Julio Rojas, MD, PhD
Associate Professor
Neurology
School of Medicine

Education & Training

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• Fellowship Behavioral Neurology University of California, San Francisco 2017
• Neurology Department of Neurology & Neurotherapeutics Univesity of Texas Southwestern Medical Center 2014
• PhD Institute for Neuroscience University of Texas at Austin 2010
• MD Escuela de Medicina Tecnologico de Monterrey, ITESM 2003

Interests

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• Clinical trials
• fluid biomarkers
• non-pharmacological management
• Alzheimer's disease
• PSP
• FTD

Websites

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• Posts on X JulioCRojas10 (X.com)
• Clinical Trials (boxerlab.ucsf.edu)
• Memory Clinic (ucsfhealth.org)

Grants and Projects

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• Proteomics for fluid biomarker discovery in frontotemporal dementia, NIH, 2019-2024

Publications (119)

Top publication keywords:
Disease ProgressionAmyloid beta-PeptidesNeuroprotective AgentsSupranuclear Palsy, ProgressiveNeurofilament ProteinsRotenoneFrontotemporal Lobar DegenerationBiomarkersGlial Fibrillary Acidic Proteintau ProteinsFrontotemporal DementiaMethylene BlueNeurodegenerative DiseasesTauopathiesAlzheimer Disease

• Reduced diffusion associated with amyloid-related imaging abnormalities in three patients treated with donanemab.
  Neurocase 2026 Schwartz NU, Dietz CD, Lin Z, Tammewar G, Bui N, La Joie R, Wang Y, Sreekrishnan A, Suhami D, VandeVrede L, Ljubenkov PA, Rojas JC
• Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia.
  JAMA neurology 2026 Olzinski M, Downer J, Cobigo Y, Rajbanshi B, Li J, Loureiro J, Worringer KA, Heuer H, Ljubenkov P, Vandevrede L, Staffaroni A, Lario-Lago A, Leichter D, Wolf A, Wise A, Sanderson-Cimino M, Barragan E,…
• Mixed primary progressive aphasia and alcohol use disorder: a case of detailed clinical phenotyping outperforming molecular imaging.
  Neurocase 2026 Okoye O, Aguzzoli CS, Battista P, Ramos C, Meenan K, Abu Raya M, Ratnasiri B, Rojas JC, de Leon J, Miller B, Gorno-Tempini ML, La Joie R, Spina S
• Association of [18F]Flortaucipir-PET and Plasma p-Tau217 With Tau Neuropathology in Alzheimer Disease and Other Neurodegenerative Disorders.
  Neurology 2026 Vrillon A, Spina S, Mejía-Pérez J, Lamore T, Yballa C, Soleimani-Meigooni DN, Blazhenets G, Boxer AL, Rojas JC, Lario Lago A, Jagust WJ, Miller BL, Rosen HJ, Seeley WW, Grinberg LT, Rabinovici GD, …
• Potential role of MRI to optimize clinical trial design for progressive supranuclear palsy and corticobasal degeneration.
  The journal of prevention of Alzheimer's disease 2026 García-Castro J, VandeVrede L, Donohue MC, Vaqué-Alcázar L, Rubio-Guerra S, Selma-González J, Heuer HW, Morcillo-Nieto AO, Franquesa M, Dols-Icardo O, Bejanin A, Belbin O, Fortea J, Alcolea D, Carmona…

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• Plasma placental growth factor as a susceptibility biomarker for longitudinal cognitive change.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 VandeBunte AM, Paolillo EW, Hinman JD, Saloner R, Olzinski M, Dutt S, Cadwallader CJ, Diaz VE, Hallgarth S, Rojas JC, Maillard P, Casaletto KB, Kramer JH
• Blood-based Alzheimer's disease biomarkers in a behavioral neurology clinic: Real-world implementation, clinical utility, and diagnostic performance.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Prufer Q C Araujo I, Ellingson T, Schwartz NU, Dietz CD, Tammewar G, Deniz K, Eslami-Amirabadi M, Breithaupt AG, Rosenberg M, Bui NM, Gonzalez Y, La Joie R, Ljubenkov PA, Possin KL, Rojas JC, …
• Development and validation of the TabCAT-EXAMINER: A tablet-based executive functioning battery for research and clinical trials.
