Joshua Berke, PhD
Professor
Neurology
School of Medicine

Josh Berke's laboratory at UCSF investigates brain mechanisms involved in learning, motivation and decision-making, and how these mechanisms go awry in disorders such as drug addiction, Parkinson's Disease and Huntington's Disease. (see www.berkelab.org). He is also Director of the Alcohol and Addiction Research Group, and holds the Rudi Schmid Distinguished Professorship in Neurology.

Websites

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• Berke Lab (berkelab.org)

Grants and Projects

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• Striatal Microcircuit Dynamics, NIH, 2021-2026
• Neural mechanisms linking need to reward, NIH, 2020-2023
• Dopaminergic mechanisms for motivation and reinforcement learning, NIH, 2018-2023
• Dopaminergic mechanisms for motivation and reinforcement learning, NIH/NIDA, 2018-2023
• Assessment of Striatal Indirect Pathway Function in Normal and HD Rats, CHDI, 2018-2021
• Encoding and regulation of compulsion-like alcohol drinking by subtypes of nucleus accumbens core neurons, NIH, 2018-2020
• Carbon Thread Arrays for High Resolution Multi-Modal Analysis of Microcircuits, NIH, 2015-2019
• Basal Ganglia Pathways for Stopping and Switching, NIH, 2013-2018
• Striatal Microcircuits: Regulation and Function, NIH, 2012-2018
• Reinforcement Learning and Striatal Patch/Matrix Architecture, NIH, 2011-2014
• Combining optogenetics and electrophysiology to dissect accumbens microcircuits, NIH, 2011-2014
• Multiple Memory Systems in Action Selection, NIH, 2001-2007
• Striatal and Hippocampal Representations of Habits, NIH, 2000-1900

Publications (71)

Top publication keywords:
Dopaminergic NeuronsGlobus PallidusRewardSubstantia NigraBehavior, AnimalInterneuronsAction PotentialsRatsCorpus StriatumBasal GangliaRats, Long-EvansPars ReticulataDopamineLearningMotivation

• Dopamine transients follow a striatal gradient of reward time horizons.
  Nature neuroscience 2024 Mohebi A, Wei W, Pelattini L, Kim K, Berke JD
• Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.
  bioRxiv : the preprint server for biology 2024 Taniguchi J, Melani R, Chantranupong L, Wen MJ, Mohebi A, Berke J, Sabatini B, Tritsch N
• Selective encoding of reward predictions and prediction errors by globus pallidus subpopulations.
  Current biology : CB 2023 Farries MA, Faust TW, Mohebi A, Berke JD
• Dual credit assignment processes underlie dopamine signals in a complex spatial environment.
  Neuron 2023 Krausz TA, Comrie AE, Kahn AE, Frank LM, Daw ND, Berke JD
• Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation.
  eLife 2023 Mohebi A, Collins VL, Berke JD

