Julie Saba, MD, PhD
Professor
Pediatrics
School of Medicine

(she/her/hers)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome called sphingosine phosphate lyase insufficiency syndrome (SPLIS), which is characterized by defects of kidney, adrenal gland, neurological system, skin and immune system. We are now developing several therapeutic approaches to the treatment of SPLIS including gene therapy and cofactor supplementation.

• Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis.
  The Journal of pathology 2024 Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD
• Prevalence estimate of sphingosine phosphate lyase insufficiency syndrome in worldwide and select populations.
  Genetics in Medicine Open 2024 Joni C. Sedillo, Chansonette Badduke, Steven J. Schrodi, Vinod Scaria, Onur Emre Onat, Majid Alfadhel, Carole Ober, William Wentworth-Sheilds, Robert D. Steiner, Julie D. Saba
• AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome.
  International journal of molecular sciences 2023 Khan R, Oskouian B, Lee JY, Hodgin JB, Yang Y, Tassew G, Saba JD
• 148 Exploring dual targeting of host and microbial sphingosine-1-phosphate lyase as antimicrobial strategy in cystic fibrosis.
  Journal of Cystic Fibrosis 2023 C. Costantini, G. Pampalone, M. Pariano, T. Zelante, L. Macchioni, R. Galarini, E. Camaioni, F. Paoletti, F. Catalano, M. Davidescu, C. Stincardini, M. Bellet, J. Saba, G. Giardina, S. Giovagnoli, B. …
• Sphingosine phosphate lyase insufficiency syndrome: a systematic review.
  World journal of pediatrics : WJP 2022 Pournasiri Z, Madani A, Nazarpack F, Sayer JA, Chavoshzadeh Z, Nili F, Tran P, Saba JD, Jamee M
• Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency.
  Frontiers in cellular neuroscience 2022 Atreya KB, Saba JD
• Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
  International journal of molecular sciences 2022 De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD
• Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus.
  DNA and cell biology 2022 Wolf JJ, Saba JD, Hahm B
• 521: Dual targeting of host and fungal sphingosine-1-phosphate lyase as antifungal strategy in cystic fibrosis.
  Journal of Cystic Fibrosis 2021 C. Costantini, M. Pariano, G. Pampalone, T. Zelante, L. Macchioni, R. Galarini, E. Costanzi, M. Bellet, S. Giovagnoli, J. Saba, B. Cellini, L. Romani
• Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
  International journal of molecular sciences 2021 Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D
• Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome.
  Cell biochemistry and biophysics 2021 Saba JD, Keller N, Wang JY, Tang F, Slavin A, Shen Y
• Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome.
  JCI insight 2021 Zhao P, Tassew GB, Lee JY, Oskouian B, Muñoz DP, Hodgin JB, Watson GL, Tang F, Wang JY, Luo J, Yang Y, King S, Krauss RM, Keller N, Saba JD
• Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
  Investigational new drugs 2019 Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD
• Unraveling the β-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor.
  Neurochemistry international 2019 Durand D, Turati J, Rudi MJ, Ramírez D, Saba J, Caruso C, Carniglia L, von Bernhardi R, Lasaga M
• Sphingosine 1-phosphate lyase promotes the type I interferon-mediated innate immune response to influenza but is subjected to degradation by influenza A virus NS1.
  The Journal of Immunology 2019 Jennifer J Wolf, Chuan Xia, Madhuvanthi Vijayan, Yuleum Song, Caleb J Studstill, Hanh Ngo, Marc C Johnson, Julie D Saba, Stephen Alexander, Bumsuk Hahm
• Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism.
  Advances in biological regulation 2018 Choi YJ, Saba JD
• Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.
  Journal of neurochemistry 2018 Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C
• Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study.
  Inflammatory bowel diseases 2018 Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba JD
• Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
  Investigational new drugs 2018 Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD
• S100 Calcium Binding Protein A6.
  2018 Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Igor Prudovsky, Thallapuranam Krishnaswamy Suresh Kumar, Rosario Donato, Rosario Donato, Guglielmo Sorci, Ileana Giambanco, Isadora Carolina …
• Sphingosine-1-Phosphate.
  Encyclopedia of Signaling Molecules 2018 Ashok Kumar, Julie D. Saba
• The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress.
  Journal of immunological sciences 2017 Saba JD
• S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.
  Mediators of inflammation 2017 Kumar A, Zamora-Pineda J, Degagné E, Saba JD
• Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.
  The Journal of biological chemistry 2017 Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E
• An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2017 Suh JH, Makarova AM, Gomez JM, Paul LA, Saba JD
• SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
  Autophagy 2017 Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G
• Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia.