  Journal of the International Neuropsychological Society : JINS 2025 Sanderson-Cimino M, Possin KL, Mungas DM, Paolillo EW, Asken BM, Tsoy E, Jarrott S, Cobigo Y, Saloner R, Casaletto KB, Considine C, Fields JA, Molden J, Rascovsky K, Weintraub S, Wong B, Heuer HW, …
• Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Coulborn S, Roy ARK, Sokolowski A, Cryns NG, Lago AL, Cobigo Y, Rojas JC, Spina S, Grinberg LT, Rankin KP, Boxer AL, Krystal AD, Mackin RS, Kramer JH, Miller BL, Seeley WW, Rosen HJ, VandeVrede L, …
• The association of human apolipoprotein ε4 with dementia, cognition, imaging, and plasma biomarkers of neurodegeneration in a sample of older adults in the Democratic Republic of the Congo.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Ikanga J, Patel SS, Schwinne M, Obenauf CA, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Rojas JC, Chan B, Lago AL, Boxer AL, Jeromin A, Omba E, Gross AL, …
• Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers.
  Annals of clinical and translational neurology 2025 Flagan TM, Chu SA, Häkkinen S, Zhang L, McFall D, Rohrer JD, Brown JA, Lee AJ, Fernhoff K, Pasquini L, Rankin KP, Mandelli ML, Gorno-Tempini ML, Yokoyama JS, Sturm VE, Appleby B, Dickerson BC, Domoto-…
• Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Lee SY, Diaz VE, Emanuel OM, Matusz EF, Webb J, Chan B, Lago AL, Wang WE, DeSimone J, Rojas JC, VandeVrede L, La Joie R, Levy SA, Arias F, Wiens BA, Velez-Uribe I, Barker WW, Paolillo EW, Sanderson-…
• Neurodegenerative plasma biomarkers for prediction of hippocampal atrophy in older adults with suspected Alzheimer's disease in Kinshasa, Democratic Republic of Congo.
  Journal of Alzheimer's disease : JAD 2025 Ikanga J, Jean K, Medina P, Patel SS, Schwinne M, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Stringer A, Rojas JC, Chan B, Lago AL, Boxer AL, Jeromin A, …
• Association between neuropsychiatric symptoms and neurodegeneration-related plasma biomarkers in older adults with and without clinical dementia in the Democratic Republic of the Congo.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Ikanga J, Patel SS, Schwinne M, Obenauf C, Gikelekele G, Epenge E, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Rojas JC, Yohe EO, Alonso A, Gross AL
• Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Nature aging 2025 Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, …
• BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults.
  Alzheimer's & dementia (New York, N. Y.) 2025 Cadwallader CJ, VandeBunte AM, Fischer DL, Chen C, Diaz VE, Lee SY, Chan B, Lario-Lago A, Rojas JC, Ramos EM, Rexach JE, Yokoyama JS, Kramer JH, Paolillo EW, Saloner R, Casaletto KB
• Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease.
  Neurology. Clinical practice 2025 Schwartz NU, Dietz CD, Prufer Araújo I, Villanueva-Meyer JE, Chiong W, Lane-Donovan C, Vandevrede L, Ljubenkov PA, Wang Y, Soleimani-Meigooni DN, La Joie R, Rojas JC
• Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Nature aging 2025 Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, …
• Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults.
  Alzheimer's research & therapy 2025 VandeBunte AM, Ortiz BL, Paolillo EW, Saloner R, Diaz V, Dutt S, Cadwallader CJ, Chen C, Lago AL, Rojas JC, Chan B, Sible I, Kramer JH, Casaletto KB
• Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Memel M, Staffaroni AM, Ilan-Gala I, Castro JG, Kornak J, Tartaglia CM, Saloner R, VandeBunte AM, Paolillo EW, Cadwallader CJ, Chen C, Gorno-Tempini ML, Mandelli M, Apostolova L, Graff-Radford N, …
• Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change During the Disease Course.