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• Dual credit assignment processes underlie dopamine signals in a complex spatial environment.
  bioRxiv : the preprint server for biology 2023 Krausz TA, Comrie AE, Frank LM, Daw ND, Berke JD
• Altered basal ganglia output during self-restraint.
  eLife 2022 Gu BM, Berke JD
• Dopamine subsystems that track internal states.
  Nature 2022 Grove JCR, Gray LA, La Santa Medina N, Sivakumar N, Ahn JS, Corpuz TV, Berke JD, Kreitzer AC, Knight ZA
• Coupling between motor cortex and striatum increases during sleep over long-term skill learning.
  eLife 2021 Lemke SM, Ramanathan DS, Darevksy D, Egert D, Berke JD, Ganguly K
• Improved inference in coupling, encoding, and decoding models and its consequence for neuroscientific interpretation.
  Journal of neuroscience methods 2021 Sachdeva PS, Livezey JA, Dougherty ME, Gu BM, Berke JD, Bouchard KE
• High density carbon fiber arrays for chronic electrophysiology, fast scan cyclic voltammetry, and correlative anatomy.
  Journal of neural engineering 2020 Patel PR, Popov P, Caldwell CM, Welle EJ, Egert D, Pettibone JR, Roossien DH, Becker JB, Berke JD, Chestek CA, Cai D
• Cellular-scale silicon probes for high-density, precisely localized neurophysiology.
  Journal of neurophysiology 2020 Egert D, Pettibone JR, Lemke S, Patel PR, Caldwell CM, Cai D, Ganguly K, Chestek CA, Berke JD
• An expanded palette of dopamine sensors for multiplex imaging in vivo.
  Nature methods 2020 Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L
• Globus pallidus dynamics reveal covert strategies for behavioral inhibition.
  eLife 2020 Gu BM, Schmidt R, Berke JD
• The Degree of Nesting between Spindles and Slow Oscillations Modulates Neural Synchrony.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Silversmith DB, Lemke SM, Egert D, Berke JD, Ganguly K
• Dopamine release drives motivation, independently from dopamine cell firing.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Mohebi A, Berke JD
• Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci.
  eNeuro 2019 Pettibone JR, Yu JY, Derman RC, Faust TW, Hughes ED, Filipiak WE, Saunders TL, Ferrario CR, Berke JD
• Publisher Correction: Dissociable dopamine dynamics for learning and motivation.
  Nature 2019 Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD
• Dissociable dopamine dynamics for learning and motivation.
  Nature 2019 Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD
• What does dopamine mean?
  Nature neuroscience 2018 Berke JD
• Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning.
  Cell 2018 Owen SF, Berke JD, Kreitzer AC
• Sensorimotor Processing in the Basal Ganglia Leads to Transient Beta Oscillations during Behavior.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mirzaei A, Kumar A, Leventhal D, Mallet N, Aertsen A, Berke J, Schmidt R
• (Invited) Carbon Fiber Electrode Array for the Detection of Electrophysiological and Dopaminergic Activity.
  ECS Meeting Abstracts 2017 Paras R. Patel, Pavlo Popov, Ali Mohebi, Arif Hamid, Jeffrey Pettibone, Doug Roossien, Brandon Aragona, Dawen Cai, Joshua Berke, Cynthia Chestek
• A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2017 Schmidt R, Berke JD
• Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Howe WM, Gritton HJ, Lusk NA, Roberts EA, Hetrick VL, Berke JD, Sarter M
• Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.
  PLoS computational biology 2016 Angulo-Garcia D, Berke JD, Torcini A
• Arkypallidal Cells Send a Stop Signal to Striatum.
  Neuron 2016 Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD
• Cortical cholinergic signaling controls the detection of cues.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Gritton HJ, Howe WM, Mallory CS, Hetrick VL, Berke JD, Sarter M
• Cell assembly dynamics of sparse inhibitory networks: a simple model for the activity of the Medium Spiny Neurons.
  BMC Neuroscience 2015 David Angulo-Garcia, Alessandro Torcini, Joshua D Berke
• Mesolimbic dopamine signals the value of work.
  Nature neuroscience 2015 Hamid AA, Pettibone JR, Mabrouk OS, Hetrick VL, Schmidt R, Vander Weele CM, Kennedy RT, Aragona BJ, Berke JD
• Silk-Backed Structural Optimization of High-Density Flexible Intracortical Neural Probes.
  Journal of Microelectromechanical Systems 2015 Fan Wu, Lee W. Tien, Fujun Chen, Joshua D. Berke, David L. Kaplan, Euisik Yoon
• Silk-backed structural optimization of high-density flexible intracortical neural probes
  IEEE Journal on Microelectromechanical Systems 2015 Wu F, Tien LW, Chen F, Berke J, Kaplan DL, Yoon E.
• New roles for the external globus pallidus in basal ganglia circuits and behavior.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Gittis AH, Berke JD, Bevan MD, Chan CS, Mallet N, Morrow MM, Schmidt R
• Dissociable effects of dopamine on learning and performance within sensorimotor striatum.
  Basal ganglia 2014 Leventhal DK, Stoetzner C, Abraham R, Pettibone J, DeMarco K, Berke JD