  Clinical case reports 2017 Saba J, Logan AC
• Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
  The Journal of clinical investigation 2017 Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G…
• Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases.
  Mediators of inflammation 2017 Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M
• Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.
  Scientific reports 2016 Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G
• Sphingosine-1-Phosphate.
  Encyclopedia of Signaling Molecules 2016 Ashok Kumar, Julie D. Saba
• Regulation of Immune Cell Migration by Sphingosine-1-Phosphate.
  Cellular and molecular biology (OMICS) 2015 Kumar A, Saba JD
• Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire.
  Translational cancer research 2015 Suh JH, Saba JD
• A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity.
  Chemistry and physics of lipids 2015 Suh JH, Eltanawy A, Rangan A, Saba JD
• A B cell-dependent mechanism restrains T cell transendothelial migration.
  Nature medicine 2015 Saba JD
• Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
  The Journal of clinical investigation 2014 Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD
• Tracking hippo in the cancer jungle.
  Chemistry & biology 2014 Suh JH, Saba JD
• S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer.
  Clinical and experimental gastroenterology 2014 Degagné E, Saba JD
• Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD
• Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway.
  Biomolecules 2013 Smith GS, Kumar A, Saba JD
• A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.
  Molecular and cellular biology 2012 Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y
• Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development.
  Gene expression patterns : GEP 2012 Newbigging S, Zhang M, Saba JD
• Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.
  Journal of lipid research 2012 Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD
• S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase.
  Biochimica et biophysica acta 2012 Saba JD, de la Garza-Rodea AS
• The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.
  Biochemical and biophysical research communications 2012 Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS
• Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
  PloS one 2012 Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD
• Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer.
  Carcinogenesis 2012 Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD
• Corrigendum to “The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner” [Cell. Signal. 23(7) (2011) 1144-1152].
  Cellular Signalling 2012 Ashok Kumar, Hoe-Sup Byun, Robert Bittman, Julie D. Saba
• S100 Calcium-Binding Protein.
  2012 Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward,…
• Sphingosine-1-Phosphate.
  Encyclopedia of Signaling Molecules 2012 Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward,…
• Truth and consequences of sphingosine-1-phosphate lyase.
  Advances in biological regulation 2012 Aguilar A, Saba JD
• A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
  PloS one 2011 McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R
• Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.
  Anti-cancer agents in medicinal chemistry 2011 Loh KC, Baldwin D, Saba JD
• A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity.
  PloS one 2011 Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S
• S1P lyase regulates DNA damage responses in vitro and in vivo.
  The FASEB Journal 2011 Julie Deane Saba, Ashok Kumar, Babak Oskouian, Henrik Fyrst, Meng Zhang
• The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner.
  Cellular signalling 2011 Kumar A, Byun HS, Bittman R, Saba JD
• S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.
  American journal of physiology. Heart and circulatory physiology 2011 Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD
• S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.
  Cell death & disease 2011 Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD
• Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
  The Journal of biological chemistry 2010 Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL
• Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.
  American journal of respiratory cell and molecular biology 2010 Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V
• Erratum: An update on sphingosine-1-phosphate and other sphingolipid mediators.
  Nature Chemical Biology 2010 Henrik Fyrst, Julie D Saba
• An update on sphingosine-1-phosphate and other sphingolipid mediators.
  Nature chemical biology 2010 Fyrst H, Saba JD
• S1P metabolism in cancer and other pathological conditions.
  Biochimie 2010 Leong WI, Saba JD
• Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.
  Radiation research 2010 Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, …
• Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
  The Journal of biological chemistry 2010 Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL
• Cancer treatment strategies targeting sphingolipid metabolism.
  Advances in experimental medicine and biology 2010 Oskouian B, Saba JD
• Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis.
  Cancer research 2009 Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD
• Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
  Advances in enzyme regulation 2009 Serra M, Saba JD
• Normalization of diabetic wound healing.
  Surgery 2009 Francis-Goforth KN, Harken AH, Saba JD
• Lyase to live by: sphingosine phosphate lyase as a therapeutic target.
  Expert opinion on therapeutic targets 2009 Kumar A, Saba JD
• Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate.
  Biochemical and biophysical research communications 2009 Bandhuvula P, Li Z, Bittman R, Saba JD
• Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.
  Circulation research 2008 Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D
• Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight.
  Biochimica et biophysica acta 2008 Fyrst H, Saba JD
• Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes.
  Journal of lipid research 2007 Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD
• A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity.
  Journal of lipid research 2007 Bandhuvula P, Fyrst H, Saba JD
• Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.
  Developmental biology 2007 Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL
• Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.
  Trends in molecular medicine 2007 Bandhuvula P, Saba JD
• Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again.
  Cell cycle (Georgetown, Tex.) 2007 Oskouian B, Saba J
• Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.
