Julia Carnevale, MD
Assistant Professor
Medicine
School of Medicine

Dr. Carnevale is a physician-scientist who treats patients with gastrointestinal cancers, and also performs research into finding novel therapies for these diseases.

Education & Training

Show all (4) Hide

• Oncology - ABIM Research Pathway UCSF 06/2017
• Internal Medicine Residency UCSF 06/2013
• M.D. Cancer Biology Harvard Medical School 05/2011
• B.A. Human Biology Stanford University 05/2005

Grants and Projects

Show all (2) Hide

• Using CRISPR engineering to develop more potent T cell therapies that are resistant to suppression in the tumor microenvironment, Burroughs Wellcome Fund, 2020-2025
• Targeting SOCS1 and RASA2 to Engineer More Potent Adoptive T Cell Therapies for Cancer Treatment., NIH, 2020-2025

Publications (38)

Top publication keywords:
T-LymphocytesMethotrexateBRCA2 ProteinPancreatic NeoplasmsLymphoma, Non-HodgkinSuburban PopulationCamptothecinBRCA1 ProteinRituximabChemoradiotherapyras GTPase-Activating ProteinsAntigens, NeoplasmCarcinoma, Pancreatic DuctalSucroseGerm-Line Mutation

• Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence.
  Cancer cell 2022 Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT
• Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.
  Molecular & cellular proteomics : MCP 2022 Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA
• Durable response after immune checkpoint inhibitor-related diabetes in mismatch repair-deficient pancreatic cancer.
  Immunotherapy 2021 Tsang ES, Walker EJ, Carnevale J, Fisher GA, Ko AH
• Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
  Cell 2018 Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A
• Reprogramming human T cell function and specificity with non-viral genome targeting.
  Nature 2018 Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta…
• SYK regulates mTOR signaling in AML.
  Leukemia 2013 Carnevale J, Ross L, Puissant A, Banerji V, Stone RM, DeAngelo DJ, Ross KN, Stegmaier K

Show all (32 more) Hide

• CLDN18.2 chimeric antigen receptor T cell therapy for patients with advanced gastric and pancreatic adenocarcinoma: Results of ELIMYN18.2 phase 1b clinical trial.
  Journal of Clinical Oncology 2024 Gregory P. Botta, Ronan Joseph Kelly, Zhaohui Jin, Hong Ma, Geoffrey Yuyat Ku, Dan Zhao, Rutika Mehta, Julia C. Carnevale, Gloria Sierra, Jie JIA, Raffaele Baffa, Zhonghai Li, Dae Won Kim, Harry H. …
• Ablation of Cullin-5 in Primary Human T Cells Improves Tumor Killing and Persistence in BCMA-Targeting CAR-T Cells in a Multiple Myeloma Model.
  Blood 2023 Stefanie Bachl, Alexis Talbot, Carter Ching, Nupura Kale, Zhongmei Li, Morgan Diolaiti, Amy Peixin Chen, Joseph Muldoon, Chang Liu, Thomas Martin, Justin Eyquem, Julia Carnevale
• Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.
  Cell 2023 Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, …
• Abstract No. 266 Phase I Prospective Trial of TAS-102 (Trifluridine and Tipiracil) and Radioembolization with 90Y Resin Microspheres for Chemo-Refractory Colorectal Liver Metastases.
  Journal of Vascular and Interventional Radiology 2023 N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, A. Venook, K. Van Loon
• Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.
  BMC cancer 2022 Fidelman N, Atreya CE, Griffith M, Milloy MA, Carnevale J, Cinar P, Venook AP, Van Loon K
• Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2.
  Cancer research 2022 O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A
• RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
  Nature 2022 Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, …
• Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC).
  Journal of Clinical Oncology 2022 Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Bridget P Keenan, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan …
• The Additional Diagnostic Benefit of Pancreatic Cancer Molecular Profiling After Germline Testing.
  Pancreas 2022 Walker EJ, Blanco AM, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH
• Implementation of an Embedded In-Clinic Genetic Testing Station to Optimize Germline Testing for Patients with Pancreatic Adenocarcinoma.
  The oncologist 2021 Walker EJ, Goldberg D, Gordon KM, Pedley C, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH, Blanco AM, Dhawan M
• 512O Interim results from a phase II study of the ATR inhibitor ceralasertib in ARID1A-deficient and ARID1A-intact advanced solid tumor malignancies.
  Annals of Oncology 2021 R. Aggarwal, S. Umetsu, M. Dhawan, J. Grabowsky, J. Carnevale, M. Howell, L. Wilch, J. Chapman, E. Alvarez, S. Calabrese, S. Smith, N. Shah, E. Dean, P. Munster, E. Collisson
• Investigating tumor molecular profiling as a possible contributor to racial/ethnic disparities in pancreatic cancer.
  Journal of Clinical Oncology 2021 Evan Justin Walker, Sorbarikor Piawah, Ann Griffin, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko
• The marginal diagnostic benefit of pancreatic cancer molecular profiling after germline testing.
  Journal of Clinical Oncology 2021 Evan Justin Walker, Amie Blanco, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko
• Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC): Interim analysis.
  Journal of Clinical Oncology 2021 Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela …
• Combined Immunotherapy and Hypofractionated Radiotherapy for Metastatic Cancers.
  International Journal of Radiation Oncology • Biology • Physics 2020 S. Sinha, C. Greene, R.K. Kelley, P. Cinar, A.P. Venook, C. Atreya, J. Gordan, J. Carnevale, M. Anwar, M. Feng
• Abstract PR08: Discovery of immune regulators in primary human T cells using genome-wide CRISPR screens.
  Cancer Immunology Research 2020 Julia Carnevale, Eric Shifrut, Victoria Tobin, Theodore Roth, Jonathan Woo, Christina Bui, Jonathan Li, Morgan Diolaiti, Alan Ashworth, Alexander Marson
• 3:54 PM Abstract No. 243 Phase I Prospective Trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.
  Journal of Vascular and Interventional Radiology 2020 N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, P. Cinar, A. Venook, K. Van Loon
• Phase I prospective trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.
  Journal of Clinical Oncology 2020 Nicholas Fidelman, Chloe Evelyn Atreya, Madeline J Griffith, Marion Alexandra Milloy, Julia C. Carnevale, Pelin Cinar, Alan P. Venook, Katherine Van Loon
• Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
  The Journal of Immunology 2019 Eric Shifrut, Julia Carnevale, Alan Ashworth, Alexander Marson
• Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma.
  Familial cancer 2019 Walker EJ, Carnevale J, Pedley C, Blanco A, Chan S, Collisson EA, Tempero MA, Ko AH
• Referral patterns and attrition rate for germline testing in pancreatic cancer (PC) patients.
  Journal of Clinical Oncology 2018 Evan Justin Walker, Julia C. Carnevale, Christina Pedley, Amie Blanco, Salina Chan, Eric Andrew Collisson, Andrew H. Ko
• Current and Emerging Therapies in Pancreatic Cancer. Editors: Tanios Bekaii-Saab and Bassel Le-Rayes
  Targeting the Tumor Microenvironment. 2018 Carnevale J, Ko A.
• Targeting the Tumor Microenvironment.
  Current and Emerging Therapies in Pancreatic Cancer 2018 Julia Carnevale, Andrew H. Ko
• The Challenge of Primary Central Nervous System Lymphoma.
  Hematology/oncology clinics of North America 2016 Carnevale J, Rubenstein JL
• MM-398 (nanoliposomal irinotecan): emergence of a novel therapy for the treatment of advanced pancreatic cancer.
  Future oncology (London, England) 2015 Carnevale J, Ko AH
• Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Carnevale J, Ashworth A
• Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies.
  Familial cancer 2014 Renella R, Carnevale J, Schneider KA, Hornick JL, Rana HQ, Janeway KA
• Progress in central nervous system lymphomas.
  British journal of haematology 2014 Wang CC, Carnevale J, Rubenstein JL
• The crimson care collaborative: a student-faculty initiative to increase medical students' early exposure to primary care.
  Academic medicine : journal of the Association of American Medical Colleges 2012 Berman R, Powe C, Carnevale J, Chao A, Knudsen J, Nguyen A, Edgman-Levitan S
• Knowledge base and caretaker-child communication about HIV in peri-urban schoolchildren of Lusaka, Zambia.
  AIDS care 2011 Carnevale J, Gropper AB, Agnew-Blais J, Mimiaga MJ, Mhango A, Bail R, Ngoma M
• Schistosomiasis haematobium prevalence and risk factors in a school-age population of peri-urban Lusaka, Zambia.
  Journal of tropical pediatrics 2009 Agnew-Blais J, Carnevale J, Gropper A, Shilika E, Bail R, Ngoma M
• The development of sentence interpretation: effects of perceptual, attentional and semantic interference.
  Developmental science 2007 Leech R, Aydelott J, Symons G, Carnevale J, Dick F