Julie Sneddon, PhD
Associate Professor
Cell and Tissue Biology
School of Dentistry

Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. The hope is that a deeper understanding of the identity and biology of non-epithelial “niche” cell types within the pancreas will enable a more directed and efficient attempt at replacing lost cell and organ function via regenerative medicine.

• Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective.
  Cell metabolism 2021 Migliorini A, Nostro MC, Sneddon JB
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
  Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV
• A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.
  Cell stem cell 2020 Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD
• A single-cell atlas and lineage analysis of the adult Drosophila ovary.
  Nature communications 2020 Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG
• Beta Living through Alpha Cells.
  Cell stem cell 2019 Patzek S, Sneddon JB
• Pancreatic development: one cell at a (pseudo)time.
  The EMBO journal 2019 Liu Z, Sneddon JB
• Lineage dynamics of murine pancreatic development at single-cell resolution.
  Nature communications 2018 Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB
• Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
  The Journal of clinical investigation 2018 Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T
• Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.
  Cell stem cell 2018 Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M
• Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
  Development (Cambridge, England) 2017 Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM
• Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.
  Cell 2017 Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD
• Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.
  Stem cells (Dayton, Ohio) 2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA
• Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
  Nature 2012 Sneddon JB, Borowiak M, Melton DA
• The contribution of niche-derived factors to the regulation of cancer cells.
  Methods in molecular biology (Clifton, N.J.) 2009 Sneddon JB
• Location, location, location: the cancer stem cell niche.
  Cell stem cell 2007 Sneddon JB, Werb Z
• The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Welm AL, Sneddon JB, Taylor C, Nuyten DS, van de Vijver MJ, Hasegawa BH, Bishop JM
• When should one subtract background fluorescence in 2-color microarrays?
  Biostatistics (Oxford, England) 2006 Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G
• Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO
• Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
  Breast cancer research : BCR 2006 Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ
• Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, Dai H, He YD, van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ
• Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
  PLoS biology 2004 Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO