Juan Qin, PhD
Associate Researcher
Medicine
School of Medicine

1. Immune-Mediated Cardiotoxicity and Cardio-Oncology:

• Investigating the mechanisms and management strategies of myocarditis associated with immune checkpoint inhibitors.
• Evaluating cardiovascular toxicity resulting from various cancer therapies. 2. Cardiac Immunology and Inflammatory Cardiac Diseases:

• Studying the pathogenesis and therapeutic management of inflammatory cardiac diseases, including diverse types of myocarditis.
• Examining the role of immune checkpoints in cardiac homeostasis, ischemic injury, tissue repair, and regeneration.
• Researching immune-mediated cardiac injury and exploring novel therapeutic interventions. 3. Translational Cardiology and Precision Medicine:

• Developing innovative therapeutics for the treatment of immune-related cardiac diseases.
• Utilizing machine learning and multi-omics approaches to facilitate biomarker discovery and improve patient stratification. Dr. Qin employs state-of-the-art techniques, including preclinical models, patient-derived samples, large-scale clinical data, machine learning, and single-cell spatial multi-omics, to elucidate disease mechanisms, identify novel therapeutic targets, and develop advanced therapies. Her interdisciplinary approach bridges basic immunology with translational cardiology, advancing precision medicine in the fields of cardio-oncology and immune-mediated cardiac diseases.

• Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
  Circulation 2023 Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, He R, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
• HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
  EMBO reports 2023 Yang J, Liu Y, Yin H, Xie S, Zhang L, Dong X, Ni H, Bu W, Ma H, Liu P, Zhu H, Guo R, Sun L, Wu Y, Qin J, Sun B, Li D, Luo HR, Liu M, Xuan C, Zhou J
• Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis.
  Cancer discovery 2023 Salem JE, Bretagne M, Abbar B, Leonard-Louis S, Ederhy S, Redheuil A, Boussouar S, Nguyen LS, Procureur A, Stein F, Fenioux C, Devos P, Gougis P, Dres M, Demoule A, Psimaras D, Lenglet T, Maisonobe T,…
• Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
  bioRxiv : the preprint server for biology 2023 Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, Jimenez J, Parks A, Amrute J, Villanueva A, Liu Y, Lin CY, Mack M, Amancherla K, Moslehi J, Lavine KJ
• Single-Nuclear RNA Sequencing of Endomyocardial Biopsies Identifies Persistence of Donor-Recipient Chimerism With Distinct Signatures in Severe Cardiac Allograft Vasculopathy.
  Circulation. Heart failure 2022 Amancherla K, Qin J, Hulke ML, Pfeiffer RD, Agrawal V, Sheng Q, Xu Y, Schlendorf KH, Lindenfeld J, Shah RV, Freedman JE, Tucker NR, Moslehi J
• T cells specific for α-myosin drive immunotherapy-related myocarditis.
  Nature 2022 Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC, Hanna A, Zhang S, Amancherla K, Tai W, Wright JJ, Wei SC, Opalenik SR, Toren AL, Rathmell JC, …
• Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis.
  Science translational medicine 2022 Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, …
• Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, Xie S, Zhang X, Liu L, Liu M, Zhou J
• RNA-Sequencing Reveals a Distinct Transcriptomic Signature for Giant Cell Myocarditis and Identifies Novel Druggable Targets.
  Circulation research 2021 Amancherla K, Qin J, Wang Y, Axelrod ML, Balko JM, Schlendorf KH, Hoffman RD, Xu Y, Lindenfeld J, Moslehi J
• Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development.
  Journal of cellular physiology 2017 Qin J, Yang Y, Gao S, Liu Y, Yu F, Zhou Y, Lyu R, Liu M, Liu X, Li D, Zhou J
• Apoptosis-linked gene 2 promotes breast cancer growth and metastasis by regulating the cytoskeleton.
  Oncotarget 2017 Qin J, Li D, Zhou Y, Xie S, Du X, Hao Z, Liu R, Liu X, Liu M, Zhou J
• Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer.
  The American journal of pathology 2017 Shi X, Li D, Wang Y, Liu S, Qin J, Wang J, Ran J, Zhang Y, Huang Q, Liu X, Zhou J, Liu M
• Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.
  Oncotarget 2016 Ran J, Yu F, Qin J, Zhang Y, Yang Y, Li D, Zhou J, Liu M
• Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization.
  Scientific reports 2016 Xie S, Qin J, Liu S, Zhang Y, Wang J, Shi X, Li D, Zhou J, Liu M
• Identification of novel microtubule-binding proteins by taxol-mediated microtubule stabilization and mass spectrometry analysis.
  Thoracic cancer 2015 He X, Liu Z, He Q, Qin J, Liu N, Zhang L, Li D, Zhou J, Shui W, Liu M
• Lonafarnib is a potential inhibitor for neovascularization.
  PloS one 2015 Sun L, Xie S, Peng G, Wang J, Li Y, Qin J, Zhong D
• Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal region.
  Cell & bioscience 2014 Zhang L, Qin J, Li Y, Wang J, He Q, Zhou J, Liu M, Li D