Joshua Combs, PhD
Postdoctoral Scholar
Cellular Molecular Pharmacology
School of Medicine

Publications (5)

Top publication keywords:
VirulenceAcyl-ButyrolactonesAcinetobacter InfectionsPseudomonas InfectionsBacterial ProteinsLigandsHomocysteineRepressor ProteinsQuorum SensingSmall Molecule LibrariesAcinetobacter baumanniiPseudomonas aeruginosaTrans-Activators4-ButyrolactoneDose-Response Relationship, Drug

• Correction to "N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa".
  ACS chemical biology 2020 Boursier ME, Combs JB, Blackwell HE
• N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa.
  ACS chemical biology 2019 Boursier ME, Combs JB, Blackwell HE
• Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR.
  ACS chemical biology 2018 Boursier ME, Moore JD, Heitman KM, Shepardson-Fungairino SP, Combs JB, Koenig LC, Shin D, Brown EC, Nagarajan R, Blackwell HE
• A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence.
  Bioorganic & medicinal chemistry 2018 Boursier ME, Manson DE, Combs JB, Blackwell HE
• Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling.
  ACS chemical biology 2017 Gerdt JP, Wittenwyler DM, Combs JB, Boursier ME, Brummond JW, Xu H, Blackwell HE