Juan Irwin, MD, PhD
Recall NFA
Ob/Gyn, Reproductive Sciences
School of Medicine
Publications (36)
Top publication keywords:
FibroblastsSingle-Cell AnalysisEpithelial CellsProgestinsEndometriosisCervix UteriAtlases as TopicCell CommunicationAdenomyosisStromal CellsEndometriumCellsTranscriptomeProgesteroneGene Expression Regulation
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Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach.
iScience 2024 Oskotsky TT, Bhoja A, Bunis D, Le BL, Tang AS, Kosti I, Li C, Houshdaran S, Sen S, Vallvé-Juanico J, Wang W, Arthurs E, Govil A, Mahoney L, Lang L, Gaudilliere B, Stevenson DK, Irwin JC, Giudice LC, … -
ENDOMETRIAL SUBCELLULAR ALTERATIONS IN ENDOMETRIOSIS IDENTIFIED BY SINGLE-CELL ANALYSIS ACROSS THE MENSTRUAL CYCLE.
Fertility and Sterility 2023 Ana Laura Almonte, Wanxin Wang, Emily Flynn, Sahar Houshdaran, Júlia Vallvé-Juanico, Juan Irwin, Divyashree Kushnoor, Alexis Combes, Gabriela K. Fragiadakis, Marina Sirota, Linda C. Giudice -
Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function.
Communications biology 2023 Mortlock S, Houshdaran S, Kosti I, Rahmioglu N, Nezhat C, Vitonis AF, Andrews SV, Grosjean P, Paranjpe M, Horne AW, Jacoby A, Lager J, Opoku-Anane J, Vo KC, Manvelyan E, Sen S, Ghukasyan Z, Collins F,… -
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.
Nature genetics 2023 Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, … -
Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.
Reproductive biomedicine online 2022 Zhai J, Li S, Sen S, Vallvé-Juanico J, Irwin JC, Vo KC, Wan J, Du Y, Chen ZJ, Giudice LC
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The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
Science (New York, N.Y.) 2022 Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, … -
Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood.
BMC medicine 2022 Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC -
Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis.
Frontiers in immunology 2022 Bunis DG, Wang W, Vallvé-Juanico J, Houshdaran S, Sen S, Ben Soltane I, Kosti I, Vo KC, Irwin JC, Giudice LC, Sirota M -
Patterns of sex hormone receptor expression in stimulated endometrium from oocyte donors.
Human fertility (Cambridge, England) 2021 Manvelyan E, Houshdaran S, Irwin JC, Giudice LC, Aghajanova L -
Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions.
International journal of molecular sciences 2020 Houshdaran S, Chen JC, Vallvé-Juanico J, Balayan S, Vo KC, Smith-McCune K, Greenblatt RM, Irwin JC, Giudice LC -
A Pilot Cancer-Phenome Biobanking System in a Low-Resource Southeast Asian Setting: The Philippine General Hospital Biobank Experience.
Biopreservation and biobanking 2020 Sajo MEJV, Teves JMY, Corachea AJM, Diaz LA, Chan AFO, Valparaiso AP, Dy Echo AVV, Macalindong SS, Uy GLB, Dofitas RB, Habana MAE, Gerona RR, Irwin JC, Giudice LC, Velarde MC -
In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration.
Journal of assisted reproduction and genetics 2018 Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, Giudice LC -
Effects of noncavity-distorting fibroids on endometrial gene expression and function.
Biology of reproduction 2017 Aghajanova L, Houshdaran S, Irwin JC, Giudice LC -
Estrogen and progesterone receptors show distinct patterns in differentendometrial cells of oocyte donors after ovarian stimulation.
Fertility and Sterility 2017 E. Manvelyan, L. Aghajanova, S. Houshdaran, J. Irwin, L.C. Giudice -
Stromal fibroblasts from perimenopausal endometrium exhibit a different transcriptome than those from the premenopausal endometrium.
Biology of reproduction 2017 Erikson DW, Barragan F, Piltonen TT, Chen JC, Balayan S, Irwin JC, Giudice LC -
Platelets for endometrial regeneration: a novel approach.
Fertility and Sterility 2016 L. Aghajanova, S. Houshdaran, S. Balayan, J. Irwin, H. Huddleston, L. Giudice -
Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis.
