Julie Sneddon, PhD
Associate Professor
Cell and Tissue Biology
School of Dentistry

The primary focus of Dr. Sneddon’s research is pancreatic development, disease, and regeneration. In parallel with work to decipher the developmental trajectories taken by endocrine cells in the developing pancreas, her group has retained a sharp focus on the generation of functional, mature replacement beta cells and their efficient transplantation to cure diabetes.

Awards

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• New Frontier Research Award, Program for Breakthrough Biomedical Research, 2021
• Young Investigator Travel Award, American Pancreatic Association, 2019
• Helmholtz Young Investigator in Diabetes Award, Zentrum Munchen, 2019
• New Frontier Research Award, Program for Breakthrough Biomedical Research, 2017

Education & Training

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• A.B. Biochemical Sciences Harvard University
• Postdoctoral Fellowship Diabetes & Stem Cells Harvard University
• Ph.D. Genomics & Biochemistry Stanford University

Websites

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• Posts on X @JulieBSneddon (X.com)
• Sneddon Lab Website (diabetes.ucsf.edu)

Publications (27)

Top publication keywords:
PancreasCell LineageGene Expression Regulation, DevelopmentalGlucagon-Secreting CellsSingle-Cell AnalysisIslets of Langerhans TransplantationIslets of LangerhansEndodermInsulin-Secreting CellsInsulinsDiabetes MellitusChromatinInsulinMesodermRegenerative Medicine

• A multimodal cross-species comparison of pancreas development.
  Nature communications 2025 Yang K, Spitzer H, Sterr M, Hrovatin K, de la O S, Zhang X, Setyono ESA, Ud-Dean M, Walzthoeni T, Flisikowski K, Flisikowska T, Schnieke A, Scheibner K, Wells JM, Sneddon JB, Kessler B, Wolf E, Kemter…
• Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.
  Bioengineering & translational medicine 2023 Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA
• Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs.
  Molecular metabolism 2023 de la O S, Yao X, Chang S, Liu Z, Sneddon JB
• Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass.
  Developmental biology 2023 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O
• Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.
  iScience 2023 Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB

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• Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
  Hepatology (Baltimore, Md.) 2021 Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN
• Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective.
  Cell metabolism 2021 Migliorini A, Nostro MC, Sneddon JB
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
  Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV
• A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.
  Cell stem cell 2020 Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD
• A single-cell atlas and lineage analysis of the adult Drosophila ovary.
  Nature communications 2020 Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG
• Beta Living through Alpha Cells.
  Cell stem cell 2019 Patzek S, Sneddon JB
• Pancreatic development: one cell at a (pseudo)time.
  The EMBO journal 2019 Liu Z, Sneddon JB
• Lineage dynamics of murine pancreatic development at single-cell resolution.
  Nature communications 2018 Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB
• Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
  The Journal of clinical investigation 2018 Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T
• Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.
  Cell stem cell 2018 Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M
• Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
  Development (Cambridge, England) 2017 Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM
• Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.
  Cell 2017 Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD
• Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.
  Stem cells (Dayton, Ohio) 2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA
• Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
  Nature 2012 Sneddon JB, Borowiak M, Melton DA
• The contribution of niche-derived factors to the regulation of cancer cells.
  Methods in molecular biology (Clifton, N.J.) 2009 Sneddon JB
• Location, location, location: the cancer stem cell niche.
  Cell stem cell 2007 Sneddon JB, Werb Z
• The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Welm AL, Sneddon JB, Taylor C, Nuyten DS, van de Vijver MJ, Hasegawa BH, Bishop JM
• When should one subtract background fluorescence in 2-color microarrays?
  Biostatistics (Oxford, England) 2006 Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G
• Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO
• Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
  Breast cancer research : BCR 2006 Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ
• Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, Dai H, He YD, van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ
• Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
  PLoS biology 2004 Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO