Jue Lin, PhD
Professional Research
Biochemistry and Biophysics
School of Medicine

Education & Training

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• Postdoctoral Studies Molecular and Cell Biology University of California, San Francisco 07/2004
• Ph.D. Molecular and Cell Biology Cornell University 05/1999
• B.S. Biochemistry Fudan University 07/1992

Grants and Projects

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• Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study, NIH, 2015-2025
• Optimization and standardization of telomere length measurement by qPCR for population-based health research, NIH, 2019-2022

Publications (32)

Top publication keywords:
Parkinson DiseaseTelomereDyskinesia, Drug-InducedTelomere ShorteningTaiwanDystonic DisordersTongue DiseasesSpecimen HandlingPeptidyl-Dipeptidase AChoreaLithium CarbonateTelomere HomeostasisSubstantia NigraGTP CyclohydrolasePolymorphism, Genetic

• Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.
  JAMA neurology 2020 Foo JN, Chew EGY, Chung SJ, Peng R, Blauwendraat C, Nalls MA, Mok KY, Satake W, Toda T, Chao Y, Tan LCS, Tandiono M, Lian MM, Ng EY, Prakash KM, Au WL, Meah WY, Mok SQ, Annuar AA, Chan AYY, Chen L, …
• Evaluating Mild Cognitive Dysfunction in Patients with Parkinson's Disease in Clinical Practice in Taiwan.
  Scientific reports 2020 Yu RL, Lee WJ, Li JY, Chang YY, Chen CC, Lin JJ, Sung YF, Lin TK, Fuh JL
• Telomere length measurement by qPCR - Summary of critical factors and recommendations for assay design.
  Psychoneuroendocrinology 2018 Lin J, Smith DL, Esteves K, Drury S
• In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.
  Psychoneuroendocrinology 2018 Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E
• Variability of presynaptic nigrostriatal dopaminergic function and clinical heterogeneity in a dopa-responsive dystonia family with GCH-1 gene mutation.
  Journal of neurology 2017 Lin JJ, Lu CS, Tsai CH

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• Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
  Neurobiology of aging 2016 Wang L, Heckman MG, Aasly JO, Annesi G, Bozi M, Chung SJ, Clarke C, Crosiers D, Eckstein G, Garraux G, Hadjigeorgiou GM, Hattori N, Jeon B, Kim YJ, Kubo M, Lesage S, Lin JJ, Lynch T, Lichtner P, …
• PDD-5S: A useful screening tool for Parkinson's disease dementia.
  Parkinsonism & related disorders 2016 Lee WJ, Wu SL, Li JY, Chen CC, Lin JJ, Peng GS, Lin TK, Wang SJ, Chen RS, Yang YH, Tsai CH, Hsu JL, Liao YC, Chen SP, Fuh JL
• Large-scale assessment of polyglutamine repeat expansions in Parkinson disease.
  Neurology 2015 Wang L, Aasly JO, Annesi G, Bardien S, Bozi M, Brice A, Carr J, Chung SJ, Clarke C, Crosiers D, Deutschländer A, Eckstein G, Farrer MJ, Goldwurm S, Garraux G, Hadjigeorgiou GM, Hicks AA, Hattori N, …
• Prevalence and risk factors of cognitive impairment in Parkinson disease: a population-based case-control study in Taiwan.
  Medicine 2015 Huang YC, Wu ST, Lin JJ, Lin CC, Kao CH
• TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study.
  Parkinsonism & related disorders 2014 Ortega-Cubero S, Lorenzo-Betancor O, Lorenzo E, Agúndez JA, Jiménez-Jiménez FJ, Ross OA, Wurster I, Mielke C, Lin JJ, Coria F, Clarimon J, Ezquerra M, Brighina L, Annesi G, Alonso-Navarro H, García-…
• Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization.
  Neurology 2014 Guo YC, Lin JJ, Liao YC, Tsai PC, Lee YC, Soong BW
• Comparison of activities of daily living impairments in Parkinson's disease patients as defined by the Pill Questionnaire and assessments by neurologists.
  Journal of neurology, neurosurgery, and psychiatry 2013 Lee WJ, Chang YY, Lin JJ, Sung YF, Li JY, Wang SJ, Chen RS, Yang YH, Hu CJ, Tsai CH, Wang HC, Wu SL, Chang MH, Fuh JL
• Reversible oro-lingual dyskinesia related to lithium intoxication.
  Acta neurologica Taiwanica 2013 Chen WY, Chen AC, Tsai SJ, Lin JJ
• A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.
  Journal of medical genetics 2012 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou …
• Familial paroxysmal nonkinesigenic dyskinesia: clinical and genetic analysis of a Taiwanese family.
  Journal of the neurological sciences 2012 Yeh TH, Lin JJ, Lai SC, Wu-Chou YH, Chen AC, Yueh KC, Chen RS, Lu CS
• Large-scale replication and heterogeneity in Parkinson disease genetic loci.
  Neurology 2012 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou…
• Telomeres and lifestyle factors: roles in cellular aging.
  Mutation research 2011 Lin J, Epel E, Blackburn E
• Generalized chorea in the syndrome of acute bilateral basal ganglia lesions in patients with diabetic uremia.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2011 Lin JJ
• Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.
  The New England journal of medicine 2011 Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, …
• High frequency of multiexonic deletion of the GCH1 gene in a Taiwanese cohort of dopa-response dystonia.
  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010 Wu-Chou YH, Yeh TH, Wang CY, Lin JJ, Huang CC, Chang HC, Lai SC, Chen RS, Weng YH, Huang CL, Lu CS
• A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
  Neurobiology of aging 2009 Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, …
• Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
  Journal of immunological methods 2009 Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E
• Safety/Tolerability and efficacy of rivastigmine in taiwanese patients with Alzheimer's disease: a prospective post-marketing surveillance study.
  Clinical drug investigation 2009 Chiu PY, Dai DE, Hsu HP, Lee C, Lin JJ, Kuo HC, Huang YC, Liu YC, Tsai CP
• 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson's disease.
  Acta neurologica Taiwanica 2007 Lin JJ, Yueh KC, Liu CS, Liu JT, Lin SZ
• Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease.
  Journal of the neurological sciences 2006 Lin JJ, Yueh KC, Lin SZ, Harn HJ, Liu JT
• Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
  Pharmacogenetics and genomics 2006 Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT
• Homozygous deletion genotype of angiotensin converting enzyme confers protection against migraine in man.
  Acta neurologica Taiwanica 2005 Lin JJ, Wang PJ, Chen CH, Yueh KC, Lin SZ, Harn HJ
• Lumbar zygapophyseal joint injections in patients with chronic lower back pain.
  Journal of the Chinese Medical Association : JCMA 2005 Shih C, Lin GY, Yueh KC, Lin JJ
• Camptocormia in Parkinson's disease.
  Acta neurologica Taiwanica 2004 Lin JJ
• Improvement of generalised dystonia by olanzapine treatment.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2004 Lin JJ, Chang DC
• The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients.
  Journal of the neurological sciences 2003 Lin JJ, Yueh KC, Chang DC, Chang CY, Yeh YH, Lin SZ
• Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease.
  Journal of the neurological sciences 2002 Lin JJ, Yueh KC, Chang DC, Lin SZ