  The Journal of neuropsychiatry and clinical neurosciences 2025 Morrow CB, Onyike C, Pantelyat A, Smith GS, Leoutsakos J, Faria AV, Graff-Radford NR, Darby RR, Ghoshal N, Staffaroni AM, Rascovsky K, Miyagawa T, Balaji A, Tsapkini K, Lapid MI, Mendez MF, Litvan I, …
• Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.
  Psychiatry and clinical neurosciences 2025 Morrow CB, Kamath V, Dickerson BC, Eldaief M, Rezaii N, Wong B, McGinnis S, Darby R, Staffaroni AM, Lapid MI, Pascual B, Rojas JC, Masdeu JC, Tsapkini K, Huey ED, Fisher DW, Pantelyat A, Balaji A, Sah…
• Correction to: Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.
  Acta neuropathologica 2025 VandeVrede L, La Joie R, Horiki S, Mundada NS, Koestler M, Hwang JH, Ljubenkov PA, Rojas JC, Rabinovici GD, Boxer AL, Seeley WW
• Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo.
  Frontiers in aging neuroscience 2025 Ikanga J, Patel SS, Schwinne M, Obenauf C, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Rojas JC, Chan B, Lago AL, Kramer JH, Boxer AL, Jeromin A, Omba E, …
• Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers.
  JAMA neurology 2025 VandeVrede L, Cho H, Sanderson-Cimino M, Wekselman F, Cobigo Y, Gorno-Tempini ML, Heuer HW, Kramer JH, Lario Lago A, Leichter D, Ljubenkov P, Miller BL, Perry DC, Rabinovici GD, Rojas JC, Rosen HJ, …
• Clinical and neuropathological associations of plasma Aβ42/Aβ40, p-tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2025 Rajbanshi B, Prufer Q C Araujo I, VandeVrede L, Ljubenkov PA, Staffaroni AM, Heuer HW, Lario Lago A, Ramos EM, Petrucelli L, Gendron T, Dage JL, Seeley WW, Grinberg LT, Spina S, Bateman RJ, Rosen HJ, …
• Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
  Brain communications 2025 Casaletto KB, Saloner R, Kornak J, Staffaroni AM, Villeda S, Paolillo E, VandeBunte AM, Cadwallader CJ, Lario Lago A, Webb J, Chen C, Rascovsky K, Miyagawa T, Ramos EM, Masdeu JC, Pantelyat A, …
• Preliminary reference values for Alzheimer's disease plasma biomarkers in Congolese individuals with and without dementia.
  Frontiers in aging neuroscience 2024 Ikanga J, Jean K, Medina P, Patel SS, Schwinne M, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Stringer A, Rojas JC, Chan B, Lario Lago A, Kramer JH, Boxer AL, …
• Neuropsychiatric Symptoms Cluster and Fluctuate Over Time in Behavioral Variant Frontotemporal Dementia.
  medRxiv : the preprint server for health sciences 2024 Morrow CB, Kamath V, Dickerson BC, Eldaief M, Rezaii N, Wong B, McGinnis S, Darby R, Staffaroni AM, Lapid MI, Pascual B, Rojas JC, Masdeu JC, Tsapkini K, Huey ED, Fisher DW, Pantelyat A, Balaji A, Sah…
• Neurodegenerative Plasma Biomarkers for Prediction of Hippocampal Atrophy in Older Adults with Suspected Alzheimer's Disease in Kinshasa, Democratic Republic of Congo.
  medRxiv : the preprint server for health sciences 2024 Ikanga J, Jean K, Medina P, Patel SS, Schwinne M, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Stringer A, Rojas JC, Chan B, Lago AL, Kramer JH, Boxer AL, …
• Preliminary reference values for Alzheimer's disease plasma biomarkers in Congolese individuals with and without Alzheimer's disease.
  medRxiv : the preprint server for health sciences 2024 Ikanga J, Jean K, Medina P, Patel SS, Schwinne M, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Mananga L, Teunissen CE, Stringer A, Rojas JC, Chan B, Lago AL, Kramer JH, Boxer AL, …
• CSF Proteomics in Patients With Progressive Supranuclear Palsy.
  Neurology 2024 Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, …
• Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.
