe MB
• Ascending thoracic aortic aneurysm wall stress analysis using patient-specific finite element modeling of in vivo magnetic resonance imaging.
  Interactive cardiovascular and thoracic surgery 2015 Krishnan K, Ge L, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Tseng EE
• A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging.
  Journal of biomechanical engineering 2015 Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM
• Modeling Pathologies of Diastolic and Systolic Heart Failure.
  Annals of biomedical engineering 2015 Genet M, Lee LC, Baillargeon B, Guccione JM, Kuhl E
• Heterogeneous growth-induced prestrain in the heart.
  Journal of biomechanics 2015 Genet M, Rausch MK, Lee LC, Choy S, Zhao X, Kassab GS, Kozerke S, Guccione JM, Kuhl E
• Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.
  Cardiovascular engineering and technology 2015 Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM
• Effect of mitral annuloplasty device shape and size on leaflet and myofiber stress following repair of posterior leaflet prolapse: a patient-specific finite element simulation.
  The Journal of heart valve disease 2014 Morrel WG, Ge L, Zhang Z, Grossi EA, Guccione JM, Ratcliffe MB
• Patient-specific finite element analysis of ascending thoracic aortic aneurysm.
  The Journal of heart valve disease 2014 Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE
• Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.
  The Annals of thoracic surgery 2014 Pantoja JL, Ge L, Zhang Z, Morrel WG, Guccione JM, Grossi EA, Ratcliffe MB
• Invited commentary.
  The Annals of thoracic surgery 2014 Lee LC, Genet M, Guccione JM
• Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress.
  Journal of biomechanics 2014 Lee LC, Wall ST, Genet M, Hinson A, Guccione JM
• A computational model that predicts reverse growth in response to mechanical unloading.
  Biomechanics and modeling in mechanobiology 2014 Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E
• Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments.
  Journal of applied physiology (Bethesda, Md. : 1985) 2014 Genet M, Lee LC, Nguyen R, Haraldsson H, Acevedo-Bolton G, Zhang Z, Ge L, Ordovas K, Kozerke S, Guccione JM
• Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function.
  Medical & biological engineering & computing 2014 Lee LC, Ge L, Zhang Z, Pease M, Nikolic SD, Mishra R, Ratcliffe MB, Guccione JM
• Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure.
  The Journal of heart valve disease 2014 Wisneski AD, Matthews PB, Azadani AN, Mookhoek A, Chitsaz S, Guccione JM, Ge L, Tseng EE
• Applications of computational modeling in cardiac surgery.
  Journal of cardiac surgery 2014 Lee LC, Genet M, Dang AB, Ge L, Guccione JM, Ratcliffe MB
• Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation.
  The Annals of thoracic surgery 2014 Ge L, Morrel WG, Ward A, Mishra R, Zhang Z, Guccione JM, Grossi EA, Ratcliffe MB
• Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis.
  PloS one 2013 Huo Y, Luo T, Guccione JM, Teague SD, Tan W, Navia JA, Kassab GS
• Biomechanical properties of human ascending thoracic aortic aneurysms.
  The Annals of thoracic surgery 2013 Azadani AN, Chitsaz S, Mannion A, Mookhoek A, Wisneski A, Guccione JM, Hope MD, Ge L, Tseng EE
• Analysis of patient-specific surgical ventricular restoration: importance of an ellipsoidal left ventricular geometry for diastolic and systolic function.
  Journal of applied physiology (Bethesda, Md. : 1985) 2013 Lee LC, Wenk JF, Zhong L, Klepach D, Zhang Z, Ge L, Ratcliffe MB, Zohdi TI, Hsu E, Navia JL, Kassab GS, Guccione JM
• Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.
  The Annals of thoracic surgery 2013 Wenk JF, Ge L, Zhang Z, Mojsejenko D, Potter DD, Tseng EE, Guccione JM, Ratcliffe MB
• Reduction in left ventricular wall stress and improvement in function in failing hearts using Algisyl-LVR.
  Journal of visualized experiments : JoVE 2013 Lee LC, Zhihong Z, Hinson A, Guccione JM
• Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.
  The Annals of thoracic surgery 2013 Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB
• Left ventricular pressure gating in ovine cardiac studies: a software-based method.
  Journal of biomechanical engineering 2013 Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB
• Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart.