  The EMBO journal 2007 Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM
• Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD
• Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
  Molecular and cellular biology 2006 Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T
• S1P Lyase Expression Hypersensitizes Cells to DNA Damage and Other Stress Conditions via p53 and p38 Apoptosis Pathways.
  The FASEB Journal 2006 Julie Deane Saba, Babak Oskouian, Prathap Sooriyakumaran
• Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
  Arthritis and rheumatism 2006 Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY
• Sphingosine-1-Phosphate Lyase.
  Sphingolipid Biology 2006 Julie D. Saba
• Directed Donor Cord Blood Transplantation for Hematological Disorders.
  Blood 2005 Mark C. Walters, Lynn Quirolo, Sandie Edwards, Joanna Lee, Shanda Robertson, Julie D. Saba, Elizabeth Trachtenberg, Keith C. Quirolo, Bert Lubin
• The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
  The Journal of biological chemistry 2005 Bandhuvula P, Tam YY, Oskouian B, Saba JD
• Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
  The Journal of biological chemistry 2005 Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD
• Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program.
  Annals of the New York Academy of Sciences 2005 Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B
• gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN
• Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate.
  Seminars in cell & developmental biology 2004 Oskouian B, Saba JD
• Lysophospholipids in development: Miles apart and edging in.
  Journal of cellular biochemistry 2004 Saba JD
• Point-counterpoint of sphingosine 1-phosphate metabolism.
  Circulation research 2004 Saba JD, Hla T
• Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.
  The Journal of biological chemistry 2004 Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL
• Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
  The Journal of biological chemistry 2003 Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD
• Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster.
  Journal of lipid research 2003 Fyrst H, Herr DR, Harris GL, Saba JD
• Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.
  Development (Cambridge, England) 2003 Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD
• Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.
  The Journal of biological chemistry 2003 Mendel J, Heinecke K, Fyrst H, Saba JD
• Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease.
  Blood 2002 Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH
• Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.
  The Journal of biological chemistry 2001 Birchwood CJ, Saba JD, Dickson RC, Cunningham KW
• Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae.
  Genetics 2000 Kim S, Fyrst H, Saba J
• Molecular cloning - and functional characterization of the human sphingosine-1 -phosphate lyase gene.
  Journal of Pediatric Hematology/Oncology 2000 J. Zhou, U. Reiss, J. D. Saba
• A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples.
  Analytical biochemistry 2000 Caligan TB, Peters K, Ou J, Wang E, Saba J, Merrill AH
• The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.
  Biochemical Journal 1999 MAO Cungui, Julie D. SABA, Lina M. OBEID
• The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.
  The Biochemical journal 1999 Mao C, Saba JD, Obeid LM
• The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase.
  Biochemistry 1999 Fyrst H, Oskouian B, Kuypers FA, Saba JD
• The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae.
  Molecular cell biology research communications : MCBRC 1999 Gottlieb D, Heideman W, Saba JD
• YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae.
  Molecular & general genetics : MGG 1999 Oskouian B, Saba JD
• Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants.
  The Biochemical journal 1998 Lanterman MM, Saba JD
• Cost-effectiveness of antiviral drug therapy to reduce mother-to-child HIV transmission in sub-Saharan Africa.
  AIDS (London, England) 1998 Marseille E, Kahn JG, Saba J
• Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.
  Biochemical and biophysical research communications 1998 Zhou J, Saba JD
• The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.
  The Journal of biological chemistry 1997 Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA
• Ceramide: an intracellular mediator of apoptosis and growth suppression.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996 Saba JD, Obeid LM, Hannun YA
• Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.
  The Journal of biological chemistry 1993 Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA
• A seven-month-old infant with fever and neutrophilic leukocytosis.
  The Journal of pediatrics 1992 Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J
• Large-cell lymphoma presenting with a distinctive inflammatory dermatosis.
  Journal of the American Academy of Dermatology 1991 Tope WD, Fishbein JD, White PF, Prose NS
• Pelger-Huet anomaly in an infant with multiple congenital anomalies.
  American journal of hematology 1991 Fishbein JD, Falletta JM
• A piece of my mind. The poetry of medicine.
  JAMA 1990 Fishbein J
• Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion.
  The Pediatric infectious disease journal 1990 Fishbein JD, Friedman HS, Bennett BB, Falletta JM
• Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells.
  Biochemical medicine 1980 Fishbein WN, Davis JI, Winkert JW, Fishbein JD
• Journal of Immunological Sciences
  The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress Saba JD
• Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study
  Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study Suh JH Degagné E Gleghorn EE Setty M Rodriguez A Park KT Verstraete SG Heyman MB Patel AS Irek M Gildengorin GL Hubbard NE Borowsky AD Saba JD