Biology of reproduction 2016 Houshdaran S, Nezhat CR, Vo KC, Zelenko Z, Irwin JC, Giudice LC -
Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis.
Biology of reproduction 2016 Barragan F, Irwin JC, Balayan S, Erikson DW, Chen JC, Houshdaran S, Piltonen TT, Spitzer TL, George A, Rabban JT, Nezhat C, Giudice LC -
Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity.
Fertility and sterility 2015 Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC -
Mid-secretory eutopic endometrium in intramural fibroids and severe endometriosis: relevance to fertility.
Fertility and Sterility 2015 L. Aghajanova, J. Irwin, L.C. Giudice -
Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study.
PloS one 2015 Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC -
Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix.
Reproductive sciences (Thousand Oaks, Calif.) 2015 Goldfien GA, Barragan F, Chen J, Takeda M, Irwin JC, Perry J, Greenblatt RM, Smith-McCune KK, Giudice LC -
Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract.
AIDS Research and Human Retroviruses 2014 Karen Smith-McCune, Joseph Chen, Ruth Greenblatt, Barbara Shacklett, Uma Shanmugasundaram, Joan Hilton, Brittni Johnson, Fatima Barragan, Juan Irwin, Margaret Takeda, Jane Pannell, Jean Perry, Linda … -
Molecular classification of endometriosis and disease stage using high-dimensional genomic data.
Endocrinology 2014 Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Burney RO, Nezhat C, DePaolo LV, Giudice LC -
Ovarian hormones induce differential DNA methylome in decidualizing versus non-decidualizing fibroblasts in patients with endometriosis.
Fertility and Sterility 2014 S. Houshdaran, J.C. Irwin, L.C. Giudice -
Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation.
Molecular endocrinology (Baltimore, Md.) 2014 Houshdaran S, Zelenko Z, Irwin JC, Giudice LC -
Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
Human reproduction (Oxford, England) 2014 Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR -
Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis.
Journal of Endometriosis and Pelvic Pain Disorders 2014 David W. Erikson, Joseph C. Chen, Terhi T. Piltonen, Marco Conti, Juan C. Irwin, Linda C. Giudice -
Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production.
Fertility and sterility 2013 Chen JC, Erikson DW, Piltonen TT, Meyer MR, Barragan F, McIntire RH, Tamaresis JS, Vo KC, Giudice LC, Irwin JC -
Aberrant steroid hormone response and increased pro-inflammatory cytokine secretion in endometrial stromal fibroblasts from women with PCOS.
Fertility and Sterility 2012 T.T. Piltonen, J. Chen, T.L.B. Spitzer, J.C. Irwin, L.C. Giudice -
Human endometrial co-culture system reveals novel cell-specific effects of nonoxynol-9 on endometrial transcriptome and chemokine secretion.
Fertility and Sterility 2012 J.C. Chen, D.W. Erikson, F. Barragan, J.C. Irwin, W.C. Greene, L.C. Giudice -
Pro-inflammatory effects of seminal plasma on human endometrium: implications for implantation and human immunodeficiency virus (HIV) transmission.
Fertility and Sterility 2012 B.A. Johnson, J. Chen, N. Roan, F. Barragan, J. Irwin, L.C. Giudice -
Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype.
Biology of reproduction 2012 Spitzer TL, Rojas A, Zelenko Z, Aghajanova L, Erikson DW, Barragan F, Meyer M, Tamaresis JS, Hamilton AE, Irwin JC, Giudice LC -
Comparative transcriptome analysis of human trophectoderm and embryonic stem cell-derived trophoblasts reveal key participants in early implantation.
Biology of reproduction 2012 Aghajanova L, Shen S, Rojas AM, Fisher SJ, Irwin JC, Giudice LC -
Effects of Nonoxynol-9 on Endometrial Cytokine Secretion Using an In Vitro Co-Culture System in HIV-Negative Women.
Biology of Reproduction 2011 Joseph C. Chen, Juan C. Irwin, Michelle R. Meyer, Ramsey H. McIntire, Zara Zelenko, John S. Tamaresis, Kim Chi Vo, Linda C. Giudice -
Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development.
Fertility and sterility 2011 Sheldon E, Vo KC, McIntire RA, Aghajanova L, Zelenko Z, Irwin JC, Giudice LC