  JMIR aging 2024 Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, …
• Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study.
  Annals of neurology 2024 Soleimani-Meigooni DN, Smith R, Provost K, Lesman-Segev OH, Allen IE, Chen MK, Cho H, Edwards L, Janelidze S, La Joie R, Mundada N, Ossenkoppele R, Stomrud E, Strandberg O, Strom A, Boxer AL, Dage JL,…
• Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.
  Annals of neurology 2024 Garcia-Cordero I, Anastassiadis C, Khoja A, Morales-Rivero A, Thapa S, Vasilevskaya A, Davenport C, Sumra V, Couto B, Multani N, Taghdiri F, Anor C, Misquitta K, Vandevrede L, Heuer H, Tang-Wai D, …
• Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
  Research square 2024 Saloner R, Staffaroni A, Dammer E, Johnson ECB, Paolillo E, Wise A, Heuer H, Forsberg L, Lago AL, Webb J, Vogel J, Santillo A, Hansson O, Kramer J, Miller B, Li J, Loureiro J, Sivasankaran R, …
• Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L
• Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo.
  Frontiers in neurology 2024 Ikanga J, Patrick SD, Schwinne M, Patel SS, Epenge E, Gikelekele G, Tshengele N, Kavugho I, Mampunza S, Yarasheski KE, Teunissen CE, Stringer A, Levey A, Rojas JC, Chan B, Lario Lago A, Kramer JH, …
• Plasma SOMAmer proteomics of postoperative delirium.
  Brain and behavior 2024 Leung JM, Rojas JC, Sands LP, Chan B, Rajbanshi B, Du Z, Du P, Perioperative Medicine Research group
• Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Tsoy E, La Joie R, VandeVrede L, Rojas JC, Yballa C, Chan B, Lago AL, Rodriguez AM, Goode CA, Erlhoff SJ, Tee BL, Windon C, Lanata S, Kramer JH, Miller BL, Dilworth-Anderson P, Boxer AL, Rabinovici GD…
• [18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2023 Blazhenets G, Soleimani-Meigooni DN, Thomas W, Mundada N, Brendel M, Vento S, VandeVrede L, Heuer HW, Ljubenkov P, Rojas JC, Chen MK, Amuiri AN, Miller Z, Gorno-Tempini ML, Miller BL, Rosen HJ, Litvan…
• Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium.
  Anesthesiology 2023 Leung JM, Rojas JC, Tang C, Chan B, Lario-Lago A, Boxer AL, Do Q, Kramer JH, Du Z, Du P, Sands LP, Perioperative Medicine Research Group
• Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.
  Alzheimer's research & therapy 2023 Mundada NS, Rojas JC, Vandevrede L, Thijssen EH, Iaccarino L, Okoye OC, Shankar R, Soleimani-Meigooni DN, Lago AL, Miller BL, Teunissen CE, Heuer H, Rosen HJ, Dage JL, Jagust WJ, Rabinovici GD, Boxer …
• Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.
  Acta neuropathologica 2023 VandeVrede L, La Joie R, Horiki S, Mundada NS, Koestler M, Hwang JH, Ljubenkov PA, Rojas JC, Rabinovici GD, Boxer AL, Seeley WW
• Anti-Amyloid Immunotherapies for Alzheimer's Disease: A 2023 Clinical Update.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2023 Yadollahikhales G, Rojas JC
• Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome.
  Alzheimer's research & therapy 2023 Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL…
• A call to address structural barriers to Hispanic/Latino representation in clinical trials on Alzheimer's disease and related dementias: A micro-meso-macro perspective.
  Alzheimer's & dementia (New York, N. Y.) 2023 Aranda MP, Marquez DX, Gallagher-Thompson D, Pérez A, Rojas JC, Hill CV, Reyes Y, Dilworth-Anderson P, Portacolone E
• Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Taylor JC, Heuer HW, Clark AL, Wise AB, Manoochehri M, Forsberg L, Mester C, Rao M, Brushaber D, Kramer J, Welch AE, Kornak J, Kremers W, Appleby B, Dickerson BC, Domoto-Reilly K, Fields JA, Ghoshal N…
• Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome.
