Joshua Barrios, PhD
Assistant Professor
Medicine
School of Medicine

Current projects include building foundation models for cardiovascular signals, developing scalable multimodal architectures for clinical data, and designing computational methods that can generalize across heterogeneous patient populations. Dr. Barrios is actively involved in mentoring students and trainees from computational, engineering, and biomedical backgrounds, and welcomes interdisciplinary collaboration.

• Foundation models for generalizable electrocardiogram interpretation: comparison of supervised and self-supervised electrocardiogram foundation models.
  medRxiv : the preprint server for health sciences 2025 Nolin-Lapalme A, Sowa A, Delfrate J, Tastet O, Corbin D, Kulbay M, Ozdemir D, Noël MJ, Marois-Blanchet FC, Harvey F, Sharma S, Ansari M, Chiu IM, Dsouza V, Friedman SF, Chassé M, Potter BJ, Afilalo J,…
• Oxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum.
  Current biology : CB 2024 Penalva-Tena A, Bedke J, Gaudin A, Barrios JP, Bertram EPL, Douglass AD
• Automated Assessment of Right Atrial Pressure From Ultrasound Videos Using Machine Learning.
  JACC. Advances 2024 Yurk D, Barrios JP, Labrecque Langlais E, Avram R, Aras MA, Abu-Mostafa Y, Padmanabhan A, Tison GH
• Genetics of Cardiac Aging Implicate Organ-Specific Variation.
  medRxiv : the preprint server for health sciences 2024 Brundage J, Barrios JP, Tison GH, Pirruccello JP
• Artificial Intelligence to Complement, Not Replace, Clinical Knowledge: Reading Between the Lines.
  JACC. CardioOncology 2024 Barrios JP, Seshadri MR, Tison GH
• Continuous Atrial Fibrillation Monitoring From Photoplethysmography: Comparison Between Supervised Deep Learning and Heuristic Signal Processing.
  JACC. Clinical electrophysiology 2024 Antiperovitch P, Mortara D, Barrios J, Avram R, Yee K, Khaless AN, Cristal A, Tison G, Olgin J
• Patient-Level Artificial Intelligence-Enhanced Electrocardiography in Hypertrophic Cardiomyopathy: Longitudinal Treatment and Clinical Biomarker Correlations.
  JACC. Advances 2023 Siontis KC, Abreau S, Attia ZI, Barrios JP, Dewland TA, Agarwal P, Balasubramanyam A, Li Y, Lester SJ, Masri A, Wang A, Sehnert AJ, Edelberg JM, Abraham TP, Friedman PA, Olgin JE, Noseworthy PA, Tison…
• CathAI: fully automated coronary angiography interpretation and stenosis estimation.
  NPJ digital medicine 2023 Avram R, Olgin JE, Ahmed Z, Verreault-Julien L, Wan A, Barrios J, Abreau S, Wan D, Gonzalez JE, Tardif JC, So DY, Soni K, Tison GH
• Identifying Mitral Valve Prolapse at Risk for Arrhythmias and Fibrosis From Electrocardiograms Using Deep Learning.
  JACC. Advances 2023 Tison GH, Abreau S, Barrios J, Lim LJ, Yang M, Crudo V, Shah DJ, Nguyen T, Hu G, Dixit S, Nah G, Arya F, Bibby D, Lee Y, Delling FN
• Identification of supraventricular tachycardia mechanisms with surface electrocardiograms using a convolutional neural network.
  Heart rhythm O2 2023 Higuchi S, Li R, Gerstenfeld EP, Liem LB, Im SI, Kalantarian S, Ansari M, Abreau S, Barrios J, Scheinman MM, Tison GH
• Automated Assessment of Cardiac Systolic Function From Coronary Angiograms With Video-Based Artificial Intelligence Algorithms.
  JAMA cardiology 2023 Avram R, Barrios JP, Abreau S, Goh CY, Ahmed Z, Chung K, So DY, Olgin JE, Tison GH
• Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury.
  Scientific reports 2023 Chaudhari GR, Mayfield JJ, Barrios JP, Abreau S, Avram R, Olgin JE, Tison GH
• Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning.
  Journal of cardiac failure 2023 Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH
• Advancing cardiovascular medicine with machine learning: Progress, potential, and perspective.
  Cell reports. Medicine 2022 Barrios JP, Tison GH
• Worldwide physical activity trends since COVID-19 onset.
  The Lancet. Global health 2022 Tison GH, Barrios J, Avram R, Kuhar P, Bostjancic B, Marcus GM, Pletcher MJ, Olgin JE
• Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease.
  Journal of the American College of Cardiology 2022 Elias P, Poterucha TJ, Rajaram V, Moller LM, Rodriguez V, Bhave S, Hahn RT, Tison G, Abreau SA, Barrios J, Torres JN, Hughes JW, Perez MV, Finer J, Kodali S, Khalique O, Hamid N, Schwartz A, Homma S, …
• Regenerated interneurons integrate into locomotor circuitry following spinal cord injury.
  Experimental neurology 2021 Vasudevan D, Liu YC, Barrios JP, Wheeler MK, Douglass AD, Dorsky RI
• Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish.
  Current biology : CB 2020 Barrios JP, Wang WC, England R, Reifenberg E, Douglass AD
• Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets.
  Nature neuroscience 2019 Wee CL, Nikitchenko M, Wang WC, Luks-Morgan SJ, Song E, Gagnon JA, Randlett O, Bianco IH, Lacoste AMB, Glushenkova E, Barrios JP, Schier AF, Kunes S, Engert F, Douglass AD
• Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival.
  Journal of neurogenetics 2018 Julien DP, Chan AW, Barrios J, Mathiaparanam J, Douglass A, Wolman MA, Sagasti A
• The Midline Axon Crossing Decision Is Regulated through an Activity-Dependent Mechanism by the NMDA Receptor.
  eNeuro 2018 Gao J, Stevenson TJ, Douglass AD, Barrios JP, Bonkowsky JL
• Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.
  Current biology : CB 2016 McPherson AD, Barrios JP, Luks-Morgan SJ, Manfredi JP, Bonkowsky JL, Douglass AD, Dorsky RI
• Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons.
  Scientific reports 2016 Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL
• Chromatin insulator bodies are nuclear structures that form in response to osmotic stress and cell death.
  The Journal of cell biology 2013 Schoborg T, Rickels R, Barrios J, Labrador M