  International journal of cardiology 2013 Lee LC, Wall ST, Klepach D, Ge L, Zhang Z, Lee RJ, Hinson A, Gorman JH, Gorman RC, Guccione JM
• Finite element modeling of mitral leaflet tissue using a layered shell approximation.
  Medical & biological engineering & computing 2012 Wenk JF, Ratcliffe MB, Guccione JM
• Material properties of CorCap passive cardiac support device.
  The Annals of thoracic surgery 2012 Chitsaz S, Wenk JF, Ge L, Wisneski A, Mookhoek A, Ratcliffe MB, Guccione JM, Tseng EE
• Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress.
  The Annals of thoracic surgery 2012 Carrick R, Ge L, Lee LC, Zhang Z, Mishra R, Axel L, Guccione JM, Grossi EA, Ratcliffe MB
• Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.
  Annals of biomedical engineering 2012 Sankaran S, Esmaily Moghadam M, Kahn AM, Tseng EE, Guccione JM, Marsden AL
• The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.
  Frontiers in physiology 2012 Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB
• Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration.
  Mechanics research communications 2012 Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM
• First evidence of depressed contractility in the border zone of a human myocardial infarction.
  The Annals of thoracic surgery 2012 Wenk JF, Klepach D, Lee LC, Zhang Z, Ge L, Tseng EE, Martin A, Kozerke S, Gorman JH, Gorman RC, Guccione JM
• A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
  Computer methods in biomechanics and biomedical engineering 2012 Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM
• The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.
  The Annals of thoracic surgery 2012 Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L
• Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study.
  American journal of physiology. Heart and circulatory physiology 2011 Wall ST, Guccione JM, Ratcliffe MB, Sundnes JS
• Invited commentary.
  The Annals of thoracic surgery 2011 Wenk J, Guccione J, Ratcliffe M
• Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
  The Annals of thoracic surgery 2011 Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB
• A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
  Journal of biomechanical engineering 2011 Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM
• A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.
  The Annals of thoracic surgery 2011 Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM
• Simulation of mechanical environment in active lead fixation: effect of fixation helix size.
  Journal of biomechanical engineering 2011 Zhao X, Wenk JF, Burger M, Liu Y, Das MK, Combs W, Ge L, Guccione JM, Kassab GS
• Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
  Journal of biomechanical engineering 2011 Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM
• Simulation of LV pacemaker lead in marginal vein: potential risk factors for acute dislodgement.
  Journal of biomechanical engineering 2011 Zhao X, Burger M, Liu Y, Das MK, Combs W, Wenk JF, Guccione JM, Kassab GS
• Impact of surgical ventricular restoration on ventricular shape, wall stress, and function in heart failure patients.
  American journal of physiology. Heart and circulatory physiology 2011 Zhong L, Su Y, Gobeawan L, Sola S, Tan RS, Navia JL, Ghista DN, Chua T, Guccione J, Kassab GS
• Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
  The Annals of thoracic surgery 2011 Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB
• Finite element modeling of the pulmonary autograft at systemic pressure before remodeling.
  The Journal of heart valve disease 2011 Matthews PB, Jhun CS, Yaung S, Azadani AN, Guccione JM, Ge L, Tseng EE
• Comparison of porcine pulmonary and aortic root material properties.
  The Annals of thoracic surgery 2010 Matthews PB, Azadani AN, Jhun CS, Ge L, Guy TS, Guccione JM, Tseng EE
• First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
  The Annals of thoracic surgery 2010 Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
• Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.
  The Journal of thoracic and cardiovascular surgery 2010 Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
• Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future.
  International journal for numerical methods in engineering 2010 Einstein DR, Del Pin F, Jiao X, Kuprat AP, Carson JP, Kunzelman KS, Cochran RP, Guccione JM, Ratcliffe MB
• Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study.
  The Annals of thoracic surgery 2010 Jhun CS, Wenk JF, Zhang Z, Wall ST, Sun K, Sabbah HN, Ratcliffe MB, Guccione JM
• A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns.
  Journal of biomechanical engineering 2009 Wenk JF, Wall ST, Peterson RC, Helgerson SL, Sabbah HN, Burger M, Stander N, Ratcliffe MB, Guccione JM
• A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.
  Journal of biomechanical engineering 2009 Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM
• Biomechanical perspective on the porcine pulmonary root prior to Ross remodeling.