  JAMA neurology 2023 VandeVrede L, La Joie R, Thijssen EH, Asken BM, Vento SA, Tsuei T, Baker SL, Cobigo Y, Fonseca C, Heuer HW, Kramer JH, Ljubenkov PA, Rabinovici GD, Rojas JC, Rosen HJ, Staffaroni AM, Boeve BF, …
• Gamma neuromodulation improves episodic memory and its associated network in amnestic mild cognitive impairment: a pilot study.
  Neurobiology of aging 2023 Jones KT, Gallen CL, Ostrand AE, Rojas JC, Wais P, Rini J, Chan B, Lago AL, Boxer A, Zhao M, Gazzaley A, Zanto TP
• Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist.
  Neurology 2023 Alcolea D, Beeri MS, Rojas JC, Gardner RC, Lleó A
• Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Toller G, Cobigo Y, Callahan P, Appleby BS, Brushaber D, Domoto-Reilly K, Forsberg LK, Ghoshal N, Graff-Radford J, Graff-Radford NR, Grossman M, Heuer HW, Kornak J, Kremers W, Lapid MI, Leger G, …
• Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers.
  JAMA neurology 2023 Casaletto KB, Kornack J, Paolillo EW, Rojas JC, VandeBunte A, Staffaroni AS, Lee S, Heuer H, Forsberg L, Ramos EM, Miller BL, Kramer JH, Yaffe K, Petrucelli L, Boxer A, Boeve B, Gendron TF, Rosen H, …
• Temporal order of clinical and biomarker changes in familial frontotemporal dementia.
  Nature medicine 2022 Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, …
• Sensitivity of the Social Behavior Observer Checklist to Early Symptoms of Patients With Frontotemporal Dementia.
  Neurology 2022 Toller G, Cobigo Y, Ljubenkov PA, Appleby BS, Dickerson BC, Domoto-Reilly K, Fong JC, Forsberg LK, Gavrilova RH, Ghoshal N, Heuer HW, Knopman DS, Kornak J, Lapid MI, Litvan I, Lucente DE, Mackenzie IR…
• Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Berry K, Asken BM, Grab JD, Chan B, Lario Lago A, Wong R, Seetharaman S, LaHue SC, Possin KL, Rojas JC, Kramer JH, Boxer AL, Lai JC, VandeVrede L
• Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis.
  Journal of neurology, neurosurgery, and psychiatry 2022 Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, …
• Visual Impairment as a Modifiable Risk Factor in Dementia Prevention and Management.
  JAMA neurology 2022 Deal J, Rojas JC
• Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.
  Neurology 2022 Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici …
• Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.
  Cell reports. Medicine 2022 Gendron TF, Heckman MG, White LJ, Veire AM, Pedraza O, Burch AR, Bozoki AC, Dickerson BC, Domoto-Reilly K, Foroud T, Forsberg LK, Galasko DR, Ghoshal N, Graff-Radford NR, Grossman M, Heuer HW, Huey ED…
• Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.
  JAMA network open 2022 Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, …
• Sex Differences between Medical Students in the Assessment of the Fear of COVID-19.
  International journal of environmental research and public health 2022 Trapp MDC, Wiskur BJ, Suh JH, Brand MW, Kuhn KG, Rojas J
• Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial.
  JAMA network open 2021 Ljubenkov PA, Edwards L, Iaccarino L, La Joie R, Rojas JC, Koestler M, Harris B, Boeve BF, Borroni B, van Swieten JC, Grossman M, Pasquier F, Frisoni GB, Mummery CJ, Vandenberghe R, Le Ber I, …
• Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
  The Lancet. Neurology 2021 Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin…
• Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care.
  Frontiers in neurology 2021 Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R, Duquette A, Fernandez HH, Fleisher JE, Grossman M, Howell M, Kerwin DR, Leegwater-Kim J, …
• Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
  Journal of the International Neuropsychological Society : JINS 2021 Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB
• Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease.
  Annals of clinical and translational neurology 2021 Younes K, Rojas JC, Wolf A, Sheng-Yang GM, Paoletti M, Toller G, Caverzasi E, Luisa Mandelli M, Illán-Gala I, Kramer JH, Cobigo Y, Miller BL, Rosen HJ, Geschwind MD
• Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.