• Control of basal ganglia output by direct and indirect pathway projection neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC
• Canceling actions involves a race between basal ganglia pathways.
  Nature neuroscience 2013 Schmidt R, Leventhal DK, Mallet N, Chen F, Berke JD
• Basal ganglia beta oscillations accompany cue utilization.
  Neuron 2012 Leventhal DK, Gage GJ, Schmidt R, Pettibone JR, Case AC, Berke JD
• Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Gittis AH, Leventhal DK, Fensterheim BA, Pettibone JR, Berke JD, Kreitzer AC
• Investigating striatal function through cell-type-specific manipulations.
  Neuroscience 2011 Kreitzer AC, Berke JD
• Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.
  Frontiers in systems neuroscience 2011 Klaus A, Planert H, Hjorth JJ, Berke JD, Silberberg G, Kotaleski JH
• Functional properties of striatal fast-spiking interneurons.
  Frontiers in systems neuroscience 2011 Berke JD
• Integrating early results on ventral striatal gamma oscillations in the rat.
  Frontiers in neuroscience 2010 van der Meer MA, Kalenscher T, Lansink CS, Pennartz CM, Berke JD, Redish AD
• Selective activation of striatal fast-spiking interneurons during choice execution.
  Neuron 2010 Gage GJ, Stoetzner CR, Wiltschko AB, Berke JD
• Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats.
  PloS one 2010 Chang CH, Berke JD, Maren S
• Memory formation: from network structure to neural dynamics.
  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2010 Feldt S, Wang JX, Hetrick VL, Berke JD, Zochowski M
• Local dynamics of gap-junction-coupled interneuron networks.
  Physical biology 2010 Lau T, Gage GJ, Berke JD, Zochowski M
• Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Wiltschko AB, Pettibone JR, Berke JD
• State-dependent plasticity of the corticostriatal pathway.
  Neuroscience 2009 Stoetzner CR, Pettibone JR, Berke JD
• Corticostriatal Interactions during Learning, Memory Processing, and Decision Making.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Pennartz CM, Berke JD, Graybiel AM, Ito R, Lansink CS, van der Meer M, Redish AD, Smith KS, Voorn P
• Striatal interneurons and reward prediction errors (Commentary on Apicella et al.).
  The European journal of neuroscience 2009 Berke JD
• Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs.
  The European journal of neuroscience 2009 Berke JD
• Functional clustering algorithm for the analysis of dynamic network data.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2009 Feldt S, Waddell J, Hetrick VL, Berke JD, Zochowski M
• Striatal versus hippocampal representations during win-stay maze performance.
  Journal of neurophysiology 2009 Berke JD, Breck JT, Eichenbaum H
• Procedural Learning: Striatum.
  Encyclopedia of Neuroscience 2009 J.D. Berke
• Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Berke JD
• Functional structure from dynamic clustering of spike train data.
  BMC Neuroscience 2008 Sarah Feldt, Jack Waddell, Vaughn L Hetrick, Joshua D Berke, Michal Zochowski
• Wavelet filtering before spike detection preserves waveform shape and enhances single-unit discrimination.
  Journal of neuroscience methods 2008 Wiltschko AB, Gage GJ, Berke JD
• Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments.
  Hippocampus 2008 Berke JD, Hetrick V, Breck J, Greene RW
• The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.
  Biochemical and biophysical research communications 2006 Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE
• Participation of Striatal Neurons in Large-Scale Oscillatory Networks.
  The Basal Ganglia VIII 2005 Joshua D. Berke
• Oscillatory Entrainment of Striatal Neurons in Freely Moving Rats.
  Neuron 2004 Joshua D. Berke, Murat Okatan, Jennifer Skurski, Howard B. Eichenbaum
• Oscillatory entrainment of striatal neurons in freely moving rats.
  Neuron 2004 Berke JD, Okatan M, Skurski J, Eichenbaum HB
• Analysis of mRNA expression in striatal tissue by differential display polymerase chain reaction.
  Methods in molecular medicine 2003 Berke JD
• Learning and memory mechanisms involved in compulsive drug use and relapse.
  Methods in molecular medicine 2003 Berke JD
• Drug addiction and the hippocampus.
  Science (New York, N.Y.) 2001 Berke JD, Eichenbaum HB
• Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.
  Neuron 2001 Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE
• Addiction, dopamine, and the molecular mechanisms of memory.
  Neuron 2000 Berke JD, Hyman SE
• A complex program of striatal gene expression induced by dopaminergic stimulation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR
• Acute effects of cocaine on human brain activity and emotion.
  Neuron 1997 Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE
• Molecular adaptations to psychostimulants in striatal neurons: toward a pathophysiology of addiction.
  Neurobiology of disease 1997 Genova L, Berke J, Hyman SE
• Activation of striatum and amygdala during reward conditioning: An FMRI study.
  NeuroImage 1996 H.C. Breiter, J.D. Berke, W.A. Kennedy, B.R. Rosen, S.E. Hyman