  The Journal of heart valve disease 2009 Matthews PB, Kim B, Azadani AN, Guy TS, Guccione JM, Ge L, Tseng EE
• Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations.
  Biomechanics and modeling in mechanobiology 2009 Carson JP, Kuprat AP, Jiao X, Dyedov V, Del Pin F, Guccione JM, Ratcliffe MB, Einstein DR
• Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch.
  The Journal of heart valve disease 2009 Azadani AN, Jaussaud N, Matthews PB, Chuter TA, Ge L, Guy TS, Guccione J, Tseng EE
• Significant material property differences between the porcine ascending aorta and aortic sinuses.
  The Journal of heart valve disease 2008 Gundiah N, Matthews PB, Karimi R, Azadani A, Guccione J, Guy TS, Saloner D, Tseng EE
• Asymmetric mechanical properties of porcine aortic sinuses.
  The Annals of thoracic surgery 2008 Gundiah N, Kam K, Matthews PB, Guccione J, Dwyer HA, Saloner D, Chuter TA, Guy TS, Ratcliffe MB, Tseng EE
• Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm.
  The Journal of thoracic and cardiovascular surgery 2008 Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM
• Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep.
  The Journal of thoracic and cardiovascular surgery 2007 Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB
• Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging.
  American journal of physiology. Heart and circulatory physiology 2007 Jiang Y, Guccione JM, Ratcliffe MB, Hsu EW
• Theoretical impact of the injection of material into the myocardium: a finite element model simulation.
  Circulation 2006 Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM
• The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.
  The Journal of thoracic and cardiovascular surgery 2006 Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB
• Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
  The Journal of thoracic and cardiovascular surgery 2005 Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB
• MRI-based finite-element analysis of left ventricular aneurysm.
  American journal of physiology. Heart and circulatory physiology 2005 Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM
• Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep.
  The Journal of thoracic and cardiovascular surgery 2005 Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB
• Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.
  The Annals of thoracic surgery 2005 Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB
• Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study.
  American journal of physiology. Heart and circulatory physiology 2004 Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB
• Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study.
  The Annals of thoracic surgery 2003 Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB
• Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study.
  Circulation 2002 Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, Sundt TM, Pasque MK
• A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2002 Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB
• Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study.
  The Journal of thoracic and cardiovascular surgery 2001 Guccione JM, Moonly SM, Wallace AW, Ratcliffe MB
• Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.
  The Annals of thoracic surgery 2001 Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK
• Epicardial suction: a new approach to mechanical testing of the passive ventricular wall.
  Journal of biomechanical engineering 2000 Okamoto RJ, Moulton MJ, Peterson SJ, Li D, Pasque MK, Guccione JM
• The effects of cross-fiber deformation on axial fiber stress in myocardium.
  Journal of biomechanical engineering 1999 Zahalak GI, de Laborderie V, Guccione JM
• A distribution-moment model of deactivation in cardiac muscle.
  Journal of biomechanics 1998 Guccione JM, Motabarzadeh I, Zahalak GI
• Measurements of active myocardial tension under a wide range of physiological loading conditions.
  Journal of biomechanics 1997 Guccione JM, Le Prell GS, de Tombe PP, Hunter WC
• Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection.
  The American journal of physiology 1997 Guccione JM, O'Dell WG, McCulloch AD, Hunter WC
• A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates.
  Journal of biomechanical engineering 1996 Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD
• A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates.
  Journal of biomechanical engineering 1996 Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD
• Finite element stress analysis of left ventricular mechanics in the beating dog heart.
  Journal of biomechanics 1995 Guccione JM, Costa KD, McCulloch AD
• Mechanics of active contraction in cardiac muscle: Part I--Constitutive relations for fiber stress that describe deactivation.
  Journal of biomechanical engineering 1993 Guccione JM, McCulloch AD
• Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle.
  Journal of biomechanical engineering 1993 Guccione JM, Waldman LK, McCulloch AD
• Large-scale finite element analysis of the beating heart.
  Critical reviews in biomedical engineering 1992 McCulloch A, Waldman L, Rogers J, Guccione J
• Passive material properties of intact ventricular myocardium determined from a cylindrical model.
  Journal of biomechanical engineering 1991 Guccione JM, McCulloch AD, Waldman LK