  Neurology 2021 Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, …
• Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
  Journal of Alzheimer's disease : JAD 2021 Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer …
• Multimodal MRI staging for tracking progression and clinical-imaging correlation in sporadic Creutzfeldt-Jakob disease.
  NeuroImage. Clinical 2020 Sacco S, Paoletti M, Staffaroni AM, Kang H, Rojas J, Marx G, Goh SY, Luisa Mandelli M, Allen IE, Kramer JH, Bastianello S, Henry RG, Rosen HJ, Caverzasi E, Geschwind MD
• Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease.
  Neurology 2020 Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, …
• Four-Repeat Tauopathies: Current Management and Future Treatments.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 VandeVrede L, Ljubenkov PA, Rojas JC, Welch AE, Boxer AL
• Open-Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy.
  Movement disorders clinical practice 2020 VandeVrede L, Dale ML, Fields S, Frank M, Hare E, Heuer HW, Keith K, Koestler M, Ljubenkov PA, McDermott D, Ohanesian N, Richards J, Rojas JC, Thijssen EH, Walsh C, Wang P, Wolf A, Quinn JF, Tsai R, …
• Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.
  Nature medicine 2020 Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H,…
• Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial.
  JAMA neurology 2020 Tsai RM, Miller Z, Koestler M, Rojas JC, Ljubenkov PA, Rosen HJ, Rabinovici GD, Fagan AM, Cobigo Y, Brown JA, Jung JI, Hare E, Geldmacher DS, Natelson-Love M, McKinley EC, Luong PN, Chuu EL, Powers R,…
• Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
  Molecular neurodegeneration 2020 Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L
• Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2020 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
  Journal of Alzheimer's disease : JAD 2020 Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer …
• Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.
  Science translational medicine 2020 La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, …
• 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2019 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency.
  Frontiers in neurology 2019 Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL
• Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.
  JAMA neurology 2019 Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE, and the NFL Group, Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, …
• Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease.
  JAMA neurology 2019 Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD
• Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia.
  Journal of neurology, neurosurgery, and psychiatry 2019 Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija …
• Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
  Annals of clinical and translational neurology 2018 Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, …
• A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence?
  Cytokine 2018 Casaletto KB, Elahi FM, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher BM, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH
• Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers.
  Annals of clinical and translational neurology 2018 Meeter LHH, Gendron TF, Sias AC, Jiskoot LC, Russo SP, Donker Kaat L, Papma JM, Panman JL, van der Ende EL, Dopper EG, Franzen S, Graff C, Boxer AL, Rosen HJ, Sanchez-Valle R, Galimberti D, Pijnenburg…
• Multiproteinopathy, neurodegeneration and old age: a case study.
  Neurocase 2018 Rojas JC, Stephens ML, Rabinovici GD, Kramer JH, Miller BL, Seeley WW
• CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP.
  Neurology 2017 Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL, AL-108-231 Investigators
• ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
  Nature 2017 Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, …
• Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy.
  Journal of Alzheimer's disease : JAD 2017 Fong JC, Rojas JC, Bang J, Legati A, Rankin KP, Forner S, Miller ZA, Karydas AM, Coppola G, Grouse CK, Ralph J, Miller BL, Geschwind MD
• Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid.
  Journal of Parkinson's disease 2016 Boman A, Svensson S, Boxer A, Rojas JC, Seeley WW, Karydas A, Miller B, Kågedal K, Svenningsson P
• Plasma neurofilament light chain predicts progression in progressive supranuclear palsy.
  Annals of clinical and translational neurology 2016 Rojas JC, Karydas A, Bang J, Tsai RM, Blennow K, Liman V, Kramer JH, Rosen H, Miller BL, Zetterberg H, Boxer AL
• Neurodegenerative disease in 2015: Targeting tauopathies for therapeutic translation.
  Nature reviews. Neurology 2016 Rojas JC, Boxer AL
• Factors contributing to delay in diagnosis of Guillain-Barré syndrome and impact on clinical outcome.
  Muscle & nerve 2015 Dubey D, Kapotic M, Freeman M, Sawhney A, Rojas JC, Warnack W, Vernino S
• Neuritis ossificans. Response.
  Journal of neurosurgery 2014 Kemper CM, Rojas JC, Bauserman S
• Mitochondrial respiration as a target for neuroprotection and cognitive enhancement.
  Biochemical pharmacology 2013 Gonzalez-Lima F, Barksdale BR, Rojas JC
• Clinical Reasoning: a woman with recurrent aphasia and visual field defects.
  Neurology 2013 Nourbakhsh B, Rojas JC, Banerjee C, Novakovic RL, Warnack W
• Neurological and psychological applications of transcranial lasers and LEDs.
  Biochemical pharmacology 2013 Rojas JC, Gonzalez-Lima F
• Pearls and oy-sters: acute ischemic stroke caused by atypical thrombotic thrombocytopenic purpura.
  Neurology 2013 Rojas JC, Banerjee C, Siddiqui F, Nourbakhsh B, Powell CM
• Low-level light therapy improves cortical metabolic capacity and memory retention.
  Journal of Alzheimer's disease : JAD 2012 Rojas JC, Bruchey AK, Gonzalez-Lima F
• Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.
  Progress in neurobiology 2011 Rojas JC, Bruchey AK, Gonzalez-Lima F
• Low-level light therapy of the eye and brain.
  Eye and brain 2011 Rojas JC, Gonzalez-Lima F
• Beneficial network effects of methylene blue in an amnestic model.
  NeuroImage 2010 Riha PD, Rojas JC, Gonzalez-Lima F
• [Genetic thrombophilia and markers of endothelial activation in patients with preeclampsia].
  Ginecologia y obstetricia de Mexico 2010 Rojas JC, Luna M, Rangel-Nava H, Baños D, Collados MT
• Neuritis ossificans of a cranial nerve.
  Journal of neurosurgery 2010 Kemper CM, Rojas JC, Bauserman S
• In vivo low-level light therapy increases cytochrome oxidase in skeletal muscle.
  Photochemistry and photobiology 2010 Hayworth CR, Rojas JC, Padilla E, Holmes GM, Sheridan EC, Gonzalez-Lima F
• Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies.
  Eye and brain 2010 Rojas JC, Gonzalez-Lima F
• Striatal neuroprotection with methylene blue.
  Neuroscience 2009 Rojas JC, Simola N, Kermath BA, Kane JR, Schallert T, Gonzalez-Lima F
• Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy.
  Neurotoxicity research 2009 Rojas JC, John JM, Lee J, Gonzalez-Lima F
• Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Rojas JC, Lee J, John JM, Gonzalez-Lima F
• Prevalence of CYP2C9 variants in the Mexican population.
  Archives of medical research 2008 Aguilar B, Rojas JC, Collados MT
• Neuroprotective effects of memantine in a mouse model of retinal degeneration induced by rotenone.
  Brain research 2008 Rojas JC, Saavedra JA, Gonzalez-Lima F
• Animal model of posterior cingulate cortex hypometabolism implicated in amnestic MCI and AD.
  Neurobiology of learning and memory 2008 Riha PD, Rojas JC, Colorado RA, Gonzalez-Lima F
• Transgenic mice expressing cyan fluorescent protein as a reporter strain to detect the effects of rotenone toxicity on retinal ganglion cells.
  Journal of toxicology and environmental health. Part A 2008 Hayworth CR, Rojas JC, Gonzalez-Lima F
• Methylene blue prevents neurodegeneration caused by rotenone in the retina.
  Neurotoxicity research 2006 Zhang X, Rojas JC, Gonzalez-Lima F
• Pharmacogenetics of oral anticoagulants.
  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2005 Rojas JC, Aguilar B, Rodríguez-Maldonado E, Collados MT
• Metabolism of homocysteine and its relationship with cardiovascular disease.
  Journal of thrombosis and thrombolysis 2004 Aguilar B, Rojas JC, Collados MT
• Induction of apoptosis and effect on CD20+ using rituximab on autologous peripheral blood stem cell harvests from patients with B cell lymphomas.
  Stem cells and development 2004 Borbolla-Escoboza JR, Leon MI, Collados MT, Baez E, Baltasar S, Hernández R, Rojas JC